目的:比较曲妥珠单抗和帕妥珠单抗(trastuzumab plus pertuzumab,HP)联合紫杉类+铂类(TCbHP)、紫杉类单药(THP)、蒽环类序贯紫杉类(AC-THP)三种化疗方案在真实世界临床实践中新辅助治疗HER-2阳性乳腺癌的疗效、安全性及耐受性。方法:回...目的:比较曲妥珠单抗和帕妥珠单抗(trastuzumab plus pertuzumab,HP)联合紫杉类+铂类(TCbHP)、紫杉类单药(THP)、蒽环类序贯紫杉类(AC-THP)三种化疗方案在真实世界临床实践中新辅助治疗HER-2阳性乳腺癌的疗效、安全性及耐受性。方法:回顾性分析2019年6月至2021年12月于保定市第一中心医院等河北省共11家三级甲等医院接受三种方案新辅助治疗并完成后续手术的180例HER-2阳性乳腺癌患者的临床病理资料,其中TCbHP组78例、THP组70例、AC-THP组32例,比较三种治疗方案的疗效、安全性及耐受性,并采用统计学方法分析临床病理因素对总体病理完全缓解(total pathologic complete response,tpCR)率的影响。结果:总人群tpCR率为58.9%(106/180)。TCbHP组的tpCR率为64.1%(50/78),高于THP组的54.3%(38/70)和AC-THP组的56.3%(18/32),差异无统计学意义(P=0.454)。TCbHP组的3级及以上不良反应发生率为12.8%(10/78),高于THP组的4.3%(3/70)和AC-THP组的9.4%(3/32),差异无统计学意义(P=0.255)。THP组的既定方案完成率为98.6%(69/70),高于TCbHP组的92.3%(72/78)和AC-THP组的90.6%(29/32),差异无统计学意义(P=0.147)。180例患者中绝经后组与绝经前组的tpCR率分别为65.4%(70/107)与49.3%(36/73),HER-2免疫组织化学法(IHC)3+组与HER-2 IHC2+且荧光原位杂交(FISH)+组的tpCR率分别为65.0%(102/157)与17.4%(4/23),激素受体(HR)阴性组与HR阳性组的tpCR率分别为78.0%(64/82)与42.9%(42/98),白蛋白结合型紫杉醇组与其他紫杉类药物组的tpCR率分别为66.3%(65/98)与50.0%(41/82),组间进行比较差异均具有统计学意义(均P<0.05)。Logistic回归多因素分析表明,HER-2 IHC3+、HR阴性、使用白蛋白结合型紫杉醇为tpCR率的独立影响因素。结论:TCbHP、THP、AC-THP方案新辅助治疗HER-2阳性乳腺癌在真实世界临床实践中疗效确切,安全性及耐受性良好。TCbHP方案可考虑作为HER-2阳性乳腺癌新辅助治疗的优选方案。展开更多
To investigate the operational mechanism and quality improvement strategies of a reed upright conveying device,first,the structural design was completed,and a force analysis of the conveying process was conducted.A ri...To investigate the operational mechanism and quality improvement strategies of a reed upright conveying device,first,the structural design was completed,and a force analysis of the conveying process was conducted.A rigid-flexible coupling simulation model of reed stalks and the conveying mechanism was then employed to examine the effects of the structural parameters of the conveying chain links on the maximum contact force exerted on the reed stalks and to identify the optimal parameter combination.High-speed photography experiments were carried out during the conveying process to capture the motion states and trajectories of the reed stalks,elucidating the causes of stalk breakage and blockages.Subsequently,response surface experiments were conducted to investigate the primary factors influencing upright conveying quality.Mathematical models for predicting damage rate and conveying rate were established,and the effects of various factors on these indicators were analyzed.Multi-objective optimization of the regression models was performed based on practical production requirements,yielding an optimal parameter combination:transverse conveying speed of the chain at 1.1 m/s,speed ratio of 1.2,and upper conveying chain position at 1.37 m.Experimental results indicated a damage rate of 11.90%and a conveying rate of 95.11%,meeting the operational requirements for mechanized reed harvesting and conveying.These findings provide fundamental theoretical data for the development of reed harvester conveying components and the selection of operational parameters.展开更多
Dissolved organic carbon （DOC） is an important component for both carbon cycle and energy balance. The concentration, UV absorbance, and export flux of DOC in the natural environment dominate many important transpor...Dissolved organic carbon （DOC） is an important component for both carbon cycle and energy balance. The concentration, UV absorbance, and export flux of DOC in the natural environment dominate many important transport processes. To better understand the temporal and spatial variation of DOC, 7 sites along the Lower Dagu River were chosen to conduct a comprehensive measure- ment from March 2013 to February 2014. Specifically, water samples were collected from the Lower Dagu River between the 26th and 29th of every month during the experimental period. The DOC concentration （Cooc） and UV absorbance were analyzed using a total organic carbon analyzer and the ultraviolet-visible absorption spectrum, and the DOC export flux was estimated with a simple empirical model. The results showed that the CDoc of the Lower Dagu River varied from 1.32 to 12.56 mg/L, consistent with global rivers. The CDoc and UV absorbance showed significant spatial variation in the Dagu River during the experiential period because of the upstream natural processes and human activities in the watershed. The spatial variation is mainly due to dam or reservoir constructions, riverside ecological environment changes, and non-point source or wastewater discharge. The seasonal variation of CDoc was mainly related to the source of water DOC, river runoff, and temperature, and the UV absorbance and humification degree of DOC had no obvious differences