Genetic transformation has been an effective technology for improving the agronomic traits of maize.However,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype dependence.In this study,...Genetic transformation has been an effective technology for improving the agronomic traits of maize.However,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype dependence.In this study,we performed genomic sequencing for 80 core maize germplasms and constructed a high-density genomic variation map using our newly developed pipeline(MQ2Gpipe).Based on the induction rate of EC(REC),these inbred lines were categorized into three subpopulations.The low-REC germplasms displayed more abundant genetic diversity than the high-REC germplasms.By integrating a genome-wide selective signature screen and region-based association analysis,we revealed 95.23 Mb of selective regions and 43 REC-associated variants.These variants had phenotypic variance explained values ranging between 21.46 and 49.46%.In total,103 candidate genes were identified within the linkage disequilibrium regions of these REC-associated loci.These genes mainly participate in regulation of the cell cycle,regulation of cytokinesis,and other functions,among which MYB15 and EMB2745 were located within the previously reported QTL for EC induction.Numerous leaf area-associated variants with large effects were closely linked to several REC-related loci,implying a potential synergistic selection of REC and leaf size during modern maize breeding.展开更多
The research progress of a novel traffic solution,a submerged floating tunnel（SFT）,is reviewed in terms of a study approach and loading scenario.Among existing publications,the buoyancy-weight ratio（BWR） is usuall...The research progress of a novel traffic solution,a submerged floating tunnel（SFT）,is reviewed in terms of a study approach and loading scenario.Among existing publications,the buoyancy-weight ratio（BWR） is usually predefined.However,BWR is a critical structural parameter that tremendously affects the dynamic behaviour of not only the tunnel tube itself but also the cable system.In the context of a SFT prototype（SFTP） project in Qiandao Lake（Zhejiang Province,China）,the importance of BWR is illustrated by finite element analysis and subsequently,an optimized BWR is proposed within a reasonable range in the present study.In the numerical model,structural damping is identified to be of importance.Rayleigh damping and the corresponding Rayleigh coefficients are attained through a sensitivity study,which shows that the adopted damping ratios are fairly suitable for SFTP.Lastly,the human sense of security is considered by quantifying the comfort index,which helps further optimize BWR in the SFTP structural parameter design.展开更多
Background context:Metastatic spinal cord compression(MSCC)seriously affects the survival rate.Objective:The therapeutic effects of two treatment strategies for MSCC:percutaneous vertebroplasty(PVP)combined with radio...Background context:Metastatic spinal cord compression(MSCC)seriously affects the survival rate.Objective:The therapeutic effects of two treatment strategies for MSCC:percutaneous vertebroplasty(PVP)combined with radiofrequency ablation(RFA)and PVP combined with^(125)I particle implantation,were compared.Study design:Retrospective study.Patient sample:40 patients with MSCC were divided into two groups:19 cases in the RFA group and 21 cases in the^(125)I group.Method:All patients were accessed to determine the differences in pain,which was evaluated using the visual analog scale(VAS)at 1 week,1 month,and 3 months after the operation,and spinal stenosis rates(SSRs),which were measured at 1 and 3 months after the operation,between the two groups.Results:The VAS scores and SSRs at baseline were comparable between the RFA group and the^(125)I group(7.19±2.07 vs 7.42±1.95,37.7%±11.2%vs 41.1%±11.4%).The VAS scores and SSRs at 1 month and 3 months after the operation were significantly reduced in both groups,compared with those at baseline.The VAS scores and SSRs in the^(125)I group were lower than those in the RFA group at 3 months after the operation(1.09±0.97 vs 1.75±1.06 p=0.048 and 12.3%±6.4%vs 18.1%±10.1%p=0.034),while the VAS scores at1 week after the operation in the RFA group were lower than those in the^(125)I group(4.39±1.34 vs 5.05±1.82 p=0.049).Conclusion:PVP combined with RFA has a slight advantage in relieving pain in the short term,while PVP combined with^(125)I particle implantation may have a better effect in the relieving pain and decreasing the SSRs at 3 months after the operation.展开更多
Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic dist...Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.展开更多
The current assembled maize genomes cannot represent the broad genetic diversity of maize germplasms.Acquiring more genome sequences is critical for constructing a pan-genome and elucidating the linkage between genoty...The current assembled maize genomes cannot represent the broad genetic diversity of maize germplasms.Acquiring more genome sequences is critical for constructing a pan-genome and elucidating the linkage between genotype and phenotype in maize.Here we describe the genome sequence and annotation of A188,a maize inbred line with high phenotypic variation relative to other lines,acquired by single-molecule sequencing and optical genome mapping.We assembled a 2210-Mb genome with a scaffold N50 size of 11.61 million bases(Mb),compared to 9.73 Mb for B73 and 10.2 Mb for Mo17.Based on the B73_Ref Gen_V4 genome,295 scaffolds(2084.35 Mb,94.30%of the final genome assembly)were anchored and oriented on ten chromosomes.Comparative analysis revealed that~30%of the predicted A188 genes showed large structural divergence from B73,Mo17,and W22 genomes,which causes high protein divergence and may lead to phenotypic variation among the four inbred lines.As a line with high embryonic callus(EC)induction capacity,A188 provides a convenient tool for elucidating the molecular mechanism underlying the formation of EC in maize.Combining our new A188 genome with previously reported QTL and RNA sequencing data revealed eight genes with large structural variation and two differentially expressed genes playing potential roles in maize EC induction.展开更多
