A mobile marine seismometer(MMS)is a vertical underwater vehicle that detects ocean seismic waves.One of the critical operational requirements for an MMS is that it remains suspended at a desired depth.This article ai...A mobile marine seismometer(MMS)is a vertical underwater vehicle that detects ocean seismic waves.One of the critical operational requirements for an MMS is that it remains suspended at a desired depth.This article aimed to propose a fixed-depth suspension control for the MMS with a limited onboard energy supply.The research team established a kinematic model to analyze fluctuations in the vertical motion of the MMS and the delayed response of the system.We ascertained a direct one-to-one correlation between the displacement volume of the mobile ocean seismic instrument and the depth at which it reaches a state of neutral buoyancy(commonly referred to as the hover depth).A fixed-depth control algorithm was introduced,allowing a gradual approach to the necessary displacement volume to reach the desired suspension depth.The study optimized the boundary conditions to reduce unnecessary adjustments and mitigate the time delay caused by the instrument’s inertia,thereby significantly minimizing energy consumption.This method does not require calculating the hydrodynamic parameters or transfer functions of the MMS,thereby considerably reducing the implementation complexity.In the three-month sea trial in the South China Sea,the seismic instrument was set to hover at 800 m,with a permissible fluctuation of±100 m,operating on a seven-day cycle.The experimental results show that the seismic instrument has an average hover error of 34.6 m,with a vertical drift depth of 29.6 m per cycle,and the buoyancy adjustment system made six adjustments,indicating that our proposed control method performs satisfactorily.In addition,this method provides new insights for the fixed-depth control of other ocean observation devices that rely on buoyancy adjustment.展开更多
BACKGROUND The clinical manifestations of trisomy 7 mosaicism are diverse and nonspecific,so prenatal diagnosis is very difficult.CASE SUMMARY Two pregnant women with abnormal prenatal screening results were included....BACKGROUND The clinical manifestations of trisomy 7 mosaicism are diverse and nonspecific,so prenatal diagnosis is very difficult.CASE SUMMARY Two pregnant women with abnormal prenatal screening results were included.One was a 22-year-old woman(G1P0).At 31st week of gestation,ultrasound revealed that the posterior horn of the left lateral ventricle was 10 mm and the right renal pelvis had a separation of 7 mm.The other pregnant woman was 33 years old(G2P1L1A0),and her fetus was found to have a cardiac malformation at the 24th week of gestation.Copy number variation sequencing,whole-exome sequencing and karyotype analysis were carried out after amniocentesis,and both fetuses were diagnosed with trisomy 7 mosaicism.After parental counseling,one woman continued the pregnancy,and the other woman terminated the pregnancy.CONCLUSION In trisomy 7 mosaicism,the low proportion of trisomy does not lead to abortion,but can result in abnormal fetal development,which can be detected via ultrasound.Therefore,clinicians need to pay more attention to various aspects of fetal growth and development,combining with imaging,cellular,molecular genetics and other methods to perform comprehensive evaluations of fetuses to provide more reliable genetic counseling for pregnant women.展开更多
This study proposes an image-based three-dimensional(3D)vector reconstruction of industrial parts that can gener-ate non-uniform rational B-splines(NURBS)surfaces with high fidelity and flexibility.The contributions o...This study proposes an image-based three-dimensional(3D)vector reconstruction of industrial parts that can gener-ate non-uniform rational B-splines(NURBS)surfaces with high fidelity and flexibility.The contributions of this study include three parts:first,a dataset of two-dimensional images is constructed for typical industrial parts,including hex-agonal head bolts,cylindrical gears,shoulder rings,hexagonal nuts,and cylindrical roller bearings;second,a deep learning algorithm is developed for parameter extraction of 3D industrial parts,which can determine the final 3D parameters and pose information of the reconstructed model using two new nets,CAD-ClassNet and CAD-ReconNet;and finally,a 3D vector shape reconstruction of mechanical parts is presented to generate NURBS from the obtained shape parameters.The final reconstructed models show that the proposed approach is highly accurate,efficient,and practical.展开更多
BACKGROUND Multiple congenital anomalies-hypotonia-seizures syndrome 1(MCAHS1)associated with mutations in PIGN gene.CASE SUMMARY The authors report 1 case of a 16 years old girl who was presented with epilepsy,develo...BACKGROUND Multiple congenital anomalies-hypotonia-seizures syndrome 1(MCAHS1)associated with mutations in PIGN gene.CASE SUMMARY The authors report 1 case of a 16 years old girl who was presented with epilepsy,developmental delay and cerebellar atrophy.She harbors a compound heterozygous variant in the PIGN gene,include a nonsense splice site mutation(c.2557A>C)which was inherited from her mother,and a novel site mutation(c.980del)which was inherited from her father.CONCLUSION This case report expands the mutation spectrum found in PIGN gene,and strengthens the association between PIGN mutation and MCAHS1.Mutations in PIGN gene may be an underestimated cause of epilepsy.The authors recommend that,for patients with epilepsy or prenatal diagnosis of highly suspicious fetus,gene sequencing should be the preferred detection method.展开更多
