Exosomes are essential mediators of intercellular communication,yet the molecular mechanisms regulating their secretion remain incompletely understood.Tumor cells exhibit enhanced exosome release alongside elevated gl...Exosomes are essential mediators of intercellular communication,yet the molecular mechanisms regulating their secretion remain incompletely understood.Tumor cells exhibit enhanced exosome release alongside elevated glucose metabolism and increased protein O-linked β-N-acetylglucosaminylation(O-GIcNAcylation) through the hexosamine biosynthetic pathway(HBP) [1,2].However,whether HBP-derived O-GIcNAcylation contributes to exosome secretion has not been clarified.展开更多
基金supported by the grants from Key Research and Development Program,Ministry of Science and Technology of China(grant number 2022YFC2303300)the National Natural Science Foundation of China(grant numbers 32261143735 and 82472278)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(grant number XDB29010205)Program of Shanghai Academic/Technology Research Leader(grant number 22XD1403800)to J.Z.
文摘Exosomes are essential mediators of intercellular communication,yet the molecular mechanisms regulating their secretion remain incompletely understood.Tumor cells exhibit enhanced exosome release alongside elevated glucose metabolism and increased protein O-linked β-N-acetylglucosaminylation(O-GIcNAcylation) through the hexosamine biosynthetic pathway(HBP) [1,2].However,whether HBP-derived O-GIcNAcylation contributes to exosome secretion has not been clarified.