BACKGROUND Congenital agenesis of the gallbladder(CAGB)is a rare condition often misdiagnosed as cholecystolithiasis,leading to unnecessary surgeries.Accurate diagnosis and surgical exploration are crucial in patients...BACKGROUND Congenital agenesis of the gallbladder(CAGB)is a rare condition often misdiagnosed as cholecystolithiasis,leading to unnecessary surgeries.Accurate diagnosis and surgical exploration are crucial in patients with suspected CAGB or atypical gallbladder stone symptoms.Preoperative imaging,such as magnetic resonance cholangiopancreatography(MRCP),plays a vital role in confirming the diagnosis.Careful intraoperative dissection is necessary to avoid iatrogenic injuries and misdiagnosis.Multidisciplinary consultations and collaboration,along with the use of various diagnostic methods,can minimize associated risks.CASE SUMMARY We present the case of a 34-year-old female with suspected gallbladder stones,ultimately diagnosed with CAGB through surgical exploration.The patient underwent laparoscopic examination followed by open exploratory surgery,which confirmed absence of the gallbladder.Subsequent imaging studies supported the diagnosis.The patient received appropriate postoperative care and experienced a successful recovery.CONCLUSION This case highlights the rarity of CAGB and the importance of considering this condition in the differential diagnosis of patients with gallbladder stone symptoms.Accurate diagnosis using preoperative imaging,such as MRCP,is crucial to prevent unnecessary surgeries.Surgeons should exercise caution and conduct meticulous dissection during surgery to avoid iatrogenic injuries and ensure accurate diagnosis.Multidisciplinary collaboration and utilization of various diagnostic methods are essential to minimize the risk of misdiagnosis.Selection of the optimal treatment strategy should prioritize minimizing trauma and maintaining open communication with the patient and their family members.展开更多
With the deep integration of electrochemical research with energy,environment,catalysis,and other fields,more and more new electrochemical catalytic reactions have entered our research field.Alloy catalysts have recen...With the deep integration of electrochemical research with energy,environment,catalysis,and other fields,more and more new electrochemical catalytic reactions have entered our research field.Alloy catalysts have recently emerged as a new type of nanomaterial due to the rapid development of kinetic controlled synthesis technology.These materials offer several advantages over monometallic catalysts,including larger element combinations,complex geometries,bifunctional sites,and reduced use of precious metals.This paper provides a review of alloy electrocatalysts that are designed and prepared specifically for electrocatalytic applications.The use of alloy materials in electrocatalyst design is also discussed,highlighting their widespread application in this field.First,various synthesis methods and synthesis mechanisms are systematically summarized.Following that,by correlating the properties of materials with the structure,relevant strategies toward advanced alloy electrocatalysts including composition regulation,size,morphology,surface engineering,defect engineering,interface engineering and strain engineering are classified.In addition,the important electrocatalytic applications and mechanisms of alloy electrocatalysts are described and summarized.Finally,the current challenges and prospects regarding the development of alloy nanomaterials are proposed.This review serves as a springboard from a fundamental understanding of alloy structural dynamics to design and various applications of electrocatalysts,particularly in energy and environmental sustainability.展开更多
A novel integrated approach to remove the free alkalis and stabilize solid-phase alkalinity by controlling the release of Ca from desulfurization gypsum was developed.The combination of recycled FeCl_(3)solution and E...A novel integrated approach to remove the free alkalis and stabilize solid-phase alkalinity by controlling the release of Ca from desulfurization gypsum was developed.The combination of recycled FeCl_(3)solution and EDTA activated desulfurization gypsum lowered the bauxite residue pH to 7.20.Moreover,it also improved the residual Ca state,with its contribution to the total exchangeable cations increased(68%-92%).Notably,the slow release of exchangeable Ca introduced through modified desulfurization gypsum induced a phase transition of the alkaline minerals.This treatment stabilized the dealkalization effect of bauxite residue via reducing its overall acid neutralization capacity in abating pH rebound.Hence,this approach can provide guidance for effectively utilizing desulfurization gypsum to achieve stable regulation of alkalinity in bauxite residue.展开更多
The WW domain-containing oxidoreductase（WWOX） is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-f...The WW domain-containing oxidoreductase（WWOX） is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-free survival rate among breast cancer patients. Though several WWOX partners have been identified, the functional mechanisms of WWOX＇s role in cancers have not been fully addressed to date. In the current study, we found WWOX suppresses expression of KLF5—an oncogenic transcription factor—at protein level, and suppresses cancer cell proliferation in both bladder and breast cancer cell lines. Furthermore, we demonstrated that WWOX physically interacts with KLF5 via the former＇s WW domains and the latter＇s PY motifs. Interestingly, we found the expression of WWOX negatively correlates with KLF5 expression in a panel of breast cancer cell lines. Taken together, we conjecture that WWOX may suppress cancer cell proliferation partially by reducing the expression of KLF5.展开更多
This study investigated the transformations of heavy metals(HMs) and polycyclic aromatic hydrocarbons(PAHs) in rhizosphere soils and adaptive responses of rhizobacterial community under the real field conditions durin...This study investigated the transformations of heavy metals(HMs) and polycyclic aromatic hydrocarbons(PAHs) in rhizosphere soils and adaptive responses of rhizobacterial community under the real field conditions during four growth stages(e.g., greening, tillering, heading, and maturity) of early rice(Zhongjiazao 17) and late rice(Zhongyou 9918) in Jiangshe village(JSV) and Yangji village(YJV). Results showed that rhizosphere soils of YJV were mildly polluted by Cd and PAHs compared to that of JSV. The relative abundance of bioavailable Cd(bio-Cd) and bioavailable As(bio-As) in rhizosphere soil increased before the heading stage but decreased at the subsequent growth stage, but the content of ΣPAHs in rhizosphere soil decreased gradually during whole growth period. The dominant rhizobacteria genera at YJV(e.g., Bacillus, Massilia, Sphingomonas, and Geobacter) increased at an abundance level from the tillering to heading stage. Rhizobacteria interacted with the above co-pollutant more intensely at the tillering and heading stage, where genes involved in HM-resistance and PAH-degradation appeared to have a significant enhancement. The contents of bioCd and bio-As in rhizosphere soil of early rice were higher than that of late rice at each growth stage, especially at the heading stage. Bio-Cd, ΣPAHs, and organic matter were key factors influencing the community structure of rhizobacteria. Results of this study provide valuable insights about the interactions between HM-PAH co-pollutant and rhizobacterial community under real field conditions and thus develop in-situ rhizosphere remediation techniques for contaminated paddy fields.展开更多