Gate-grounded n-channel metal-oxide-semiconductor(GGNMOS)devices have been widely implemented as power clamps to protect semiconductor devices from electrostatic discharge stress owing to their simple construction,eas...Gate-grounded n-channel metal-oxide-semiconductor(GGNMOS)devices have been widely implemented as power clamps to protect semiconductor devices from electrostatic discharge stress owing to their simple construction,easy triggering,and low power dissipation.We present a novel I-V characterization of the GGNMOS used as the power clamp in complementary metal-oxide-semiconductor circuits as a result of switching the ESD paths under different impact energies.This special effect could cause an unexpected latch-up or pre-failure phenomenon in some applications with relatively large capacitances from power supply to power ground,and thus should be urgently analyzed and resolved.Transmission-linepulse,human-body-modal,and light-emission tests were performed to explore the root cause.展开更多
Reverse transcriptase (rt) fragments from LINE retrotransposons in the mulberry genome were analyzed in terms of heterogeneity, phylogeny, and chromosomal distribution. We amplified and characterized conserved domains...Reverse transcriptase (rt) fragments from LINE retrotransposons in the mulberry genome were analyzed in terms of heterogeneity, phylogeny, and chromosomal distribution. We amplified and characterized conserved domains of the rt using degenerate primer pairs. Sequence analyses indicated that the rt fragments were highly heterogeneous and rich in A/T bases. The sequence identity ranged from 31.8% to 99.4%. Based on sequence similarities, the rt fragments were categorized into eight groups. Furthermore, similar stop codon distribution patterns among a series of clones in the same group indicated that they underwent a similar evolutionary process. Interestingly, phylogenetic analyses of the rt fragments isolated from mulberry and 13 other plant species revealed that two distantly related taxa (mulberry and Paeonia suffruticosa) grouped together. It does not appear that this phenomenon resulted from horizontal transposable element transfer. Fluorescence in situ hybridization analysis revealed that most of the rt fragments were concentrated in the subtelomeric and pericentromeric regions of the mulberry chromosomes, but that these elements were not abundant in the mulberry genome. Future studies will focus on the potential roles of these elements in the subtelomeric and pericentromeric regions of the mulberry genome.展开更多
Gate-grounded N-channel MOSFET(GGNMOS)has been extensively used for on-chip electrostatic discharge(ESD)protection.However,the ESD performance of the conventional GGNMOS is significantly degraded by the current crowdi...Gate-grounded N-channel MOSFET(GGNMOS)has been extensively used for on-chip electrostatic discharge(ESD)protection.However,the ESD performance of the conventional GGNMOS is significantly degraded by the current crowding effect.In this paper,an enhanced GGNMOS with P-base layer(PB-NMOS)are proposed to improve the ESD robustness in BCD process without the increase in layout area or additional layer.TCAD simulations are carried out to explain the underlying mechanisms of that utilizing the P-base layer can effectively restrain the current crowing effect in proposed devices.All devices are fabricated in a 0.5-μm BCD process and measured using the transmission line pulsing(TLP)tester.Compared with the conventional GGNMOS,the proposed PB-NMOS devices offer a higher failure current than its conventional counterpart,which can be increased by 15.38%.Furthermore,the PB-NMOS type 3 possesses a considerably lower trigger voltage than the conventional GGNMOS to protect core circuit effectively.展开更多
A robust electron device called the enhanced gated-diode-triggered silicon-controlled rectifier (EGDTSCR) for electrostatic discharge (ESD) protection applications has been proposed and implemented in a 0.18-μm 5-V/2...A robust electron device called the enhanced gated-diode-triggered silicon-controlled rectifier (EGDTSCR) for electrostatic discharge (ESD) protection applications has been proposed and implemented in a 0.18-μm 5-V/24-V BCD process. The proposed EGDTSCR is constructed by adding two gated diodes into a conventional ESD device called the modified lateral silicon-controlled rectifier (MLSCR). With the shunting effect of the surface gated diode path, the proposed EGDTSCR, with a width of 50 μm, exhibits a higher failure current (i.e., 3.82 A) as well as a higher holding voltage (i.e., 10.21 V) than the MLSCR.展开更多
This paper presents a novel algorithm for planar G1 interpolation using typical curves with monotonic curvature.The G1 interpolation problem is converted into a system of nonlinear equations and sufficient conditions ...This paper presents a novel algorithm for planar G1 interpolation using typical curves with monotonic curvature.The G1 interpolation problem is converted into a system of nonlinear equations and sufficient conditions are provided to check whether there is a solution.The proposed algorithm was applied to a curve completion task.The main advantages of the proposed method are its simple construction,compatibility with NURBS,and monotonic curvature.展开更多
Gears play an important role in virtual manufacturing systems for digital twins;however,the image of gear tooth defects is difficult to acquire owing to its non-convex shape.In this study,a deep learning network is pr...Gears play an important role in virtual manufacturing systems for digital twins;however,the image of gear tooth defects is difficult to acquire owing to its non-convex shape.In this study,a deep learning network is proposed to detect gear defects based on their point cloud representation.This approach mainly consists of three steps:(1)Various types of gear defects are classified into four cases(fracture,pitting,glue,and wear);A 3D gear dataset was constructed with 10000 instances following the aforementioned classification.(2)Gear-PCNet++introduces a novel Combinational Convolution Block,proposed based on the gear dataset for gear defect detection to effectively extract the local gear information and identify its complex topology;(3)Compared with other methods,experiments show that this method can achieve better recognition results for gear defects with higher efficiency and practicability.展开更多
