A green chelate-like phosphate-based adsorbent functionalized by glycine(CP@Glycine)was first designed,synthesized,and applied to selectively separate Be(Ⅱ)from uranium–beryllium-containing(U/Be)solutions.The optima...A green chelate-like phosphate-based adsorbent functionalized by glycine(CP@Glycine)was first designed,synthesized,and applied to selectively separate Be(Ⅱ)from uranium–beryllium-containing(U/Be)solutions.The optimal adsorption conditions were:WH3PO_(4)/WCa(OH)_(2)/WGlycine(wt/wt/wt)of 3:3:1,pH=6,resulting in the maximum adsorption efficiency of 99%in the case of adsorbent of 2 g·L^(−1).CP@Glycine exhibited excellent selectivity for Be(Ⅱ)(K_( d)=2.53×10^(4) mL·g^(−1))toward Fe,U,Zn,Mn,Na,and Ca in solutions.After 5 adsorption–desorption cycles,the removal efficiency of Be(Ⅱ)remained at 85%,and the desorption rate of Be(Ⅱ)was above 90%.Adsorption kinetics and thermodynamics studies showed that the theoretical maximum adsorption capacity(Qe)of CP@Glycine was 66 mg·g^(−1),which was higher than the state-of-the-art adsorption materials.Besides,the surface of CP@Glycine exhibited abundant active sites with negative charges which would have a potential electrostatic attraction with Be(Ⅱ).Moreover,the adsorption mechanism of CP@Glycine was methodically revealed through a combination of various characterizations and DFT investigations.It was found that BeNH_(4)PO_(4) and Be(OH)_(2) were formed as stable precipitates on the surface of CP@Glycine,which implied that Be(Ⅱ)was coordinated with the amino and the phosphate groups from CP@Glycine,thus achieving the chelation effect of Be(Ⅱ)with CP@Glycine for the adsorption process.The results of DFT investigations further confirmed that Be(Ⅱ)owned strong bonding affinity to the amino group and the phosphate group from the as-prepared CP@Glycine.The results indicated that the calculated binding energy of the Be complex coordinated with glycine and phosphate(−229.37 kcal·mol^(−1))was lower than that of other possible Be complexes.The above findings revealed that CP@Glycine could be a promising adsorbent for the selective separation and recovery of Be(Ⅱ)from U/Be wastewater.展开更多
Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven ...Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven deposition during cycling would result in significant capacity decay,low Coulombic efficiency,and electrolyte consumption,thus the undesirable cyclability severely hampers the practical applications.Herein,a phosphorus-doped carbon protective layer was coated onto the surface of Zn anode via using the plasma-enhanced chemical vapor deposition(PECVD)approach.Enhanced conductivity and lower nucleation overpotential induced by the P-doped carbon protective layer can effectively facilitate the ion diffusion kinetics and suppress side reactions.The as-fabricated P-C/Zn anode demonstrated excellent cycling stability during the zinc plating/stripping process,maintaining a low voltage hysteresis(34.8 m V)for over 1000 h under a current density of 2 m A/cm^(2)and a capacity of 2 m Ah/cm^(2).Moreover,the P-C/Zn||MnO_(2)full cell exhibited high specific capacity of about 252.5 m Ah/g at 2 A/g upon 700 long cycles.This study is helpful to design more efficient zinc-ion batteries towards the future applications.展开更多
Aqueous zinc-ion batteries(ZIBs) have been considered as one of the most promising electrochemical devices for large-scale energy storage system owing to their low cost and high safety. Herein, Na2V6O16·2.14H2O n...Aqueous zinc-ion batteries(ZIBs) have been considered as one of the most promising electrochemical devices for large-scale energy storage system owing to their low cost and high safety. Herein, Na2V6O16·2.14H2O nanobelts are synthesized and applied as cathode material for ZIBs. The sample displays a high capacity of 466 m Ahg^-1 at 100 mAg^-1 and stable cycling performance with a capacity retention of 90% over 20 0 0 cycles at the 20 Ag^-1. Moreover, Na2V6O16·2.14H2O presents a capable rate ability and a high energy density of 312 Wh kg^-1 at a specific power of 70 Wkg^-1. The superior electrochemical performance is attributed to the large interlayer spacing and outstanding structure stability, which promise the highly reversible intercalation and extraction of zinc ion. The electrochemical kinetics and zinc ion storage mechanism are also investigated. This work demonstrates that nanoscale electrode materials with large interlayer spacing can effectively enhance the electrochemical performance of aqueous ZIBs, which can be extended to other metal ion batteries, such as magnesium ion batteries and aluminum ion batteries.展开更多
