Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k...Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.展开更多
SnS has emerged as an attractive catalyst for the electrochemical CO_(2)reduction reaction(CO_(2)RR)to formate,while its long-term operational stability is hindered by the self-reduction of Sn^(2+) and sulfur dissolut...SnS has emerged as an attractive catalyst for the electrochemical CO_(2)reduction reaction(CO_(2)RR)to formate,while its long-term operational stability is hindered by the self-reduction of Sn^(2+) and sulfur dissolution.Thus,maintaining high current efficiency across a wide negative potential range to achieve high production rates of formate remains a significant challenge.In this study,we present a heterostructure constructed with SnS and CuS for efficient CO_(2)RR to formate.The SnS-CuS(30)exhibits a remarkable formate Faradaic efficiency(FE_(f))of 93.94%at−1 V vs.reversible hydrogen electrode(RHE)and demonstrates long-term stability for 7.5 h,maintaining high activity(with an average FE_(f)of 85.6%)across a wide negative potential range(from-0.8 to-1.2 V(vs.RHE)).The results reveal that the heterogeneous interface between SnS and CuS mitigates the self-reduction issue of SnS by sacrificing Cu^(2+),highlighting that the true active species is SnS,which effectively resists structural changes during the electrolysis process under the protection of CuS.The synergistic interaction within the CuS and SnS heterostructure,combined with the tendency for electron self-conduction,enables the catalyst to maintain high formate activity and selectivity across a wide potential range.Furthermore,theoretical results further indicate that the incorporation of CuS enhances CO_(2)adsorption and lowers the energy barrier for the formation of formate intermediates.This study inspires the concept of applying protective layers to active species,promoting high selectivity in Sn-based electrocatalysts.展开更多
Stem-leaf saponins from Panax notoginseng(SLSP)comprise numerous PPD-type saponins with diverse pharmacological properties;however,their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinf...Stem-leaf saponins from Panax notoginseng(SLSP)comprise numerous PPD-type saponins with diverse pharmacological properties;however,their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation,remains unclear.This study evaluated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models,including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia.Our findings revealed that SLSP mitigated behavioral impairments and excessive microglial activation in models of PD,including MPTP-treated mice.Additionally,SLSP inhibited the upregulation of inducible nitric oxide synthase(i NOS)and cyclooxygenase-2(COX2)and attenuated the phosphorylation of PI3K,protein kinase B(AKT),nuclear factor-κB(NFκB),and inhibitor of NFκB proteinα(IκBα)both in vivo and in vitro.Moreover,SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β,IL-6,and tumor necrosis factor alpha(TNF-α)in LPS-stimulated BV-2cells.Notably,the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPStreated BV-2 cells.These results suggest that SLSP inhibit microglia-mediated neuroinflammation in experimental PD models,likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway.These novel findings indicate that SLSP may offer therapeutic potential for PD by attenuating microglia-mediated neuroinflammation.展开更多
BACKGROUND Cox health behavior interventions combined with psychological care have the potential to improve recovery outcomes and psychological well-being in patients with hypertensive cerebral hemorrhage accompanied ...BACKGROUND Cox health behavior interventions combined with psychological care have the potential to improve recovery outcomes and psychological well-being in patients with hypertensive cerebral hemorrhage accompanied by mental disorders.AIM To explore the impact of combining the Cox Health Behavior Interaction Model with multifaceted psychological nursing in patients with hypertensive intracerebral hemorrhage(ICH)complicated by mental disorders and to provide a reference for the nursing intervention in patients with hypertensive ICH.METHODS Overall,128 patients with hypertensive ICH complicated by mental disorders who were admitted to the Affiliated Hospital of Nantong University between January 2022 and December 2024 were divided into groups using a random number table.The control group(n=64)received multifaceted psychological nursing,and the observation