[Objectives]To analyze the common compatibility contraindications of breviscapine for injection,and to provide references for clinical rational drug use.[Methods]The pH distribution of the combined drugs in the report...[Objectives]To analyze the common compatibility contraindications of breviscapine for injection,and to provide references for clinical rational drug use.[Methods]The pH distribution of the combined drugs in the report on the compatibility contraindications of breviscapine for injection and was analyzed.[Results]Breviscapine for injection may become turbid or precipitated when mixed with drugs whose pH are lower;it can make the liquid discoloration in a strong alkaline solution.[Conclusions]Breviscapine for injection should not be combined with drugs whose pH are lower,especially drugs with pH lower than 4.2.Breviscapine for injection should not be used with drugs with strong alkaline.It is recommended to use Breviscapine for injection separately.展开更多
[Objectives]To analyze the occurrence rules and factors influencing adverse reactions of breviscapine for injection,explore potential drug risks,and guide the clinical rational medication.[Methods]The retrospective an...[Objectives]To analyze the occurrence rules and factors influencing adverse reactions of breviscapine for injection,explore potential drug risks,and guide the clinical rational medication.[Methods]The retrospective analysis method was used to analyze the case reports of adverse reactions of breviscapine for injection,and analyze the gender and age distribution of the cases,the patient's medication status,the adverse reactions involving organ/system damage and clinical manifestations,the occurrence time,duration,and outcome of the adverse reactions.[Results]Adverse reactions of breviscapine for injection were mainly concentrated in middle-aged and elderly patients aged 45 and above,accounting for 85.35%;in the gender distribution,females were higher than males;adverse reactions involved multiple organ/system damages.Among them,75.86%of patients had adverse reactions after the first medication,and 11.77%of reported patients had concomitant medications.[Conclusions]The adverse reactions caused by breviscapine for injection may be related to the patient's age,gender and irrational medication.展开更多
Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 exp...Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 expression.Therefore,the mechanisms through which serum iron overload activates the BMP/SMAD pathway remain unclear.This study aimed to clarify the role of SMURF1 in serum iron overload and the BMP/SMAD pathway.Methods:A cell model of serum iron overload was established by treating hepatocytes with 2 mg/mL of holo-transferrin(Holo-Tf).A serum iron overload mouse model and a liver iron overload mouse model were established by intraperitoneally injecting 10 mg of Holo-Tf into C57BL/6 mice and administering a high-iron diet for 1 week followed by a low-iron diet for 2 days.Western blotting and real-time PCR were performed to evaluate the activation of the BMP/SMAD pathway and the expression of hepcidin.Results:Holo-Tf augmented the sensitivity and responsiveness of hepatocytes to BMP6.The E3 ubiquitin-protein ligase SMURF1 mediated Holo-Tf-induced SMAD1/5 activation and hepcidin expression;specifically,SMURF1 expression dramatically decreased when the serum iron concentration was increased.Additionally,the expression of SMURF1 substrates,which are important molecules involved in the transduction of BMP/SMAD signaling,was significantly upregulated.Furthermore,in vivo analyses confirmed that SMURF1 specifically regulated the BMP/SMAD pathway during serum iron overload.Conclusions:SMURF1 can specifically regulate the BMP/SMAD pathway by augmenting the responsiveness of hepatocytes to BMPs during serum iron overload.展开更多
The explosive growth of social media means portrait editing and retouching are in high demand.While portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the use...The explosive growth of social media means portrait editing and retouching are in high demand.While portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the user to be highly skilled.Aiming at developing intuitive and easy-to-use portrait editing tools,we propose a novel vectorization method that can automatically convert raster images into a 3-tier hierarchical representation.The base layer consists of a set of sparse diffusion curves(DCs)which characterize salient geometric features and low-frequency colors,providing a means for semantic color transfer and facial expression editing.The middle level encodes specular highlights and shadows as large,editable Poisson regions(PRs)and allows the user to directly adjust illumination by tuning the strength and changing the shapes of PRs.The top level contains two types of pixel-sized PRs for high-frequency residuals and fine details such as pimples and pigmentation.We train a deep generative model that can produce high-frequency residuals automatically.Thanks to the inherent meaning in vector primitives,editing portraits becomes easy and intuitive.In particular,our method supports color transfer,facial expression editing,highlight and shadow editing,and automatic retouching.To quantitatively evaluate the results,we extend the commonly used FLIP metric(which measures color and feature differences between two images)to consider illumination.The new metric,illumination-sensitive FLIP,can effectively capture salient changes in color transfer results,and is more consistent with human perception than FLIP and other quality measures for portrait images.We evaluate our method on the FFHQR dataset and show it to be effective for common portrait editing tasks,such as retouching,light editing,color transfer,and expression editing.展开更多
