The efficient mineralization of phenol and its derivatives in wastewater remains a great challenge.In this study,the bimetallic CuCeO_(2)-BTC was screened from a series of MOFs-derived MCeO_(2)-BTC(M=La,Cu,Co,Fe,and M...The efficient mineralization of phenol and its derivatives in wastewater remains a great challenge.In this study,the bimetallic CuCeO_(2)-BTC was screened from a series of MOFs-derived MCeO_(2)-BTC(M=La,Cu,Co,Fe,and Mn)catalysts,and the influence of the Cu/Ce ratio on phenol removal by catalytic ozonation was carefully examined.The results indicate that Cu_(2)Ce_(1)O_(y)-BTC was the best among the Cu_(x)Ce_(1)O_(y)-BTC(x=0,1,2,and 3)catalysts,with a phenol mineralization efficiency reaching close to 100%within 200 min,approximately 30.1%higher than CeO_(2)-BTC/O_(3)and 70.3%higher than O_(3)alone.The order of mineralization efficiency of phenol was Cu_(2)Ce_(1)O_(y)-BTC>Cu_(3)Ce_(1)O_(y)-BTC>Cu_(1)Ce_(1)O_(y)-BTC>CeO_(2)-BTC.CeO_(2)-BTC exhibited a broccoli-like morphology,and Cu_(x)Ce_(1)O_(y)-BTC(x=1,2,and 3)exhibited an urchin-like morphology.Compared with Cu_(x)Ce_(1)O_(y)-BTC(x=0,1,and 3),Cu_(2)Ce_(1)O_(y)-BTC exhibited a larger specific surface area and pore volume.This characteristic contributed to the availability of more active sites for phenol degradation.The redox ability was greatly enhanced as well.Besides,the surface of Cu_(2)Ce_(1)O_(y)-BTC exhibited a higher concentration of Ce^(3+)species and hydroxyl groups,which facilitated the dissociation of ozone and the generation of active radicals.Based on the results of radical quenching experiments and the intermediates detected by LC-MS,a potential mechanism for phenol degradation in the Cu_(2)Ce_(1)O_(y)-BTC/O_(3)system was postulated.This study offers novel perspectives on the advancement of MOFs-derived catalysts for achieving the complete mineralization of phenol in wastewater through catalytic ozonation.展开更多
Objective:To construct a nomogram based on the albumin-bilirubin(ALBI)grade to provide prognostic value for hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC)patients who underwent ultrasound-guided percutan...Objective:To construct a nomogram based on the albumin-bilirubin(ALBI)grade to provide prognostic value for hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC)patients who underwent ultrasound-guided percutaneous microwave ablation(US-PMWA).Methods:From April 2005 to January 2018,183 treatment-naIve patients with 251 HCV-related HCCs according to the Milan criteria received US-PMWA subsequently.The overall survival(OS)and recurrence-free survival(RFS)were compared between groups classified by ALBI grade.Cox proportional hazard regression model based on risk factors for survival and recurrence was used to construct the nomogram.Results:The cumulative OS rates at 1-,3-,5-and 10-year were 97.7%,73.6%,54.5%and 34.5%,respectively.Stratified according to ALBI grade,the 1-,3-,and 5-year OS in the ALBI grade 1 group and grade 2 group were 99.2%,92.4%,77.9% and 97.7%,52.3%,38.6%,respectively,with significant statistical difference(P<0.001).No significant statistical difference was detected in the1-,3-,and 5-year RFS rates in the ALBI grade 1 group and grade 2 group(P=0.220).The major complication rate was 1.6%.Multivariate analysis results showed age,α-fetoprotein level,tumor number,platelet count,location,Child-Turcotte-Pugh(CTP)and ALBI grade were associated with OS,which generated the nomograms.Internal validation with 1000 bootstrapped sample sets had good concordance index of 0.769(95%CI 0.699-0.839)in OS.Conclusions:This nomogram based on ALBI grade was a visualization risk model,which could provide personalized prediction of long-term outcomes for HCV-related HCC patients after US-PMWA.展开更多
Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who un...Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who underwent MWA were included and divided into cholecystectomy(n=114)and non-cholecystectomy groups(n=807).After propensity score matching(PSM)at a 1:2 ratio,overall survival(OS)and disease-free survival(DFS)rates were analyzed to compare prognostic outcomes between the cholecystectomy(«=114)and non-cholecystectomy groups(n=228).Univariate and multivariate Cox analyses were performed to assess potential risk factors for OS and DFS.Major complications were also compared between the groups.Results:After matching,no significant differences between groups were observed in baseline characteristics.The 1-,3-,and 5-year OS rates were 96.5%,82.1%,and 67.1%in the cholecystectomy group,and 97.4%,85.2%,and 74.4%in the non-cholecystectomy group(P=0.396);the 1-,3-,and 5-year DFS rates were 58.4%,34.5%,and 26.6%in the cholecystectomy group,and 73.6%,44.7%,and 32.2%in the non-cholecystectomy group(P=0.026),respectively.The intrahepatic distant recurrence rate in the cholecystectomy group was significantly higher than that in the non-cholecystectomy group(P=0.026),and the local tumor recurrence and extrahepatic recurrence rates did not significantly differ between the groups(P=0.609 and P=0.879).Multivariate analysis revealed that cholecystectomy(HR=1.364,95%Cl 1.023-1.819,P=0.035),number of tumors(2 vs.1:HR=2.744,95%Cl 1.925-3.912,P<0.001;3 vs.1:HR=3.411,95%Cl 2.021-5.759,P<0.001),and y-GT levels(HR=1.003,95%Cl 1.000-1.006,P<0.024)were independent risk factors for DFS.The best y-GT level cut-off value for predicting median DFS was 39.6 U/L(area under the curve=0.600,P<0.05).A positive correlation was observed between cholecystectomy and y-GT level(r=0.108,95%Cl-0.001-0.214,P=0.047).Subgroup analysis showed that the DFS rates were significantly higher in the non-cholecystectomy group than the cholecystectomy group when Y-GT>39.6 U/L(i3=0.044).The 5-,10-,15-,20-,and 25-year recurrence rates from the time of cholecystectomy were 2.63%,21.93%,42.11%,58.77%,and 65.79%,respectively.A significant positive correlation was observed between cholecystectomy and the time from cholecystectomy to recurrence(r=0.205,95%Cl 0.016-0.379,P=0.029).There were no significant differences in complications between groups(P=0.685).Conclusions:Patients with HCC who underwent cholecystectomy were more likely to develop intrahepatic distant recurrence after MWA,an outcome probably associated with increased y-GT levels.Moreover,the recurrence rates increased with time.展开更多
Objective:Thermal ablation poses challenges in the surgical resection(SR)of small hepatocellular carcinoma(HCC),and its therapeutic outcomes for larger lesions remain debated.Methods:This retrospective study evaluated...Objective:Thermal ablation poses challenges in the surgical resection(SR)of small hepatocellular carcinoma(HCC),and its therapeutic outcomes for larger lesions remain debated.Methods:This retrospective study evaluated 729 patients with HCC meeting the Milan criteria,who were treated with curative SR or microwave ablation(MWA)between 2008 and 2014.Overall survival(OS),cancer-specific survival(CSS),disease-free survival(DFS),and local tumor progression(LTP)were compared after propensity score matching(PSM).Co-variates associated with OS,CSS,LTP,and DFS were identified.The risk of death and tumor progression were compared.Results:During the median follow-up of 78.6 months,253 patients were included in each group after PSM.For tumors≤3.0 cm and 3.1–4.0 cm,MWA achieved comparable results in terms of OS,CSS,DFS,and LTP.For tumors 4.1–5.0 cm,MWA had lower OS,CSS,and DFS rates(all P<0.05)than SR.Higher LTP rates were observed in the MWA group for tumors 4.1–5.0 cm,although the difference was not significant(P=0.18).Complication rates(P=0.41)were similar,but MWA led to less estimated blood loss(P<0.01)and shorter postoperative hospitalization times(P<0.01).Conclusions:MWA achieved comparable long-term oncologic outcomes with SR for≤4 cm HCC,with lower complication rates and faster recovery.展开更多
