The large amount of harmful particles in coal dust not only pollutes the production environment,affects the production efficiency and resource utilization of enterprises,but also poses a risk to human health.Effective...The large amount of harmful particles in coal dust not only pollutes the production environment,affects the production efficiency and resource utilization of enterprises,but also poses a risk to human health.Effectively controlling coal dust is of great significance to clean production.Water-based dust suppressants are extensively employed to mitigate coal dust.This paper provides a comprehensive review of the water-based dust suppression materials for coal dust control.Accord-ing to the difference of mechanism,the dust suppressants are divided into wetting type,hygroscopic coalescence type,cohesive agglomeration type,and composite type.The evaluation methods for dust suppressants key properties such as wettability,permeability,moisture absorption and water retention,and consolidation are summarized.The review results show that coal dust suppressants are no longer limited to a single dust suppression function.For example,it is necessary to develop multi-functional coal suppressants to meet the needs for synergistic suppression both coal dust and coal spon-taneous combustion.Driven by the concept of green,low-carbon and sustainable development,attention should be paid to the development of bio-based environmentally friendly coal dust suppressants.In addition,the evaluation method system for the key performance of water-based dust suppressants should also be improved,and further research is necessary.展开更多
During the development of therapeutic microRNAs(miRNAs or miRs),it is essential to define their pharmacological actions.Rather,miRNA research and therapy mainly use miRNA mimics synthesized in vitro.After experimental...During the development of therapeutic microRNAs(miRNAs or miRs),it is essential to define their pharmacological actions.Rather,miRNA research and therapy mainly use miRNA mimics synthesized in vitro.After experimental screening of unique recombinant miRNAs produced in vivo,three lead antiproliferative miRNAs against human NSCLC cells,miR-22-3p,miR-9-5p,and miR-218-5p,were revealed to target folate metabolism by bioinformatic analyses.Recombinant miR-22-3p,miR-9-5p,and miR-218-5p were shown to regulate key folate metabolic enzymes to inhibit folate metabolism and subsequently alter amino acid metabolome in NSCLC A549 and H1975 cells.Isotope tracing studies further confirmed the disruption of one-carbon transfer from serine to folate metabolites by all three miRNAs,inhibition of glucose uptake by miR-22-3p,and reduction of serine biosynthesis from glucose by miR-9-5p and-218-5p in NSCLC cells.With greater activities to interrupt NSCLC cell respiration,glycolysis,and colony formation than miR-9-5p and-218-5p,recombinant miR-22-3p was effective to reduce tumor growth in two NSCLC patient-derived xenograft mouse models without causing any toxicity.These results establish a common antifolate mechanism and differential actions on glucose uptake and metabolism for three lead anticancer miRNAs as well as antitumor efficacy for miR-22-3p nanomedicine,which shall provide insight into developing antimetabolite RNA therapies.展开更多
基金supported by the National Natural Science Foundation of China(52474226,52322404)Basic scientific research projects in higher education institutions of Liaoning Province(JYTZD2023079)。
文摘The large amount of harmful particles in coal dust not only pollutes the production environment,affects the production efficiency and resource utilization of enterprises,but also poses a risk to human health.Effectively controlling coal dust is of great significance to clean production.Water-based dust suppressants are extensively employed to mitigate coal dust.This paper provides a comprehensive review of the water-based dust suppression materials for coal dust control.Accord-ing to the difference of mechanism,the dust suppressants are divided into wetting type,hygroscopic coalescence type,cohesive agglomeration type,and composite type.The evaluation methods for dust suppressants key properties such as wettability,permeability,moisture absorption and water retention,and consolidation are summarized.The review results show that coal dust suppressants are no longer limited to a single dust suppression function.For example,it is necessary to develop multi-functional coal suppressants to meet the needs for synergistic suppression both coal dust and coal spon-taneous combustion.Driven by the concept of green,low-carbon and sustainable development,attention should be paid to the development of bio-based environmentally friendly coal dust suppressants.In addition,the evaluation method system for the key performance of water-based dust suppressants should also be improved,and further research is necessary.
基金supported in part by the National Cancer Institute[R01CA225958,R01253230]National Institute of General Medical Sciences[R35GM140835]+3 种基金National Institutes of Health(USA)supported by grants from the Chinese National Key Research and Development Program(2017YFE0109900,China)supported by a scholarship from the Chinese Scholarship Council(No.201806380133,China)the Molecular Pharmacology,Flow Cytometry,and Mouse Biology Shared Resources funded by the UC Davis Comprehensive Cancer Center Support Grant awarded by the National Cancer Institute(P30CA093373),National Institutes of Health。
文摘During the development of therapeutic microRNAs(miRNAs or miRs),it is essential to define their pharmacological actions.Rather,miRNA research and therapy mainly use miRNA mimics synthesized in vitro.After experimental screening of unique recombinant miRNAs produced in vivo,three lead antiproliferative miRNAs against human NSCLC cells,miR-22-3p,miR-9-5p,and miR-218-5p,were revealed to target folate metabolism by bioinformatic analyses.Recombinant miR-22-3p,miR-9-5p,and miR-218-5p were shown to regulate key folate metabolic enzymes to inhibit folate metabolism and subsequently alter amino acid metabolome in NSCLC A549 and H1975 cells.Isotope tracing studies further confirmed the disruption of one-carbon transfer from serine to folate metabolites by all three miRNAs,inhibition of glucose uptake by miR-22-3p,and reduction of serine biosynthesis from glucose by miR-9-5p and-218-5p in NSCLC cells.With greater activities to interrupt NSCLC cell respiration,glycolysis,and colony formation than miR-9-5p and-218-5p,recombinant miR-22-3p was effective to reduce tumor growth in two NSCLC patient-derived xenograft mouse models without causing any toxicity.These results establish a common antifolate mechanism and differential actions on glucose uptake and metabolism for three lead anticancer miRNAs as well as antitumor efficacy for miR-22-3p nanomedicine,which shall provide insight into developing antimetabolite RNA therapies.