Learning and inferring underlying motion patterns of captured 2D scenes and then re-creating dynamic evolution consistent with the real-world natural phenomena have high appeal for graphics and animation.To bridge the...Learning and inferring underlying motion patterns of captured 2D scenes and then re-creating dynamic evolution consistent with the real-world natural phenomena have high appeal for graphics and animation.To bridge the technical gap between virtual and real environments,we focus on the inverse modeling and reconstruction of visually consistent and property-verifiable oceans,taking advantage of deep learning and differentiable physics to learn geometry and constitute waves in a self-supervised manner.First,we infer hierarchical geometry using two networks,which are optimized via the differentiable renderer.We extract wave components from the sequence of inferred geometry through a network equipped with a differentiable ocean model.Then,ocean dynamics can be evolved using the reconstructed wave components.Through extensive experiments,we verify that our new method yields satisfactory results for both geometry reconstruction and wave estimation.Moreover,the new framework has the inverse modeling potential to facilitate a host of graphics applications,such as the rapid production of physically accurate scene animation and editing guided by real ocean scenes.展开更多
Erratum to Xueguang Xie,Yang Gao,Fei Hou,Aimin Hao&Hong Qin.Dynamic ocean inverse modeling based on differentiable rendering.Computational Visual Media Vol.10,No.2,279–294,2024.https://doi10.1007/s41095-023-0338-...Erratum to Xueguang Xie,Yang Gao,Fei Hou,Aimin Hao&Hong Qin.Dynamic ocean inverse modeling based on differentiable rendering.Computational Visual Media Vol.10,No.2,279–294,2024.https://doi10.1007/s41095-023-0338-4 The authors apologize for a hidden error in the article.It is that the images in Figs.14(a)and 14(d)were mistakenly presented as left–right mirror images.The authors have flipped them to ensure that the figures now correspond correctly with others in the subfigures(b,c,e,f).The accurate version of Fig.14 is provided as below.展开更多
Adequate oxygen supply is essential for maintaining the body's normal physiological function.In chronic inflammatory conditions such as inflammatory bowel disease(IBD),insufficient oxygen reaching the intestine tr...Adequate oxygen supply is essential for maintaining the body's normal physiological function.In chronic inflammatory conditions such as inflammatory bowel disease(IBD),insufficient oxygen reaching the intestine triggers the regulatory system in response to environmental changes.However,the pathogenesis of IBD is still under investigation.Recent research has highlighted the significant role of hypoxia in IBD,particularly the involvement of hypoxia-inducible factors(HIF)and their regulatory mechanisms,making them promising therapeutic targets for IBD.This review will delve into the role of hypoxia,HIF,and the associated hypoxia-inflammatory microenvironment in the context of IBD.Potential interventions for addressing these challenging gastrointestinal inflammatory diseases will also be discussed within this framework.展开更多
To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in...To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in critically ill patients.^([1])The Swansea diagnostic criteria have been widely used in the diagnosis of AFLP worldwide since their proposal.The Swansea criteria include clinical symptoms and laboratory tests,imaging,and pathological examination results.展开更多
Background::Recently,T-helper 17(Th17)cells have been proved to play an important role in promoting cervical cancer.But,till now,few study has been carried out to understand the involvement of these cells in efficacy ...Background::Recently,T-helper 17(Th17)cells have been proved to play an important role in promoting cervical cancer.But,till now,few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor treatments.This study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer(LACC)patients before and after concurrent chemoradiotherapy(cCRT)and to analyze the correlations between the alterations in Th17 cells and treatment efficacy.Methods::A prospective study with 49 LACC(International federation of gynecology and obstetrics[FIGO]stage IIB-IIIB)patients and 23 controls was conducted.Patients received the same cCRT schedule and were followed up for 3 years.Circulating Th17 cells(CD3+CD8-interleukin[IL]-17+T cells)and related cytokines IL-17,transforming growth factor-β(TGF-β),IL-10,IL-23,IL-6,and IL-22 were detected before and after cCRT.Correlations between alterations of circulating Th17 cells and treatment efficacy were analyzed.Kaplan-Meier analysis was used for overall survival(OS)and progression-free survival(PFS).Results::We found that 40 patients finished the entire cCRT schedule and met the endpoint of this study.The percentage of circulating Th17 cells in the LACC patients was higher than that in the controls,and it significantly decreased after cCRT(P<0.05).After cCRT,patients were divided into two groups based on the average of the Th17 cells declined.The subgroup of patients with a prominent decrease in circulating Th17 cells after cCRT had a higher treatment efficacy and longer PFS and OS times.Compared with the control patients,LACC patients had higher IL-6,IL-10,IL-22,TGF-βlevels and a lower IL-23 level(P<0.05).After cCRT,IL-6,IL-10,IL-17,IL-23 level significantly increased and TGF-βlevel significantly decreased compared with the levels before cCRT(P<0.05).Conclusion::Circulating Th17 cells in the LACC patients(FIGO stage IIB-IIIB)were higher than those in the controls,but they generally decreased after cCRT.A more pronounced decrease in circulating Th17 cells after cCRT was correlated with better therapeutic effect and longer PFS and OS times.展开更多
基金The National Key Research and Development Program of China under contract Nos.2021YFC3101401 and 2022YFC3003802the Deep Blue Fund under contract No.SL2103+2 种基金the Zhejiang Provincial Key Research and Development Program under contract No.2021C03186the Zhejiang Provincial Natural Science Foundation of China under contract No.LDQ24D060001the Open Fund Project of Key Laboratory of Ocean Observation Technology,MNR under contract No.2024klootA11.
