The multi-stage geological evolution and extensive continental deformations during the course of its history make the Central Asian metallogenic region（CAMR） a unique and complicated large-scale metal domain. New ge...The multi-stage geological evolution and extensive continental deformations during the course of its history make the Central Asian metallogenic region（CAMR） a unique and complicated large-scale metal domain. New geological observations and precise age-data allow an improved reconstruction of the geological evolution of the CAMR. This paper summarizes the Paleozoic orogenic evolution and related ore formation in the core part of the CAMR based on the geological data published both during the Soviet period and the last decades. Four ore-formation provinces（Altay, BalkhashJunggar, Chu-Yili-Tianshan, and Southwest Tianshan） could be classified. The Balkhash-Junggar and Chu-Yili-Tianshan provinces are the major topics of this paper. The Balkhash-Junggar province consists of 4 huge ore-forming belts（Zharma-Saur, Tarbahtay-Xiemistay, Aktogay-Baerluke, Balkhashwestern Junggar） with 11 large ore-college areas. The Chu-Yili-Tianshan province consists of 4 huge ore-forming belts（Alatau-Sairimu, Chu-Yili-Bolehuole, Issyk-Awulale, Kazharman-Nalaty） with 22 large ore-college areas. Formation of large ore-college area corresponds to a specific stage of continental crust growth. Comparison of geology and ore deposits in the CAMR provides rich information for future exploration and understanding of ore-forming processes. The Paleo-Junggar Ocean closed at Early Devonian in the Balkhash-western Junggar ore-forming belt. Afterwards, widespread volcanic- sedimentary rocks formed at extensional stage due to delamination of the thick lower crust formed during previous accretionary processes. Felsic magma intrusion caused formation of porphyry Cu-Au deposit at ~310 Ma and related hydrothermal gold deposits about 10 Ma later. For example, in the Hatu-Baobei-Sartohay Au-Cr ore-college area in the Balkhash-western Junggar ore-forming belt, small granitic to diorite plutons and various dykes（312–277 Ma） and large granite bodies（~300 Ma） intruded into the Devonian to Early Carboniferous volcano-sedimentary basin. These magmatic activities and fault systems mainly controlled ore-forming processes.展开更多
Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse mo...Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, followed by treatment with 40, 20, or 10 mg/kg orientin, vitexin, or a positive control （vitamin E） via intragastric administration for an additional 8 weeks. Orientin, vitexin, and vitamin E improved the general medical status of the aging mice and significantly increased their brain weights. They also produced an obvious rise in total antioxidant capacity, superoxide dismutase, catalase, and glutathione peroxidase levels in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na＋-K＋-ATP enzyme, and Ca2＋-Mg2＋-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced malondialdehyde levels in the liver, brain and kidney and lipofuscin levels in the brain. They also significantly improved the neuronal ultrastructure. The 40 mg/kg dose of orientin and vitexin had the same antioxidant capacity as vitamin E. These experimental findings indicate that orientin and vitexin engender anti-aging effects through their antioxidant capacities.展开更多
A synthesis involving the data for the Nalati mountain region（NMR） in west Tianshan with a dataset including zircon U-Pb ages, Hf isotopic composition, major and trace elements of Paleozoic intrusions are presented ...A synthesis involving the data for the Nalati mountain region（NMR） in west Tianshan with a dataset including zircon U-Pb ages, Hf isotopic composition, major and trace elements of Paleozoic intrusions are presented to improve the understanding of regional geodynamic evolution. Paleozoic intrusive rocks in the NMR could be classified into four categories based on chronological and geochemical data： 480？5 Ma, 445–410 Ma, 345–320 Ma, and 295 Ma, which correspond to（1） closure of the Terskey Ocean and the opening of the south Tianshan back-arc basin, which was followed with the opening of the south Tianshan Ocean,（2） initial subduction of the south Tianshan oceanic crust,（3） major subduction stage, and（4） collision to post-collisional stage, respectively. Following the closure of the Terskey Ocean, the south Tianshan Ocean opened at Early Silurian and subducted under Yili-central Tianshan by the end of Early Carboniferous Period. The following breakoff of the subducted slab triggered partial melting of continental crust and formed voluminous granitic rocks in the NMR.展开更多
AIM:To evaluate the outcomes of intravitreal antivascular endothelial growth factor(anti-VEGF)agents for patients with retinal vein occlusion(RVO)related-macular edema(ME)in Tibetan.METHODS:A retrospective,observation...AIM:To evaluate the outcomes of intravitreal antivascular endothelial growth factor(anti-VEGF)agents for patients with retinal vein occlusion(RVO)related-macular edema(ME)in Tibetan.METHODS:A retrospective,observational,single-center study.The demographic and clinical data of 90 RVO Tibetan patients(93 eyes)treated with either ranibizumab or conbercept in Tibet Autonomous Region People’s Hospital from Jan 2018 to December 2019 were collected.RESULTS:The mean patient age was 56.8±10.6y,45(50%)of them were female.The mean living altitude was 3867.8±567.9 m.At the last visit,the best-corrected visual acuity(BCVA)significantly increased(52.2±21.8 letters)in comparison with the baseline(38.2±24.1 letters,P<0.001);while the central retinal thickness(CRT)significantly reduced(245.5±147.6μm)in comparison with the baseline(504.1±165.2μm,P<0.001).The 43.0%of the eyes gained≥15 letters,60.2%of the eyes gained≥10 letters,and 78.5%of the eyes gained≥5 letters.No vision loss was noted in 92.5%of the eyes,4 eyes lost more than 10 letters during follow-up period.The mean number of injections was 2.4±1.8.No severe ocular or systemic adverse events related to either the drug or injection were noted.CONCLUSION:Anti-VEGF therapy is effective and safe in Tibetan patients for the treatment of RVO related ME.展开更多
