随着新型电力系统中可再生能源渗透率的不断攀升,以及传统火电机组的比例持续下降,新型电力系统面临严峻的频率控制问题,而分布式电池储能系统BESS(battery energy storage system)可为解决上述问题提供有效途径。基于此,首先提出1种基...随着新型电力系统中可再生能源渗透率的不断攀升,以及传统火电机组的比例持续下降,新型电力系统面临严峻的频率控制问题,而分布式电池储能系统BESS(battery energy storage system)可为解决上述问题提供有效途径。基于此,首先提出1种基于稀疏通信网络的分布式BESSs鲁棒负载频率控制LFC(loadfrequency control)方法。接着,为了抑制与系统运行相关的不确定性,设计了双层模型预测控制以改善BESS的响应特性,从而提升LFC效果。所提方法可满足系统各种运行物理约束,以实现区域控制误差的最小化。然后,考虑通信延迟对BESS参与频率调节性能的影响,设计了1种模糊协调控制器件以协调BESS和传统发电机,可避免传统发电机在长延迟情况下误运行。最后,通过仿真实验对所提方案进行验证,结果表明在不同容量、额定功率、充放电系数、荷电状态和时间常数等参数下,分布式BESS中的响应能力和调频效果明显优于传统方法。展开更多
Background:Alzheimer's disease(AD)and lung cancer are leading causes of mortality among the older population.Epidemiological evidence suggests an antagonistic relationship between them,whereby patients with AD exh...Background:Alzheimer's disease(AD)and lung cancer are leading causes of mortality among the older population.Epidemiological evidence suggests an antagonistic relationship between them,whereby patients with AD exhibit a reduced risk of developing cancer and vice versa.However,the precise mechanism by which AD antagonizes lung cancer progression warrants further elucidation.Methods:To this end,we established a co-morbidity model using 5xFAD transgenic mice induced with the carcinogen urethane.We visualized and quantified surface lung tumor colonies,assessed pathological parameters associated with lung cancer and AD using histopathological analysis,and employed single-cell sequencing and molecular pathological analyses to explore the mechanisms by which AD confers resistance to lung cancer.Results:Our findings revealed a significant reduction in lung tumor incidence in the AD group compared with that in the wild-type(WT)group.The results indicated a close association between AD-induced inhibition of lung tumor progression and iron homeostasis imbalance and increased oxidative stress.Moreover,greater CD8^(+)T cytotoxic lymphocyte and effector natural killer cell infiltration in the lung tumor tissues of AD mice and enhanced CD8^(+)T cytotoxic lymphocyte-mediated killing of target cells may be the primary factors contributing to the inhibition of lung tumor growth in the presence of AD.Conclusion:This study identified essential mechanisms through which AD suppresses lung tumorigenesis,thereby providing targets for potential therapeutic interventions in these diseases.展开更多
A new electrical toothed band brake is proposed based on the planetary gear shifting transmission.The corresponding mathematical model and the finite element model are established to investigate the braking dynamic ch...A new electrical toothed band brake is proposed based on the planetary gear shifting transmission.The corresponding mathematical model and the finite element model are established to investigate the braking dynamic characteristics and the stress distribution of brake components.According to the structural features and working principle of the brake,the braking process can be divided into a gap elimination stage,a sliding stage,a meshing stage,and a collision stage.The greater the initial speed of brake drum,the higher the impact torque in the collision stage,and the larger the stress of brake components.The ideal range of initial speed is 50-100 r/min,and the ultimate stress is 514 MPa appeared in the right brake band.This study present a wide range of possibilities for further investigation and application of the electrical toothed band brake.展开更多
文摘随着新型电力系统中可再生能源渗透率的不断攀升,以及传统火电机组的比例持续下降,新型电力系统面临严峻的频率控制问题,而分布式电池储能系统BESS(battery energy storage system)可为解决上述问题提供有效途径。基于此,首先提出1种基于稀疏通信网络的分布式BESSs鲁棒负载频率控制LFC(loadfrequency control)方法。接着,为了抑制与系统运行相关的不确定性,设计了双层模型预测控制以改善BESS的响应特性,从而提升LFC效果。所提方法可满足系统各种运行物理约束,以实现区域控制误差的最小化。然后,考虑通信延迟对BESS参与频率调节性能的影响,设计了1种模糊协调控制器件以协调BESS和传统发电机,可避免传统发电机在长延迟情况下误运行。最后,通过仿真实验对所提方案进行验证,结果表明在不同容量、额定功率、充放电系数、荷电状态和时间常数等参数下,分布式BESS中的响应能力和调频效果明显优于传统方法。
基金CAMS Innovation Fund for Medical Science,Grant/Award Number:2021-I2M-1-034The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,Grant/Award Number:2023-PT180-01。
文摘Background:Alzheimer's disease(AD)and lung cancer are leading causes of mortality among the older population.Epidemiological evidence suggests an antagonistic relationship between them,whereby patients with AD exhibit a reduced risk of developing cancer and vice versa.However,the precise mechanism by which AD antagonizes lung cancer progression warrants further elucidation.Methods:To this end,we established a co-morbidity model using 5xFAD transgenic mice induced with the carcinogen urethane.We visualized and quantified surface lung tumor colonies,assessed pathological parameters associated with lung cancer and AD using histopathological analysis,and employed single-cell sequencing and molecular pathological analyses to explore the mechanisms by which AD confers resistance to lung cancer.Results:Our findings revealed a significant reduction in lung tumor incidence in the AD group compared with that in the wild-type(WT)group.The results indicated a close association between AD-induced inhibition of lung tumor progression and iron homeostasis imbalance and increased oxidative stress.Moreover,greater CD8^(+)T cytotoxic lymphocyte and effector natural killer cell infiltration in the lung tumor tissues of AD mice and enhanced CD8^(+)T cytotoxic lymphocyte-mediated killing of target cells may be the primary factors contributing to the inhibition of lung tumor growth in the presence of AD.Conclusion:This study identified essential mechanisms through which AD suppresses lung tumorigenesis,thereby providing targets for potential therapeutic interventions in these diseases.
基金funded by the National Natural Science Foundation of China(Nos.52205047,52175037)China Postdoctoral Science Foundation(No.2021M700422)Beijing Key Laboratory Foundation(No.KF20212223201).
文摘A new electrical toothed band brake is proposed based on the planetary gear shifting transmission.The corresponding mathematical model and the finite element model are established to investigate the braking dynamic characteristics and the stress distribution of brake components.According to the structural features and working principle of the brake,the braking process can be divided into a gap elimination stage,a sliding stage,a meshing stage,and a collision stage.The greater the initial speed of brake drum,the higher the impact torque in the collision stage,and the larger the stress of brake components.The ideal range of initial speed is 50-100 r/min,and the ultimate stress is 514 MPa appeared in the right brake band.This study present a wide range of possibilities for further investigation and application of the electrical toothed band brake.