文摘A mobile marine seismometer(MMS)is a vertical underwater vehicle that detects ocean seismic waves.One of the critical operational requirements for an MMS is that it remains suspended at a desired depth.This article aimed to propose a fixed-depth suspension control for the MMS with a limited onboard energy supply.The research team established a kinematic model to analyze fluctuations in the vertical motion of the MMS and the delayed response of the system.We ascertained a direct one-to-one correlation between the displacement volume of the mobile ocean seismic instrument and the depth at which it reaches a state of neutral buoyancy(commonly referred to as the hover depth).A fixed-depth control algorithm was introduced,allowing a gradual approach to the necessary displacement volume to reach the desired suspension depth.The study optimized the boundary conditions to reduce unnecessary adjustments and mitigate the time delay caused by the instrument’s inertia,thereby significantly minimizing energy consumption.This method does not require calculating the hydrodynamic parameters or transfer functions of the MMS,thereby considerably reducing the implementation complexity.In the three-month sea trial in the South China Sea,the seismic instrument was set to hover at 800 m,with a permissible fluctuation of±100 m,operating on a seven-day cycle.The experimental results show that the seismic instrument has an average hover error of 34.6 m,with a vertical drift depth of 29.6 m per cycle,and the buoyancy adjustment system made six adjustments,indicating that our proposed control method performs satisfactorily.In addition,this method provides new insights for the fixed-depth control of other ocean observation devices that rely on buoyancy adjustment.
文摘BACKGROUND The clinical manifestations of trisomy 7 mosaicism are diverse and nonspecific,so prenatal diagnosis is very difficult.CASE SUMMARY Two pregnant women with abnormal prenatal screening results were included.One was a 22-year-old woman(G1P0).At 31st week of gestation,ultrasound revealed that the posterior horn of the left lateral ventricle was 10 mm and the right renal pelvis had a separation of 7 mm.The other pregnant woman was 33 years old(G2P1L1A0),and her fetus was found to have a cardiac malformation at the 24th week of gestation.Copy number variation sequencing,whole-exome sequencing and karyotype analysis were carried out after amniocentesis,and both fetuses were diagnosed with trisomy 7 mosaicism.After parental counseling,one woman continued the pregnancy,and the other woman terminated the pregnancy.CONCLUSION In trisomy 7 mosaicism,the low proportion of trisomy does not lead to abortion,but can result in abnormal fetal development,which can be detected via ultrasound.Therefore,clinicians need to pay more attention to various aspects of fetal growth and development,combining with imaging,cellular,molecular genetics and other methods to perform comprehensive evaluations of fetuses to provide more reliable genetic counseling for pregnant women.
基金supported by the Aeronautical Science Foundation of China,No.2023Z0680510022021 Special Scientific Research on Civil Aircraft Project+1 种基金the Natural Science Foundation of China,Nos.61572056 and 61872347the Special Plan for the Development of Distinguished Young Scientists of ISCAS,No.Y8RC535018.
文摘This study proposes an image-based three-dimensional(3D)vector reconstruction of industrial parts that can gener-ate non-uniform rational B-splines(NURBS)surfaces with high fidelity and flexibility.The contributions of this study include three parts:first,a dataset of two-dimensional images is constructed for typical industrial parts,including hex-agonal head bolts,cylindrical gears,shoulder rings,hexagonal nuts,and cylindrical roller bearings;second,a deep learning algorithm is developed for parameter extraction of 3D industrial parts,which can determine the final 3D parameters and pose information of the reconstructed model using two new nets,CAD-ClassNet and CAD-ReconNet;and finally,a 3D vector shape reconstruction of mechanical parts is presented to generate NURBS from the obtained shape parameters.The final reconstructed models show that the proposed approach is highly accurate,efficient,and practical.
文摘BACKGROUND Multiple congenital anomalies-hypotonia-seizures syndrome 1(MCAHS1)associated with mutations in PIGN gene.CASE SUMMARY The authors report 1 case of a 16 years old girl who was presented with epilepsy,developmental delay and cerebellar atrophy.She harbors a compound heterozygous variant in the PIGN gene,include a nonsense splice site mutation(c.2557A>C)which was inherited from her mother,and a novel site mutation(c.980del)which was inherited from her father.CONCLUSION This case report expands the mutation spectrum found in PIGN gene,and strengthens the association between PIGN mutation and MCAHS1.Mutations in PIGN gene may be an underestimated cause of epilepsy.The authors recommend that,for patients with epilepsy or prenatal diagnosis of highly suspicious fetus,gene sequencing should be the preferred detection method.
