Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular benefits.Empagliflozin,in particular,has demonstrated cardioprotective ...Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular benefits.Empagliflozin,in particular,has demonstrated cardioprotective effects beyond its glucose-lowering action,reducing heart failure hospitalizations and improving cardiac function.Of note,the cardioprotective mechanisms appear to be independent of glucose lowering,possibly mediated through several mechanisms involving shifts in cardiac metabolism and anti-fibrotic,anti-inflammatory,and anti-oxidative pathways.This editorial summarizes the multifaceted cardiovascular advantages of SGLT2 inhibitors,highlighting the need for further research to elucidate their full therapeutic potential in cardiac care.展开更多
Magnesium alloys usually exhibit poor ductility attributed to their intrinsic hexagonal close-packed(hcp)structure,which fails to provide sufficient independent slip systems for homogeneous deformation.Here we demonst...Magnesium alloys usually exhibit poor ductility attributed to their intrinsic hexagonal close-packed(hcp)structure,which fails to provide sufficient independent slip systems for homogeneous deformation.Here we demonstrate that multiple deformation mechanisms can be activated with increasing tensile strain in a fine-grained Mg-3Gd with a weak basal texture.<c+a>slip,tension twinning and compression/double twinning exhibit a high orientation dependence at an early stage of deformation,whereas the orientation dependence becomes less obvious with further increasing strain.The high work hardening rate at the strain of 2%–5%is accompanied by the significant increase of<c+a>slip and tension twinning activities.The fine microstructure strongly restricts the activation and growth of twinning,resulting in a slow exhaust of tension twinning and thin compression twins.The restriction of twinning and the activation of profuse<c+a>slip near grain/twin boundaries,relaxing the stress concentration,sustain the homogeneous deformation to a high strain.展开更多
In quadrupeds,the cervical and lumbar circuits work together to achieve the speed-dependent gait expression.While most studies have focused on how local lumbar circuits regulate limb coordination and gaits,relatively ...In quadrupeds,the cervical and lumbar circuits work together to achieve the speed-dependent gait expression.While most studies have focused on how local lumbar circuits regulate limb coordination and gaits,relatively few studies are known about cervical circuits and even less about locomotor gaits.We use the previously published models by Danner et al.(DANNER,S.M.,SHEVTSOVA,N.A.,FRIGON,A.,and RYBAK,I.A.Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds.e Life,6,e31050(2017))as a basis,and modify it by proposing an asymmetric organization of cervical and lumbar circuits.First,the model reproduces the typical speed-dependent gait expression in mice and more biologically appropriate locomotor parameters,including the gallop gait,locomotor frequencies,and limb coordination of the forelimbs.Then,the model replicates the locomotor features regulated by the M-current.The walk frequency increases with the M-current without affecting the interlimb coordination or gaits.Furthermore,the model reveals the interaction mechanism between the brainstem drive and ionic currents in regulating quadrupedal locomotion.Finally,the model demonstrates the dynamical properties of locomotor gaits.Trot and bound are identified as attractor gaits,walk as a semi-attractor gait,and gallop as a transitional gait,with predictable transitions between these gaits.The model suggests that cervical-lumbar circuits are asymmetrically recruited during quadrupedal locomotion,thereby providing new insights into the neural control of speed-dependent gait expression.展开更多
Variations in temperature and precipitation affect local ecosystems. Considerable spatial and temporal heterogeneity exists in arid ecosystems such as desert steppes. In this study, we analyzed the spatiotemporal dy- ...Variations in temperature and precipitation affect local ecosystems. Considerable spatial and temporal heterogeneity exists in arid ecosystems such as desert steppes. In this study, we analyzed the spatiotemporal dy- namics of climate and vegetation phenology in the desert steppe of Inner Mongolia, China using meteorological data （1961-2010） from 11 stations and phenology data （2004-2012） from 6 ecological observation stations. We also estimated the gross primary production for the period of 1982-2009 and found that the annual mean tem- perature increased at a rate of 0.47~C/decade during 1961-2010, with the last 10 years being consistently warmer than the 50 years as an average. The most significant warming occurred in winters. Annual precipitation slightly decreased during the 50-year period, with summer precipitation experiencing the highest drop in the last 10 years, and spring precipitation, a rise. Spatially, annual precipitation increased significantly in the northeastern and eastern central areas next to the typical steppe. From 2004 to 2012, vegetation green-up and senescence date advanced in the study area, shortening the growing season. Consequently, the primary productivity of the desert steppe de- creased along the precipitation gradient from southeast to northwest. Temporally, productivity increased during the period of 1982-1999 and significantly decreased after 2000. Overall, the Last decade witnessed the most dramatic climatic changes that were likely to negatively affect the desert steppe ecosystem. The decreased primary produc- tivity, in particular, decreases ecosystem resilience and impairs the livelihood of local farmers and herdsmen.展开更多
Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared ...Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 Han Chinese narcolepsy patients.Blood,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring SNPs.Genetic risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic curves.Mean sleep latency was significantly shorter in early-onset cases than in late-onset cases.Symptom severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more symptoms.Hypocretin levels did not differ significantly between early-and late-onset cases.Only rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset cases.Only GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,respectively.Neither GRS1 nor GRS5 included SNPs in HLA regions.Our results indicate that symptomology and genetic risk factors differ between early-and late-onset narcolepsy.This protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval No.Yuanlunshenlinyi 86)in October 2011.展开更多
The effect of initial grain size on the recrystallization and recrystallization texture of a rolled Mg–3Gd(wt.%)alloy is studied in detail.The results show that the deformation microstructure of an initially coarse-g...The effect of initial grain size on the recrystallization and recrystallization texture of a rolled Mg–3Gd(wt.%)alloy is studied in detail.The results show that the deformation microstructure of an initially coarse-grained(CG)sample has a larger twinned area and a higher density of twin boundaries than a fine-grained(FG)sample.After annealing,the CG sample recrystallizes preferentially in the twinned area,whereas the FG sample adopts the higher density grain boundaries as the nucleation sites.Furthermore,weak recrystallization texture components appear from the grain nucleation stage,regardless of the initial grain size,and are preserved after complete recrystallization due to uniform grain growth.The majority of recrystallization texture is deviated 20°–45°away from normal direction(ND),accounting for more than 50%.Especially,the recrystallization texture of the FG sample is a“Rare Earth texture”,in contrast to the widely reported texture modification unrelated to grain boundary nucleation.Only a scattered basal texture is observed in the CG sample,which also differs from the reported“Rare Earth texture”originating from shear band nucleation in dilute Mg–Gd alloys.Finally,based on the Johnson–Mehl–Avrami–Kolmogorov(JMAK)model,the recrystallization kinetics are calculated,and it is found that the initial grain size mainly affects the nucleation rate,and has limited effect on the grain growth rate.展开更多
As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the TP.In this study,b...As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the TP.In this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya cf.weylandii.The discovery of Cyclocarya cf.weylandii demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam Basin.This is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early Oligocene.The living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is prevalent.Integrating the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.展开更多
A sustainable management of national park requires collaboration between park staff, NGOs, local organizations and stakeholders, and government intervention. This collaboration promotes community-based welfare and ins...A sustainable management of national park requires collaboration between park staff, NGOs, local organizations and stakeholders, and government intervention. This collaboration promotes community-based welfare and inspires a sense of responsibility, thus promoting more benefits than conflicts. A survey administered to residents surrounding Nyungwe National Park was used to evaluate the relationship between Nyungwe National Park management and local communities. The residents acknowledged a positive attitude towards participating in conservation organizations where there was involvement, while a negative response revealed weak community mobilization. The community’s opinions about protection and tourism progression noted weak conflict resolution, but a positive attitude towards tourism activities in the area since they believed employment was likely as a result. In addition, the residents asked for support from government investments and stakeholders to develop the local private sector, and asked to be involved during the planning process. Approaches including the design of coordination mechanisms and integrated conservation and developments projects are suggested to promote a management structure leading to community involvement in conservation and tourism activities. This will increase visitor numbers and contribute to economic development not only in the region but also in the whole country. Empirical studies along with the factors shaping tourism and conservation activities should be considered as the basis for sustainable decision and policy making for sustainable management, and will contribute to government, stakeholders and park manager collaborations at Nyungwe national park.展开更多
文摘Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular benefits.Empagliflozin,in particular,has demonstrated cardioprotective effects beyond its glucose-lowering action,reducing heart failure hospitalizations and improving cardiac function.Of note,the cardioprotective mechanisms appear to be independent of glucose lowering,possibly mediated through several mechanisms involving shifts in cardiac metabolism and anti-fibrotic,anti-inflammatory,and anti-oxidative pathways.This editorial summarizes the multifaceted cardiovascular advantages of SGLT2 inhibitors,highlighting the need for further research to elucidate their full therapeutic potential in cardiac care.
