Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immun...Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear inflammation.The distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related degeneration.However,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains unclear.Here,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune response.In particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic injury.We hope this review will provide new perspectives and a basis for future research on cochlear inflammation.展开更多
Cortico-thalamic projections(the hyper-direct pathway)are implicated in levodopa-induced dyskinesia(LID),a challenging complication in the advanced stages of Parkinson’s disease(PD).Excessive beta and gamma activity ...Cortico-thalamic projections(the hyper-direct pathway)are implicated in levodopa-induced dyskinesia(LID),a challenging complication in the advanced stages of Parkinson’s disease(PD).Excessive beta and gamma activity in PD and LID has frequently been reported in recent cross-sectional studies.We aimed to investigate the temporal features of beta and gamma activity in the hyper-direct pathway during the development of PD and LID in rats,as well as the regulatory role of the dopamine receptors DI(D1Rs)and DIII(D3Rs)in these disorders.We recorded motor behavior and electrophysiological data during the development of PD and LID,and after interventions with D1R and D3R antagonists and agonists.We demonstrated exaggerated beta-band activity in the PD state and excessive gamma-band activity during on-state dyskinesia.Subsequently,process-dependent increased beta activity correlated with bradykinesia during PD modeling,while process-dependent increased gamma activity correlated with dyskinesia under the cumulative effects of levodopa during on-state dyskinesia.Finally,both D1Rs and D3Rs were found to be involved in regulating dyskinesia and gamma activity.Dynamic oscillations are closely associated with motor behavior,and mapping dynamic oscillations may be associated with optimizing deep brain stimulation parameters and developing personalized neurotherapeutic targeting.Moreover,D1Rs and D3Rs may ameliorate dyskinesia by mediating gamma oscillations.展开更多
基金supported by the China Postdoctoral Science Foundation(2022M712892)the Joint project Henan Province Medical Science and Technology Project(LHGJ20210297).
文摘Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear inflammation.The distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related degeneration.However,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains unclear.Here,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune response.In particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic injury.We hope this review will provide new perspectives and a basis for future research on cochlear inflammation.
基金supported by the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2020-PT310-01).
文摘Cortico-thalamic projections(the hyper-direct pathway)are implicated in levodopa-induced dyskinesia(LID),a challenging complication in the advanced stages of Parkinson’s disease(PD).Excessive beta and gamma activity in PD and LID has frequently been reported in recent cross-sectional studies.We aimed to investigate the temporal features of beta and gamma activity in the hyper-direct pathway during the development of PD and LID in rats,as well as the regulatory role of the dopamine receptors DI(D1Rs)and DIII(D3Rs)in these disorders.We recorded motor behavior and electrophysiological data during the development of PD and LID,and after interventions with D1R and D3R antagonists and agonists.We demonstrated exaggerated beta-band activity in the PD state and excessive gamma-band activity during on-state dyskinesia.Subsequently,process-dependent increased beta activity correlated with bradykinesia during PD modeling,while process-dependent increased gamma activity correlated with dyskinesia under the cumulative effects of levodopa during on-state dyskinesia.Finally,both D1Rs and D3Rs were found to be involved in regulating dyskinesia and gamma activity.Dynamic oscillations are closely associated with motor behavior,and mapping dynamic oscillations may be associated with optimizing deep brain stimulation parameters and developing personalized neurotherapeutic targeting.Moreover,D1Rs and D3Rs may ameliorate dyskinesia by mediating gamma oscillations.