基金Project supported by the National Natural Science Foundation of China(Grant No.61974017)。
文摘Gate-grounded n-channel metal-oxide-semiconductor(GGNMOS)devices have been widely implemented as power clamps to protect semiconductor devices from electrostatic discharge stress owing to their simple construction,easy triggering,and low power dissipation.We present a novel I-V characterization of the GGNMOS used as the power clamp in complementary metal-oxide-semiconductor circuits as a result of switching the ESD paths under different impact energies.This special effect could cause an unexpected latch-up or pre-failure phenomenon in some applications with relatively large capacitances from power supply to power ground,and thus should be urgently analyzed and resolved.Transmission-linepulse,human-body-modal,and light-emission tests were performed to explore the root cause.
文摘Reverse transcriptase (rt) fragments from LINE retrotransposons in the mulberry genome were analyzed in terms of heterogeneity, phylogeny, and chromosomal distribution. We amplified and characterized conserved domains of the rt using degenerate primer pairs. Sequence analyses indicated that the rt fragments were highly heterogeneous and rich in A/T bases. The sequence identity ranged from 31.8% to 99.4%. Based on sequence similarities, the rt fragments were categorized into eight groups. Furthermore, similar stop codon distribution patterns among a series of clones in the same group indicated that they underwent a similar evolutionary process. Interestingly, phylogenetic analyses of the rt fragments isolated from mulberry and 13 other plant species revealed that two distantly related taxa (mulberry and Paeonia suffruticosa) grouped together. It does not appear that this phenomenon resulted from horizontal transposable element transfer. Fluorescence in situ hybridization analysis revealed that most of the rt fragments were concentrated in the subtelomeric and pericentromeric regions of the mulberry chromosomes, but that these elements were not abundant in the mulberry genome. Future studies will focus on the potential roles of these elements in the subtelomeric and pericentromeric regions of the mulberry genome.
文摘Gate-grounded N-channel MOSFET(GGNMOS)has been extensively used for on-chip electrostatic discharge(ESD)protection.However,the ESD performance of the conventional GGNMOS is significantly degraded by the current crowding effect.In this paper,an enhanced GGNMOS with P-base layer(PB-NMOS)are proposed to improve the ESD robustness in BCD process without the increase in layout area or additional layer.TCAD simulations are carried out to explain the underlying mechanisms of that utilizing the P-base layer can effectively restrain the current crowing effect in proposed devices.All devices are fabricated in a 0.5-μm BCD process and measured using the transmission line pulsing(TLP)tester.Compared with the conventional GGNMOS,the proposed PB-NMOS devices offer a higher failure current than its conventional counterpart,which can be increased by 15.38%.Furthermore,the PB-NMOS type 3 possesses a considerably lower trigger voltage than the conventional GGNMOS to protect core circuit effectively.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61874098 and 61974017)the Fundamental Research Project for Central Universities,China(Grant No.ZYGX2018J025).
文摘A robust electron device called the enhanced gated-diode-triggered silicon-controlled rectifier (EGDTSCR) for electrostatic discharge (ESD) protection applications has been proposed and implemented in a 0.18-μm 5-V/24-V BCD process. The proposed EGDTSCR is constructed by adding two gated diodes into a conventional ESD device called the modified lateral silicon-controlled rectifier (MLSCR). With the shunting effect of the surface gated diode path, the proposed EGDTSCR, with a width of 50 μm, exhibits a higher failure current (i.e., 3.82 A) as well as a higher holding voltage (i.e., 10.21 V) than the MLSCR.
基金This work was supported by opening fund of State Key Laboratory of Lunar and Planetary Sciences(Macao University of Science and Technology),No.119/2017/A3the Natural Science Foundation of China,Nos.61572056 and 61872347+1 种基金the Special Plan for the Development of Distinguished Young Scientists of ISCAS,No.Y8RC535018the Science and Technology Development Fund of Macao,No.0105/2020/A3.
文摘This paper presents a novel algorithm for planar G1 interpolation using typical curves with monotonic curvature.The G1 interpolation problem is converted into a system of nonlinear equations and sufficient conditions are provided to check whether there is a solution.The proposed algorithm was applied to a curve completion task.The main advantages of the proposed method are its simple construction,compatibility with NURBS,and monotonic curvature.
基金opening fund of State Key Laboratory of Lunar and Planetary Sciences(Macao University of Science and Technology),No.119/2017/A3the Natural Science Foundation of China,Nos.61572056 and 61872347the Special Plan for the Development of Distinguished Young Scientists of ISCAS,No.Y8RC535018.