基金Financial support from NSFC (Nos. 41372062, 41330210)the International Science & Technology Cooperation Program of China (No. 2010DFB23390) is greatly appreciated
文摘The multi-stage geological evolution and extensive continental deformations during the course of its history make the Central Asian metallogenic region（CAMR） a unique and complicated large-scale metal domain. New geological observations and precise age-data allow an improved reconstruction of the geological evolution of the CAMR. This paper summarizes the Paleozoic orogenic evolution and related ore formation in the core part of the CAMR based on the geological data published both during the Soviet period and the last decades. Four ore-formation provinces（Altay, BalkhashJunggar, Chu-Yili-Tianshan, and Southwest Tianshan） could be classified. The Balkhash-Junggar and Chu-Yili-Tianshan provinces are the major topics of this paper. The Balkhash-Junggar province consists of 4 huge ore-forming belts（Zharma-Saur, Tarbahtay-Xiemistay, Aktogay-Baerluke, Balkhashwestern Junggar） with 11 large ore-college areas. The Chu-Yili-Tianshan province consists of 4 huge ore-forming belts（Alatau-Sairimu, Chu-Yili-Bolehuole, Issyk-Awulale, Kazharman-Nalaty） with 22 large ore-college areas. Formation of large ore-college area corresponds to a specific stage of continental crust growth. Comparison of geology and ore deposits in the CAMR provides rich information for future exploration and understanding of ore-forming processes. The Paleo-Junggar Ocean closed at Early Devonian in the Balkhash-western Junggar ore-forming belt. Afterwards, widespread volcanic- sedimentary rocks formed at extensional stage due to delamination of the thick lower crust formed during previous accretionary processes. Felsic magma intrusion caused formation of porphyry Cu-Au deposit at ~310 Ma and related hydrothermal gold deposits about 10 Ma later. For example, in the Hatu-Baobei-Sartohay Au-Cr ore-college area in the Balkhash-western Junggar ore-forming belt, small granitic to diorite plutons and various dykes（312–277 Ma） and large granite bodies（~300 Ma） intruded into the Devonian to Early Carboniferous volcano-sedimentary basin. These magmatic activities and fault systems mainly controlled ore-forming processes.
基金supported by the Foundation of Zhangjiakou Science and Technology Committee, No.0711046D-9 and No.11110015D
文摘Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, followed by treatment with 40, 20, or 10 mg/kg orientin, vitexin, or a positive control （vitamin E） via intragastric administration for an additional 8 weeks. Orientin, vitexin, and vitamin E improved the general medical status of the aging mice and significantly increased their brain weights. They also produced an obvious rise in total antioxidant capacity, superoxide dismutase, catalase, and glutathione peroxidase levels in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na＋-K＋-ATP enzyme, and Ca2＋-Mg2＋-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced malondialdehyde levels in the liver, brain and kidney and lipofuscin levels in the brain. They also significantly improved the neuronal ultrastructure. The 40 mg/kg dose of orientin and vitexin had the same antioxidant capacity as vitamin E. These experimental findings indicate that orientin and vitexin engender anti-aging effects through their antioxidant capacities.
基金financially supported by the National Natural Science Foundation of China (Nos.41372062, 41330210, 41672047)
文摘A synthesis involving the data for the Nalati mountain region（NMR） in west Tianshan with a dataset including zircon U-Pb ages, Hf isotopic composition, major and trace elements of Paleozoic intrusions are presented to improve the understanding of regional geodynamic evolution. Paleozoic intrusive rocks in the NMR could be classified into four categories based on chronological and geochemical data： 480？5 Ma, 445–410 Ma, 345–320 Ma, and 295 Ma, which correspond to（1） closure of the Terskey Ocean and the opening of the south Tianshan back-arc basin, which was followed with the opening of the south Tianshan Ocean,（2） initial subduction of the south Tianshan oceanic crust,（3） major subduction stage, and（4） collision to post-collisional stage, respectively. Following the closure of the Terskey Ocean, the south Tianshan Ocean opened at Early Silurian and subducted under Yili-central Tianshan by the end of Early Carboniferous Period. The following breakoff of the subducted slab triggered partial melting of continental crust and formed voluminous granitic rocks in the NMR.
文摘AIM:To evaluate the outcomes of intravitreal antivascular endothelial growth factor(anti-VEGF)agents for patients with retinal vein occlusion(RVO)related-macular edema(ME)in Tibetan.METHODS:A retrospective,observational,single-center study.The demographic and clinical data of 90 RVO Tibetan patients(93 eyes)treated with either ranibizumab or conbercept in Tibet Autonomous Region People’s Hospital from Jan 2018 to December 2019 were collected.RESULTS:The mean patient age was 56.8±10.6y,45(50%)of them were female.The mean living altitude was 3867.8±567.9 m.At the last visit,the best-corrected visual acuity(BCVA)significantly increased(52.2±21.8 letters)in comparison with the baseline(38.2±24.1 letters,P<0.001);while the central retinal thickness(CRT)significantly reduced(245.5±147.6μm)in comparison with the baseline(504.1±165.2μm,P<0.001).The 43.0%of the eyes gained≥15 letters,60.2%of the eyes gained≥10 letters,and 78.5%of the eyes gained≥5 letters.No vision loss was noted in 92.5%of the eyes,4 eyes lost more than 10 letters during follow-up period.The mean number of injections was 2.4±1.8.No severe ocular or systemic adverse events related to either the drug or injection were noted.CONCLUSION:Anti-VEGF therapy is effective and safe in Tibetan patients for the treatment of RVO related ME.