Phase separation rate is a critical character in determining the usefulness of a solvent extraction system in hydrometallurgy. A survey of the synergistic mixture containing dinonylnaphthalene sulfonic acid (HDNNS) an...Phase separation rate is a critical character in determining the usefulness of a solvent extraction system in hydrometallurgy. A survey of the synergistic mixture containing dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexly 4-pyridinecarboxylate ester (4PC) for the extraction of cobalt from acidic single metal sulfate solution was carried out to suggest how the physicochemical properties and the morphology of the reverse micelles in the loaded organic phase affect the phase separation. The results show that effective parameters affecting the phase separation are the viscosity and the excess water uptake of the loaded organic phase. It is obvious that the specific settling rate (SSR) decreases with the apparent increase of these two parameters. The measurement of small angle X-ray scattering (SAXS) proves that the morphology of the reversed micelles in the loaded organic phase changes evidently with the change of the specific settling rate (SSR).展开更多
Zn(CF_(3)SO_(3))_(2)as an electrolyte has been widely used to improve the electrochemical performance for ZIBs due to that the bulky CF_(3)SO_(3)-can reduce the solvation effect of Zn^(2+)and promote the ionic diffusi...Zn(CF_(3)SO_(3))_(2)as an electrolyte has been widely used to improve the electrochemical performance for ZIBs due to that the bulky CF_(3)SO_(3)-can reduce the solvation effect of Zn^(2+)and promote the ionic diffusion.Herein,we found that Zn(CF_(3)SO_(3))_(2)electrolyte can induce different electrochemical mechanisms from ZnSO_(4)electrolyte.Compared to the ZnSO^(4)electrolyte,the HNaV_(6)O_(16)·4H2_(O)electrode with Zn(CF_(3)SO_(3))_(2)electrolyte exhibits a high capacity of 444 mAh·g^(-1)at 500 mA·g^(-1)with a capacity retention of 92.3%after 80 cycles.Even,at a high rate of 5 Ag-1,the HNaV_(6)O_(16)·4H_(2)O electrode delivers an initial discharge capacity of 328 mAh·g^(-1)with a capacity retention of 93.7%after 1000 cycles.Differing from the mechanism with ZnSO4 electrolyte,the excellent cycle stability of HNaV_(6)O_(16)·4H_(2)Oelectrode can be attributed to the in-situ phase transformation to ZnxV_(2)O_(5)·nH_(2)O based on the co-intercalation of Zn^(2+)/H^(+).展开更多
Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domesti...Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd.展开更多
Exploring high-performance cathode materials for aqueous zinc ion batteries(ZIBs)is still one of the critical issues.Copper vanadate compound has become a potential cathode material for ZIBs with a novel displacement ...Exploring high-performance cathode materials for aqueous zinc ion batteries(ZIBs)is still one of the critical issues.Copper vanadate compound has become a potential cathode material for ZIBs with a novel displacement reaction mechanism of reversible reduction/oxidation of Cu^(2+)/Cu^(0).Herein,we reported Cu_(0.95)V_(2)O_(5)nanoflowers prepared using a hydrothermal synthesis method as a capable cathode material for ZIBs.The Cu_(0.95)V_(2)O_(5)nanoflowers exhibit high specific capacity of 405 mAh·g^(-1) at the current density of 100 mA·g^(-1),benefiting from the displacement reaction mechanism and phase transformation mechanism from Cu_(0.95)V_(2)O_(5)to the open and stable architecture Cu_(0.4)V_(2)O_(5)and Zn3(OH)2V2O7·2H2O phase.The cathode exhibits excellent rate performance with a high capacity of-200 mAh·g^(-1)at 5 A·g^(-1) and outstanding cycle stability with a capacity retention of 92%after 1000 cycles.It is anticipated that the novel Cu_(0.95)V_(2)O_(5)nanoflowers are promising cathode material in the application for zinc ion batteries.展开更多
Aqueous rechargeable zinc-ion batteries(ARZIBs) are expected to replace organic electrolyte batteries owing to its low price,safe and environmentally friendly characteristics.Herein,we fabricated vanadium-based Na1.25...Aqueous rechargeable zinc-ion batteries(ARZIBs) are expected to replace organic electrolyte batteries owing to its low price,safe and environmentally friendly characteristics.Herein,we fabricated vanadium-based Na1.25V3O8 nanosheets as a cathode material for ARZIBs,which present a high performance by electrochemical de-sodium at high voltage to form Na2V6O16 phase in the first cycle:high capacity of 390 mAh/g at 0.1 A/g,high rate perfo rmance(162 mAh/g at 10 A/g) and superior cycle stability(179 mAh/g with a high capacity retention of 88.2% of the maximum capacity after 2000 cycles).In addition,the cell exhibits a high energy density of 416.9 Wh/kg at 143.6 W/kg,suggesting great potential of the as-prepared Na1.25V3O8 nanosheets for ARZIBs.展开更多
