植被侵蚀是导致长城结构坍塌的重要潜在因素,相关检测研究主要包括人工巡检与自动化模型。前者现场勘查效率低下;后者受限于小目标漏检与计算冗余,难以实现精准高效的监测。因此,提出一种基于YOLOv11网络架构改进的长城植被侵蚀智能检...植被侵蚀是导致长城结构坍塌的重要潜在因素,相关检测研究主要包括人工巡检与自动化模型。前者现场勘查效率低下;后者受限于小目标漏检与计算冗余,难以实现精准高效的监测。因此,提出一种基于YOLOv11网络架构改进的长城植被侵蚀智能检测算法GWVE-YOLO(the Great Wall vegetation erosion,you only look once)。通过新增P2尺度小目标检测层,增强高分辨率浅层特征提取能力,显著降低微小病害目标的漏检率;在主干与颈部浅层引入RCS-OSA(reparameterized convolution based on channel shuffle of one-shot aggregation)模块,通过通道重排与结构重参数化技术优化特征融合效率,在维持精度的同时降低计算冗余;采用动态非单调聚焦机制的W-IoU(wise intersection over union)v3损失函数,自适应调整低质量样本梯度权重,以提升复杂背景下小目标定位精度。在自建无人机长城病害数据集,经实验表明,所提方法的m AP50达到78.8%、精确率达到79.8%,每秒帧数114,综合性能优于YOLO系列及其已有改进等主流检测模型。展开更多
This paper deals with the inhibitory mechanisms of ginsenoside \{G Rh 2\} on the growth of tumor cells. \{G Rh 2\} significantly inhibited the proliferation of human cervical adenocarcinoma HeLa cells in a time ...This paper deals with the inhibitory mechanisms of ginsenoside \{G Rh 2\} on the growth of tumor cells. \{G Rh 2\} significantly inhibited the proliferation of human cervical adenocarcinoma HeLa cells in a time and dose dependent manner. G Rh 2 induced apoptotic manifestations in HeLa cells as evidenced by the changes in the cell morphology, the DNA fragmentation and the activation of caspases. Caspase inhibitors, caspase family inhibitor, z Val Ala Asp fmk(z VAD fmk); caspase 1 inhibitor, Ac Tyr Val Ala Asp chloromethyl ketone(Ac YVAD cmk); caspase 3 inhibitor, z Asp Glu Val Asp fmk(z DEVE fmk) and caspase 8 inhibitor, \{z Ile \}Glu Asp fmk(z IETD fmk) effectively attenuated G Rh 2 induced cell death. The activities of caspase 1 and caspase 3 were increased in the G Rh 2 induced apoptotic process. However, caspase inhibitors can not inhibit G Rh - 2 induced cell death completely. These results suggest that G Rh 2 induced cell death is mediated by the activation of caspase cascade, but there might be some other pathways for induction of this apoptosis.展开更多
Summary: By using the method of clonal analysis the evidence to prove that Hemophagocytic syndrome (HPS) is reactive or malignant was investigated to probe into the pathogenesis of HPS and its relations with clinical ...Summary: By using the method of clonal analysis the evidence to prove that Hemophagocytic syndrome (HPS) is reactive or malignant was investigated to probe into the pathogenesis of HPS and its relations with clinical prognosis. The macrophages abnormally proliferated in bone marrow were isolated. Electrophoresis analysis was made after DNA extraction, enzyme restriction of human ardrogen receptor (HUMARA) genetic locus, and PCR amplification. In the 9 specimens, clonal proliferation was found in 2 cases and nonclonal proliferation in 7. Among the 7 cases of nonclonal proliferation, 3 were voluntarily discharged without clinical outcome, 2 cases fully recovered after 2-3 week treatment of large dose gamma globulin intravenous drip and hormone therapy, 1 case died at the 43th day after the hormone and anti-infection therapy, and one case was found to have granular leukoblast in peripheral blood after 3 weeks and diagnosed as having M2a after bone puncture. For the two patients with clonal proliferation, one obtained remission after chemotherapy and the other was died after 32 days without chemotherapy. It was concluded that there do exist clonal or malignant proliferation in HPS, so not every case is reactive.展开更多
Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which...Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which is critical for FGF binding. The synthesized peptide can effectively inhibit the mitogenic activity of aFGF, and has a potential to become a therapeutic agent as an aFGF antagonist.展开更多
Key to energize State-Owned-Enterprises (hereinafter SOEs) is to set up effective incentive and discipline mechanisms. First of all, the paper analyses the problems existing in the current incentive and discipline mec...Key to energize State-Owned-Enterprises (hereinafter SOEs) is to set up effective incentive and discipline mechanisms. First of all, the paper analyses the problems existing in the current incentive and discipline mechanism system in SOEs, including low transparency income and considerable covert income, insider control,corporate governance nominalization and so on; next,the paper explores the causes behind these problems,such as incomplete corporate governance and imperfect market mechanism; finally, the paper proposes a series of solutions from the aspects of incentive mechanism and discipline mechanism.展开更多
Using atom force microscopy (AFM), in vitro transcription, PAGE and other experimental technologies, it is observed that, in active genes of mice (Balb/c) nuclear DNA fragments of non-transcriptional state, only regul...Using atom force microscopy (AFM), in vitro transcription, PAGE and other experimental technologies, it is observed that, in active genes of mice (Balb/c) nuclear DNA fragments of non-transcriptional state, only regulation sequences at both ends are associated with scaffold proteins (indissociable proteins) and some transcriptional factors such as complexes (dissociable proteins) made of gene-coding proteins and specific auxiliary small molecules, while there are no combining proteins in intermediate coding sequences. However, in active genes of transcriptional state, both regulation sequences and intermediate coding sequences are associated with active transcriptional factors by non-covalent bonds.This paper shows the prospective application of AFM observation and in vitro transcription in the research on gene expression and regulation. It also offers some theoretical basis for localization of specific genes in human genomes.展开更多