The effects of tension on vortex-induced vibration (VIV) responses for a tension-dominated long cylinder with an aspect ratio of 550 in uniform flows are experimentally investigated in this paper. The results show tha...The effects of tension on vortex-induced vibration (VIV) responses for a tension-dominated long cylinder with an aspect ratio of 550 in uniform flows are experimentally investigated in this paper. The results show that elevated tension suppresses fluctuations of maximum displacement with respect to flow velocity and makes chaotic VIV more likely to appear. With respect to periodic VIV, if elevated tension is applied, the dominant vibration frequency in the in-line (IL) direction will switch from a fundamental vibration frequency to twice the value of the fundamental vibration frequency, which results in a ratio of the dominant vibration frequency in the IL direction to that in the cross-flow direction of 2.0. The suppression of the elevated tension in the fluctuation of the maximum displacement causes the axial tension to become an active control parameter for the VIV maximum displacement of a tension-dominated long riser or tether of an engineering structure in deep oceans. However, the axial tension must be optimized before being used since the high dominant vibration frequency due to the elevated tension may unfavorably affect the fatigue life of the riser or tether.展开更多
A novel‐structured Mo‐Cu‐Fe‐O composite was successfully prepared by co‐precipitation and impregnation method.The properties of the as‐prepared samples were determined using X‐ray diffraction,temperature‐progr...A novel‐structured Mo‐Cu‐Fe‐O composite was successfully prepared by co‐precipitation and impregnation method.The properties of the as‐prepared samples were determined using X‐ray diffraction,temperature‐programmed reduction by H2,cyclic voltammetry,and temperature‐programmed desorption by O2.The results showed that Mo6+diffused into the Cu‐Fe‐O crystal lattice and then formed a new crystalline phase of CuMoO4.The Mo‐Cu‐Fe‐O catalyst had redox properties,and its surface contained active sites for oxygen adsorption.In addition,the catalytic activity of the Mo‐Cu‐Fe‐O composite was evaluated by the degradation of Cationic Red GTL,Crystal Violet,and Acid Red in catalytic wet air oxidation(CWAO)at ambient temperature and pressure.The Mo‐Cu‐Fe‐O catalyst showed excellent activity at basic conditions for the degradation of Cationic Red GTL.High removal efficiencies of91.5%and92.8%were achieved for Cationic Red GTL and Crystal Violet,respectively,in wastewater,and the efficiency remained high after seven cycles.However,almost no degradation of Acid Red occurred in the CWAO process.Furthermore,hydroxyl radicals were formed in the CWAO process,which induced the decomposition of the two cationic dyes in wastewater,and the toxicity of their effluents was decreased after degradation.The results indicate that the Mo‐Cu‐Fe‐O composite shows excellent catalytic activity for the treatment of wastewater contaminated with cationic dyes.展开更多
We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone（HBQ） disinfection byproducts（DBPs） produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, ...We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone（HBQ） disinfection byproducts（DBPs） produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, produced 2,6-dichloro-1,4-benzoquinone（2,6-DCBQ）, the most prevalent HBQ DBP in disinfected water. Under varying p H conditions（p H 6.0–9.0）, 2,6-DCBQ formation ranged from 0.3 to 2.1 μg/mg C with maximum formation at p H 8.0. To evaluate the contribution of organic components of C. vulgaris to 2,6-DCBQ formation, we separated the organics into two fractions, the protein-rich fraction of intracellular organic matter（IOM） and the polysaccharide-laden fraction of extracellular organic matter（EOM）. Chlorination of IOM and EOM produced 1.4 μg/mg C and 0.7 μg/mg C of 2,6-DCBQ, respectively. The IOM generated a two-fold higher 2,6-DCBQ formation potential than the EOM fraction, suggesting that proteins are potent 2,6-DCBQ precursors. This was confirmed by the chlorination of proteins extracted from C. vulgaris： the amount of 2,6-DCBQ produced is linearly correlated with the concentration of total algal protein（R2= 0.98）. These results support that proteins are the primary precursors of 2,6-DCBQ in algae, and control of green algal bloom outbreaks in source waters is important for management of HBQ DBPs.展开更多
Purpose:This paper proposes a method of detecting emerging trends in research topics from a more micro perspective.Design/methodology/approach:Through co-word clustering to identify research topics and analyzing posit...Purpose:This paper proposes a method of detecting emerging trends in research topics from a more micro perspective.Design/methodology/approach:Through co-word clustering to identify research topics and analyzing position changes of topic words in the keywords life-cycle diagram during different time periods,we detected emerging trends in research topics from a more micro perspective.I'he method was applied to the field of nanotechnology to verify its effectiveness and practicability.Findings:The results show that this method can be used to detect emerging trends in research topics from a more micro perspective,as it divides keywords into five categories:Potential keywords,emerging keywords,hot keywords,stable keywords and recession keywords,through which more details of topic changes can be found.Research limitations:We used keywords provided by authors and database indexers for keywords extraction.But this approach may lead to the problem of 'indexer effect'.The method may have a limited effect when applied to a disciplinary domain such as mathematics,which evolves slowly.Practical implications:This study provides information analysts with insights into the way to better understand specialty areas of a discipline domain and formulate research policies and strategic plans.Originality/value:This study contributes to the current literature by proposing a new method,which can detect emerging trends in research topics from a more micro perspective.展开更多
The skin wound is susceptible to bacterial invasion,which hinders the healing of the wound,especially when infected with multi-drug resistant strains.This demands novel bioactive materials to combat bacterial infectio...The skin wound is susceptible to bacterial invasion,which hinders the healing of the wound,especially when infected with multi-drug resistant strains.This demands novel bioactive materials to combat bacterial infections.In this study,gallium oxide nanoparticles(Ga_(2)O_(3) NPs)were successfully synthesized through high-temperature thermal decomposition,exhibiting excellent biocompatibility and photocatalytic antimicrobial activity.The Ga_(2)O_(3) NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel(Ga_(2)O_(3) NPs hydrogel)for use in photocatalytic antimicrobial therapy(PCAT).The prepared Ga_(2)O_(3) NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against E.coli and S.aureus.It effectively eradicates biofilms,promotes reactive oxygen species production,disrupts bacterial cell membranes,and induces nucleic acid leakage,ultimately resulting in bacterial death.Additionally,it exhibits excellent biosafety.Both in vitro pigskin and in vivo mouse wound infection models have confirmed the remarkable efficacy of Ga_(2)O_(3) NPs hydrogel in PCAT.Notably,Ga_(2)O_(3) NPs hydrogel created a moist environment for the wound in an MDR S.aureus-infected mouse wound model,demonstrating significant potential to facilitate wound healing and minimize scar formation.This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.展开更多
