Periodontitis is a common oral disease caused by bacteria coupled with an excessive host immune response.Stem cell therapy can be a promising treatment strategy for periodontitis,but the relevant mechanism is complica...Periodontitis is a common oral disease caused by bacteria coupled with an excessive host immune response.Stem cell therapy can be a promising treatment strategy for periodontitis,but the relevant mechanism is complicated.This study aimed to explore the therapeutic potential of mitochondria from human embryonic stem cell-derived mesenchymal stem cells(hESC-MSCs)for the treatment of periodontitis.The gingival tissues of periodontitis patients are characterized by abnormal mitochondrial structure.Human gingival fibroblasts(HGFs)were exposed to 5μg/mL lipopolysaccharide(LPS)for 24 h to establish a cell injury model.When treated with hESC-MSCs or mitochondria derived from hESC-MSCs,HGFs showed reduced expression of inflammatory genes,increased adenosine triphosphate(ATP)level,decreased reactive oxygen species(ROS)production,and enhanced mitochondrial function compared to the control.The average efficiency of isolated mitochondrial transfer by hESC-MSCs was determined to be 8.93%.Besides,a therapy of local mitochondrial injection in mice with LPS-induced periodontitis showed a reduction in inflammatory gene expression,as well as an increase in both the mitochondrial number and the aspect ratio in gingival tissues.In conclusion,our results indicate that mitochondria derived from hESC-MSCs can reduce the inflammatory response and improve mitochondrial function in HGFs,suggesting that the transfer of mitochondria between hESC-MSCs and HGFs serves as a potential mechanism underlying the therapeutic effect of stem cells.展开更多
The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have ste...The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have stepped out of a historical painting,gracefully dancing on the unbreakable doll apparatus.Every gesture and expression exudes the unparalleled elegance of the Tang Dynasty.This paper primarily analyzes the mechanical principles behind the Tang Dynasty Night City’s Unbreakable Doll Performance,starting with structural design to examine its mechanical principles and summarize its dynamic mechanical control mechanisms.展开更多
The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,arti...The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider unmanned aerial vehicles(UAVs)as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical references and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.展开更多
The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,arti...The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider UAVs as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical reference and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.展开更多
The addition of 2,5-pyridinedicarboxylic acid(2,5-PDCA)to the Mg-Al LDH coating,which was prepared by one-step hydrothermal synthesis,had extremely enhanced the corrosion protection of AZ31 Mg alloy,although the 2,5-P...The addition of 2,5-pyridinedicarboxylic acid(2,5-PDCA)to the Mg-Al LDH coating,which was prepared by one-step hydrothermal synthesis,had extremely enhanced the corrosion protection of AZ31 Mg alloy,although the 2,5-PDCA could not be intercalated into the interlayer spacing.The corrosion current density of 0.05 mol L^(−1)2,5-PDCA LDH containing LDH coating is 3.18 nA cm^(−2),reduced by two orders of magnitude compared to the LDH coating without inhibitor,and the corrosion inhibition efficiency of the coating is 98.05%.The coating formed on the surface of AZ31 was peeled off from the substrate by using a mechanical method and SEM observation of the cross-section showed that the coating consisted of three different layers.The innermost layer is a thick layer that consists of Mg(OH)_(2)and the intermediate layer is LDH,which is vertical to the substrate and the outmost layer is a thin but very dense deposit layer of LDH agglomerates with complexes of 2,5-PDCA and Mg.This kind of sediment/LDH/Mg(OH)_(2)three-layer composite structure was accountable for the increase in the corrosion resistance of AZ31 Mg alloy.展开更多
Determining the application and version of nodes in the Internet of Things （IoT） is very important for warning about and managing vulnerabilities in the IoT. This article defines the attributes for determining the a...Determining the application and version of nodes in the Internet of Things （IoT） is very important for warning about and managing vulnerabilities in the IoT. This article defines the attributes for determining the application and version of nodes in the roT. By improving the structure of the Internet web crawler, which obtains raw data from nodes, we can obtain data from nodes in the IoT. We improve on the existing strategy, in which only determinations are stored, by also storing downloaded raw data locally in MongoDB. This stored raw data can be conveniently used to determine application type and node version when a new determination method emerges or when there is a new application type or node version. In such instances, the crawler does not have to scan the Internet again. We show through experimentation that our crawler can crawl the loT and obtain data necessary for determining the application type and node version.展开更多
Network innovation and business transformation are both necessary for telecom operators to adapt to new situations, but operators face challenges in terms of network bearer complexity, business centralization, and IT/...Network innovation and business transformation are both necessary for telecom operators to adapt to new situations, but operators face challenges in terms of network bearer complexity, business centralization, and IT/CT integration. Network function virtualization （NFV） may inspire new development ideas, but many doubts still exist within industry, especially about how to introduce NFV into an operator＇ s network. This article describes the latest progress in NFV standardization, NFV requirements and hot technology issues, and typical NFV applications in an operator networks.展开更多