基金This project has received funding from the National Key Research and Development Program(2021YFB3702100)TY was supported by a research grant(VIL50197)from VILLUM FONDEN。
文摘Magnesium alloys usually exhibit poor ductility attributed to their intrinsic hexagonal close-packed(hcp)structure,which fails to provide sufficient independent slip systems for homogeneous deformation.Here we demonstrate that multiple deformation mechanisms can be activated with increasing tensile strain in a fine-grained Mg-3Gd with a weak basal texture.<c+a>slip,tension twinning and compression/double twinning exhibit a high orientation dependence at an early stage of deformation,whereas the orientation dependence becomes less obvious with further increasing strain.The high work hardening rate at the strain of 2%–5%is accompanied by the significant increase of<c+a>slip and tension twinning activities.The fine microstructure strongly restricts the activation and growth of twinning,resulting in a slow exhaust of tension twinning and thin compression twins.The restriction of twinning and the activation of profuse<c+a>slip near grain/twin boundaries,relaxing the stress concentration,sustain the homogeneous deformation to a high strain.
基金Project supported by the National Natural Science Foundation of China(Nos.12272092 and 12332004)。
文摘In quadrupeds,the cervical and lumbar circuits work together to achieve the speed-dependent gait expression.While most studies have focused on how local lumbar circuits regulate limb coordination and gaits,relatively few studies are known about cervical circuits and even less about locomotor gaits.We use the previously published models by Danner et al.(DANNER,S.M.,SHEVTSOVA,N.A.,FRIGON,A.,and RYBAK,I.A.Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds.e Life,6,e31050(2017))as a basis,and modify it by proposing an asymmetric organization of cervical and lumbar circuits.First,the model reproduces the typical speed-dependent gait expression in mice and more biologically appropriate locomotor parameters,including the gallop gait,locomotor frequencies,and limb coordination of the forelimbs.Then,the model replicates the locomotor features regulated by the M-current.The walk frequency increases with the M-current without affecting the interlimb coordination or gaits.Furthermore,the model reveals the interaction mechanism between the brainstem drive and ionic currents in regulating quadrupedal locomotion.Finally,the model demonstrates the dynamical properties of locomotor gaits.Trot and bound are identified as attractor gaits,walk as a semi-attractor gait,and gallop as a transitional gait,with predictable transitions between these gaits.The model suggests that cervical-lumbar circuits are asymmetrically recruited during quadrupedal locomotion,thereby providing new insights into the neural control of speed-dependent gait expression.
基金supported by the State Key Basic Research Development Program of China (2012CB722201)the National Basic Research Program of China (31200414, 31060320, 30970504)+1 种基金the National Basic Research Program of Inner Mongolia (2009ms0603)the Earmarked Fund for Modern Agro-Industry Technology Research System
文摘Variations in temperature and precipitation affect local ecosystems. Considerable spatial and temporal heterogeneity exists in arid ecosystems such as desert steppes. In this study, we analyzed the spatiotemporal dy- namics of climate and vegetation phenology in the desert steppe of Inner Mongolia, China using meteorological data （1961-2010） from 11 stations and phenology data （2004-2012） from 6 ecological observation stations. We also estimated the gross primary production for the period of 1982-2009 and found that the annual mean tem- perature increased at a rate of 0.47~C/decade during 1961-2010, with the last 10 years being consistently warmer than the 50 years as an average. The most significant warming occurred in winters. Annual precipitation slightly decreased during the 50-year period, with summer precipitation experiencing the highest drop in the last 10 years, and spring precipitation, a rise. Spatially, annual precipitation increased significantly in the northeastern and eastern central areas next to the typical steppe. From 2004 to 2012, vegetation green-up and senescence date advanced in the study area, shortening the growing season. Consequently, the primary productivity of the desert steppe de- creased along the precipitation gradient from southeast to northwest. Temporally, productivity increased during the period of 1982-1999 and significantly decreased after 2000. Overall, the Last decade witnessed the most dramatic climatic changes that were likely to negatively affect the desert steppe ecosystem. The decreased primary produc- tivity, in particular, decreases ecosystem resilience and impairs the livelihood of local farmers and herdsmen.