group(n=64)received the Cox Health Behavior Interaction Model intervention based on multifaceted psychological nursing.The mental state,psychological resilience,self-efficacy,and quality of life of the two groups were compared.RESULTS Post-intervention,the mental states of anxiety and depression in the observation group(38.82±3.67 points and 35.14±2.75 points,respectively)were lower than those in the control group(46.96±5.12 points and 41.36±3.71 points,respectively),and the psychological resilience levels(tenacity,self-improvement,and optimism)were higher than those in the control group(P<0.05).Postintervention,the General Self-Efficacy Scale score in the observation group(31.75±2.75 points)was higher than that in the control group(26.76±2.93 points),and the physical health-and social and mental health-related quality of life were both higher than those in the control group(P<0.05).CONCLUSION Combining the Cox Health Behavior Interaction Model with multifaceted psychological nursing for patients with hypertensive ICH and mental disorders relieves anxiety and depression and improves resilience,self-efficacy,and quality of life.展开更多
Anode-free sodium metal batteries(AFSMBs)have gained attention as next-generation storage systems with high energy density and cost-effectiveness.However,non-uniform sodium(Na)deposition and an unsteady solid electrol...Anode-free sodium metal batteries(AFSMBs)have gained attention as next-generation storage systems with high energy density and cost-effectiveness.However,non-uniform sodium(Na)deposition and an unsteady solid electrolyte interphase(SEI)lead to dendrite-related issues and severe irreversible Na^(+)plating/stripping,greatly aggravating their cycle deterioration.In this study,we effectively modified the 3D current collector's electronic structure by introducing Zn-N_(x)active sites(Zn-CNF),which enhances lateral Na^(+)diffusion and the Na planar growth,enabling uniform deep Na deposition at an exceptionally high capacity of 10 mA h cm^(-2).Furthermore,the Zn-N_(x)bonds enhance the adsorption capacity of PF6and contribute to forming a stable inorganic-rich SEI layer.Consequently,Zn-CNF with the electronic structure regulation endows an ultra-low nucleation overpotential(8 mV)and ultra-high Coulombic efficiency of 99.94%over 1,600 cycles.Symmetric cells demonstrate stable Na^(+)plating/stripping behavior for more than 4,400 h at 1 mA cm^(-2).Moreover,under high cathode loading(7.97 mg cm^(-2)),the AFSMBs achieve a high energy density of 374 W h kg^(-1)and retain a high discharge capacity of 82.49 mA h g^(-1)with a capacity retention of 80.4%after 120 cycles.This work proposes a viable strategy to achieving high-energy-density AFSMBs.展开更多
Single-atom catalysts are promising for H_(2)O_(2) photosynthesis from O_(2) and H_(2)O,but their efficiency is still limited by the ill-defined electronic structure.In this study,Co single-atoms with unique four plan...Single-atom catalysts are promising for H_(2)O_(2) photosynthesis from O_(2) and H_(2)O,but their efficiency is still limited by the ill-defined electronic structure.In this study,Co single-atoms with unique four planar N-coordination and one axial P-coordination(Co-N_(4)P_(1))are decorated on the lateral edges of nanorod-like crystalline g-C_(3)N_(4)(CCN)photocatalysts.Significantly,the electronic structures of central Co as active sites for O_(2) reduction reaction(ORR)and planar N-coordinator as active sites for H_(2)O oxidation reaction(WOR)in Co-N_(4)P_(1) can be well regulated by the synergetic effects of introducing axial P-coordinator,in contrast to the decorated Co single-atoms with only four planar N-coordination(Co-N_(4)).Specifically,directional photoelectron accumulation at central Co active sites,induced by an introduced midgap level in Co-N_(4)P_(1),mediates the ORR active sites from 4e–-ORR-selective terminal–NH_(2) sites to 2e–-ORR-selective Co sites,moreover,an elevated d-band center of Co 3d orbital strengthens ORR intermediate*OOH adsorption,thus jointly facilitating a highly selective and active 2e^(–)-ORR pathway to H_(2)O_(2) photosynthesis.Simultaneously,a downshifted p-band center of N_(2)p orbital in Co-N_(4)P_(1) weakens WOR intermediate*OH adsorption,thus enabling a preferable 2e^(–)-WOR pathway toward H_(2)O_(2) photosynthesis.Subsequently,Co-N_(4)P_(1) exhibits exceptional H_(2)O_(2) photosynthesis efficiency,reaching 295.6μmol g^(-1) h^(-1) with a remarkable solar-to-chemical conversion efficiency of 0.32%,which is 15 times that of Co-N_(4)(19.2μmol g^(-1) h^(-1))and 10 times higher than CCN(27.6μmol g^(-1) h^(-1)).This electronic structure modulation on single-atom catalysts offers a promising strategy for boosting the activity and selectivity of H_(2)O_(2) photosynthesis.展开更多
Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy...Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).展开更多
LiMn_(2)O_(4)(LMO) represents one of the most prevalent cathode materials utilized in lithium-ion batteries(LIBs), yet its broader application is often hampered by its limited achievable capacity and significant capac...LiMn_(2)O_(4)(LMO) represents one of the most prevalent cathode materials utilized in lithium-ion batteries(LIBs), yet its broader application is often hampered by its limited achievable capacity and significant capacity degradation during cycling. In this work, a novel dual-doping strategy involving Al^(3+) and Zr^(4+) ions has been employed to refine the atomic structure of LMO's spinel framework. The resultant dual-doped material, Li_(1.06)Mn_(1.97)Zr_(0.01)Al_(0.02)O_(4), exhibits enhanced electrochemical properties, boasting a discharge capacity of 124.9 m Ah/g at a rate of 0.1 C. Furthermore, the formation of stronger Al–O and Zr–O bonds contributes to the stabilization of the delithiated LMO structure. Impressively, 97.7%of its initial capacity is retained after 100 cycles at a 5 C rate. Additionally, enhancements in rate performance and hightemperature cycling stability have also been observed. This study underscores the potential of Al^(3+) and Zr^(4+) dual-doping as a promising approach to enhance LMO cathodes, providing a scalable and efficient means of improving the performance of lithium manganese oxide cathode materials through the incorporation of multiple ions.展开更多
Research on supercontinuum sources on silicon has made significant progress in the past few decades.However,conventional approaches to broaden the spectral bandwidth often rely on complex and critical dispersion engin...Research on supercontinuum sources on silicon has made significant progress in the past few decades.However,conventional approaches to broaden the spectral bandwidth often rely on complex and critical dispersion engineering by optimizing the core thickness or introducing the cladding with special materials and structures.We propose and demonstrate supercontinuum generation using long-periodgrating(LPG)waveguides on silicon with a C-band pump.The LPG waveguide is introduced for quasi-phase matching,and the generated supercontinuum spectrum is improved greatly with grating-induced dispersive waves.In addition,the demonstrated LPG waveguide shows a low propagation loss comparable with regular silicon photonic waveguides without gratings.In experiments,when using a 1550-nm 75-fs pulse pump with a pulse energy of 200 pJ,the supercontinuum spectrum generated with the present LPG waveguide shows an ultrabroad extent from 1150 to 2300 nm,which is much wider by 200 nm than that achieved by dispersionengineered uniform silicon photonic waveguides on the same chip.This provides a promising option for on-chip broadband light source for silicon photonic systems.展开更多
The red clay in Chenzhou, Hunan province is mostly in unsaturated state. Simply applying the mechanical properties that derived from classic saturated soil mechanics often leads to slope failures in this region. In or...The red clay in Chenzhou, Hunan province is mostly in unsaturated state. Simply applying the mechanical properties that derived from classic saturated soil mechanics often leads to slope failures in this region. In order to study the shear strength characteristic of unsaturated red clay in Chenzhou and to explore a shear strength equation that can be easily applied in engineering practice, a series of triaxial tests of saturated and unsaturated red clay samples were performed using the regular triaxial testing apparatus. The testing results show that the peak strength of red clay drops slightly before the moisture content of 30% but decreases sharply after that. The friction angle of red clay under unsaturated state is basically equal to the effective friction angle under saturated state, while the cohesion of unsaturated red clay is far much bigger than that of saturated one, which indicates that the matric suction makes a great contribution to the cohesion. By fitting the testing results with appropriate curves, the relationships between total strength parameters and with moisture content were obtained. The total increases logarithmically before the moisture content of 35% then decreases linearly, while decreases cubically with increasing moisture content.展开更多