Waterborne microbial contamination represents a significant global environmental challenge.Microorganisms can induce water pollution,precipitating infectious disease outbreaks and posing a substantial threat to human ...Waterborne microbial contamination represents a significant global environmental challenge.Microorganisms can induce water pollution,precipitating infectious disease outbreaks and posing a substantial threat to human health.Currently,the excessive use of conventional antibiotics has resulted in the emergence of bacterial resistance,posing a challenge to the design and development of antimicrobial agents with high antibacterial efficacy in diverse water such as rivers,lakes,and wastewater from microbiology laboratories.Bimetallic nanomaterials,that amalgamate the distinctive characteristics of diverse metals,are garnering attention due to their synergistic properties.In this study,PVP-FeMo_(2)S_(3)(PVP:Polyvinylpyrrolidone)and PVP-ZnMo_(2)S_(3)nanocrystals were synthesized by a high-temperature reaction.The prepared nanocrystals exhibited excellent biocompatibility,regular morphology,long-term stability,and remarkable antibacterial e ects.The bacterial biofilms could be eradicated by the combination of photothermal(PTT)and photodynamic synergistic e ects of PVP-FeMo_(2)S_(3)and PVP-ZnMo_(2)S_(3)nanocrystals.PVP-ZnMo_(2)S_(3)nanocrystals exhibited enhanced PTT conversion efficiency for water treatment.Remarkably,even after 20 cycles of recycling,PVP-ZnMo_(2)S_(3)retained substantial antibacterial e cacy.The excellent biosafety of PVP-ZnMo_(2)S_(3)further guarantees the safety of water quality post-treatment.Thus,PVP-ZnMo_(2)S_(3)bimetallic nanocrystals can serve as a novel antimicrobial agent for the treatment of microbial contamination in water.This study offers a potential strategy to mitigate secondary water pollution and prevent the development of drug resistance among pathogenic microorganisms.展开更多
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors.Several international authoritative societies have developed a number of guidelines to standardize clinical pr...Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors.Several international authoritative societies have developed a number of guidelines to standardize clinical practice for the emerging discipline of cardio-oncology,aiming to allow patients to receive cancer treatment while reducing the risk of cardio-vascular events.Anthracyclines,as the earliest first-line chemotherapy drugs,have attracted much attention from researchers due to their severe cardiotoxicity.Although targeted therapy and immunotherapy strategies improve anticancer efficacy,they also increase the risk of cardiotoxicity.Therefore,anthracyclines are still indispensable in cancer treatment,and in-depth understanding of the mechanism of cardiotoxicity will help to develop effective therapeutic strategies.This review aims to summarize the new mechanisms of cardiotoxicity caused by anthracyclines and cur-rent emerging therapeutic strategies.展开更多
Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastas...Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention.展开更多
Limited to the direct modulation on the surface acoustic wave(SAW)by the rotation,the conventional SAW gyroscopes incur weak Coriolis effects and gyroscopic effects.In this paper,we innovatively utilize a phononic met...Limited to the direct modulation on the surface acoustic wave(SAW)by the rotation,the conventional SAW gyroscopes incur weak Coriolis effects and gyroscopic effects.In this paper,we innovatively utilize a phononic metamaterial(PM)operated at whispering-gallery modes(WGMs)as the vehicle for the Coriolis effect rather than SAW itself.The gyroscopic effects of this PM are investigated,and a new SAW gyroscope is subsequently proposed based on the slow SAW in PM.We show,combining theoretical modeling and finite element method simulation,that the rate of rotation can linearly induce the splitting of WGMs and modulate the phase velocity of SAW down to 4600 m/s(initial phase velocity of 5355 m/s);the direction of rotation results in the chiral symmetry of the PM vibration and the asymmetric distribution of the transmissive SAW.Besides,the proposed SAW gyroscope measures the angular velocity by detecting the phase shift resulting from rotation-dependent slow SAW in PM,obtaining a sensitivity of 0.016 deg/Hz when 50-cell PM.Compared with the existing SAW gyroscopes based on phase velocity modulation,the gyroscopic gain factor in this paper is enhanced by 430–1600 times.This work jumps out of the framework of directly modulating SAW in gyroscopes and provides an innovative scheme of the indirect modulations from the rotation-dependent PM on SAW,showing excellent performance and potential for angular velocity measurement in extreme environments.展开更多
基金supported by the National Key Research and Development Program of China(2021YFF1000303)the National Nature Science Foundation of China(32072073,32001500,and 32101777)the Sichuan Science and Technology Program,China(2021JDTD0004 and 2021YJ0476)。
文摘Genetic transformation has been an effective technology for improving the agronomic traits of maize.However,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype dependence.In this study,we performed genomic sequencing for 80 core maize germplasms and constructed a high-density genomic variation map using our newly developed pipeline(MQ2Gpipe).Based on the induction rate of EC(REC),these inbred lines were categorized into three subpopulations.The low-REC germplasms displayed more abundant genetic diversity than the high-REC germplasms.By integrating a genome-wide selective signature screen and region-based association analysis,we revealed 95.23 Mb of selective regions and 43 REC-associated variants.These variants had phenotypic variance explained values ranging between 21.46 and 49.46%.In total,103 candidate genes were identified within the linkage disequilibrium regions of these REC-associated loci.These genes mainly participate in regulation of the cell cycle,regulation of cytokinesis,and other functions,among which MYB15 and EMB2745 were located within the previously reported QTL for EC induction.Numerous leaf area-associated variants with large effects were closely linked to several REC-related loci,implying a potential synergistic selection of REC and leaf size during modern maize breeding.
