“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health problem.Although severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain elusive.The emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and function.Mesenchymal stem cells,as large living cells responsive to the environment,secrete various factors and exosomes.The latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem cells.Exosomes have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based therapies.Despite ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical translation.This review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying mechanisms.Subsequently,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and exosomes.Finally,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.展开更多
Regenerative rehabilitation is a novel and rapidly developing multidisciplinaryfield that converges regenerative medicine and rehabilitation science,aiming to maximize the functions of disabled patients and their indep...Regenerative rehabilitation is a novel and rapidly developing multidisciplinaryfield that converges regenerative medicine and rehabilitation science,aiming to maximize the functions of disabled patients and their independence.While regenerative medicine provides state-of-the-art technologies that shed light on difficult-to-treated diseases,regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative medicine.However,regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each other’sfield.This disconnect has impeded the development of thisfield.Therefore,this reviewfirst introduces cutting-edge tech-nologies such as stem cell technology,tissue engineering,biomaterial science,gene editing,and computer sciences that promote the progress pace of regenerative medicine,followed by a summary of preclinical studies and examples of clinical investigations that integrate rehabilitative methodologies into regenerative medicine.Then,challenges in thisfield are discussed,and possible solutions are provided for future directions.We aim to provide a platform for regenerative and rehabilitative professionals and clinicians in other areas to better understand the progress of regenerative rehabilitation,thus contributing to the clinical translation and management of innovative and reliable therapies.展开更多
基金supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
文摘“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health problem.Although severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain elusive.The emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and function.Mesenchymal stem cells,as large living cells responsive to the environment,secrete various factors and exosomes.The latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem cells.Exosomes have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based therapies.Despite ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical translation.This review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying mechanisms.Subsequently,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and exosomes.Finally,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.
基金funded by grants from the National Natural Science Foundation of China (82171422)Key Research and Development Project of Hubei Province of China (2022BCA028).
文摘Regenerative rehabilitation is a novel and rapidly developing multidisciplinaryfield that converges regenerative medicine and rehabilitation science,aiming to maximize the functions of disabled patients and their independence.While regenerative medicine provides state-of-the-art technologies that shed light on difficult-to-treated diseases,regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative medicine.However,regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each other’sfield.This disconnect has impeded the development of thisfield.Therefore,this reviewfirst introduces cutting-edge tech-nologies such as stem cell technology,tissue engineering,biomaterial science,gene editing,and computer sciences that promote the progress pace of regenerative medicine,followed by a summary of preclinical studies and examples of clinical investigations that integrate rehabilitative methodologies into regenerative medicine.Then,challenges in thisfield are discussed,and possible solutions are provided for future directions.We aim to provide a platform for regenerative and rehabilitative professionals and clinicians in other areas to better understand the progress of regenerative rehabilitation,thus contributing to the clinical translation and management of innovative and reliable therapies.
