Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study w...Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute COVID-19.Methods The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive analysis.The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and proteinuria.Results A total of 115 patients were included in the study.About a third of the individuals had elevated blood creatinine levels or proteinuria.In addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)patients.Conclusions One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our data.Although,the rate of proximal tubular dysfunction was lower than in adults,it should be noted.The recovery of proximal tubular function in children with COVID-19 should be followed.展开更多
文摘Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute COVID-19.Methods The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive analysis.The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and proteinuria.Results A total of 115 patients were included in the study.About a third of the individuals had elevated blood creatinine levels or proteinuria.In addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)patients.Conclusions One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our data.Although,the rate of proximal tubular dysfunction was lower than in adults,it should be noted.The recovery of proximal tubular function in children with COVID-19 should be followed.