Objective:To explore core acupoints and acupoint selection principles in acupuncture and moxibustion for obesity,from syndrome differentiation prescriptions of the acupuncture-moxibustion therapy in 808 obesity prescr...Objective:To explore core acupoints and acupoint selection principles in acupuncture and moxibustion for obesity,from syndrome differentiation prescriptions of the acupuncture-moxibustion therapy in 808 obesity prescriptions,by using node centrality and cluster analysis methods in complex network.Methods:Firstly,an acupoint network model is established,and acupoint nodes are assessed and calculated in multiple aspects by introducing the node centrality analysis idea of complex network,to excavate core acupoint nodes.Secondly,a cluster analysis is carried out on acupoint network by the cluster algorithm Q-PSO for complex network,to investigate the acupoint combination principles.Results:Zusanli(足三里ST36),Tianshu(天枢ST25),Fenglong(丰隆ST40),Zhongwan(中脘CV12)and Qihai(气海CV6),etc.,were included into the core acupoint Sanyinjiao(三阴交SP6)community.Zhigou(支沟TE6),Neiting(内庭ST44),Shangjuxu(上巨虚ST37),and Pishu(脾俞BL20)etc.,were included into the core acupoint Yinlingquan(阴陵泉SP9)community.Baihuanshu(白环俞BL30)and Zhiyang(至阳GV9)were included into the core acupoint Dachangshu(大肠俞BL25)community.Biguan(髀关ST31)was a single core community.Among all the acupoint nodes,SP6,ST25,SP9,ST36,CV6,Quchi(曲池L111),and Guanyuan(关元CV4)were of high degree centrality and eigenvector centrality,directly reflecting their importance in acupoint selection prescriptions.Conclusion:The Q-PSO algorithm is characterized with high precision and high efficiency,etc.The core acupoints and their combination principles explored by this algorithm are in accordance with clinical experiences.展开更多
A method for preparing a graphene oxide/polyaniline （GO/PANI） composite electrode was developed to investigate the effect of GO doped in PANI. PANI was first prepared by the polymerisation of aniline and then dedope...A method for preparing a graphene oxide/polyaniline （GO/PANI） composite electrode was developed to investigate the effect of GO doped in PANI. PANI was first prepared by the polymerisation of aniline and then dedoped by NH4OH to form emeraldine base （EB）. The dedoped PANI and as-prepared GO were dissolved in N-methyl-2-pyrrolidone （NMP） to generate a homogeneous dispersion. The GO/PANI composites were redoped in HCI before use as electrode materials. These composites were characterised by Raman spectroscopy, X-ray diffraction, UV-vis adsorption spectroscopy, scanning electron microscopy, atomic force microscopy and electrochemical measurements. The GO/PANI composite electrode （containing 2.5% GO） has an initial gravimetric capacitance of 896 F g-1 at a scan rate of 5 mV s-1 and a retention life of 51% after 500 cycles, which is an improvement over that of pure PANI （23%）. The results show that the synergy of GO and PANI attributes to the good electrochemical performance of the GO/PANI composite electrode.展开更多
Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of P...Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration time and period.As theranostic nanomedicine is driven by multifunctional therapeutics that aim to achieve targeted tissue delivery and image-guided therapy, fluorescent PS nanoparticle(NP)accumulation in target tissues can be ascertained through fluorescence imaging to optimize the light dose and administration parameters. In this regard, zebrafish larvae provide a unique transparent in vivo platform to monitor fluorescent PS bio-distribution and their therapeutic efficiency. Using fluorescent PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example.展开更多