In 21st century, more and more people see medical services of sport therapists as a promising industry due to global aging population and high biotechnology development. Hence, understanding medical word-of-mouth (WOM...In 21st century, more and more people see medical services of sport therapists as a promising industry due to global aging population and high biotechnology development. Hence, understanding medical word-of-mouth (WOM) process among patients in medical services of sport therapists could be interesting and useful. This study would find out the role of WOM on patients psychology when choosing the sport therapists, understand how patients look for sport therapists’ information and which information source is important to them. As a pioneer, this study would like to improve medical WOM marketing of sport therapists. The authors designed a questionnaire based on how patients choosing sport therapists, including questions search importance of different information sources of sport therapists with medical service decision, and respondents’ psychological demographics. We released 253 questionnaires of judo therapy clinics inTaiwan. More than half of the respondents see sport therapists due to others’ recommendations (referral of family, friends and professionals). Women are more likely to seek medical word-of-mouth information than men;and respondents who think choosing sport therapists are important tend to seek medical word-of-mouth information. Further, patients focus on “therapist’s behavior”, “therapist’s skills”, and “therapist’s ethic”.展开更多
In response to real-world scenarios,the domain generalization(DG)problem has spurred considerable research in person re-identification(ReID).This challenge arises when the target domain,which is significantly differen...In response to real-world scenarios,the domain generalization(DG)problem has spurred considerable research in person re-identification(ReID).This challenge arises when the target domain,which is significantly different from the source domains,remains unknown.However,the performance of current DG ReID relies heavily on labor-intensive source domain annotations.Considering the potential of unlabeled data,we investigate unsupervised domain generalization(UDG)in ReID.Our goal is to create a model that can generalize from unlabeled source domains to semantically retrieve images in an unseen target domain.To address this,we propose a new approach that trains a domain-agnostic expert(DaE)for unsupervised domain-generalizable person ReID.This involves independently training multiple experts to account for label space inconsistencies between source domains.At the same time,the DaE captures domain-generalizable information for testing.Our experiments demonstrate the effectiveness of this method for learning generalizable features under the UDG setting.The results demonstrate the superiority of our method over state-of-the-art techniques.We will make our code and models available for public use.展开更多
基金supported by the National Natural Science Foundation of China(No.22206013).
文摘The efficient mineralization of phenol and its derivatives in wastewater remains a great challenge.In this study,the bimetallic CuCeO_(2)-BTC was screened from a series of MOFs-derived MCeO_(2)-BTC(M=La,Cu,Co,Fe,and Mn)catalysts,and the influence of the Cu/Ce ratio on phenol removal by catalytic ozonation was carefully examined.The results indicate that Cu_(2)Ce_(1)O_(y)-BTC was the best among the Cu_(x)Ce_(1)O_(y)-BTC(x=0,1,2,and 3)catalysts,with a phenol mineralization efficiency reaching close to 100%within 200 min,approximately 30.1%higher than CeO_(2)-BTC/O_(3)and 70.3%higher than O_(3)alone.The order of mineralization efficiency of phenol was Cu_(2)Ce_(1)O_(y)-BTC>Cu_(3)Ce_(1)O_(y)-BTC>Cu_(1)Ce_(1)O_(y)-BTC>CeO_(2)-BTC.CeO_(2)-BTC exhibited a broccoli-like morphology,and Cu_(x)Ce_(1)O_(y)-BTC(x=1,2,and 3)exhibited an urchin-like morphology.Compared with Cu_(x)Ce_(1)O_(y)-BTC(x=0,1,and 3),Cu_(2)Ce_(1)O_(y)-BTC exhibited a larger specific surface area and pore volume.This characteristic contributed to the availability of more active sites for phenol degradation.The redox ability was greatly enhanced as well.Besides,the surface of Cu_(2)Ce_(1)O_(y)-BTC exhibited a higher concentration of Ce^(3+)species and hydroxyl groups,which facilitated the dissociation of ozone and the generation of active radicals.Based on the results of radical quenching experiments and the intermediates detected by LC-MS,a potential mechanism for phenol degradation in the Cu_(2)Ce_(1)O_(y)-BTC/O_(3)system was postulated.This study offers novel perspectives on the advancement of MOFs-derived catalysts for achieving the complete mineralization of phenol in wastewater through catalytic ozonation.