At the present stage,each big enterprise bases itself on the human resource inside the enterprise,increases the human capital investment one after another,pays attention to the human capital investment and the talente...At the present stage,each big enterprise bases itself on the human resource inside the enterprise,increases the human capital investment one after another,pays attention to the human capital investment and the talented person education and training.This paper analyzes how the return on human capital investment is realized in the enterprise and how the enterprise realizes the highest return on human capital investment.展开更多
We experimentally demonstrate two kinds of all few-mode fiber(FMF) ring lasers with high-order mode(HOM)oscillation in the laser cavity. One kind is a switchable-wavelength all-FMF HOM laser with an output of tunable ...We experimentally demonstrate two kinds of all few-mode fiber(FMF) ring lasers with high-order mode(HOM)oscillation in the laser cavity. One kind is a switchable-wavelength all-FMF HOM laser with an output of tunable optical vortex beams(OVBs); the other is a Q-switched all-FMF HOM laser with an output of pulsed cylindrical vector beams(CVBs). The lasers are composed of all-FMF components and few-mode erbium-doped fiber. A Sagnac interferometer made of a 3 dB FMF coupler functions as the wavelength selector, and switchable multiwavelength tunable OVBs are experimentally realized. Carbon nanotube-based saturable absorbers and the nonlinear polarization rotation technique are used to achieve Q-switched CVB lasers. This is the first report, to our knowledge, on the generation of switchable-wavelength and Q-switched HOM beams in all-FMF laser cavities.展开更多
This paper studies Chinese firms’earnings management strategy in response to the trade dispute investigations initiated by the U.S.from 2001 to 2018.This topic is important given the increasingly severe international...This paper studies Chinese firms’earnings management strategy in response to the trade dispute investigations initiated by the U.S.from 2001 to 2018.This topic is important given the increasingly severe international trade environment and the significant influence of macro economy on financial reporting.We find that firms affected by the U.S.-initiated trade dispute investigations engage in more upward earnings management.Additionally,the result is more pronounced in firms with a more negative market reaction around the announcement of the investigations.Cross-sectional tests provide evidence that the positive relation is stronger among firms whose U.S.operating revenue and management ownership is high,firms in provinces with weak investor protection,and firms that performed well one year after initiation of the investigations.Moreover,investors react positively to the earnings management by the affected firms.Our results are robust to a variety of sensitivity checks.Overall,our findings suggest that companies will manage their earnings upward to mitigate the negative impacts of the U.S.-initiated trade dispute investigations.展开更多
基金supported by the Key R&D Program of Zhejiang(No.2023C03072)the Medical and Health Science and Technology Program of Zhejiang Province(No.2021PY007)and the National Key Research and Development Program of China(Nos.2021YFA1301100 and 2021YFA1301101).
文摘Periodontitis is a common oral disease caused by bacteria coupled with an excessive host immune response.Stem cell therapy can be a promising treatment strategy for periodontitis,but the relevant mechanism is complicated.This study aimed to explore the therapeutic potential of mitochondria from human embryonic stem cell-derived mesenchymal stem cells(hESC-MSCs)for the treatment of periodontitis.The gingival tissues of periodontitis patients are characterized by abnormal mitochondrial structure.Human gingival fibroblasts(HGFs)were exposed to 5μg/mL lipopolysaccharide(LPS)for 24 h to establish a cell injury model.When treated with hESC-MSCs or mitochondria derived from hESC-MSCs,HGFs showed reduced expression of inflammatory genes,increased adenosine triphosphate(ATP)level,decreased reactive oxygen species(ROS)production,and enhanced mitochondrial function compared to the control.The average efficiency of isolated mitochondrial transfer by hESC-MSCs was determined to be 8.93%.Besides,a therapy of local mitochondrial injection in mice with LPS-induced periodontitis showed a reduction in inflammatory gene expression,as well as an increase in both the mitochondrial number and the aspect ratio in gingival tissues.In conclusion,our results indicate that mitochondria derived from hESC-MSCs can reduce the inflammatory response and improve mitochondrial function in HGFs,suggesting that the transfer of mitochondria between hESC-MSCs and HGFs serves as a potential mechanism underlying the therapeutic effect of stem cells.
文摘The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have stepped out of a historical painting,gracefully dancing on the unbreakable doll apparatus.Every gesture and expression exudes the unparalleled elegance of the Tang Dynasty.This paper primarily analyzes the mechanical principles behind the Tang Dynasty Night City’s Unbreakable Doll Performance,starting with structural design to examine its mechanical principles and summarize its dynamic mechanical control mechanisms.
文摘The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider unmanned aerial vehicles(UAVs)as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical references and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.