AIM: To evaluate the effect of amniotic membrane loaded with 5-fluorouracil poly(lactic-co-glycolic acid)(PLGA) nanoparticles(5-FU-NPs) in the surgical outcomes of experimental trabeculectomy in rabbits.METHODS: Thirt...AIM: To evaluate the effect of amniotic membrane loaded with 5-fluorouracil poly(lactic-co-glycolic acid)(PLGA) nanoparticles(5-FU-NPs) in the surgical outcomes of experimental trabeculectomy in rabbits.METHODS: Thirty-two New Zealand white rabbits were randomly categorized into four groups with 8 rabbits in each group. Group 1, the control group, performed traditional trabeculectomy without adjuvant treatment.While the experimental groups performed compound trabeculectomy with different implantations including amniotic membrane(group 2), 5-FU-NPs(group 3) and amniotic membrane loaded with 5-FU-NPs(group 4).Clinical evaluations including IOP measurement and filtration bleb analysis were performed in all groups postoperatively.RESULTS: There is no significant difference of mean IOP in all groups at first 7d after surgery. While at P14,mean IOPs of experimental group 2(9.8 ±2.1 mm Hg),groups 3(8.9 ±2.8 mm Hg) and group 4(7.6 ±2.3 mm Hg)were significantly reduced compared to control group(12.4 ±2.6 mm Hg; n =8, P 【0.05). At P21, mean IOPs of groups 3(11.7±3.2 mm Hg) and group 4(9.9±1.6 mm Hg)were significantly decreased compare to control group(17.9±1.6 mm Hg) and group 2(16.6 ±2.8 mm Hg; n =8,P 【0.05). At P28, mean IOPs of groups 3(13.8±3.3 mm Hg)and group 4(10.6 ±2.0 mm Hg) were also significantly reduced compare to control group(19.4±2.3 mm Hg) and group 2(18.5 ±2.4 mm Hg; n =8, P 【0.05). Meanwhile mean IOP of group 4 is significantly decreased compared to group 3 at P28(n =8, P 【0.05). Survival analysis of functional filtration blub in all groups revealed the longest survival time in group 4(24.9±5.1d) compared to that in group 3(20.6 ±4.3d), group 2(15.0 ±5.2d) and control group(10.1±5.7d).CONCLUSION: Amniotic membrane loaded with 5-FuNPs may function as an effective anti-scarring implant and provides improved long-term surgical outcomes for experimental trabeculectomy in rabbits.展开更多
BACKGROUND The SEMA3A gene,which is located at 7q21.11,is involved in hypothalamic neuron migration,heart development,kidney development,and skeleton metabolism.Mutation of the SEMA3A gene is associated with Kallmann ...BACKGROUND The SEMA3A gene,which is located at 7q21.11,is involved in hypothalamic neuron migration,heart development,kidney development,and skeleton metabolism.Mutation of the SEMA3A gene is associated with Kallmann syndrome 16 with or without a normal sense of smell.In addition,two case reports showed that mutation of the SEMA3A gene could cause short stature,low gonadotropin,hypogonadism,thoracic deformity,a high scapula,rib and lower limb deformity,facial deformity(long face,epicanthic folds,backwards ears),and arterial malformation.CASE SUMMARY We reported the case of a 26-year-old Chinese man who was admitted because of short stature.Physical examination showed that he had many abnormal symptoms,including a short neck,facial moles,knee valgus,transverse palm,continuous grade 5/6 murmurs in the pulmonary auscultation area,no whiskers,or pubic hair,no Adam’s apple,short penis and cryptorchidism.Radiological examination showed pituitary,gonad,heart,kidney and skeletal dysplasia.The laboratory tests revealed low growth hormone,luteinizing hormone,folliclestimulating hormone,testosterone and estrogen.Clinical whole-exome detection showed that our patient,unlike previously reported patients,has a new SEMA3A gene mutation(c.950A>G).Now,his height has increased by 3 cm.In addition,he has a good appetite and reduced subcutaneous fat over 3 mo of recombinant human growth hormone injections therapy.Unfortunately,he refuses further treatment about gonad.CONCLUSION Patients who come to a hospital because of their short stature must undergo gene detection if they have other simultaneous abnormal phenotypes.展开更多
As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in dat...As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,etc.To guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration Service System combining Blockchain with Federated Learning,termed FL-HMChain.This system is composed of three layers:Data extraction and storage,data management,and data application.Focusing on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and integrity.An improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training process.Furthermore,healthcare and medical data collaboration services in real-world scenarios have been discussed and developed.To further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image identification.This model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),respectively.Furthermore,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.展开更多
基金supported by the National Key R&D Program of China(No.2023YFC2907802)The National Natural Science Foundation of China(52204363)The Research Project of Hunan Provincial Education Department of China(No.22B0440)。