From 17 November to 27 December 2022, extremely cold snowstorms frequently swept across North America and Eurasia. Diagnostic analysis reveals that these extreme cold events were closely related to the establishment o...From 17 November to 27 December 2022, extremely cold snowstorms frequently swept across North America and Eurasia. Diagnostic analysis reveals that these extreme cold events were closely related to the establishment of blocking circulations. Alaska Blocking(AB) and subsequent Ural Blocking(UB) episodes are linked to the phase transition of the North Atlantic Oscillation(NAO) and represent the main atmospheric regimes in the Northern Hemisphere. The downstream dispersion and propagation of Rossby wave packets from Alaska to East Asia provide a large-scale connection between AB and UB episodes. Based on the nonlinear multi-scale interaction(NMI) model, we found that the meridional potential vorticity gradient(PVy) in November and December of 2022 was anomalously weak in the mid-high latitudes from North America to Eurasia and provided a favorable background for the prolonged maintenance of UB and AB events and the generation of associated severe extreme snowstorms. However, the difference in the UB in terms of its persistence,location, and strength between November and December is related to the positive(negative) NAO in November(December). During the La Ni?a winter of 2022, the UB and AB events are related to the downward propagation of stratospheric anomalies, in addition to contributions by La Ni?a and low Arctic sea ice concentrations as they pertain to reducing PVyin mid-latitudes.展开更多
Iron(Ⅱ)tetra-(1,4-dithin)-porphyrazine,(FePz(dtn)_(4))is able to activate molecule oxygen for oxygenation degradation of rhodamine B(RhB)in an extensive pH region without light excitation.Experiments indicate that th...Iron(Ⅱ)tetra-(1,4-dithin)-porphyrazine,(FePz(dtn)_(4))is able to activate molecule oxygen for oxygenation degradation of rhodamine B(RhB)in an extensive pH region without light excitation.Experiments indicate that the RhB can be degraded nearly 52%in alkaline aqueous solution,bubbling with dioxygen for seven hours in the presence of FePz(dtn)_(4)and the hydrogen peroxides as an active intermediate were determined by DPD method.The catalyst is recyclable and the catalyst activity was maintained after 10 recycles.展开更多
Collagen protein is an ideal scaffold material for the transplantation of neural stem cells. In this study rat neural stern cells were seeded into a three-dimensional collagen gel scaffold, with suspension cultured ne...Collagen protein is an ideal scaffold material for the transplantation of neural stem cells. In this study rat neural stern cells were seeded into a three-dimensional collagen gel scaffold, with suspension cultured neural stem cells being used as a control group. Neural stem cells, which were cultured in medium containing epidermal growth factor and basic fibroblast growth factor, actively expanded and formed neurospheres in both culture groups. In serum-free medium conditions, the processes extended from neurospheres in the collagen gel group were much longer than those in the suspension culture group. Immunofluorescence staining showed that neurespheres cultured in collagen gels were stained positive for nestin and differentiated cells were stained positive for the neuronal marker βIII-tubulin, the astrocytic marker glial fibrillary acidic protein and the oligodendrocytic marker 2＇,3＇-cyclic nucleotide 3＇-phosphodiesterase. Compared with neurospheres cultured in suspension, the differentiation potential of neural stem cells cultured in collagen gels increased, with the formation of neurons at an early stage. Our results show that the three-dimensional collagen gel culture system is superior to suspension culture in the proliferation, differentiation and process outgrowth of neural stem cells.展开更多
基金funded by grants from the Suzhou Gusu Health Talents Project(grant No.GSWS2024050 to Liu W)Natural Science Foundation Project of Nanjing University of Chinese Medicine(grant No.XZR2021043 to Liu W and grant No.XZR2023021 to Huang F)+1 种基金Suzhou Science Education Health Youth Project(grant No.KJXW2021046 to Liu W)Suzhou Major Disease Multi-center Clinical Research Project(grant No.DZXYJ202410 to Huang F).
