Excessive inflammatory responses lead to increased mortality from the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Nearly all deceased patients infected with SARS-CoV-2 are found to have cytokine storm ...Excessive inflammatory responses lead to increased mortality from the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Nearly all deceased patients infected with SARS-CoV-2 are found to have cytokine storm syndrome and viral sepsis.They are prone to superinfections exacerbating the course of disease.1 Therefore,preventing hyperinflammation is critical for avoiding this cytokine storm syndrome.Currently,specific immunomodulators are under clinical research or application,including targeting inflammatory cytokines(sarilumab,anakinra,tocilizumab,infliximab,adalimumab)and inflammatory pathway(baricitinib,ruxolitinib).展开更多
基金This study was supported by the National Key Research and Development Project(2017YFA0504300)Chengdu Science and Technology Program(2021-YF05-01681-SN).
文摘Excessive inflammatory responses lead to increased mortality from the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Nearly all deceased patients infected with SARS-CoV-2 are found to have cytokine storm syndrome and viral sepsis.They are prone to superinfections exacerbating the course of disease.1 Therefore,preventing hyperinflammation is critical for avoiding this cytokine storm syndrome.Currently,specific immunomodulators are under clinical research or application,including targeting inflammatory cytokines(sarilumab,anakinra,tocilizumab,infliximab,adalimumab)and inflammatory pathway(baricitinib,ruxolitinib).
