Weathered rock(especially granite)slopes are prone to failure under the action of rainfall,making it necessary to study the response of weathered rock slope to rainfall infiltration for landslide prevention.In this st...Weathered rock(especially granite)slopes are prone to failure under the action of rainfall,making it necessary to study the response of weathered rock slope to rainfall infiltration for landslide prevention.In this study,a series of model tests of weathered rock slope under different conditions were conducted.The matric suction,volumetric water content,earth pressure and deformation of slope were monitored in real time during rainfall.The response of the slope to rainfall infiltration,failure process and failure mode of slope under different conditions were analyzed,and the early warning criterion for the failure of weathered rock slope caused by rainfall was studied.The results show that the slope deformation evolution process under rainfall condition was closely related to the dissipation of matric suction.When the distribution of the matrix suction(or water content)of slope met the condition that the resistance to sliding of the slip-mass was overcome,the displacement increased sharply and landslide occurred.Three factors including rainfall process,lithologic condition and excavation condition significantly affect the response of weathered rock slope to rainfall.It can be found from the test results under different conditions that compared with intermittent rainfall condition,the rainfall intensity and infiltration depth were smaller when the slope entering accelerated deformation stage under the condition of incremental rainfall.The accumulated rainfall when weathered clastic landslide occurring was greater than that of weathered granite,which results in greater disaster risk.The excavation angle and moisture distribution of a slope were the main factors affecting the stability of a slope.In addition,the evolution processes and critical displacement velocities of slopes were studied by combining the deformation curves and matrix suction curves,which can be used as reference for early warning of rainfall-induced weathered rock landslide.展开更多
The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors i...The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study.展开更多
To study IgG subclasses for the hepatitis B virus （HBV） core antigen （anti-HBc） in different populations, a comparison was made between 104 chronic carriers （60 male and 44 female） and 434 recovered individuals ...To study IgG subclasses for the hepatitis B virus （HBV） core antigen （anti-HBc） in different populations, a comparison was made between 104 chronic carriers （60 male and 44 female） and 434 recovered individuals （247 male and 192 female）. Biochemistry analyses of AST （aspartate aminotransferase） and ALT （alanine aminotransferase） were also performed. Among the 104 chronic carriers, 21 patients were found to be ALT and AST abnormal （〉 25 IU/ml）. After comparing these ALT and AST abnormal patients with other ALT and AST normal chronic carriers, no statistical difference was observed in the OD values of the anti-HBe （p 〉 0.05）. The ELISA results showed the anti-HBc IgG subclass pattern was IgG1 〉 IgG3 〉 IgG4 in chronic carriers and IgG3 〉 IgG1 〉 IgG4 in recovered individuals （p 〈 0.05）. This result suggests the IgG1/IgG3 ratio may be related with HBV status. However, in spite of the different anti-HBc IgG1/IgG3 patterns demonstrated in different populations, both anti-HBc IgG1 and IgG3 concentrations were significantly higher in chronic carriers （p 〈 0.05）. Therefore, both the anti-HBc IgG1/IgG3 ratio and their amounts differed. They may play a significant role in chronic carriers and recovered individuals. The anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liver inflammation, and were independent of sex and age.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52179110,51309025,41877280 and 41672320)Geological Survey project of China Geological Survey(Nos.DD20160257,DD20190263,121201009000150023,202007000000180506).
文摘Weathered rock(especially granite)slopes are prone to failure under the action of rainfall,making it necessary to study the response of weathered rock slope to rainfall infiltration for landslide prevention.In this study,a series of model tests of weathered rock slope under different conditions were conducted.The matric suction,volumetric water content,earth pressure and deformation of slope were monitored in real time during rainfall.The response of the slope to rainfall infiltration,failure process and failure mode of slope under different conditions were analyzed,and the early warning criterion for the failure of weathered rock slope caused by rainfall was studied.The results show that the slope deformation evolution process under rainfall condition was closely related to the dissipation of matric suction.When the distribution of the matrix suction(or water content)of slope met the condition that the resistance to sliding of the slip-mass was overcome,the displacement increased sharply and landslide occurred.Three factors including rainfall process,lithologic condition and excavation condition significantly affect the response of weathered rock slope to rainfall.It can be found from the test results under different conditions that compared with intermittent rainfall condition,the rainfall intensity and infiltration depth were smaller when the slope entering accelerated deformation stage under the condition of incremental rainfall.The accumulated rainfall when weathered clastic landslide occurring was greater than that of weathered granite,which results in greater disaster risk.The excavation angle and moisture distribution of a slope were the main factors affecting the stability of a slope.In addition,the evolution processes and critical displacement velocities of slopes were studied by combining the deformation curves and matrix suction curves,which can be used as reference for early warning of rainfall-induced weathered rock landslide.
基金the National Key Research and Development Program(No.2016YFA0502304)the National Natural Science Foundation of China(No.81825020)+3 种基金the Shanghai Committee of Science and Technology(No.20S11901000)the Fundamental Research Funds for the Central Universitiessponsored by the National Program for Special Supports of Eminent Professionalsthe National Program for Support of Top-Notch Young Professionals。
文摘The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study.
文摘To study IgG subclasses for the hepatitis B virus （HBV） core antigen （anti-HBc） in different populations, a comparison was made between 104 chronic carriers （60 male and 44 female） and 434 recovered individuals （247 male and 192 female）. Biochemistry analyses of AST （aspartate aminotransferase） and ALT （alanine aminotransferase） were also performed. Among the 104 chronic carriers, 21 patients were found to be ALT and AST abnormal （〉 25 IU/ml）. After comparing these ALT and AST abnormal patients with other ALT and AST normal chronic carriers, no statistical difference was observed in the OD values of the anti-HBe （p 〉 0.05）. The ELISA results showed the anti-HBc IgG subclass pattern was IgG1 〉 IgG3 〉 IgG4 in chronic carriers and IgG3 〉 IgG1 〉 IgG4 in recovered individuals （p 〈 0.05）. This result suggests the IgG1/IgG3 ratio may be related with HBV status. However, in spite of the different anti-HBc IgG1/IgG3 patterns demonstrated in different populations, both anti-HBc IgG1 and IgG3 concentrations were significantly higher in chronic carriers （p 〈 0.05）. Therefore, both the anti-HBc IgG1/IgG3 ratio and their amounts differed. They may play a significant role in chronic carriers and recovered individuals. The anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liver inflammation, and were independent of sex and age.