文摘Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.
基金supported by the National Key Research and Development Program of China(No.2018YFB1501405)the National Natural Science Foundation of China(No.52476185).
文摘SnS has emerged as an attractive catalyst for the electrochemical CO_(2)reduction reaction(CO_(2)RR)to formate,while its long-term operational stability is hindered by the self-reduction of Sn^(2+) and sulfur dissolution.Thus,maintaining high current efficiency across a wide negative potential range to achieve high production rates of formate remains a significant challenge.In this study,we present a heterostructure constructed with SnS and CuS for efficient CO_(2)RR to formate.The SnS-CuS(30)exhibits a remarkable formate Faradaic efficiency(FE_(f))of 93.94%at−1 V vs.reversible hydrogen electrode(RHE)and demonstrates long-term stability for 7.5 h,maintaining high activity(with an average FE_(f)of 85.6%)across a wide negative potential range(from-0.8 to-1.2 V(vs.RHE)).The results reveal that the heterogeneous interface between SnS and CuS mitigates the self-reduction issue of SnS by sacrificing Cu^(2+),highlighting that the true active species is SnS,which effectively resists structural changes during the electrolysis process under the protection of CuS.The synergistic interaction within the CuS and SnS heterostructure,combined with the tendency for electron self-conduction,enables the catalyst to maintain high formate activity and selectivity across a wide potential range.Furthermore,theoretical results further indicate that the incorporation of CuS enhances CO_(2)adsorption and lowers the energy barrier for the formation of formate intermediates.This study inspires the concept of applying protective layers to active species,promoting high selectivity in Sn-based electrocatalysts.
基金supported by the Educational Commission of Shanghai in China(No.2021LK114)the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02)the Xinglin Young Talent Program at Shanghai University of Traditional Chinese Medicine(No.A1-U17205010430)。
文摘Stem-leaf saponins from Panax notoginseng(SLSP)comprise numerous PPD-type saponins with diverse pharmacological properties;however,their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation,remains unclear.This study evaluated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models,including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia.Our findings revealed that SLSP mitigated behavioral impairments and excessive microglial activation in models of PD,including MPTP-treated mice.Additionally,SLSP inhibited the upregulation of inducible nitric oxide synthase(i NOS)and cyclooxygenase-2(COX2)and attenuated the phosphorylation of PI3K,protein kinase B(AKT),nuclear factor-κB(NFκB),and inhibitor of NFκB proteinα(IκBα)both in vivo and in vitro.Moreover,SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β,IL-6,and tumor necrosis factor alpha(TNF-α)in LPS-stimulated BV-2cells.Notably,the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPStreated BV-2 cells.These results suggest that SLSP inhibit microglia-mediated neuroinflammation in experimental PD models,likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway.These novel findings indicate that SLSP may offer therapeutic potential for PD by attenuating microglia-mediated neuroinflammation.
