Tourism-oriented livelihoods represent a significant avenue for transforming traditional agricultural practices.Analyzing their environmental impacts offers a novel perspective for exploring the complex interplay amon...Tourism-oriented livelihoods represent a significant avenue for transforming traditional agricultural practices.Analyzing their environmental impacts offers a novel perspective for exploring the complex interplay among human production,consumption,and the ecological environment at a micro level.In this study,Shaanxi Province farmers were selected as field survey participants.Based on a quantitative assessment of farmers’ecological footprints within the study area,how their participation in rural tourism affected ecological footprints was analyzed using the propensity score matching model,and the heterogeneity of the impact and underlying mechanisms were further explored.Results indicate that the ecological footprint of farmers varies significantly across land-use types and consumption categories.Moreover,the spatial distribution of the ecological footprints exhibits a distinct“high at both ends and low in the middle”pattern.Participation in rural tourism significantly reduces the ecological footprint,particularly among farmers with higher levels of social trust or lower economic status.Further analysis shows that habitat quality and vegetation coverage are key ecological indicators that exert a significant positive moderating effect on the negative impact of rural tourism participation on farmers’ecological footprints.These findings highlight the importance of integrating ecological conservation with economic development.Accordingly,tailored policies,improved ecological service systems,and enhanced regional ecological quality are recommended to increase resource-use efficiency and promote a virtuous cycle between environmental sustainability and rural economic growth.展开更多
Demand for food plays an important role in the adjustment of prices for agricultural products and for adjusting agricultural structure.By using the extended linear expenditure system(ELES),we analyzed the food consump...Demand for food plays an important role in the adjustment of prices for agricultural products and for adjusting agricultural structure.By using the extended linear expenditure system(ELES),we analyzed the food consumption structure of rural residents in the Ganzhou district of Zhangye city,and determined the basic food-consumption demand,the marginal propensity of consumption,the income elasticities of demand,and the own-price and cross-price elasticities of local rural residents,all of which illustrate the influencing factors on food consumption of rural residents and for forecasting the food-consumption structure.Those analyses show the following:the rural residents’ expenditure on household basic food consumption reaches about 7,050.35 Yuan;the marginal propensities of consumption of fruits and vegetables are relatively high(0.062 and 0.106,respectively),followed by meat(0.044);the demands for various foods are increasing as income increases,with the largest income elasticity of demand corresponding to fruits(1.354) and the lowest to cereal(0.310);fruits and vegetables have relatively high own-price elasticities(respectively-0.879 and-0.442),with the cereal having the lowest one(-0.184).An increase in cereal prices would greatly affect demand for other products;with the rising size of rural households,the consumption for meat is decreasing whereas it is increasing for cereal.The improvement of household education levels will lead to the increase of fruit consumption(E = 0.297),which indicates that people will pay more attention to diet and nutrition structure with the improvement of education.Further,although the amount of cereal expenditure is continually growing,the share will be declining with the increase of household income in 2006-2012.For all these reasons,therefore,the government should encourage the cultivation of economic crops and guide the development of stockbreeding to ensure the stability of cereal output.In order to attain the balance between supply and demand,it is important to rationally adjust the prices of fruits and vegetables on the basis of the stable price of cereal.展开更多
Increasing evidence suggests that low to mod- erate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion; however, the underlying mechanism has not been elucidated. In the pres...Increasing evidence suggests that low to mod- erate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion; however, the underlying mechanism has not been elucidated. In the present study, we showed that expression of the neuronal large-conductance, Ca2＋-activated K＋ channel （BKca） α- subunit was upregulated in cultured neurons exposed to oxygen-glucose deprivation/reoxygenation （OGD/R） compared with controls. Preconditioning with low-dose ethanol （10 mmol/L） increased cell survival rate in neurons subjected to OGD/R, attenuated the OGD/R-induced elevation of cytosolic Ca2＋ levels, and reduced the number of apoptotic neurons. Western blots revealed that ethanol preconditioning upregulated expression of the anti-apoptotic protein Bcl-2 and downregulated the pro-apoptotic protein Bax. The protective effect of ethanol precondi- tioning was antagonized by a BKα channel inhibitor, paxilline. Inside-out patches in primary neurons also demonstrated the direct activation of the BKCa channel by 10 mmol/L ethanol. The above results indicated that low- dose ethanol preconditioning exerts its neuroprotective effects by attenuating the elevation of cytosolic Ca2＋ and preventing neuronal apoptosis, and this is mediated by BKca channel activation.展开更多
Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss t...Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions.展开更多
BACKGROUND The incidence of primary liver cancer is increasing year by year.In 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of c...BACKGROUND The incidence of primary liver cancer is increasing year by year.In 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of cases.HCC is the most common primary liver cancer.China has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese people.The onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when diagnosed.Therefore,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of patients.Protein tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further studied.AIM To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in HCC.METHODS The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and immunoblotting.The value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological features.Finally,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical staining.RESULTS The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC patients.Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that PTPN2 was associated with various pathways,including cancer-related pathways,the Notch signaling pathway,and the MAPK signaling pathway.Gene Set Enrichment Analysis showed that PTPN2 was highly expressed in various immune-related pathways,such as the epithelial mesenchymal transition process.A risk model score based on PTPN2 showed that immune escape was significantly enhanced in the high-risk group compared with the low-risk group.CONCLUSION This study investigated PTPN2 from multiple biological perspectives,revealing that PTPN2 can function as a biomarker of poor prognosis and mediate immune evasion in HCC.展开更多
[Objectives] This study was conducted to analyze the differences in procyanidine content in grapes caused by different producing areas. [Methods]With Muscat Hamburg grape from different producing areas as an experimen...[Objectives] This study was conducted to analyze the differences in procyanidine content in grapes caused by different producing areas. [Methods]With Muscat Hamburg grape from different producing areas as an experimental material,procyanidine content was determined by n-butanol-hydrochloric acid colorimetry. [Results] The procyanidins contents in different parts of the same variety ranked as grape seed > grape skin > grape flesh. The procyanidins contents in grapes from different producing areas were in order of Changli County,Hebei Province > Dazeshan Town,Shandong Province > Hangu District,Tianjin City.[Conclusions]The procyanidins contents in Muscat Hamburg grapes from different producing areas differ to a certain degree.展开更多
The security and quality of the livelihood of farmers is of paramount concern in rural areas of China. Livelihood stability would force the related polity to act coordinately while eradicating poverty and promoting re...The security and quality of the livelihood of farmers is of paramount concern in rural areas of China. Livelihood stability would force the related polity to act coordinately while eradicating poverty and promoting resource sustainability. For this study, the livelihood approach was used as a framework of analysis that is based upon Sustainable Livelihoods Framework, the core of which is livelihood assets. Livelihood capitals provide substantial contributions to the well-being of numerous rural dwellers. However, the level and degree of reliance on livelihood capital differ across households. Factors that contribute to the economic reliance of households on a particular economic activity in general and on livelihood capital in particular may vary depending upon the type of resource endowment, household demographic, and economic characteristic as well as exoge- nous factors such as markets, prices, policies, and technologies. This study identifies factors that influence a household＇s live- lihood strategy choice with a particular focus on livelihood assets. The study applies a preliminary investigation concerning the relationship between livelihood assets and livelihood strategies, that is, the allocation of assets. Environmentally augmented household livelihood assets were collected from 300 sample households within the Heihe River Basin. Results show that physical assets possess a maximum value （0.609） for farmers and human assets possess a relatively high value （0.516） fol- lowed by social assets （0.354）. Besides, financial and natural assets possess relatively low values （0.286 and 0.241, respec- tively）. An increment of one unit should reduce the occurrence of choosing non-agricultural activities for natural capital while an increment of one unit should increase the occurrence of choosing non-agricultural activities for financial capital, while other variables remain constant. Governments, therefore, should enhance funding and technological support to achieve livelihood diversity and strengthen the facility of farmers by way of establishing relevant polity. It would enable farmers and provide themselves with the ability and asset reserves to transition from agricultural production to secondary and tertiary industries in order to improve the livelihood of farmers overall.展开更多
基金supported by the National Natural Science Foundation of China[Grant No.42171281,72442020]the Shaanxi Provincial Social Science Fund Project[Grant No.2024ES04]Shaanxi Province Postdoctoral Science Foundation[Grant No.2024BSHSDZZ013].