In this paper, systematic review on Ant System (AS) algorithm research and application is made, and the authors works of introducing As algorithm into continuous space application are summarized. Then the applicabil...In this paper, systematic review on Ant System (AS) algorithm research and application is made, and the authors works of introducing As algorithm into continuous space application are summarized. Then the applicability characters of AS in continuous space optimization problems are also discussed.展开更多
文摘植被侵蚀是导致长城结构坍塌的重要潜在因素,相关检测研究主要包括人工巡检与自动化模型。前者现场勘查效率低下;后者受限于小目标漏检与计算冗余,难以实现精准高效的监测。因此,提出一种基于YOLOv11网络架构改进的长城植被侵蚀智能检测算法GWVE-YOLO(the Great Wall vegetation erosion,you only look once)。通过新增P2尺度小目标检测层,增强高分辨率浅层特征提取能力,显著降低微小病害目标的漏检率;在主干与颈部浅层引入RCS-OSA(reparameterized convolution based on channel shuffle of one-shot aggregation)模块,通过通道重排与结构重参数化技术优化特征融合效率,在维持精度的同时降低计算冗余;采用动态非单调聚焦机制的W-IoU(wise intersection over union)v3损失函数,自适应调整低质量样本梯度权重,以提升复杂背景下小目标定位精度。在自建无人机长城病害数据集,经实验表明,所提方法的m AP50达到78.8%、精确率达到79.8%,每秒帧数114,综合性能优于YOLO系列及其已有改进等主流检测模型。
文摘This paper deals with the inhibitory mechanisms of ginsenoside \{G Rh 2\} on the growth of tumor cells. \{G Rh 2\} significantly inhibited the proliferation of human cervical adenocarcinoma HeLa cells in a time and dose dependent manner. G Rh 2 induced apoptotic manifestations in HeLa cells as evidenced by the changes in the cell morphology, the DNA fragmentation and the activation of caspases. Caspase inhibitors, caspase family inhibitor, z Val Ala Asp fmk(z VAD fmk); caspase 1 inhibitor, Ac Tyr Val Ala Asp chloromethyl ketone(Ac YVAD cmk); caspase 3 inhibitor, z Asp Glu Val Asp fmk(z DEVE fmk) and caspase 8 inhibitor, \{z Ile \}Glu Asp fmk(z IETD fmk) effectively attenuated G Rh 2 induced cell death. The activities of caspase 1 and caspase 3 were increased in the G Rh 2 induced apoptotic process. However, caspase inhibitors can not inhibit G Rh - 2 induced cell death completely. These results suggest that G Rh 2 induced cell death is mediated by the activation of caspase cascade, but there might be some other pathways for induction of this apoptosis.
文摘Summary: By using the method of clonal analysis the evidence to prove that Hemophagocytic syndrome (HPS) is reactive or malignant was investigated to probe into the pathogenesis of HPS and its relations with clinical prognosis. The macrophages abnormally proliferated in bone marrow were isolated. Electrophoresis analysis was made after DNA extraction, enzyme restriction of human ardrogen receptor (HUMARA) genetic locus, and PCR amplification. In the 9 specimens, clonal proliferation was found in 2 cases and nonclonal proliferation in 7. Among the 7 cases of nonclonal proliferation, 3 were voluntarily discharged without clinical outcome, 2 cases fully recovered after 2-3 week treatment of large dose gamma globulin intravenous drip and hormone therapy, 1 case died at the 43th day after the hormone and anti-infection therapy, and one case was found to have granular leukoblast in peripheral blood after 3 weeks and diagnosed as having M2a after bone puncture. For the two patients with clonal proliferation, one obtained remission after chemotherapy and the other was died after 32 days without chemotherapy. It was concluded that there do exist clonal or malignant proliferation in HPS, so not every case is reactive.
基金Supported by a grant from the National Natural Science Foundation of China(No.30 0 70 892 )
文摘Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which is critical for FGF binding. The synthesized peptide can effectively inhibit the mitogenic activity of aFGF, and has a potential to become a therapeutic agent as an aFGF antagonist.
文摘Key to energize State-Owned-Enterprises (hereinafter SOEs) is to set up effective incentive and discipline mechanisms. First of all, the paper analyses the problems existing in the current incentive and discipline mechanism system in SOEs, including low transparency income and considerable covert income, insider control,corporate governance nominalization and so on; next,the paper explores the causes behind these problems,such as incomplete corporate governance and imperfect market mechanism; finally, the paper proposes a series of solutions from the aspects of incentive mechanism and discipline mechanism.
文摘Using atom force microscopy (AFM), in vitro transcription, PAGE and other experimental technologies, it is observed that, in active genes of mice (Balb/c) nuclear DNA fragments of non-transcriptional state, only regulation sequences at both ends are associated with scaffold proteins (indissociable proteins) and some transcriptional factors such as complexes (dissociable proteins) made of gene-coding proteins and specific auxiliary small molecules, while there are no combining proteins in intermediate coding sequences. However, in active genes of transcriptional state, both regulation sequences and intermediate coding sequences are associated with active transcriptional factors by non-covalent bonds.This paper shows the prospective application of AFM observation and in vitro transcription in the research on gene expression and regulation. It also offers some theoretical basis for localization of specific genes in human genomes.
文摘In this paper, systematic review on Ant System (AS) algorithm research and application is made, and the authors works of introducing As algorithm into continuous space application are summarized. Then the applicability characters of AS in continuous space optimization problems are also discussed.