文摘BACKGROUND Cox health behavior interventions combined with psychological care have the potential to improve recovery outcomes and psychological well-being in patients with hypertensive cerebral hemorrhage accompanied by mental disorders.AIM To explore the impact of combining the Cox Health Behavior Interaction Model with multifaceted psychological nursing in patients with hypertensive intracerebral hemorrhage(ICH)complicated by mental disorders and to provide a reference for the nursing intervention in patients with hypertensive ICH.METHODS Overall,128 patients with hypertensive ICH complicated by mental disorders who were admitted to the Affiliated Hospital of Nantong University between January 2022 and December 2024 were divided into groups using a random number table.The control group(n=64)received multifaceted psychological nursing,and the observation group(n=64)received the Cox Health Behavior Interaction Model intervention based on multifaceted psychological nursing.The mental state,psychological resilience,self-efficacy,and quality of life of the two groups were compared.RESULTS Post-intervention,the mental states of anxiety and depression in the observation group(38.82±3.67 points and 35.14±2.75 points,respectively)were lower than those in the control group(46.96±5.12 points and 41.36±3.71 points,respectively),and the psychological resilience levels(tenacity,self-improvement,and optimism)were higher than those in the control group(P<0.05).Postintervention,the General Self-Efficacy Scale score in the observation group(31.75±2.75 points)was higher than that in the control group(26.76±2.93 points),and the physical health-and social and mental health-related quality of life were both higher than those in the control group(P<0.05).CONCLUSION Combining the Cox Health Behavior Interaction Model with multifaceted psychological nursing for patients with hypertensive ICH and mental disorders relieves anxiety and depression and improves resilience,self-efficacy,and quality of life.
基金supports by Central South University Innovation-Driven Research Programme(2023CXQD038)the Fundamental Research Funds for the Central Universities of Central South University(2025ZZTS0089)supported by the High Performance Computing Center of Central South University.
文摘Anode-free sodium metal batteries(AFSMBs)have gained attention as next-generation storage systems with high energy density and cost-effectiveness.However,non-uniform sodium(Na)deposition and an unsteady solid electrolyte interphase(SEI)lead to dendrite-related issues and severe irreversible Na^(+)plating/stripping,greatly aggravating their cycle deterioration.In this study,we effectively modified the 3D current collector's electronic structure by introducing Zn-N_(x)active sites(Zn-CNF),which enhances lateral Na^(+)diffusion and the Na planar growth,enabling uniform deep Na deposition at an exceptionally high capacity of 10 mA h cm^(-2).Furthermore,the Zn-N_(x)bonds enhance the adsorption capacity of PF6and contribute to forming a stable inorganic-rich SEI layer.Consequently,Zn-CNF with the electronic structure regulation endows an ultra-low nucleation overpotential(8 mV)and ultra-high Coulombic efficiency of 99.94%over 1,600 cycles.Symmetric cells demonstrate stable Na^(+)plating/stripping behavior for more than 4,400 h at 1 mA cm^(-2).Moreover,under high cathode loading(7.97 mg cm^(-2)),the AFSMBs achieve a high energy density of 374 W h kg^(-1)and retain a high discharge capacity of 82.49 mA h g^(-1)with a capacity retention of 80.4%after 120 cycles.This work proposes a viable strategy to achieving high-energy-density AFSMBs.
文摘Single-atom catalysts are promising for H_(2)O_(2) photosynthesis from O_(2) and H_(2)O,but their efficiency is still limited by the ill-defined electronic structure.In this study,Co single-atoms with unique four planar N-coordination and one axial P-coordination(Co-N_(4)P_(1))are decorated on the lateral edges of nanorod-like crystalline g-C_(3)N_(4)(CCN)photocatalysts.Significantly,the electronic structures of central Co as active sites for O_(2) reduction reaction(ORR)and planar N-coordinator as active sites for H_(2)O oxidation reaction(WOR)in Co-N_(4)P_(1) can be well regulated by the synergetic effects of introducing axial P-coordinator,in contrast to the decorated Co single-atoms with only four planar N-coordination(Co-N_(4)).Specifically,directional photoelectron accumulation at central Co active sites,induced by an introduced midgap level in Co-N_(4)P_(1),mediates the ORR active sites from 4e–-ORR-selective terminal–NH_(2) sites to 2e–-ORR-selective Co sites,moreover,an elevated d-band center of Co 3d orbital strengthens ORR intermediate*OOH adsorption,thus jointly facilitating a highly selective and active 2e^(–)-ORR pathway to H_(2)O_(2) photosynthesis.Simultaneously,a downshifted p-band center of N_(2)p orbital in Co-N_(4)P_(1) weakens WOR intermediate*OH adsorption,thus enabling a preferable 2e^(–)-WOR pathway toward H_(2)O_(2) photosynthesis.Subsequently,Co-N_(4)P_(1) exhibits exceptional H_(2)O_(2) photosynthesis efficiency,reaching 295.6μmol g^(-1) h^(-1) with a remarkable solar-to-chemical conversion efficiency of 0.32%,which is 15 times that of Co-N_(4)(19.2μmol g^(-1) h^(-1))and 10 times higher than CCN(27.6μmol g^(-1) h^(-1)).This electronic structure modulation on single-atom catalysts offers a promising strategy for boosting the activity and selectivity of H_(2)O_(2) photosynthesis.