文摘A green chelate-like phosphate-based adsorbent functionalized by glycine(CP@Glycine)was first designed,synthesized,and applied to selectively separate Be(Ⅱ)from uranium–beryllium-containing(U/Be)solutions.The optimal adsorption conditions were:WH3PO_(4)/WCa(OH)_(2)/WGlycine(wt/wt/wt)of 3:3:1,pH=6,resulting in the maximum adsorption efficiency of 99%in the case of adsorbent of 2 g·L^(−1).CP@Glycine exhibited excellent selectivity for Be(Ⅱ)(K_( d)=2.53×10^(4) mL·g^(−1))toward Fe,U,Zn,Mn,Na,and Ca in solutions.After 5 adsorption–desorption cycles,the removal efficiency of Be(Ⅱ)remained at 85%,and the desorption rate of Be(Ⅱ)was above 90%.Adsorption kinetics and thermodynamics studies showed that the theoretical maximum adsorption capacity(Qe)of CP@Glycine was 66 mg·g^(−1),which was higher than the state-of-the-art adsorption materials.Besides,the surface of CP@Glycine exhibited abundant active sites with negative charges which would have a potential electrostatic attraction with Be(Ⅱ).Moreover,the adsorption mechanism of CP@Glycine was methodically revealed through a combination of various characterizations and DFT investigations.It was found that BeNH_(4)PO_(4) and Be(OH)_(2) were formed as stable precipitates on the surface of CP@Glycine,which implied that Be(Ⅱ)was coordinated with the amino and the phosphate groups from CP@Glycine,thus achieving the chelation effect of Be(Ⅱ)with CP@Glycine for the adsorption process.The results of DFT investigations further confirmed that Be(Ⅱ)owned strong bonding affinity to the amino group and the phosphate group from the as-prepared CP@Glycine.The results indicated that the calculated binding energy of the Be complex coordinated with glycine and phosphate(−229.37 kcal·mol^(−1))was lower than that of other possible Be complexes.The above findings revealed that CP@Glycine could be a promising adsorbent for the selective separation and recovery of Be(Ⅱ)from U/Be wastewater.
基金financially supported by the National Natural Science Foundation of China(Nos.61904090 and 62464010)Project(No.202306)of State Key Laboratory of Physical Chemistry of Solid Surfaces(Xiamen University)。
文摘Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven deposition during cycling would result in significant capacity decay,low Coulombic efficiency,and electrolyte consumption,thus the undesirable cyclability severely hampers the practical applications.Herein,a phosphorus-doped carbon protective layer was coated onto the surface of Zn anode via using the plasma-enhanced chemical vapor deposition(PECVD)approach.Enhanced conductivity and lower nucleation overpotential induced by the P-doped carbon protective layer can effectively facilitate the ion diffusion kinetics and suppress side reactions.The as-fabricated P-C/Zn anode demonstrated excellent cycling stability during the zinc plating/stripping process,maintaining a low voltage hysteresis(34.8 m V)for over 1000 h under a current density of 2 m A/cm^(2)and a capacity of 2 m Ah/cm^(2).Moreover,the P-C/Zn||MnO_(2)full cell exhibited high specific capacity of about 252.5 m Ah/g at 2 A/g upon 700 long cycles.This study is helpful to design more efficient zinc-ion batteries towards the future applications.
基金supported by the National Natural Science Foundation of China (Nos. 51772193 , 51702063)Nature Science Fund of Liaoning Province (No. 20180550200)+1 种基金China Postdoctoral Science Foundation(2018M630340)Project of Science and Technology Plan Shenyang (No. 17-231-1-18)
文摘Aqueous zinc-ion batteries(ZIBs) have been considered as one of the most promising electrochemical devices for large-scale energy storage system owing to their low cost and high safety. Herein, Na2V6O16·2.14H2O nanobelts are synthesized and applied as cathode material for ZIBs. The sample displays a high capacity of 466 m Ahg^-1 at 100 mAg^-1 and stable cycling performance with a capacity retention of 90% over 20 0 0 cycles at the 20 Ag^-1. Moreover, Na2V6O16·2.14H2O presents a capable rate ability and a high energy density of 312 Wh kg^-1 at a specific power of 70 Wkg^-1. The superior electrochemical performance is attributed to the large interlayer spacing and outstanding structure stability, which promise the highly reversible intercalation and extraction of zinc ion. The electrochemical kinetics and zinc ion storage mechanism are also investigated. This work demonstrates that nanoscale electrode materials with large interlayer spacing can effectively enhance the electrochemical performance of aqueous ZIBs, which can be extended to other metal ion batteries, such as magnesium ion batteries and aluminum ion batteries.