基金supported by the Research Project of Central Health Care Special Fund,China,No.W2017BJ52(to JZ)
文摘Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 Han Chinese narcolepsy patients.Blood,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring SNPs.Genetic risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic curves.Mean sleep latency was significantly shorter in early-onset cases than in late-onset cases.Symptom severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more symptoms.Hypocretin levels did not differ significantly between early-and late-onset cases.Only rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset cases.Only GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,respectively.Neither GRS1 nor GRS5 included SNPs in HLA regions.Our results indicate that symptomology and genetic risk factors differ between early-and late-onset narcolepsy.This protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval No.Yuanlunshenlinyi 86)in October 2011.
基金supported by the National Key Research and Development Program of China(No.2021YFB3702101)the National Natural Science Foundation of China(Nos.52130107,52071038)+3 种基金the Fundamental Research Funds for the Central Universities(No.2023CDJXY-018)the“111”Project(No.B16007)by the Ministry of Education and the State Administration of Foreign Experts Affairs of China,Graduate Student Research Innovation Project(No.CYB21007)the Research Council of Norway(No.309724)the Center for Research based Innovation SFI PhysMet(No.309584).
文摘The effect of initial grain size on the recrystallization and recrystallization texture of a rolled Mg–3Gd(wt.%)alloy is studied in detail.The results show that the deformation microstructure of an initially coarse-grained(CG)sample has a larger twinned area and a higher density of twin boundaries than a fine-grained(FG)sample.After annealing,the CG sample recrystallizes preferentially in the twinned area,whereas the FG sample adopts the higher density grain boundaries as the nucleation sites.Furthermore,weak recrystallization texture components appear from the grain nucleation stage,regardless of the initial grain size,and are preserved after complete recrystallization due to uniform grain growth.The majority of recrystallization texture is deviated 20°–45°away from normal direction(ND),accounting for more than 50%.Especially,the recrystallization texture of the FG sample is a“Rare Earth texture”,in contrast to the widely reported texture modification unrelated to grain boundary nucleation.Only a scattered basal texture is observed in the CG sample,which also differs from the reported“Rare Earth texture”originating from shear band nucleation in dilute Mg–Gd alloys.Finally,based on the Johnson–Mehl–Avrami–Kolmogorov(JMAK)model,the recrystallization kinetics are calculated,and it is found that the initial grain size mainly affects the nucleation rate,and has limited effect on the grain growth rate.
基金supported by the National Natural Science Foundation of China(Nos.42072141and 41702363)the Geological Survey of China(No.DD20221645)。
文摘As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the TP.In this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya cf.weylandii.The discovery of Cyclocarya cf.weylandii demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam Basin.This is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early Oligocene.The living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is prevalent.Integrating the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.
文摘A sustainable management of national park requires collaboration between park staff, NGOs, local organizations and stakeholders, and government intervention. This collaboration promotes community-based welfare and inspires a sense of responsibility, thus promoting more benefits than conflicts. A survey administered to residents surrounding Nyungwe National Park was used to evaluate the relationship between Nyungwe National Park management and local communities. The residents acknowledged a positive attitude towards participating in conservation organizations where there was involvement, while a negative response revealed weak community mobilization. The community’s opinions about protection and tourism progression noted weak conflict resolution, but a positive attitude towards tourism activities in the area since they believed employment was likely as a result. In addition, the residents asked for support from government investments and stakeholders to develop the local private sector, and asked to be involved during the planning process. Approaches including the design of coordination mechanisms and integrated conservation and developments projects are suggested to promote a management structure leading to community involvement in conservation and tourism activities. This will increase visitor numbers and contribute to economic development not only in the region but also in the whole country. Empirical studies along with the factors shaping tourism and conservation activities should be considered as the basis for sustainable decision and policy making for sustainable management, and will contribute to government, stakeholders and park manager collaborations at Nyungwe national park.