基金supported by the National Key R&D Program of China (Grant No. 2017YFC0112000)the National Natural Science Foundation of China (Grants No. 81627803, 91859201, and 81871374)the State Key Project on Infectious Disease of China (Grant No. 2018ZX10723204)
文摘Objective:To construct a nomogram based on the albumin-bilirubin(ALBI)grade to provide prognostic value for hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC)patients who underwent ultrasound-guided percutaneous microwave ablation(US-PMWA).Methods:From April 2005 to January 2018,183 treatment-naIve patients with 251 HCV-related HCCs according to the Milan criteria received US-PMWA subsequently.The overall survival(OS)and recurrence-free survival(RFS)were compared between groups classified by ALBI grade.Cox proportional hazard regression model based on risk factors for survival and recurrence was used to construct the nomogram.Results:The cumulative OS rates at 1-,3-,5-and 10-year were 97.7%,73.6%,54.5%and 34.5%,respectively.Stratified according to ALBI grade,the 1-,3-,and 5-year OS in the ALBI grade 1 group and grade 2 group were 99.2%,92.4%,77.9% and 97.7%,52.3%,38.6%,respectively,with significant statistical difference(P<0.001).No significant statistical difference was detected in the1-,3-,and 5-year RFS rates in the ALBI grade 1 group and grade 2 group(P=0.220).The major complication rate was 1.6%.Multivariate analysis results showed age,α-fetoprotein level,tumor number,platelet count,location,Child-Turcotte-Pugh(CTP)and ALBI grade were associated with OS,which generated the nomograms.Internal validation with 1000 bootstrapped sample sets had good concordance index of 0.769(95%CI 0.699-0.839)in OS.Conclusions:This nomogram based on ALBI grade was a visualization risk model,which could provide personalized prediction of long-term outcomes for HCV-related HCC patients after US-PMWA.
基金the National Key R&D Program of China(Grant No.2017 YFC0112000)the National Natural Science Foundation of China(Grant Nos.81627803 and 91859201).
文摘Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who underwent MWA were included and divided into cholecystectomy(n=114)and non-cholecystectomy groups(n=807).After propensity score matching(PSM)at a 1:2 ratio,overall survival(OS)and disease-free survival(DFS)rates were analyzed to compare prognostic outcomes between the cholecystectomy(«=114)and non-cholecystectomy groups(n=228).Univariate and multivariate Cox analyses were performed to assess potential risk factors for OS and DFS.Major complications were also compared between the groups.Results:After matching,no significant differences between groups were observed in baseline characteristics.The 1-,3-,and 5-year OS rates were 96.5%,82.1%,and 67.1%in the cholecystectomy group,and 97.4%,85.2%,and 74.4%in the non-cholecystectomy group(P=0.396);the 1-,3-,and 5-year DFS rates were 58.4%,34.5%,and 26.6%in the cholecystectomy group,and 73.6%,44.7%,and 32.2%in the non-cholecystectomy group(P=0.026),respectively.The intrahepatic distant recurrence rate in the cholecystectomy group was significantly higher than that in the non-cholecystectomy group(P=0.026),and the local tumor recurrence and extrahepatic recurrence rates did not significantly differ between the groups(P=0.609 and P=0.879).Multivariate analysis revealed that cholecystectomy(HR=1.364,95%Cl 1.023-1.819,P=0.035),number of tumors(2 vs.1:HR=2.744,95%Cl 1.925-3.912,P<0.001;3 vs.1:HR=3.411,95%Cl 2.021-5.759,P<0.001),and y-GT levels(HR=1.003,95%Cl 1.000-1.006,P<0.024)were independent risk factors for DFS.The best y-GT level cut-off value for predicting median DFS was 39.6 U/L(area under the curve=0.600,P<0.05).A positive correlation was observed between cholecystectomy and y-GT level(r=0.108,95%Cl-0.001-0.214,P=0.047).Subgroup analysis showed that the DFS rates were significantly higher in the non-cholecystectomy group than the cholecystectomy group when Y-GT>39.6 U/L(i3=0.044).The 5-,10-,15-,20-,and 25-year recurrence rates from the time of cholecystectomy were 2.63%,21.93%,42.11%,58.77%,and 65.79%,respectively.A significant positive correlation was observed between cholecystectomy and the time from cholecystectomy to recurrence(r=0.205,95%Cl 0.016-0.379,P=0.029).There were no significant differences in complications between groups(P=0.685).Conclusions:Patients with HCC who underwent cholecystectomy were more likely to develop intrahepatic distant recurrence after MWA,an outcome probably associated with increased y-GT levels.Moreover,the recurrence rates increased with time.