文摘Gears play an important role in virtual manufacturing systems for digital twins;however,the image of gear tooth defects is difficult to acquire owing to its non-convex shape.In this study,a deep learning network is proposed to detect gear defects based on their point cloud representation.This approach mainly consists of three steps:(1)Various types of gear defects are classified into four cases(fracture,pitting,glue,and wear);A 3D gear dataset was constructed with 10000 instances following the aforementioned classification.(2)Gear-PCNet++introduces a novel Combinational Convolution Block,proposed based on the gear dataset for gear defect detection to effectively extract the local gear information and identify its complex topology;(3)Compared with other methods,experiments show that this method can achieve better recognition results for gear defects with higher efficiency and practicability.
文摘[Objectives]To analyze the common compatibility contraindications of breviscapine for injection,and to provide references for clinical rational drug use.[Methods]The pH distribution of the combined drugs in the report on the compatibility contraindications of breviscapine for injection and was analyzed.[Results]Breviscapine for injection may become turbid or precipitated when mixed with drugs whose pH are lower;it can make the liquid discoloration in a strong alkaline solution.[Conclusions]Breviscapine for injection should not be combined with drugs whose pH are lower,especially drugs with pH lower than 4.2.Breviscapine for injection should not be used with drugs with strong alkaline.It is recommended to use Breviscapine for injection separately.
文摘[Objectives]To analyze the occurrence rules and factors influencing adverse reactions of breviscapine for injection,explore potential drug risks,and guide the clinical rational medication.[Methods]The retrospective analysis method was used to analyze the case reports of adverse reactions of breviscapine for injection,and analyze the gender and age distribution of the cases,the patient's medication status,the adverse reactions involving organ/system damage and clinical manifestations,the occurrence time,duration,and outcome of the adverse reactions.[Results]Adverse reactions of breviscapine for injection were mainly concentrated in middle-aged and elderly patients aged 45 and above,accounting for 85.35%;in the gender distribution,females were higher than males;adverse reactions involved multiple organ/system damages.Among them,75.86%of patients had adverse reactions after the first medication,and 11.77%of reported patients had concomitant medications.[Conclusions]The adverse reactions caused by breviscapine for injection may be related to the patient's age,gender and irrational medication.
基金supported by the National Natural Science Foundation of China(No.82370898)Beijing Natural Science Foundation(No.7202034).
文摘Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 expression.Therefore,the mechanisms through which serum iron overload activates the BMP/SMAD pathway remain unclear.This study aimed to clarify the role of SMURF1 in serum iron overload and the BMP/SMAD pathway.Methods:A cell model of serum iron overload was established by treating hepatocytes with 2 mg/mL of holo-transferrin(Holo-Tf).A serum iron overload mouse model and a liver iron overload mouse model were established by intraperitoneally injecting 10 mg of Holo-Tf into C57BL/6 mice and administering a high-iron diet for 1 week followed by a low-iron diet for 2 days.Western blotting and real-time PCR were performed to evaluate the activation of the BMP/SMAD pathway and the expression of hepcidin.Results:Holo-Tf augmented the sensitivity and responsiveness of hepatocytes to BMP6.The E3 ubiquitin-protein ligase SMURF1 mediated Holo-Tf-induced SMAD1/5 activation and hepcidin expression;specifically,SMURF1 expression dramatically decreased when the serum iron concentration was increased.Additionally,the expression of SMURF1 substrates,which are important molecules involved in the transduction of BMP/SMAD signaling,was significantly upregulated.Furthermore,in vivo analyses confirmed that SMURF1 specifically regulated the BMP/SMAD pathway during serum iron overload.Conclusions:SMURF1 can specifically regulate the BMP/SMAD pathway by augmenting the responsiveness of hepatocytes to BMPs during serum iron overload.
基金This project was supported by the Ministry of Education,Singapore,under its Academic Research Fund Tier 1(RG20/20)the National Natural Science Foundation of China(61872347)the Special Plan for the Development of Distinguished Young Scientists of ISCAS(Y8RC535018).
文摘The explosive growth of social media means portrait editing and retouching are in high demand.While portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the user to be highly skilled.Aiming at developing intuitive and easy-to-use portrait editing tools,we propose a novel vectorization method that can automatically convert raster images into a 3-tier hierarchical representation.The base layer consists of a set of sparse diffusion curves(DCs)which characterize salient geometric features and low-frequency colors,providing a means for semantic color transfer and facial expression editing.The middle level encodes specular highlights and shadows as large,editable Poisson regions(PRs)and allows the user to directly adjust illumination by tuning the strength and changing the shapes of PRs.The top level contains two types of pixel-sized PRs for high-frequency residuals and fine details such as pimples and pigmentation.We train a deep generative model that can produce high-frequency residuals automatically.Thanks to the inherent meaning in vector primitives,editing portraits becomes easy and intuitive.In particular,our method supports color transfer,facial expression editing,highlight and shadow editing,and automatic retouching.To quantitatively evaluate the results,we extend the commonly used FLIP metric(which measures color and feature differences between two images)to consider illumination.The new metric,illumination-sensitive FLIP,can effectively capture salient changes in color transfer results,and is more consistent with human perception than FLIP and other quality measures for portrait images.We evaluate our method on the FFHQR dataset and show it to be effective for common portrait editing tasks,such as retouching,light editing,color transfer,and expression editing.
