Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the future.Here,we r...Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the future.Here,we report a multiple redox-mediated linear paired electrolysis system,combining the hydrogen peroxide mediated cathode process with the I2 mediated anode process,and realize the conversion of furfural to furoic acid in both side of the dividedflow cell simultaneously.By reasonably controlling the cathode potential,the undesired water splitting reaction and furfural reduction side reactions are avoided.Under the galvanostatic electrolysis,the two-mediated electrode processes have good compatibility,which reduce the energy consumption by about 22%while improving the electronic efficiency by about 125%.This system provides a green electrochemical synthesis route with commercial prospects.展开更多
Dear Editor,Continued development of novel therapeutic agents is critical to improve the survival of patients with acute myeloid leukemia(AML).RNA Polymerase I(Pol I)-mediated transcription and ribosomal biogenesis be...Dear Editor,Continued development of novel therapeutic agents is critical to improve the survival of patients with acute myeloid leukemia(AML).RNA Polymerase I(Pol I)-mediated transcription and ribosomal biogenesis become dysregulated,thereby allowing synthesis of necessary substrates to support uncontrolled cancer cell proliferation 1.The Pol I transcription rate is higher in AML cells than nonleukemic myeloid precursors 2,suggesting Pol I transcrip-tion as a therapeutic target for AML.CX-5461 is a potent Pol I transcription inhibitor and stabilizer of the DNA G-quadruplex structure,which causes G2/M-phase arrest via the ATR(ataxia telangiectasia and Rad3-related protein)-mediated DNA damage response(DDR)3–5.展开更多
The paired electrolytic system is constructed by combining the valuable organic electro-oxidation and electro-reduction reactions,which can replace the ineffective water splitting half-reaction.By reducing the energy ...The paired electrolytic system is constructed by combining the valuable organic electro-oxidation and electro-reduction reactions,which can replace the ineffective water splitting half-reaction.By reducing the energy consumption of the electrolytic cell,the value-added electrolysis is realized.The indirect electrolysis method greatly reduces the dependence of the organic electrolysis reaction on electrode potential by introducing the redox mediators,which solves the problem on the matching of anode and cathode current under potentiostatic conditions.Here,we report a more stable,efficient and energy-saving linear paired electrochemical synthesis system that can simultaneously convert furfural to furoic acid at both the anode and cathode at higher current densities.Stable three-dimensional networked PbO_(2)is used as the anode and the catalytic amount of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)is used as the mediator to realize the efficient conversion of furfural to furoic acid in a wide potential range.The cathode catalyzes two-electron oxygen reduction to hydrogen peroxide using Pb/RHPC gas-diffusion electrode,which mediates the oxidation of furfural to furoic acid simultaneously.In potentiostatic electrolysis,the selectivity of the furoic acid in the cathode and anode is 33.2%and 99.3%,respectively,and the total electron efficiency is 127.1%.The properties of the cathode and anode remain stable after the long-time electrolysis in a flow cell.By choosing a stable anode with high oxygen evolution overpotential and a gas-diffusion cathode with high hydrogen evolution overpotential,the electrolytic cell can be operated efficiently and stably by introducing reasonable mediated reactions.The two half-reactions have good compatibility during the electrolysis process,saving energy consumption by about 12.3%,for certain industrial application prospects.展开更多
基金This study is supported by the National Key Research and Development Program of China(2017YFB0307500).
文摘Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the future.Here,we report a multiple redox-mediated linear paired electrolysis system,combining the hydrogen peroxide mediated cathode process with the I2 mediated anode process,and realize the conversion of furfural to furoic acid in both side of the dividedflow cell simultaneously.By reasonably controlling the cathode potential,the undesired water splitting reaction and furfural reduction side reactions are avoided.Under the galvanostatic electrolysis,the two-mediated electrode processes have good compatibility,which reduce the energy consumption by about 22%while improving the electronic efficiency by about 125%.This system provides a green electrochemical synthesis route with commercial prospects.
基金This study was supported by Jilin University,Changchun,Chinathe Barbara Ann Karmanos Cancer Institute+2 种基金Wayne State University School of Medicinegrants from the National Natural Science Foundation of China(NSFC 31671438 and NSFC 31471295)National Key Research and Development Program of China(2017YFC1702103)。
文摘Dear Editor,Continued development of novel therapeutic agents is critical to improve the survival of patients with acute myeloid leukemia(AML).RNA Polymerase I(Pol I)-mediated transcription and ribosomal biogenesis become dysregulated,thereby allowing synthesis of necessary substrates to support uncontrolled cancer cell proliferation 1.The Pol I transcription rate is higher in AML cells than nonleukemic myeloid precursors 2,suggesting Pol I transcrip-tion as a therapeutic target for AML.CX-5461 is a potent Pol I transcription inhibitor and stabilizer of the DNA G-quadruplex structure,which causes G2/M-phase arrest via the ATR(ataxia telangiectasia and Rad3-related protein)-mediated DNA damage response(DDR)3–5.
基金supported by the National Key Research and Development Program of China(2017YFB0307500).
文摘The paired electrolytic system is constructed by combining the valuable organic electro-oxidation and electro-reduction reactions,which can replace the ineffective water splitting half-reaction.By reducing the energy consumption of the electrolytic cell,the value-added electrolysis is realized.The indirect electrolysis method greatly reduces the dependence of the organic electrolysis reaction on electrode potential by introducing the redox mediators,which solves the problem on the matching of anode and cathode current under potentiostatic conditions.Here,we report a more stable,efficient and energy-saving linear paired electrochemical synthesis system that can simultaneously convert furfural to furoic acid at both the anode and cathode at higher current densities.Stable three-dimensional networked PbO_(2)is used as the anode and the catalytic amount of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)is used as the mediator to realize the efficient conversion of furfural to furoic acid in a wide potential range.The cathode catalyzes two-electron oxygen reduction to hydrogen peroxide using Pb/RHPC gas-diffusion electrode,which mediates the oxidation of furfural to furoic acid simultaneously.In potentiostatic electrolysis,the selectivity of the furoic acid in the cathode and anode is 33.2%and 99.3%,respectively,and the total electron efficiency is 127.1%.The properties of the cathode and anode remain stable after the long-time electrolysis in a flow cell.By choosing a stable anode with high oxygen evolution overpotential and a gas-diffusion cathode with high hydrogen evolution overpotential,the electrolytic cell can be operated efficiently and stably by introducing reasonable mediated reactions.The two half-reactions have good compatibility during the electrolysis process,saving energy consumption by about 12.3%,for certain industrial application prospects.