基金supported by the National Key Research and Development Program of China(No.2022YFA1602200)the National Natural Science Foundation of China(Nos.12341501 and 12405174)the Hefei Comprehensive National Science Center for the strong support on the STCF key technology research project.
文摘Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).
基金Project supported by the National Key Research and Development Program of China (Grant No. 2022YFB2404400)。
文摘LiMn_(2)O_(4)(LMO) represents one of the most prevalent cathode materials utilized in lithium-ion batteries(LIBs), yet its broader application is often hampered by its limited achievable capacity and significant capacity degradation during cycling. In this work, a novel dual-doping strategy involving Al^(3+) and Zr^(4+) ions has been employed to refine the atomic structure of LMO's spinel framework. The resultant dual-doped material, Li_(1.06)Mn_(1.97)Zr_(0.01)Al_(0.02)O_(4), exhibits enhanced electrochemical properties, boasting a discharge capacity of 124.9 m Ah/g at a rate of 0.1 C. Furthermore, the formation of stronger Al–O and Zr–O bonds contributes to the stabilization of the delithiated LMO structure. Impressively, 97.7%of its initial capacity is retained after 100 cycles at a 5 C rate. Additionally, enhancements in rate performance and hightemperature cycling stability have also been observed. This study underscores the potential of Al^(3+) and Zr^(4+) dual-doping as a promising approach to enhance LMO cathodes, providing a scalable and efficient means of improving the performance of lithium manganese oxide cathode materials through the incorporation of multiple ions.
基金supported by the UK’s Engineering and Physical Sciences Research Council(Grant Nos.EP/V000624/1,EP/X03495X/1,EP/X041166/1,and EP/T02643X/1)the Royal Society(Grant No.RG\R2\232531).
文摘Research on supercontinuum sources on silicon has made significant progress in the past few decades.However,conventional approaches to broaden the spectral bandwidth often rely on complex and critical dispersion engineering by optimizing the core thickness or introducing the cladding with special materials and structures.We propose and demonstrate supercontinuum generation using long-periodgrating(LPG)waveguides on silicon with a C-band pump.The LPG waveguide is introduced for quasi-phase matching,and the generated supercontinuum spectrum is improved greatly with grating-induced dispersive waves.In addition,the demonstrated LPG waveguide shows a low propagation loss comparable with regular silicon photonic waveguides without gratings.In experiments,when using a 1550-nm 75-fs pulse pump with a pulse energy of 200 pJ,the supercontinuum spectrum generated with the present LPG waveguide shows an ultrabroad extent from 1150 to 2300 nm,which is much wider by 200 nm than that achieved by dispersionengineered uniform silicon photonic waveguides on the same chip.This provides a promising option for on-chip broadband light source for silicon photonic systems.
