Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analog...Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.展开更多
基金This work was supported by the National Natural Science Foundationof China(No.82173715).
文摘Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.
