配电变压器额定容量校核对配网的优化运行控制以及安全可靠运行都起着重要作用。针对Dyn11型配电变压器额定容量校核效率低、精度差等问题,提出了一种基于电压降相间-时间差分的Dyn11型配电变压器额定容量校核方法。首先利用相间差分法...配电变压器额定容量校核对配网的优化运行控制以及安全可靠运行都起着重要作用。针对Dyn11型配电变压器额定容量校核效率低、精度差等问题,提出了一种基于电压降相间-时间差分的Dyn11型配电变压器额定容量校核方法。首先利用相间差分法弱化配电变压器高压侧数据波动对校核造成的影响,其次结合时间差分法降低配电变压器运行环境所带来的扰动;然后利用基于密度的聚类算法(density-based spatial clustering of applications with noise,DBSCAN)以及异号剔除原则进行降噪处理,从而进一步提高额定容量校核的准确率;最后基于某省配网变压器开展了算例验证。研究结果表明:所提方法具有90%以上的准确度,能够对Dyn11型配电变压器的额定容量进行有效的在线校核。论文研究可为配电变压器容量校核提供参考。展开更多
Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-i...Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO.展开更多
文摘配电变压器额定容量校核对配网的优化运行控制以及安全可靠运行都起着重要作用。针对Dyn11型配电变压器额定容量校核效率低、精度差等问题,提出了一种基于电压降相间-时间差分的Dyn11型配电变压器额定容量校核方法。首先利用相间差分法弱化配电变压器高压侧数据波动对校核造成的影响,其次结合时间差分法降低配电变压器运行环境所带来的扰动;然后利用基于密度的聚类算法(density-based spatial clustering of applications with noise,DBSCAN)以及异号剔除原则进行降噪处理,从而进一步提高额定容量校核的准确率;最后基于某省配网变压器开展了算例验证。研究结果表明:所提方法具有90%以上的准确度,能够对Dyn11型配电变压器的额定容量进行有效的在线校核。论文研究可为配电变压器容量校核提供参考。
基金supported by the National Key Research and Development Program of China(reference number 2019YFA0801800)the Natural Science Foundation of China(reference numbers 32070916,82102573,8157152,81472087,81670097 and 81870085)the Natural Science Foundation of Anhui Province(reference numbers 1508085MC45 and 1908085QH359).
文摘Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO.