基金Project(2014CB643401) supported by the National Basic Research Program of ChinaProject(51674294) supported by the National Natural Science Foundation of ChinaProject(2016TP1007) supported by the Hunan Provincial Science and Technology Plan,China
文摘Phase separation rate is a critical character in determining the usefulness of a solvent extraction system in hydrometallurgy. A survey of the synergistic mixture containing dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexly 4-pyridinecarboxylate ester (4PC) for the extraction of cobalt from acidic single metal sulfate solution was carried out to suggest how the physicochemical properties and the morphology of the reverse micelles in the loaded organic phase affect the phase separation. The results show that effective parameters affecting the phase separation are the viscosity and the excess water uptake of the loaded organic phase. It is obvious that the specific settling rate (SSR) decreases with the apparent increase of these two parameters. The measurement of small angle X-ray scattering (SAXS) proves that the morphology of the reversed micelles in the loaded organic phase changes evidently with the change of the specific settling rate (SSR).
基金This study was financially supported by the National Natural Science Foundation of China(No.51772193)China Postdoctral Science Foundation(No.2019T250254).
文摘Zn(CF_(3)SO_(3))_(2)as an electrolyte has been widely used to improve the electrochemical performance for ZIBs due to that the bulky CF_(3)SO_(3)-can reduce the solvation effect of Zn^(2+)and promote the ionic diffusion.Herein,we found that Zn(CF_(3)SO_(3))_(2)electrolyte can induce different electrochemical mechanisms from ZnSO_(4)electrolyte.Compared to the ZnSO^(4)electrolyte,the HNaV_(6)O_(16)·4H2_(O)electrode with Zn(CF_(3)SO_(3))_(2)electrolyte exhibits a high capacity of 444 mAh·g^(-1)at 500 mA·g^(-1)with a capacity retention of 92.3%after 80 cycles.Even,at a high rate of 5 Ag-1,the HNaV_(6)O_(16)·4H_(2)O electrode delivers an initial discharge capacity of 328 mAh·g^(-1)with a capacity retention of 93.7%after 1000 cycles.Differing from the mechanism with ZnSO4 electrolyte,the excellent cycle stability of HNaV_(6)O_(16)·4H_(2)Oelectrode can be attributed to the in-situ phase transformation to ZnxV_(2)O_(5)·nH_(2)O based on the co-intercalation of Zn^(2+)/H^(+).
文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd.
基金This work was financially supported by the National Natural Science Foundation of China(No.51772193)China Postdoctoral Science Foundation(No.2019T120254).
文摘Exploring high-performance cathode materials for aqueous zinc ion batteries(ZIBs)is still one of the critical issues.Copper vanadate compound has become a potential cathode material for ZIBs with a novel displacement reaction mechanism of reversible reduction/oxidation of Cu^(2+)/Cu^(0).Herein,we reported Cu_(0.95)V_(2)O_(5)nanoflowers prepared using a hydrothermal synthesis method as a capable cathode material for ZIBs.The Cu_(0.95)V_(2)O_(5)nanoflowers exhibit high specific capacity of 405 mAh·g^(-1) at the current density of 100 mA·g^(-1),benefiting from the displacement reaction mechanism and phase transformation mechanism from Cu_(0.95)V_(2)O_(5)to the open and stable architecture Cu_(0.4)V_(2)O_(5)and Zn3(OH)2V2O7·2H2O phase.The cathode exhibits excellent rate performance with a high capacity of-200 mAh·g^(-1)at 5 A·g^(-1) and outstanding cycle stability with a capacity retention of 92%after 1000 cycles.It is anticipated that the novel Cu_(0.95)V_(2)O_(5)nanoflowers are promising cathode material in the application for zinc ion batteries.
