Purpose This study retrospectively investigated whether infarction in specific Alberta Stroke Program Early CT Score(ASPECTS)regions is associated with clinical outcome in patients with symptomatic non-acute internal ...Purpose This study retrospectively investigated whether infarction in specific Alberta Stroke Program Early CT Score(ASPECTS)regions is associated with clinical outcome in patients with symptomatic non-acute internal carotid or middle cerebral artery occlusion who underwent endovascular recanalisation(ER).Methods Preoperative ASPECTS and region of infarction were recorded before recanalisation.Clinical outcome was evaluated 90 days after the procedure using the modified Rankin Scale;a score>2 was defined as poor outcome.Secondary outcomes included postprocedural cerebral oedema,intracranial haemorrhage(ICH)and symptomatic ICH.Results Among the 86 patients included,90-day outcome was poor in 30(34.9%)and 40 experienced cerebral oedema(46.5%).Multivariate logistic regression models showed that lenticular nucleus infarction(OR 19.61-26.00,p<0.05),admission diastolic blood pressure(OR 1.07-1.08,p<0.05),preprocedural National Institutes of Health Stroke Scale(OR 1.96-2.05,p<0.001)and haemorrhagic transformation(OR 14.99-18.81,p<0.05)were independent predictors of poor 90-day outcome.The area under the receiver operating characteristic curve for lenticular nucleus infarction as a predictor of poor outcome was 0.73.M2 region infarction(OR 26.07,p<0.001)and low American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology collateral circulation grade(OR 0.16,p=0.001)were independent predictors of postprocedural cerebral oedema.The area under the receiver operating characteristic curve for M2 region infarction as a predictor of cerebral oedema was 0.64.Region of infarction did not significantly differ between patients with and without postprocedural ICH or symptomatic ICH.Conclusions Lenticular nucleus and M2 region infarction were independent predictors of poor 90-day outcome and postprocedural cerebral oedema,respectively,in patients with non-acute anterior circulation large artery occlusion who underwent ER.展开更多
基金Guangxi University of Traditional Chinese Medicine Postgraduate Education Innovation Project (Grant No. YCBXJ2022009)Guilin Science and Technology Bureau (Grant No. 2020011208-5)National Natural Science Foundation of China (Grant No. 81973768)。
文摘随着干细胞在阿尔茨海默病的研究越来越多,这项研究已经成为该领域的研究热点。干细胞疗法是最具前景的一种治疗方法。本研究通过文献计量学可视化分析,以探索干细胞在阿尔茨海默病的研究热点和趋势。构建干细胞对阿尔茨海默病研究的检索式,数据来自Web of Science Core Collection database,使用Cite Space和VOS viewer软件对2002至2021年的文献数据进行分析。干细胞对AD的研究涉及94个国家/地区,共有3629个机构参与,每年呈上升趋势,其中美国和中国是主要的研究国家。Takahashi团队首次培养出诱导多能干细胞,成为众多研究者理论的来源。University of California System是研究成果影响最大的机构, Plos One是最受欢迎的期刊, Maiese发现SIRT1是AD的治疗靶点,并且他的研究成果最多。研究重点包括Brain,Dentate gyrus,Amyloid-beta,Oxidative stress,Neurodegeneration,Inflammation,Pluripotent stem cells, Neural stem cells, Microglia。我们的研究揭示了干细胞在AD中的全球研究趋势,目前研究的热点是诱导多能干细胞模型在AD中的研究,为该领域的研究工作者提高了重要的信息和参考。
文摘Purpose This study retrospectively investigated whether infarction in specific Alberta Stroke Program Early CT Score(ASPECTS)regions is associated with clinical outcome in patients with symptomatic non-acute internal carotid or middle cerebral artery occlusion who underwent endovascular recanalisation(ER).Methods Preoperative ASPECTS and region of infarction were recorded before recanalisation.Clinical outcome was evaluated 90 days after the procedure using the modified Rankin Scale;a score>2 was defined as poor outcome.Secondary outcomes included postprocedural cerebral oedema,intracranial haemorrhage(ICH)and symptomatic ICH.Results Among the 86 patients included,90-day outcome was poor in 30(34.9%)and 40 experienced cerebral oedema(46.5%).Multivariate logistic regression models showed that lenticular nucleus infarction(OR 19.61-26.00,p<0.05),admission diastolic blood pressure(OR 1.07-1.08,p<0.05),preprocedural National Institutes of Health Stroke Scale(OR 1.96-2.05,p<0.001)and haemorrhagic transformation(OR 14.99-18.81,p<0.05)were independent predictors of poor 90-day outcome.The area under the receiver operating characteristic curve for lenticular nucleus infarction as a predictor of poor outcome was 0.73.M2 region infarction(OR 26.07,p<0.001)and low American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology collateral circulation grade(OR 0.16,p=0.001)were independent predictors of postprocedural cerebral oedema.The area under the receiver operating characteristic curve for M2 region infarction as a predictor of cerebral oedema was 0.64.Region of infarction did not significantly differ between patients with and without postprocedural ICH or symptomatic ICH.Conclusions Lenticular nucleus and M2 region infarction were independent predictors of poor 90-day outcome and postprocedural cerebral oedema,respectively,in patients with non-acute anterior circulation large artery occlusion who underwent ER.
