Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficie...Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.展开更多
This article presents a new synergistic extraction system composed of Cyanex 272(C272,bis(2,4,4-trimethylpentyl)phosphinic acid)and iso-octanol for Sc_(3+) separation.The proposed synergistic system possessed an Sc^(3...This article presents a new synergistic extraction system composed of Cyanex 272(C272,bis(2,4,4-trimethylpentyl)phosphinic acid)and iso-octanol for Sc_(3+) separation.The proposed synergistic system possessed an Sc^(3+) extraction efficiency of 93.5%and a back-extraction efficiency of 82.7%,with selectivity coefficients of β_(Sc/Fe)=459 and β_(Sc/Al)=4241,which are considerably higher as compared to the current extraction systems.The extraction mechanism was studied and interpreted.The enhanced extraction efficiency is attributed to the increased hydrophobicity of the ternary complex,whereas the back-extraction efficiency can be ascribed to the attenuated stability of the complex.C272 and C272–iso-octanol systems also possess considerable surface activity,which is beneficial for the phase separation in solvent extraction.Based on the solvent extraction results,a preliminary study was conducted on polymer inclusion membranes(PIMs)using the binary system for Sc^(3+) separation to avoid the formation of the third phase,achieving an optimal initial flux of PIM of 6.71×10^(−4)mol·m^(−2)·h^(−1).Our results provide valuable information on highly efficient Sc^(3+) separation,and the study on PIM extraction has shown a green alternative to solvent extraction.展开更多
基金supported by the Leading Technology Foundation Research Project of Jiangsu Province (No. BK20232035)the Key Project of Basic Research Program of Jiangsu Province(No. BK20243061)+1 种基金the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No.SKLNMZZ202302)the Haihe Laboratory of Cell Ecosystem Innovation Fund (No. 22HHXBSS00005)。
文摘Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.
基金support from the National Natural Science Foundation of China Regional Innovation and Development Joint Fund(U24A20557)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDC0230403)+3 种基金the National Natural Science Foundation of China(22378393,22208356)“Hundred Talents Program”of the Chinese Academy of Sciencesthe Chinese Academy of Sciences stably supports the youth team plan in the field of basic research(YSBR 038)Key Research&Development projects in Qinghai Province(2023-HZ-805).
文摘This article presents a new synergistic extraction system composed of Cyanex 272(C272,bis(2,4,4-trimethylpentyl)phosphinic acid)and iso-octanol for Sc_(3+) separation.The proposed synergistic system possessed an Sc^(3+) extraction efficiency of 93.5%and a back-extraction efficiency of 82.7%,with selectivity coefficients of β_(Sc/Fe)=459 and β_(Sc/Al)=4241,which are considerably higher as compared to the current extraction systems.The extraction mechanism was studied and interpreted.The enhanced extraction efficiency is attributed to the increased hydrophobicity of the ternary complex,whereas the back-extraction efficiency can be ascribed to the attenuated stability of the complex.C272 and C272–iso-octanol systems also possess considerable surface activity,which is beneficial for the phase separation in solvent extraction.Based on the solvent extraction results,a preliminary study was conducted on polymer inclusion membranes(PIMs)using the binary system for Sc^(3+) separation to avoid the formation of the third phase,achieving an optimal initial flux of PIM of 6.71×10^(−4)mol·m^(−2)·h^(−1).Our results provide valuable information on highly efficient Sc^(3+) separation,and the study on PIM extraction has shown a green alternative to solvent extraction.