文摘The research progress of a novel traffic solution,a submerged floating tunnel（SFT）,is reviewed in terms of a study approach and loading scenario.Among existing publications,the buoyancy-weight ratio（BWR） is usually predefined.However,BWR is a critical structural parameter that tremendously affects the dynamic behaviour of not only the tunnel tube itself but also the cable system.In the context of a SFT prototype（SFTP） project in Qiandao Lake（Zhejiang Province,China）,the importance of BWR is illustrated by finite element analysis and subsequently,an optimized BWR is proposed within a reasonable range in the present study.In the numerical model,structural damping is identified to be of importance.Rayleigh damping and the corresponding Rayleigh coefficients are attained through a sensitivity study,which shows that the adopted damping ratios are fairly suitable for SFTP.Lastly,the human sense of security is considered by quantifying the comfort index,which helps further optimize BWR in the SFTP structural parameter design.
文摘Background context:Metastatic spinal cord compression(MSCC)seriously affects the survival rate.Objective:The therapeutic effects of two treatment strategies for MSCC:percutaneous vertebroplasty(PVP)combined with radiofrequency ablation(RFA)and PVP combined with^(125)I particle implantation,were compared.Study design:Retrospective study.Patient sample:40 patients with MSCC were divided into two groups:19 cases in the RFA group and 21 cases in the^(125)I group.Method:All patients were accessed to determine the differences in pain,which was evaluated using the visual analog scale(VAS)at 1 week,1 month,and 3 months after the operation,and spinal stenosis rates(SSRs),which were measured at 1 and 3 months after the operation,between the two groups.Results:The VAS scores and SSRs at baseline were comparable between the RFA group and the^(125)I group(7.19±2.07 vs 7.42±1.95,37.7%±11.2%vs 41.1%±11.4%).The VAS scores and SSRs at 1 month and 3 months after the operation were significantly reduced in both groups,compared with those at baseline.The VAS scores and SSRs in the^(125)I group were lower than those in the RFA group at 3 months after the operation(1.09±0.97 vs 1.75±1.06 p=0.048 and 12.3%±6.4%vs 18.1%±10.1%p=0.034),while the VAS scores at1 week after the operation in the RFA group were lower than those in the^(125)I group(4.39±1.34 vs 5.05±1.82 p=0.049).Conclusion:PVP combined with RFA has a slight advantage in relieving pain in the short term,while PVP combined with^(125)I particle implantation may have a better effect in the relieving pain and decreasing the SSRs at 3 months after the operation.
基金supported by the National Natural Science Foundation of China(Nos.21577117 and 22076160)the Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20210521).
文摘Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.
基金supported by the National Natural Science Foundation of China(31871637,32072073,and 32001500)the Project of Transgenic New Variety Cultivation(2016ZX08003003)。
文摘The current assembled maize genomes cannot represent the broad genetic diversity of maize germplasms.Acquiring more genome sequences is critical for constructing a pan-genome and elucidating the linkage between genotype and phenotype in maize.Here we describe the genome sequence and annotation of A188,a maize inbred line with high phenotypic variation relative to other lines,acquired by single-molecule sequencing and optical genome mapping.We assembled a 2210-Mb genome with a scaffold N50 size of 11.61 million bases(Mb),compared to 9.73 Mb for B73 and 10.2 Mb for Mo17.Based on the B73_Ref Gen_V4 genome,295 scaffolds(2084.35 Mb,94.30%of the final genome assembly)were anchored and oriented on ten chromosomes.Comparative analysis revealed that~30%of the predicted A188 genes showed large structural divergence from B73,Mo17,and W22 genomes,which causes high protein divergence and may lead to phenotypic variation among the four inbred lines.As a line with high embryonic callus(EC)induction capacity,A188 provides a convenient tool for elucidating the molecular mechanism underlying the formation of EC in maize.Combining our new A188 genome with previously reported QTL and RNA sequencing data revealed eight genes with large structural variation and two differentially expressed genes playing potential roles in maize EC induction.
文摘BACKGROUND Congenital agenesis of the gallbladder(CAGB)is a rare condition often misdiagnosed as cholecystolithiasis,leading to unnecessary surgeries.Accurate diagnosis and surgical exploration are crucial in patients with suspected CAGB or atypical gallbladder stone symptoms.Preoperative imaging,such as magnetic resonance cholangiopancreatography(MRCP),plays a vital role in confirming the diagnosis.Careful intraoperative dissection is necessary to avoid iatrogenic injuries and misdiagnosis.Multidisciplinary consultations and collaboration,along with the use of various diagnostic methods,can minimize associated risks.CASE SUMMARY We present the case of a 34-year-old female with suspected gallbladder stones,ultimately diagnosed with CAGB through surgical exploration.The patient underwent laparoscopic examination followed by open exploratory surgery,which confirmed absence of the gallbladder.Subsequent imaging studies supported the diagnosis.The patient received appropriate postoperative care and experienced a successful recovery.CONCLUSION This case highlights the rarity of CAGB and the importance of considering this condition in the differential diagnosis of patients with gallbladder stone symptoms.Accurate diagnosis using preoperative imaging,such as MRCP,is crucial to prevent unnecessary surgeries.Surgeons should exercise caution and conduct meticulous dissection during surgery to avoid iatrogenic injuries and ensure accurate diagnosis.Multidisciplinary collaboration and utilization of various diagnostic methods are essential to minimize the risk of misdiagnosis.Selection of the optimal treatment strategy should prioritize minimizing trauma and maintaining open communication with the patient and their family members.
