脊髓小脑性共济失调17型(spinocerebellar ataxia type 17,SCA17)是一种罕见的常染色体显性遗传病,由位于6q27染色体上的TATA box结合蛋白基因(TBP)异常胞嘧啶-腺嘌呤-腺嘌呤/胞嘧啶-腺嘌呤-鸟嘌呤(cytosine-adenine-adenine/cytosine-a...脊髓小脑性共济失调17型(spinocerebellar ataxia type 17,SCA17)是一种罕见的常染色体显性遗传病,由位于6q27染色体上的TATA box结合蛋白基因(TBP)异常胞嘧啶-腺嘌呤-腺嘌呤/胞嘧啶-腺嘌呤-鸟嘌呤(cytosine-adenine-adenine/cytosine-adenineguanine,CAA/CAG)重复扩增引起[1]。该病的临床表现具有高度异质性,除了具有脊髓小脑共济失调(spinocerebellar ataxias,SCAs)典型的共济失调和构音障碍外,还可表现为痴呆、精神症状或舞蹈样不自主运动。目前其临床诊断主要依靠典型的临床表现、遗传家族史、特征性生化指标异常、遗传性共济失调相关神经影像学及电生理检查和基因检测。展开更多
Cadmium(Cd)is considered a toxic element of which food is the major source of acquisition,which can lead to diseases such as renal dysfunction,cancer and osteoporosis[1].Cd is classified as a group I carcinogen by the...Cadmium(Cd)is considered a toxic element of which food is the major source of acquisition,which can lead to diseases such as renal dysfunction,cancer and osteoporosis[1].Cd is classified as a group I carcinogen by the International Agency for Research on Cancer[2].The results of dietary exposure to cadmium in Europe in 2012 showed that the contribution rate from the broad food categories of grain and grain products accounted for 26.9%.展开更多
目的探讨腔镜下不同手术入路甲状腺切除术对cN0期甲状腺乳头状癌(PTC)的手术效果。方法回顾性分析2019年8月—2022年11月于本院就诊并接受腔镜手术治疗的118例cN0期PTC患者的临床资料,根据腔镜下不同手术入路,分为胸乳组与经口组,应用...目的探讨腔镜下不同手术入路甲状腺切除术对cN0期甲状腺乳头状癌(PTC)的手术效果。方法回顾性分析2019年8月—2022年11月于本院就诊并接受腔镜手术治疗的118例cN0期PTC患者的临床资料,根据腔镜下不同手术入路,分为胸乳组与经口组,应用倾向性评分匹配法各纳入59例患者。比较两组围术期相关指标。结果经口组术后引流量、住院时长均少于胸乳组(P<0.05),而手术时间、中央区淋巴结清扫数目多于胸乳组(P<0.05);经口组术后12、24 h VAS评分均低于胸乳组(P<0.05);术后3 d,经口组吞咽功能优于胸乳组(P<0.05);术后3个月,经口组瘢痕评估量表评分低于胸乳组(P<0.05);随访1年,组间术后复发、无进展生存期比较无明显差异(P>0.05)。结论经胸乳入路腔镜术与经口腔前庭腔镜术治疗cN0期PTC整体疗效相当,但经口腔前庭入路腔镜术后恢复更快,更值得应用。展开更多
基金supported by the National Key Research and Development Programme of China[2017YFC1600500]Grain Industry Research Special Funds for Public Welfare Projects[No.201513006-03].
文摘Cadmium(Cd)is considered a toxic element of which food is the major source of acquisition,which can lead to diseases such as renal dysfunction,cancer and osteoporosis[1].Cd is classified as a group I carcinogen by the International Agency for Research on Cancer[2].The results of dietary exposure to cadmium in Europe in 2012 showed that the contribution rate from the broad food categories of grain and grain products accounted for 26.9%.
文摘目的探讨腔镜下不同手术入路甲状腺切除术对cN0期甲状腺乳头状癌(PTC)的手术效果。方法回顾性分析2019年8月—2022年11月于本院就诊并接受腔镜手术治疗的118例cN0期PTC患者的临床资料,根据腔镜下不同手术入路,分为胸乳组与经口组,应用倾向性评分匹配法各纳入59例患者。比较两组围术期相关指标。结果经口组术后引流量、住院时长均少于胸乳组(P<0.05),而手术时间、中央区淋巴结清扫数目多于胸乳组(P<0.05);经口组术后12、24 h VAS评分均低于胸乳组(P<0.05);术后3 d,经口组吞咽功能优于胸乳组(P<0.05);术后3个月,经口组瘢痕评估量表评分低于胸乳组(P<0.05);随访1年,组间术后复发、无进展生存期比较无明显差异(P>0.05)。结论经胸乳入路腔镜术与经口腔前庭腔镜术治疗cN0期PTC整体疗效相当,但经口腔前庭入路腔镜术后恢复更快,更值得应用。