基金supported by The National Key R&D Program of Ministry of Science and Technology of China(Grant No.2018ZX10723-204)The National Scientific Foundation Committee of China(Grant Nos.81801722,81971625,82030047,81627803,and 91859201)and The National Scientific Foundation Committee of Beijing(Grant No.JQ18021).
文摘Objective:Thermal ablation poses challenges in the surgical resection(SR)of small hepatocellular carcinoma(HCC),and its therapeutic outcomes for larger lesions remain debated.Methods:This retrospective study evaluated 729 patients with HCC meeting the Milan criteria,who were treated with curative SR or microwave ablation(MWA)between 2008 and 2014.Overall survival(OS),cancer-specific survival(CSS),disease-free survival(DFS),and local tumor progression(LTP)were compared after propensity score matching(PSM).Co-variates associated with OS,CSS,LTP,and DFS were identified.The risk of death and tumor progression were compared.Results:During the median follow-up of 78.6 months,253 patients were included in each group after PSM.For tumors≤3.0 cm and 3.1–4.0 cm,MWA achieved comparable results in terms of OS,CSS,DFS,and LTP.For tumors 4.1–5.0 cm,MWA had lower OS,CSS,and DFS rates(all P<0.05)than SR.Higher LTP rates were observed in the MWA group for tumors 4.1–5.0 cm,although the difference was not significant(P=0.18).Complication rates(P=0.41)were similar,but MWA led to less estimated blood loss(P<0.01)and shorter postoperative hospitalization times(P<0.01).Conclusions:MWA achieved comparable long-term oncologic outcomes with SR for≤4 cm HCC,with lower complication rates and faster recovery.
文摘In 21st century, more and more people see medical services of sport therapists as a promising industry due to global aging population and high biotechnology development. Hence, understanding medical word-of-mouth (WOM) process among patients in medical services of sport therapists could be interesting and useful. This study would find out the role of WOM on patients psychology when choosing the sport therapists, understand how patients look for sport therapists’ information and which information source is important to them. As a pioneer, this study would like to improve medical WOM marketing of sport therapists. The authors designed a questionnaire based on how patients choosing sport therapists, including questions search importance of different information sources of sport therapists with medical service decision, and respondents’ psychological demographics. We released 253 questionnaires of judo therapy clinics inTaiwan. More than half of the respondents see sport therapists due to others’ recommendations (referral of family, friends and professionals). Women are more likely to seek medical word-of-mouth information than men;and respondents who think choosing sport therapists are important tend to seek medical word-of-mouth information. Further, patients focus on “therapist’s behavior”, “therapist’s skills”, and “therapist’s ethic”.
基金supported by the National Natural Science Foundation of China(Nos.62225113,62176188,and 623B2080)the Innovative Research Group Project of Hubei Province(No.2024AFA017).
文摘In response to real-world scenarios,the domain generalization(DG)problem has spurred considerable research in person re-identification(ReID).This challenge arises when the target domain,which is significantly different from the source domains,remains unknown.However,the performance of current DG ReID relies heavily on labor-intensive source domain annotations.Considering the potential of unlabeled data,we investigate unsupervised domain generalization(UDG)in ReID.Our goal is to create a model that can generalize from unlabeled source domains to semantically retrieve images in an unseen target domain.To address this,we propose a new approach that trains a domain-agnostic expert(DaE)for unsupervised domain-generalizable person ReID.This involves independently training multiple experts to account for label space inconsistencies between source domains.At the same time,the DaE captures domain-generalizable information for testing.Our experiments demonstrate the effectiveness of this method for learning generalizable features under the UDG setting.The results demonstrate the superiority of our method over state-of-the-art techniques.We will make our code and models available for public use.