基金supported by the National Natural Science Foundation of China(No.52072153)the Postdoctoral Science Foundation of China(No.2021M690023)+2 种基金the Postdoctoral Science Foundation of Jiangsu Province(No.2021K176B)the Graduate Research Innovation Program of Jiangsu Provincial(Nos.KYCX22_3694 and KYCX23_3649)the Zhenjiang Key R&D Programmes(No.SH2021021)。
文摘With the deep integration of electrochemical research with energy,environment,catalysis,and other fields,more and more new electrochemical catalytic reactions have entered our research field.Alloy catalysts have recently emerged as a new type of nanomaterial due to the rapid development of kinetic controlled synthesis technology.These materials offer several advantages over monometallic catalysts,including larger element combinations,complex geometries,bifunctional sites,and reduced use of precious metals.This paper provides a review of alloy electrocatalysts that are designed and prepared specifically for electrocatalytic applications.The use of alloy materials in electrocatalyst design is also discussed,highlighting their widespread application in this field.First,various synthesis methods and synthesis mechanisms are systematically summarized.Following that,by correlating the properties of materials with the structure,relevant strategies toward advanced alloy electrocatalysts including composition regulation,size,morphology,surface engineering,defect engineering,interface engineering and strain engineering are classified.In addition,the important electrocatalytic applications and mechanisms of alloy electrocatalysts are described and summarized.Finally,the current challenges and prospects regarding the development of alloy nanomaterials are proposed.This review serves as a springboard from a fundamental understanding of alloy structural dynamics to design and various applications of electrocatalysts,particularly in energy and environmental sustainability.
基金supported by the National Natural Science Foundation of China(No.42307521)the China Postdoctoral Science Foundation(No.2023M742934)。
文摘A novel integrated approach to remove the free alkalis and stabilize solid-phase alkalinity by controlling the release of Ca from desulfurization gypsum was developed.The combination of recycled FeCl_(3)solution and EDTA activated desulfurization gypsum lowered the bauxite residue pH to 7.20.Moreover,it also improved the residual Ca state,with its contribution to the total exchangeable cations increased(68%-92%).Notably,the slow release of exchangeable Ca introduced through modified desulfurization gypsum induced a phase transition of the alkaline minerals.This treatment stabilized the dealkalization effect of bauxite residue via reducing its overall acid neutralization capacity in abating pH rebound.Hence,this approach can provide guidance for effectively utilizing desulfurization gypsum to achieve stable regulation of alkalinity in bauxite residue.
基金supported by National Natural Science Foundation of China (81272930, 81322038, 31260208, and U1132605)the Science and Technological Key Project of Yunnan Province (2012FB185)West Light Foundation of the Chinese Academy of Sciences (to R.L.)
文摘The WW domain-containing oxidoreductase（WWOX） is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-free survival rate among breast cancer patients. Though several WWOX partners have been identified, the functional mechanisms of WWOX＇s role in cancers have not been fully addressed to date. In the current study, we found WWOX suppresses expression of KLF5—an oncogenic transcription factor—at protein level, and suppresses cancer cell proliferation in both bladder and breast cancer cell lines. Furthermore, we demonstrated that WWOX physically interacts with KLF5 via the former＇s WW domains and the latter＇s PY motifs. Interestingly, we found the expression of WWOX negatively correlates with KLF5 expression in a panel of breast cancer cell lines. Taken together, we conjecture that WWOX may suppress cancer cell proliferation partially by reducing the expression of KLF5.
基金supported by the National Natural Science Foundation of China(No.22176161)the National Natural Science Foundation of China-Hunan Joint Fund(No.U21A20293)+2 种基金the Natural Science Foundation of Hunan Province(No.2021JJ30655)the Innovation Platform Open Fund Project of Hunan Provincial Education Committee(No.19K090)the Program of Shanghai Academic/Technology Research Leader(No.19XD1434900).
文摘This study investigated the transformations of heavy metals(HMs) and polycyclic aromatic hydrocarbons(PAHs) in rhizosphere soils and adaptive responses of rhizobacterial community under the real field conditions during four growth stages(e.g., greening, tillering, heading, and maturity) of early rice(Zhongjiazao 17) and late rice(Zhongyou 9918) in Jiangshe village(JSV) and Yangji village(YJV). Results showed that rhizosphere soils of YJV were mildly polluted by Cd and PAHs compared to that of JSV. The relative abundance of bioavailable Cd(bio-Cd) and bioavailable As(bio-As) in rhizosphere soil increased before the heading stage but decreased at the subsequent growth stage, but the content of ΣPAHs in rhizosphere soil decreased gradually during whole growth period. The dominant rhizobacteria genera at YJV(e.g., Bacillus, Massilia, Sphingomonas, and Geobacter) increased at an abundance level from the tillering to heading stage. Rhizobacteria interacted with the above co-pollutant more intensely at the tillering and heading stage, where genes involved in HM-resistance and PAH-degradation appeared to have a significant enhancement. The contents of bioCd and bio-As in rhizosphere soil of early rice were higher than that of late rice at each growth stage, especially at the heading stage. Bio-Cd, ΣPAHs, and organic matter were key factors influencing the community structure of rhizobacteria. Results of this study provide valuable insights about the interactions between HM-PAH co-pollutant and rhizobacterial community under real field conditions and thus develop in-situ rhizosphere remediation techniques for contaminated paddy fields.
基金supported by the Construction Technology Program of the Ministry of Transport (Grant 2013 318 740050)
文摘The effects of tension on vortex-induced vibration (VIV) responses for a tension-dominated long cylinder with an aspect ratio of 550 in uniform flows are experimentally investigated in this paper. The results show that elevated tension suppresses fluctuations of maximum displacement with respect to flow velocity and makes chaotic VIV more likely to appear. With respect to periodic VIV, if elevated tension is applied, the dominant vibration frequency in the in-line (IL) direction will switch from a fundamental vibration frequency to twice the value of the fundamental vibration frequency, which results in a ratio of the dominant vibration frequency in the IL direction to that in the cross-flow direction of 2.0. The suppression of the elevated tension in the fluctuation of the maximum displacement causes the axial tension to become an active control parameter for the VIV maximum displacement of a tension-dominated long riser or tether of an engineering structure in deep oceans. However, the axial tension must be optimized before being used since the high dominant vibration frequency due to the elevated tension may unfavorably affect the fatigue life of the riser or tether.