基金sponsored by grants from the National Natural Science Foundation of China(62002010,61872347)the CAMS Innovation Fund for Medical Sciences(2019-I2M5-016)the Special Plan for the Development of Distinguished Young Scientists of ISCAS(Y8RC535018).
文摘Learning and inferring underlying motion patterns of captured 2D scenes and then re-creating dynamic evolution consistent with the real-world natural phenomena have high appeal for graphics and animation.To bridge the technical gap between virtual and real environments,we focus on the inverse modeling and reconstruction of visually consistent and property-verifiable oceans,taking advantage of deep learning and differentiable physics to learn geometry and constitute waves in a self-supervised manner.First,we infer hierarchical geometry using two networks,which are optimized via the differentiable renderer.We extract wave components from the sequence of inferred geometry through a network equipped with a differentiable ocean model.Then,ocean dynamics can be evolved using the reconstructed wave components.Through extensive experiments,we verify that our new method yields satisfactory results for both geometry reconstruction and wave estimation.Moreover,the new framework has the inverse modeling potential to facilitate a host of graphics applications,such as the rapid production of physically accurate scene animation and editing guided by real ocean scenes.
文摘Erratum to Xueguang Xie,Yang Gao,Fei Hou,Aimin Hao&Hong Qin.Dynamic ocean inverse modeling based on differentiable rendering.Computational Visual Media Vol.10,No.2,279–294,2024.https://doi10.1007/s41095-023-0338-4 The authors apologize for a hidden error in the article.It is that the images in Figs.14(a)and 14(d)were mistakenly presented as left–right mirror images.The authors have flipped them to ensure that the figures now correspond correctly with others in the subfigures(b,c,e,f).The accurate version of Fig.14 is provided as below.
基金supported by the National Natural Science Foundation of China[grant number 82200591].
文摘Adequate oxygen supply is essential for maintaining the body's normal physiological function.In chronic inflammatory conditions such as inflammatory bowel disease(IBD),insufficient oxygen reaching the intestine triggers the regulatory system in response to environmental changes.However,the pathogenesis of IBD is still under investigation.Recent research has highlighted the significant role of hypoxia in IBD,particularly the involvement of hypoxia-inducible factors(HIF)and their regulatory mechanisms,making them promising therapeutic targets for IBD.This review will delve into the role of hypoxia,HIF,and the associated hypoxia-inflammatory microenvironment in the context of IBD.Potential interventions for addressing these challenging gastrointestinal inflammatory diseases will also be discussed within this framework.
基金the Research Award Fund for Clinical Medicine of Beijing Hospital Authority,China(No.ZYLX201802)。
文摘To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in critically ill patients.^([1])The Swansea diagnostic criteria have been widely used in the diagnosis of AFLP worldwide since their proposal.The Swansea criteria include clinical symptoms and laboratory tests,imaging,and pathological examination results.
基金the National Key Research and Development Program of China(No:2016YFC1302904)the National Natural Science Foundation of China(No:81572559)the Key Research Project of Shandong Province(No:2017CXGC1210).
文摘Background::Recently,T-helper 17(Th17)cells have been proved to play an important role in promoting cervical cancer.But,till now,few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor treatments.This study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer(LACC)patients before and after concurrent chemoradiotherapy(cCRT)and to analyze the correlations between the alterations in Th17 cells and treatment efficacy.Methods::A prospective study with 49 LACC(International federation of gynecology and obstetrics[FIGO]stage IIB-IIIB)patients and 23 controls was conducted.Patients received the same cCRT schedule and were followed up for 3 years.Circulating Th17 cells(CD3+CD8-interleukin[IL]-17+T cells)and related cytokines IL-17,transforming growth factor-β(TGF-β),IL-10,IL-23,IL-6,and IL-22 were detected before and after cCRT.Correlations between alterations of circulating Th17 cells and treatment efficacy were analyzed.Kaplan-Meier analysis was used for overall survival(OS)and progression-free survival(PFS).Results::We found that 40 patients finished the entire cCRT schedule and met the endpoint of this study.The percentage of circulating Th17 cells in the LACC patients was higher than that in the controls,and it significantly decreased after cCRT(P<0.05).After cCRT,patients were divided into two groups based on the average of the Th17 cells declined.The subgroup of patients with a prominent decrease in circulating Th17 cells after cCRT had a higher treatment efficacy and longer PFS and OS times.Compared with the control patients,LACC patients had higher IL-6,IL-10,IL-22,TGF-βlevels and a lower IL-23 level(P<0.05).After cCRT,IL-6,IL-10,IL-17,IL-23 level significantly increased and TGF-βlevel significantly decreased compared with the levels before cCRT(P<0.05).Conclusion::Circulating Th17 cells in the LACC patients(FIGO stage IIB-IIIB)were higher than those in the controls,but they generally decreased after cCRT.A more pronounced decrease in circulating Th17 cells after cCRT was correlated with better therapeutic effect and longer PFS and OS times.