基金supported by the National Key Research and Development Program of China(No.2017YFB1103000)National Natural Science Foundation of China(Nos.51772193,51702063)+1 种基金Nature Science Fund of Liaoning Province(No.20180550200)the Hong Kong Scholars Programs(No.XJ2019024)。
文摘Aqueous rechargeable zinc-ion batteries(ARZIBs) are expected to replace organic electrolyte batteries owing to its low price,safe and environmentally friendly characteristics.Herein,we fabricated vanadium-based Na1.25V3O8 nanosheets as a cathode material for ARZIBs,which present a high performance by electrochemical de-sodium at high voltage to form Na2V6O16 phase in the first cycle:high capacity of 390 mAh/g at 0.1 A/g,high rate perfo rmance(162 mAh/g at 10 A/g) and superior cycle stability(179 mAh/g with a high capacity retention of 88.2% of the maximum capacity after 2000 cycles).In addition,the cell exhibits a high energy density of 416.9 Wh/kg at 143.6 W/kg,suggesting great potential of the as-prepared Na1.25V3O8 nanosheets for ARZIBs.
基金Supported by Hubei Health & Family Planning Commission Notice (No. [2017]20)Wuhan training project of the sixth batch of young and middle-aged medical talents, wuhan health & family planning commission (Wuhan Health & Family Planning Commission Notice No. [2018]116)Training project of the first batch of tanhualin famous doctors and students (Hubei TCM Hospital No. [2018]72)
文摘Objective:To explore core acupoints and acupoint selection principles in acupuncture and moxibustion for obesity,from syndrome differentiation prescriptions of the acupuncture-moxibustion therapy in 808 obesity prescriptions,by using node centrality and cluster analysis methods in complex network.Methods:Firstly,an acupoint network model is established,and acupoint nodes are assessed and calculated in multiple aspects by introducing the node centrality analysis idea of complex network,to excavate core acupoint nodes.Secondly,a cluster analysis is carried out on acupoint network by the cluster algorithm Q-PSO for complex network,to investigate the acupoint combination principles.Results:Zusanli(足三里ST36),Tianshu(天枢ST25),Fenglong(丰隆ST40),Zhongwan(中脘CV12)and Qihai(气海CV6),etc.,were included into the core acupoint Sanyinjiao(三阴交SP6)community.Zhigou(支沟TE6),Neiting(内庭ST44),Shangjuxu(上巨虚ST37),and Pishu(脾俞BL20)etc.,were included into the core acupoint Yinlingquan(阴陵泉SP9)community.Baihuanshu(白环俞BL30)and Zhiyang(至阳GV9)were included into the core acupoint Dachangshu(大肠俞BL25)community.Biguan(髀关ST31)was a single core community.Among all the acupoint nodes,SP6,ST25,SP9,ST36,CV6,Quchi(曲池L111),and Guanyuan(关元CV4)were of high degree centrality and eigenvector centrality,directly reflecting their importance in acupoint selection prescriptions.Conclusion:The Q-PSO algorithm is characterized with high precision and high efficiency,etc.The core acupoints and their combination principles explored by this algorithm are in accordance with clinical experiences.
基金supported by research funding from the School of Sciences of China Pharmaceutical University
文摘A method for preparing a graphene oxide/polyaniline （GO/PANI） composite electrode was developed to investigate the effect of GO doped in PANI. PANI was first prepared by the polymerisation of aniline and then dedoped by NH4OH to form emeraldine base （EB）. The dedoped PANI and as-prepared GO were dissolved in N-methyl-2-pyrrolidone （NMP） to generate a homogeneous dispersion. The GO/PANI composites were redoped in HCI before use as electrode materials. These composites were characterised by Raman spectroscopy, X-ray diffraction, UV-vis adsorption spectroscopy, scanning electron microscopy, atomic force microscopy and electrochemical measurements. The GO/PANI composite electrode （containing 2.5% GO） has an initial gravimetric capacitance of 896 F g-1 at a scan rate of 5 mV s-1 and a retention life of 51% after 500 cycles, which is an improvement over that of pure PANI （23%）. The results show that the synergy of GO and PANI attributes to the good electrochemical performance of the GO/PANI composite electrode.
基金financial support from National Research Foundation Investigatorship (R279-000-444-281)National University of Singapore (R279-000-482-133)
文摘Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration time and period.As theranostic nanomedicine is driven by multifunctional therapeutics that aim to achieve targeted tissue delivery and image-guided therapy, fluorescent PS nanoparticle(NP)accumulation in target tissues can be ascertained through fluorescence imaging to optimize the light dose and administration parameters. In this regard, zebrafish larvae provide a unique transparent in vivo platform to monitor fluorescent PS bio-distribution and their therapeutic efficiency. Using fluorescent PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example.