基金supported by the National Natural Science Foundation of China(51678511,51308484)the Natural Science Foundation of Hunan Province(13JJ4049)+3 种基金the Education Department Fund of Hunan Province(14C1094)the Open Fund of Key Laboratory of Mineralogy and Metallogeny in Chinese Academy of Sciences(KLMM20150104)the Major Talent Training Program of Xiangtan University(16PYZ09)the Specialized Research Fund for the Doctoral Program of Xiangtan University(12QDZ18)~~
文摘A novel‐structured Mo‐Cu‐Fe‐O composite was successfully prepared by co‐precipitation and impregnation method.The properties of the as‐prepared samples were determined using X‐ray diffraction,temperature‐programmed reduction by H2,cyclic voltammetry,and temperature‐programmed desorption by O2.The results showed that Mo6+diffused into the Cu‐Fe‐O crystal lattice and then formed a new crystalline phase of CuMoO4.The Mo‐Cu‐Fe‐O catalyst had redox properties,and its surface contained active sites for oxygen adsorption.In addition,the catalytic activity of the Mo‐Cu‐Fe‐O composite was evaluated by the degradation of Cationic Red GTL,Crystal Violet,and Acid Red in catalytic wet air oxidation(CWAO)at ambient temperature and pressure.The Mo‐Cu‐Fe‐O catalyst showed excellent activity at basic conditions for the degradation of Cationic Red GTL.High removal efficiencies of91.5%and92.8%were achieved for Cationic Red GTL and Crystal Violet,respectively,in wastewater,and the efficiency remained high after seven cycles.However,almost no degradation of Acid Red occurred in the CWAO process.Furthermore,hydroxyl radicals were formed in the CWAO process,which induced the decomposition of the two cationic dyes in wastewater,and the toxicity of their effluents was decreased after degradation.The results indicate that the Mo‐Cu‐Fe‐O composite shows excellent catalytic activity for the treatment of wastewater contaminated with cationic dyes.
基金supported by the National Natural Science Foundation of China (Nos. 21277114, and 21577117)the Natural Sciences and Engineering Research Council of Canada (NSERC)
文摘We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone（HBQ） disinfection byproducts（DBPs） produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, produced 2,6-dichloro-1,4-benzoquinone（2,6-DCBQ）, the most prevalent HBQ DBP in disinfected water. Under varying p H conditions（p H 6.0–9.0）, 2,6-DCBQ formation ranged from 0.3 to 2.1 μg/mg C with maximum formation at p H 8.0. To evaluate the contribution of organic components of C. vulgaris to 2,6-DCBQ formation, we separated the organics into two fractions, the protein-rich fraction of intracellular organic matter（IOM） and the polysaccharide-laden fraction of extracellular organic matter（EOM）. Chlorination of IOM and EOM produced 1.4 μg/mg C and 0.7 μg/mg C of 2,6-DCBQ, respectively. The IOM generated a two-fold higher 2,6-DCBQ formation potential than the EOM fraction, suggesting that proteins are potent 2,6-DCBQ precursors. This was confirmed by the chlorination of proteins extracted from C. vulgaris： the amount of 2,6-DCBQ produced is linearly correlated with the concentration of total algal protein（R2= 0.98）. These results support that proteins are the primary precursors of 2,6-DCBQ in algae, and control of green algal bloom outbreaks in source waters is important for management of HBQ DBPs.
基金supported by the Center of Advisory,Information Research,Academic Divisions of the Chinese Academy of Sciences
文摘Purpose:This paper proposes a method of detecting emerging trends in research topics from a more micro perspective.Design/methodology/approach:Through co-word clustering to identify research topics and analyzing position changes of topic words in the keywords life-cycle diagram during different time periods,we detected emerging trends in research topics from a more micro perspective.I'he method was applied to the field of nanotechnology to verify its effectiveness and practicability.Findings:The results show that this method can be used to detect emerging trends in research topics from a more micro perspective,as it divides keywords into five categories:Potential keywords,emerging keywords,hot keywords,stable keywords and recession keywords,through which more details of topic changes can be found.Research limitations:We used keywords provided by authors and database indexers for keywords extraction.But this approach may lead to the problem of 'indexer effect'.The method may have a limited effect when applied to a disciplinary domain such as mathematics,which evolves slowly.Practical implications:This study provides information analysts with insights into the way to better understand specialty areas of a discipline domain and formulate research policies and strategic plans.Originality/value:This study contributes to the current literature by proposing a new method,which can detect emerging trends in research topics from a more micro perspective.
基金financially supported by the Advanced Fiber Materials Engineering Research Center of Anhui Province(No.2023AFMC20)the Scientific Research Foundation for Advanced Talents of Anhui Polytechnic University(No.2022YQQ072)+5 种基金the Anhui Province Key Research and Development Program(No.2022i01020002)the Key Project Foundation of Anhui Higher Education Institutes of China(No.2023AH050941)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.22KJB180020)the Transversal Project(No.KH10004443),the Anhui Provincial Natural Science Foundation(No.2308085Y45)the Program for Excellent Sci-tech Innovation Teams of Universities in Anhui Province(No.2023AH010073)Wuhu Science and Technology Department project(No.2023jc22).
文摘The skin wound is susceptible to bacterial invasion,which hinders the healing of the wound,especially when infected with multi-drug resistant strains.This demands novel bioactive materials to combat bacterial infections.In this study,gallium oxide nanoparticles(Ga_(2)O_(3) NPs)were successfully synthesized through high-temperature thermal decomposition,exhibiting excellent biocompatibility and photocatalytic antimicrobial activity.The Ga_(2)O_(3) NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel(Ga_(2)O_(3) NPs hydrogel)for use in photocatalytic antimicrobial therapy(PCAT).The prepared Ga_(2)O_(3) NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against E.coli and S.aureus.It effectively eradicates biofilms,promotes reactive oxygen species production,disrupts bacterial cell membranes,and induces nucleic acid leakage,ultimately resulting in bacterial death.Additionally,it exhibits excellent biosafety.Both in vitro pigskin and in vivo mouse wound infection models have confirmed the remarkable efficacy of Ga_(2)O_(3) NPs hydrogel in PCAT.Notably,Ga_(2)O_(3) NPs hydrogel created a moist environment for the wound in an MDR S.aureus-infected mouse wound model,demonstrating significant potential to facilitate wound healing and minimize scar formation.This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.