文摘Tourism-oriented livelihoods represent a significant avenue for transforming traditional agricultural practices.Analyzing their environmental impacts offers a novel perspective for exploring the complex interplay among human production,consumption,and the ecological environment at a micro level.In this study,Shaanxi Province farmers were selected as field survey participants.Based on a quantitative assessment of farmers’ecological footprints within the study area,how their participation in rural tourism affected ecological footprints was analyzed using the propensity score matching model,and the heterogeneity of the impact and underlying mechanisms were further explored.Results indicate that the ecological footprint of farmers varies significantly across land-use types and consumption categories.Moreover,the spatial distribution of the ecological footprints exhibits a distinct“high at both ends and low in the middle”pattern.Participation in rural tourism significantly reduces the ecological footprint,particularly among farmers with higher levels of social trust or lower economic status.Further analysis shows that habitat quality and vegetation coverage are key ecological indicators that exert a significant positive moderating effect on the negative impact of rural tourism participation on farmers’ecological footprints.These findings highlight the importance of integrating ecological conservation with economic development.Accordingly,tailored policies,improved ecological service systems,and enhanced regional ecological quality are recommended to increase resource-use efficiency and promote a virtuous cycle between environmental sustainability and rural economic growth.
基金the funding from the National Natural Science Foundation of China (No. 40671076)CAS western Action Plan (2),"Strategy Research on Basin Integrated Water Resources Management" (KZCX2-XB2-04-04)
文摘Demand for food plays an important role in the adjustment of prices for agricultural products and for adjusting agricultural structure.By using the extended linear expenditure system(ELES),we analyzed the food consumption structure of rural residents in the Ganzhou district of Zhangye city,and determined the basic food-consumption demand,the marginal propensity of consumption,the income elasticities of demand,and the own-price and cross-price elasticities of local rural residents,all of which illustrate the influencing factors on food consumption of rural residents and for forecasting the food-consumption structure.Those analyses show the following:the rural residents’ expenditure on household basic food consumption reaches about 7,050.35 Yuan;the marginal propensities of consumption of fruits and vegetables are relatively high(0.062 and 0.106,respectively),followed by meat(0.044);the demands for various foods are increasing as income increases,with the largest income elasticity of demand corresponding to fruits(1.354) and the lowest to cereal(0.310);fruits and vegetables have relatively high own-price elasticities(respectively-0.879 and-0.442),with the cereal having the lowest one(-0.184).An increase in cereal prices would greatly affect demand for other products;with the rising size of rural households,the consumption for meat is decreasing whereas it is increasing for cereal.The improvement of household education levels will lead to the increase of fruit consumption(E = 0.297),which indicates that people will pay more attention to diet and nutrition structure with the improvement of education.Further,although the amount of cereal expenditure is continually growing,the share will be declining with the increase of household income in 2006-2012.For all these reasons,therefore,the government should encourage the cultivation of economic crops and guide the development of stockbreeding to ensure the stability of cereal output.In order to attain the balance between supply and demand,it is important to rationally adjust the prices of fruits and vegetables on the basis of the stable price of cereal.
基金supported by the National Natural Science Foundation of China(81171097 and 81271312)the Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease,China(TMCD201502)
文摘Increasing evidence suggests that low to mod- erate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion; however, the underlying mechanism has not been elucidated. In the present study, we showed that expression of the neuronal large-conductance, Ca2＋-activated K＋ channel （BKca） α- subunit was upregulated in cultured neurons exposed to oxygen-glucose deprivation/reoxygenation （OGD/R） compared with controls. Preconditioning with low-dose ethanol （10 mmol/L） increased cell survival rate in neurons subjected to OGD/R, attenuated the OGD/R-induced elevation of cytosolic Ca2＋ levels, and reduced the number of apoptotic neurons. Western blots revealed that ethanol preconditioning upregulated expression of the anti-apoptotic protein Bcl-2 and downregulated the pro-apoptotic protein Bax. The protective effect of ethanol precondi- tioning was antagonized by a BKα channel inhibitor, paxilline. Inside-out patches in primary neurons also demonstrated the direct activation of the BKCa channel by 10 mmol/L ethanol. The above results indicated that low- dose ethanol preconditioning exerts its neuroprotective effects by attenuating the elevation of cytosolic Ca2＋ and preventing neuronal apoptosis, and this is mediated by BKca channel activation.