among months （P〈 0.05）. UV absorbance was applied to test the CDOC in Lower Dagu River using wave lengths of 254 and 280 nm. The results revealed that the annual DOC export flux varied from 1.6 to 3.76x 105 g C^rn2/yr in a complete hydrological year, significantly lower than the global average. It is worth mentioning that the DOC export flux was mainly concentrated in summer （-90% of all-year flux in July and August）, since the runoff in the Dagu River took place frequently in summer. These observations implied environment change could bring the temporal-spatial variation of DOC and the exports, which would further affect the land-ocean interactions in the Lower Dagu River and the global carbon cycle.展开更多
基金supported by Special Funds for Jiangsu Province Agricultural Science and Technology Independent Innovation Fund Project(Grant No.CX3096)the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(Grant No.31-NIAM-05).
文摘To investigate the operational mechanism and quality improvement strategies of a reed upright conveying device,first,the structural design was completed,and a force analysis of the conveying process was conducted.A rigid-flexible coupling simulation model of reed stalks and the conveying mechanism was then employed to examine the effects of the structural parameters of the conveying chain links on the maximum contact force exerted on the reed stalks and to identify the optimal parameter combination.High-speed photography experiments were carried out during the conveying process to capture the motion states and trajectories of the reed stalks,elucidating the causes of stalk breakage and blockages.Subsequently,response surface experiments were conducted to investigate the primary factors influencing upright conveying quality.Mathematical models for predicting damage rate and conveying rate were established,and the effects of various factors on these indicators were analyzed.Multi-objective optimization of the regression models was performed based on practical production requirements,yielding an optimal parameter combination:transverse conveying speed of the chain at 1.1 m/s,speed ratio of 1.2,and upper conveying chain position at 1.37 m.Experimental results indicated a damage rate of 11.90%and a conveying rate of 95.11%,meeting the operational requirements for mechanized reed harvesting and conveying.These findings provide fundamental theoretical data for the development of reed harvester conveying components and the selection of operational parameters.
文摘Dissolved organic carbon （DOC） is an important component for both carbon cycle and energy balance. The concentration, UV absorbance, and export flux of DOC in the natural environment dominate many important transport processes. To better understand the temporal and spatial variation of DOC, 7 sites along the Lower Dagu River were chosen to conduct a comprehensive measure- ment from March 2013 to February 2014. Specifically, water samples were collected from the Lower Dagu River between the 26th and 29th of every month during the experimental period. The DOC concentration （Cooc） and UV absorbance were analyzed using a total organic carbon analyzer and the ultraviolet-visible absorption spectrum, and the DOC export flux was estimated with a simple empirical model. The results showed that the CDoc of the Lower Dagu River varied from 1.32 to 12.56 mg/L, consistent with global rivers. The CDoc and UV absorbance showed significant spatial variation in the Dagu River during the experiential period because of the upstream natural processes and human activities in the watershed. The spatial variation is mainly due to dam or reservoir constructions, riverside ecological environment changes, and non-point source or wastewater discharge. The seasonal variation of CDoc was mainly related to the source of water DOC, river runoff, and temperature, and the UV absorbance and humification degree of DOC had no obvious differences among months （P〈 0.05）. UV absorbance was applied to test the CDOC in Lower Dagu River using wave lengths of 254 and 280 nm. The results revealed that the annual DOC export flux varied from 1.6 to 3.76x 105 g C^rn2/yr in a complete hydrological year, significantly lower than the global average. It is worth mentioning that the DOC export flux was mainly concentrated in summer （-90% of all-year flux in July and August）, since the runoff in the Dagu River took place frequently in summer. These observations implied environment change could bring the temporal-spatial variation of DOC and the exports, which would further affect the land-ocean interactions in the Lower Dagu River and the global carbon cycle.