基金financially supported by Anhui Province Key Research and Development Program(No.2022i01020002)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.22KJB180020)+2 种基金the Scientific Research Project of Anhui Polytechnic University(No.2022YQQ072)Anhui Provincial Higher Education Institutes(No.2023AH050941)the Advanced Fiber Materials Engineering Research Center of Anhui Province(No.2023AFMC20)。
文摘Waterborne microbial contamination represents a significant global environmental challenge.Microorganisms can induce water pollution,precipitating infectious disease outbreaks and posing a substantial threat to human health.Currently,the excessive use of conventional antibiotics has resulted in the emergence of bacterial resistance,posing a challenge to the design and development of antimicrobial agents with high antibacterial efficacy in diverse water such as rivers,lakes,and wastewater from microbiology laboratories.Bimetallic nanomaterials,that amalgamate the distinctive characteristics of diverse metals,are garnering attention due to their synergistic properties.In this study,PVP-FeMo_(2)S_(3)(PVP:Polyvinylpyrrolidone)and PVP-ZnMo_(2)S_(3)nanocrystals were synthesized by a high-temperature reaction.The prepared nanocrystals exhibited excellent biocompatibility,regular morphology,long-term stability,and remarkable antibacterial e ects.The bacterial biofilms could be eradicated by the combination of photothermal(PTT)and photodynamic synergistic e ects of PVP-FeMo_(2)S_(3)and PVP-ZnMo_(2)S_(3)nanocrystals.PVP-ZnMo_(2)S_(3)nanocrystals exhibited enhanced PTT conversion efficiency for water treatment.Remarkably,even after 20 cycles of recycling,PVP-ZnMo_(2)S_(3)retained substantial antibacterial e cacy.The excellent biosafety of PVP-ZnMo_(2)S_(3)further guarantees the safety of water quality post-treatment.Thus,PVP-ZnMo_(2)S_(3)bimetallic nanocrystals can serve as a novel antimicrobial agent for the treatment of microbial contamination in water.This study offers a potential strategy to mitigate secondary water pollution and prevent the development of drug resistance among pathogenic microorganisms.
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0502605)the National Natural Science Foundation of China(82374420 and 82174364)+3 种基金the Beijing-Tianjin-Hebei Basic Research Cooperation project(J230033)the Science and Technology Department of Beijing University of Chinese Medicine(2022-JYB-JBZR-001)the Science and Technology Department of Beijing University of Chinese Medicine(BZY-BZX-2022-08)the Beijing University of Chinese Medicine Graduate Independent Project(ZJKT2023042).
文摘Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors.Several international authoritative societies have developed a number of guidelines to standardize clinical practice for the emerging discipline of cardio-oncology,aiming to allow patients to receive cancer treatment while reducing the risk of cardio-vascular events.Anthracyclines,as the earliest first-line chemotherapy drugs,have attracted much attention from researchers due to their severe cardiotoxicity.Although targeted therapy and immunotherapy strategies improve anticancer efficacy,they also increase the risk of cardiotoxicity.Therefore,anthracyclines are still indispensable in cancer treatment,and in-depth understanding of the mechanism of cardiotoxicity will help to develop effective therapeutic strategies.This review aims to summarize the new mechanisms of cardiotoxicity caused by anthracyclines and cur-rent emerging therapeutic strategies.
基金This work was supported by grants from the National Key Research and Development Program of China(2020YFA0112300 and 2018YFC2000400 to C.C.)the National Postdoctoral Program for Innovative Talents(BX20190088 to F.L.)+2 种基金the National Natural Science Foundation of China(82000817 to F.L.,81773149 to Y.K.,U2102203 and 81830087 to C.C.,82173014 and 81872414 to D.J.,81772847 to R.L.)the China Postdoctoral Science Foundation(2019M662869 to F.L.,182703 and 230794 to Y.K.,CAS Light of West China program(Young Scholar 2021000006 to D.J.)the Yunnan Applied Basic Research Projects(202101AS070050 to C.C.,202001AU070095 to H.L.,2018FB134 to Y.K.,2019FB112 and 202001AW070018 to D.J.).
文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention.
基金financial support from the National Natural Science Foundation of China 507(Grant No.62071118)the Primary Research and Development Plan of Jiangsu Province(BE2021004-3).
文摘Limited to the direct modulation on the surface acoustic wave(SAW)by the rotation,the conventional SAW gyroscopes incur weak Coriolis effects and gyroscopic effects.In this paper,we innovatively utilize a phononic metamaterial(PM)operated at whispering-gallery modes(WGMs)as the vehicle for the Coriolis effect rather than SAW itself.The gyroscopic effects of this PM are investigated,and a new SAW gyroscope is subsequently proposed based on the slow SAW in PM.We show,combining theoretical modeling and finite element method simulation,that the rate of rotation can linearly induce the splitting of WGMs and modulate the phase velocity of SAW down to 4600 m/s(initial phase velocity of 5355 m/s);the direction of rotation results in the chiral symmetry of the PM vibration and the asymmetric distribution of the transmissive SAW.Besides,the proposed SAW gyroscope measures the angular velocity by detecting the phase shift resulting from rotation-dependent slow SAW in PM,obtaining a sensitivity of 0.016 deg/Hz when 50-cell PM.Compared with the existing SAW gyroscopes based on phase velocity modulation,the gyroscopic gain factor in this paper is enhanced by 430–1600 times.This work jumps out of the framework of directly modulating SAW in gyroscopes and provides an innovative scheme of the indirect modulations from the rotation-dependent PM on SAW,showing excellent performance and potential for angular velocity measurement in extreme environments.
