Cytomegalovirus(CMV)infection is currently prevalent in populations throughout the world,and 56%-94%of the global population is seropositive for CMV.CMV infection mainly affects immunocompromised hosts.In these cases,...Cytomegalovirus(CMV)infection is currently prevalent in populations throughout the world,and 56%-94%of the global population is seropositive for CMV.CMV infection mainly affects immunocompromised hosts.In these cases,it can cause significant symptoms,tissue-invasive disease,and many sequelae including death(Dioverti and Razonable,2016).The vast majority of healthy adults with CMV infection experience an asymptomatic course;when symptomatic,it manifests as a mononucleosis-like syndrome in approximately 10%of patients(Sridhar et al.,2018).展开更多
Hepatitis B virus infection represents a major global public health challenge.1 Chronic hepatitis B(CHB)virus infection is a leading cause of liver fibrosis,a key pathological process that drives the progression of ch...Hepatitis B virus infection represents a major global public health challenge.1 Chronic hepatitis B(CHB)virus infection is a leading cause of liver fibrosis,a key pathological process that drives the progression of chronic liver disease to cirrhosis.Current clinical guidelines recommend the immediate initiation of antiviral therapy upon detection of significant liver fibrosis in patients with CHB.2–4 Early-stage fibrosis may be reversible with effective antiviral treatment,whereas advanced fibrosis or cirrhosis shows limited reversibility despite therapy.5 As such,early identification and staging of liver fibrosis,followed by timely antiviral intervention,are crucial for optimizing the management of CHB and improving longterm patient outcomes.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFC2304501).
文摘Cytomegalovirus(CMV)infection is currently prevalent in populations throughout the world,and 56%-94%of the global population is seropositive for CMV.CMV infection mainly affects immunocompromised hosts.In these cases,it can cause significant symptoms,tissue-invasive disease,and many sequelae including death(Dioverti and Razonable,2016).The vast majority of healthy adults with CMV infection experience an asymptomatic course;when symptomatic,it manifests as a mononucleosis-like syndrome in approximately 10%of patients(Sridhar et al.,2018).
基金the National Key Research and Development Program of China(2022YFC2304500)the Zhejiang Province Natural Science Foundation of China(LTGY24H160016).
文摘Hepatitis B virus infection represents a major global public health challenge.1 Chronic hepatitis B(CHB)virus infection is a leading cause of liver fibrosis,a key pathological process that drives the progression of chronic liver disease to cirrhosis.Current clinical guidelines recommend the immediate initiation of antiviral therapy upon detection of significant liver fibrosis in patients with CHB.2–4 Early-stage fibrosis may be reversible with effective antiviral treatment,whereas advanced fibrosis or cirrhosis shows limited reversibility despite therapy.5 As such,early identification and staging of liver fibrosis,followed by timely antiviral intervention,are crucial for optimizing the management of CHB and improving longterm patient outcomes.