基金Supported by National Natural Science Foundation of China(No.81060081,81241124 and 81360155)Jiangxi Provincial Natural Science Foundation(No.2008GZY00123,2010GZY0089,20114BAB205068 and 20114BAB215006)
文摘AIM: To evaluate the effect of amniotic membrane loaded with 5-fluorouracil poly(lactic-co-glycolic acid)(PLGA) nanoparticles(5-FU-NPs) in the surgical outcomes of experimental trabeculectomy in rabbits.METHODS: Thirty-two New Zealand white rabbits were randomly categorized into four groups with 8 rabbits in each group. Group 1, the control group, performed traditional trabeculectomy without adjuvant treatment.While the experimental groups performed compound trabeculectomy with different implantations including amniotic membrane(group 2), 5-FU-NPs(group 3) and amniotic membrane loaded with 5-FU-NPs(group 4).Clinical evaluations including IOP measurement and filtration bleb analysis were performed in all groups postoperatively.RESULTS: There is no significant difference of mean IOP in all groups at first 7d after surgery. While at P14,mean IOPs of experimental group 2(9.8 ±2.1 mm Hg),groups 3(8.9 ±2.8 mm Hg) and group 4(7.6 ±2.3 mm Hg)were significantly reduced compared to control group(12.4 ±2.6 mm Hg; n =8, P 【0.05). At P21, mean IOPs of groups 3(11.7±3.2 mm Hg) and group 4(9.9±1.6 mm Hg)were significantly decreased compare to control group(17.9±1.6 mm Hg) and group 2(16.6 ±2.8 mm Hg; n =8,P 【0.05). At P28, mean IOPs of groups 3(13.8±3.3 mm Hg)and group 4(10.6 ±2.0 mm Hg) were also significantly reduced compare to control group(19.4±2.3 mm Hg) and group 2(18.5 ±2.4 mm Hg; n =8, P 【0.05). Meanwhile mean IOP of group 4 is significantly decreased compared to group 3 at P28(n =8, P 【0.05). Survival analysis of functional filtration blub in all groups revealed the longest survival time in group 4(24.9±5.1d) compared to that in group 3(20.6 ±4.3d), group 2(15.0 ±5.2d) and control group(10.1±5.7d).CONCLUSION: Amniotic membrane loaded with 5-FuNPs may function as an effective anti-scarring implant and provides improved long-term surgical outcomes for experimental trabeculectomy in rabbits.
文摘BACKGROUND The SEMA3A gene,which is located at 7q21.11,is involved in hypothalamic neuron migration,heart development,kidney development,and skeleton metabolism.Mutation of the SEMA3A gene is associated with Kallmann syndrome 16 with or without a normal sense of smell.In addition,two case reports showed that mutation of the SEMA3A gene could cause short stature,low gonadotropin,hypogonadism,thoracic deformity,a high scapula,rib and lower limb deformity,facial deformity(long face,epicanthic folds,backwards ears),and arterial malformation.CASE SUMMARY We reported the case of a 26-year-old Chinese man who was admitted because of short stature.Physical examination showed that he had many abnormal symptoms,including a short neck,facial moles,knee valgus,transverse palm,continuous grade 5/6 murmurs in the pulmonary auscultation area,no whiskers,or pubic hair,no Adam’s apple,short penis and cryptorchidism.Radiological examination showed pituitary,gonad,heart,kidney and skeletal dysplasia.The laboratory tests revealed low growth hormone,luteinizing hormone,folliclestimulating hormone,testosterone and estrogen.Clinical whole-exome detection showed that our patient,unlike previously reported patients,has a new SEMA3A gene mutation(c.950A>G).Now,his height has increased by 3 cm.In addition,he has a good appetite and reduced subcutaneous fat over 3 mo of recombinant human growth hormone injections therapy.Unfortunately,he refuses further treatment about gonad.CONCLUSION Patients who come to a hospital because of their short stature must undergo gene detection if they have other simultaneous abnormal phenotypes.
基金We are thankful for the funding support fromthe Science and Technology Projects of the National Archives Administration of China(Grant Number 2022-R-031)the Fundamental Research Funds for the Central Universities,Central China Normal University(Grant Number CCNU24CG014).
文摘As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,etc.To guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration Service System combining Blockchain with Federated Learning,termed FL-HMChain.This system is composed of three layers:Data extraction and storage,data management,and data application.Focusing on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and integrity.An improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training process.Furthermore,healthcare and medical data collaboration services in real-world scenarios have been discussed and developed.To further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image identification.This model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),respectively.Furthermore,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.