文摘The“14th Five-Year Plan”and the Long-Range Objectives Through the Year 2035 propose to strengthen the construction of strategic emerging industrial clusters,promote the deep integration of the internet,big data,artificial intelligence,blockchain technology,etc.with the real economy,facilitate the development of advanced manufacturing,and consider UAVs as an important breakthrough,providing significant opportunities for the development of the UAV industry.Therefore,this article takes the current status of the UAV industry development as a starting point,analyzes the exploration and practice of the UAV development model based on the low-altitude economy,and discusses strategic suggestions to promote the development of UAVs empowered by the low-altitude economy.Through analysis,this article aims to provide theoretical reference and practical guidance for promoting the sustainable development of the UAV industry under the wave of the low-altitude economy.
文摘The addition of 2,5-pyridinedicarboxylic acid(2,5-PDCA)to the Mg-Al LDH coating,which was prepared by one-step hydrothermal synthesis,had extremely enhanced the corrosion protection of AZ31 Mg alloy,although the 2,5-PDCA could not be intercalated into the interlayer spacing.The corrosion current density of 0.05 mol L^(−1)2,5-PDCA LDH containing LDH coating is 3.18 nA cm^(−2),reduced by two orders of magnitude compared to the LDH coating without inhibitor,and the corrosion inhibition efficiency of the coating is 98.05%.The coating formed on the surface of AZ31 was peeled off from the substrate by using a mechanical method and SEM observation of the cross-section showed that the coating consisted of three different layers.The innermost layer is a thick layer that consists of Mg(OH)_(2)and the intermediate layer is LDH,which is vertical to the substrate and the outmost layer is a thin but very dense deposit layer of LDH agglomerates with complexes of 2,5-PDCA and Mg.This kind of sediment/LDH/Mg(OH)_(2)three-layer composite structure was accountable for the increase in the corrosion resistance of AZ31 Mg alloy.
基金supported by the ZTE Corporation and University Joint Research Project under Grant No.CON1307100001the National High Technology Research and Development Program of China under Grant No.2013AA013602
文摘Determining the application and version of nodes in the Internet of Things （IoT） is very important for warning about and managing vulnerabilities in the IoT. This article defines the attributes for determining the application and version of nodes in the roT. By improving the structure of the Internet web crawler, which obtains raw data from nodes, we can obtain data from nodes in the IoT. We improve on the existing strategy, in which only determinations are stored, by also storing downloaded raw data locally in MongoDB. This stored raw data can be conveniently used to determine application type and node version when a new determination method emerges or when there is a new application type or node version. In such instances, the crawler does not have to scan the Internet again. We show through experimentation that our crawler can crawl the loT and obtain data necessary for determining the application type and node version.
文摘Network innovation and business transformation are both necessary for telecom operators to adapt to new situations, but operators face challenges in terms of network bearer complexity, business centralization, and IT/CT integration. Network function virtualization （NFV） may inspire new development ideas, but many doubts still exist within industry, especially about how to introduce NFV into an operator＇ s network. This article describes the latest progress in NFV standardization, NFV requirements and hot technology issues, and typical NFV applications in an operator networks.
文摘At the present stage,each big enterprise bases itself on the human resource inside the enterprise,increases the human capital investment one after another,pays attention to the human capital investment and the talented person education and training.This paper analyzes how the return on human capital investment is realized in the enterprise and how the enterprise realizes the highest return on human capital investment.
基金National Natural Science Foundation of China(NSFC)(61635006,91750108,61520106014)Science and Technology Commission of Shanghai Municipality(STCSM)(16520720900)
文摘We experimentally demonstrate two kinds of all few-mode fiber(FMF) ring lasers with high-order mode(HOM)oscillation in the laser cavity. One kind is a switchable-wavelength all-FMF HOM laser with an output of tunable optical vortex beams(OVBs); the other is a Q-switched all-FMF HOM laser with an output of pulsed cylindrical vector beams(CVBs). The lasers are composed of all-FMF components and few-mode erbium-doped fiber. A Sagnac interferometer made of a 3 dB FMF coupler functions as the wavelength selector, and switchable multiwavelength tunable OVBs are experimentally realized. Carbon nanotube-based saturable absorbers and the nonlinear polarization rotation technique are used to achieve Q-switched CVB lasers. This is the first report, to our knowledge, on the generation of switchable-wavelength and Q-switched HOM beams in all-FMF laser cavities.
基金support from National Natural Science Foundation of China (NSFC Project Numbers 71972049)
文摘This paper studies Chinese firms’earnings management strategy in response to the trade dispute investigations initiated by the U.S.from 2001 to 2018.This topic is important given the increasingly severe international trade environment and the significant influence of macro economy on financial reporting.We find that firms affected by the U.S.-initiated trade dispute investigations engage in more upward earnings management.Additionally,the result is more pronounced in firms with a more negative market reaction around the announcement of the investigations.Cross-sectional tests provide evidence that the positive relation is stronger among firms whose U.S.operating revenue and management ownership is high,firms in provinces with weak investor protection,and firms that performed well one year after initiation of the investigations.Moreover,investors react positively to the earnings management by the affected firms.Our results are robust to a variety of sensitivity checks.Overall,our findings suggest that companies will manage their earnings upward to mitigate the negative impacts of the U.S.-initiated trade dispute investigations.