基金Project supported by the National Natural Science Foundation of China(21671201,U1632101,61905289,11904425)Postdoctoral Science Foundation of China(2017M622846,2019M663202)。
文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions.
文摘BACKGROUND The incidence of primary liver cancer is increasing year by year.In 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of cases.HCC is the most common primary liver cancer.China has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese people.The onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when diagnosed.Therefore,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of patients.Protein tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further studied.AIM To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in HCC.METHODS The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and immunoblotting.The value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological features.Finally,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical staining.RESULTS The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC patients.Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that PTPN2 was associated with various pathways,including cancer-related pathways,the Notch signaling pathway,and the MAPK signaling pathway.Gene Set Enrichment Analysis showed that PTPN2 was highly expressed in various immune-related pathways,such as the epithelial mesenchymal transition process.A risk model score based on PTPN2 showed that immune escape was significantly enhanced in the high-risk group compared with the low-risk group.CONCLUSION This study investigated PTPN2 from multiple biological perspectives,revealing that PTPN2 can function as a biomarker of poor prognosis and mediate immune evasion in HCC.
基金Supported by the Key Research and Development Foundation of Tianjin City(17YFXTZC00040)Agriculture Product Quality and Security Detection Foundation of Ministery of Agriculture(181821301092362005)Tianjin Science and Technology Program(17JCYBJC29800,16PTZSTG00020)
文摘[Objectives] This study was conducted to analyze the differences in procyanidine content in grapes caused by different producing areas. [Methods]With Muscat Hamburg grape from different producing areas as an experimental material,procyanidine content was determined by n-butanol-hydrochloric acid colorimetry. [Results] The procyanidins contents in different parts of the same variety ranked as grape seed > grape skin > grape flesh. The procyanidins contents in grapes from different producing areas were in order of Changli County,Hebei Province > Dazeshan Town,Shandong Province > Hangu District,Tianjin City.[Conclusions]The procyanidins contents in Muscat Hamburg grapes from different producing areas differ to a certain degree.
基金supported by General Research on Social Sciences of Ministry of Education of China (Granted No.12YJAZH110)Chinese Natural Science Foundation (No.41171116)the National Natural Science Foundation of China (No. 40971291)
文摘The security and quality of the livelihood of farmers is of paramount concern in rural areas of China. Livelihood stability would force the related polity to act coordinately while eradicating poverty and promoting resource sustainability. For this study, the livelihood approach was used as a framework of analysis that is based upon Sustainable Livelihoods Framework, the core of which is livelihood assets. Livelihood capitals provide substantial contributions to the well-being of numerous rural dwellers. However, the level and degree of reliance on livelihood capital differ across households. Factors that contribute to the economic reliance of households on a particular economic activity in general and on livelihood capital in particular may vary depending upon the type of resource endowment, household demographic, and economic characteristic as well as exoge- nous factors such as markets, prices, policies, and technologies. This study identifies factors that influence a household＇s live- lihood strategy choice with a particular focus on livelihood assets. The study applies a preliminary investigation concerning the relationship between livelihood assets and livelihood strategies, that is, the allocation of assets. Environmentally augmented household livelihood assets were collected from 300 sample households within the Heihe River Basin. Results show that physical assets possess a maximum value （0.609） for farmers and human assets possess a relatively high value （0.516） fol- lowed by social assets （0.354）. Besides, financial and natural assets possess relatively low values （0.286 and 0.241, respec- tively）. An increment of one unit should reduce the occurrence of choosing non-agricultural activities for natural capital while an increment of one unit should increase the occurrence of choosing non-agricultural activities for financial capital, while other variables remain constant. Governments, therefore, should enhance funding and technological support to achieve livelihood diversity and strengthen the facility of farmers by way of establishing relevant polity. It would enable farmers and provide themselves with the ability and asset reserves to transition from agricultural production to secondary and tertiary industries in order to improve the livelihood of farmers overall.