文摘The red clay in Chenzhou, Hunan province is mostly in unsaturated state. Simply applying the mechanical properties that derived from classic saturated soil mechanics often leads to slope failures in this region. In order to study the shear strength characteristic of unsaturated red clay in Chenzhou and to explore a shear strength equation that can be easily applied in engineering practice, a series of triaxial tests of saturated and unsaturated red clay samples were performed using the regular triaxial testing apparatus. The testing results show that the peak strength of red clay drops slightly before the moisture content of 30% but decreases sharply after that. The friction angle of red clay under unsaturated state is basically equal to the effective friction angle under saturated state, while the cohesion of unsaturated red clay is far much bigger than that of saturated one, which indicates that the matric suction makes a great contribution to the cohesion. By fitting the testing results with appropriate curves, the relationships between total strength parameters and with moisture content were obtained. The total increases logarithmically before the moisture content of 35% then decreases linearly, while decreases cubically with increasing moisture content.
基金support from the National Natural Science Foundation of China (Grant Nos. 41975068, 42150204, 42288101, 42075024, and 41830969)。
文摘From 17 November to 27 December 2022, extremely cold snowstorms frequently swept across North America and Eurasia. Diagnostic analysis reveals that these extreme cold events were closely related to the establishment of blocking circulations. Alaska Blocking(AB) and subsequent Ural Blocking(UB) episodes are linked to the phase transition of the North Atlantic Oscillation(NAO) and represent the main atmospheric regimes in the Northern Hemisphere. The downstream dispersion and propagation of Rossby wave packets from Alaska to East Asia provide a large-scale connection between AB and UB episodes. Based on the nonlinear multi-scale interaction(NMI) model, we found that the meridional potential vorticity gradient(PVy) in November and December of 2022 was anomalously weak in the mid-high latitudes from North America to Eurasia and provided a favorable background for the prolonged maintenance of UB and AB events and the generation of associated severe extreme snowstorms. However, the difference in the UB in terms of its persistence,location, and strength between November and December is related to the positive(negative) NAO in November(December). During the La Ni?a winter of 2022, the UB and AB events are related to the downward propagation of stratospheric anomalies, in addition to contributions by La Ni?a and low Arctic sea ice concentrations as they pertain to reducing PVyin mid-latitudes.
基金supported by the Cultivation Project of Major Achievements Transformation of Sichuan Provincial Education Department(#14CZ0005)supported by the Natural Science Foundation of China(#21406184)
基金supported by the NNSFC(No.29771025),(No.20377053)The Nine-five National Key Project of China(29833090)The Hubei Province Foundation of China(No.2003ABA071).
文摘Iron(Ⅱ)tetra-(1,4-dithin)-porphyrazine,(FePz(dtn)_(4))is able to activate molecule oxygen for oxygenation degradation of rhodamine B(RhB)in an extensive pH region without light excitation.Experiments indicate that the RhB can be degraded nearly 52%in alkaline aqueous solution,bubbling with dioxygen for seven hours in the presence of FePz(dtn)_(4)and the hydrogen peroxides as an active intermediate were determined by DPD method.The catalyst is recyclable and the catalyst activity was maintained after 10 recycles.
文摘Collagen protein is an ideal scaffold material for the transplantation of neural stem cells. In this study rat neural stern cells were seeded into a three-dimensional collagen gel scaffold, with suspension cultured neural stem cells being used as a control group. Neural stem cells, which were cultured in medium containing epidermal growth factor and basic fibroblast growth factor, actively expanded and formed neurospheres in both culture groups. In serum-free medium conditions, the processes extended from neurospheres in the collagen gel group were much longer than those in the suspension culture group. Immunofluorescence staining showed that neurespheres cultured in collagen gels were stained positive for nestin and differentiated cells were stained positive for the neuronal marker βIII-tubulin, the astrocytic marker glial fibrillary acidic protein and the oligodendrocytic marker 2＇,3＇-cyclic nucleotide 3＇-phosphodiesterase. Compared with neurospheres cultured in suspension, the differentiation potential of neural stem cells cultured in collagen gels increased, with the formation of neurons at an early stage. Our results show that the three-dimensional collagen gel culture system is superior to suspension culture in the proliferation, differentiation and process outgrowth of neural stem cells.
