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Design strategy of advanced generation breeding population of Pinus tabuliformis based on genetic variation and inbreeding level
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作者 Chengcheng Zhou fan sun +2 位作者 Zhiyuan Jiao Yousry A.El-Kassaby Wei Li 《Forest Ecosystems》 2025年第4期607-618,共12页
The level of genetic variation within a breeding population affects the effectiveness of selection strategies for genetic improvement.The relationship between genetic variation level within Pinus tabuliformis breeding... The level of genetic variation within a breeding population affects the effectiveness of selection strategies for genetic improvement.The relationship between genetic variation level within Pinus tabuliformis breeding populations and selection strategies or selection effectiveness is not fully investigated.Here,we compared the selection effectiveness of combined and individual direct selection strategies using half-and full-sib families produced from advanced-generation P.tabuliformis seed orchard as our test populations.Our results revealed that,within half-sib families,average diameter at breast height(DBH),tree height,and volume growth of superior individuals selected by the direct selection strategy were higher by 7.72%,18.56%,and 31.01%,respectively,than those selected by the combined selection strategy.Furthermore,significant differences(P<0.01)were observed between the two strategies in terms of the expected genetic gains for average tree height and volume.In contrast,within full-sib families,the differences in tree average DBH,height,and volume between the two selection strategies were relatively minor with increase of 0.17%,2.73%,and 2.21%,respectively,and no significant differences were found in the average expected genetic gains for the studied traits.Half-sib families exhibited greater phenotypic and genetic variation,resulting in improved selection efficiency with the direct selection strategy but also introduced a level of inbreeding risk.Based on genetic distance estimates using molecular markers,our comparative seed orchard design analysis showed that the Improved Adaptive Genetic Programming Algorithm(IAPGA)reduced the average inbreeding coefficient by 14.36% and 14.73% compared to sequential and random designs,respectively.In conclusion,the combination of the direct selection strategy with IAPGA seed orchard design aimed at minimizing inbreeding offered an efficient approach for establishing advanced-generation P.tabuliformis seed orchards. 展开更多
关键词 Breeding population Parental selection strategies Advanced generation seed orchard Pinus tabuliformis Seed orchard design Improved Adaptive Genetic Programming Algorithm
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Epsilon iron carbide derived from Fe_(4)N for ethanol synthesis via ester hydrogenation
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作者 Huijiang Huang Xin Shang +7 位作者 Qiang Wang Meng Cao fan sun Wei Liu Yan Xu Junhu Wang Yujun Zhao Xinbin Ma 《Journal of Energy Chemistry》 2025年第9期19-29,I0002,共12页
Ethanol synthesis via dimethyl oxalate hydrogenation has garnered increasing attention in the fields of syngas utilization.Althoughε-Fe_(2)C has been identified as a promising active species for DMO hydrogenation to ... Ethanol synthesis via dimethyl oxalate hydrogenation has garnered increasing attention in the fields of syngas utilization.Althoughε-Fe_(2)C has been identified as a promising active species for DMO hydrogenation to ethanol,its formation is kinetically challenging during carbonization.In this work,a Fe_(4)N phase was first synthesized by pretreating a 30Fe/SiO_(2)catalyst in an ammonia environment,followed by carbonization in a methanol-H_(2) flow to obtain ε-Fe_(2)C as the active phase.Fe_(4)N,rather than Fe-O-Si,facilitates the transformation into iron carbide during the carbonization process.The transformation pathway of iron nitride(Fe_(x)N)is mediated by intermediate iron carbonyl species(Fe-CO),ultimately leading to the formation of iron carbide as the active phase.The resulting catalyst exhibited 40 times higher catalytic activity than the untreated catalyst in DMO hydrogenation.Combined structure properties and DFT calculation revealed that the lower energy barrier ofε-Fe_(2)C for ester hydrogenation underpins/strengthens its superior performance,while the STY of ε-Fe_(2)C is 2.8 times that ofε'-Fe_(2.2)C and 58 times that ofχ-Fe_(5)C_(2).This study provides a novel strategy for designing highly efficient iron carbide catalysts for the esters hydrogenation system. 展开更多
关键词 Fe_(4)N Iron Carbide e-Fe_(2)C HYDROGENATION ESTER Dimethyl oxalate ETHANOL
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Preferential fatigue cracking at basal twist grain boundary (BTGB) in bimodal Ti-5Al-4V alloy: Dislocation activities and crack initiation
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作者 Zhihong Wu Hongchao Kou +6 位作者 Jinshan Li Samuel Hémery Tong Li Carlo Franke Nana Chen Frédéric Prima fan sun 《Journal of Materials Science & Technology》 2025年第14期281-295,共15页
In recent years,(0001)twist grain boundaries(BTGBs)located in primary α grain clusters were identified as fatigue crack nucleation sites in different Ti alloys.In the present study,crack initiation was investigated i... In recent years,(0001)twist grain boundaries(BTGBs)located in primary α grain clusters were identified as fatigue crack nucleation sites in different Ti alloys.In the present study,crack initiation was investigated in a bimodal Ti-5Al-4 V alloy subjected to low-cycle fatigue and dwell-fatigue loadings at room temperature.The low fraction of primary α grains was not associated with a lack of sensitivity to BTGB cracking.Transmission electron microscopy and electron back-scattered diffraction were used to characterize BTGBs in the initial microstructure.The fatigue mechanisms were then analyzed with a focus on dislocation activity.α_(p) grains adjacent to cracked BTGBs contained a high dislocation density.It was primarily composed of planar slip bands of dislocations.In addition,<c+a>dislocations were noticed in the vicinity of cracked BTGBs.They supposedly pertain to crack tip plasticity during growth,and no evidence of a role of an incoming slip event in crack nucleation was obtained.Also,basal slip bands extending across adjacent grains were found to emerge from BTGBs.This feature provides an easier path for crack extension when growth along the grain boundary becomes difficult owing to a deviation from the basal plane.Atom probe tomography analyses evidenced V and Fe segregation at a grain boundary with a significant deviation from the BTGB configuration.This suggests a possible contribution of local solute segregation to the high cracking resistance of general α_(p)/α_(p) grain boundaries.This work provides new insights into the mechanisms involved in cracking of BTGB in Ti alloys subjected to cyclic loadings. 展开更多
关键词 Low cycle fatigue Titanium alloy Crack initiation Twist boundary Dislocations
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Macro-micro damage and energy release rates of fractured sandstone subjected to dry-wet cycles
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作者 Runqiu Wang Guilin Wang +2 位作者 Liang Zhang fan sun Boyi Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第6期3563-3576,共14页
The deterioration of rock mass in the Three Gorges reservoir area results from the coupled damage effects of macro-micro cracks and dry-wet cycles,and the coupled damage progression can be characterized by energy rele... The deterioration of rock mass in the Three Gorges reservoir area results from the coupled damage effects of macro-micro cracks and dry-wet cycles,and the coupled damage progression can be characterized by energy release rate.In this study,a series of dry-wet cycle uniaxial compression tests was conducted on fractured sandstone,and a method was developed for calculating macro-micro damage(D_(R))and energy release rates(Y_(R))of fractured sandstone subjected to dry-wet cycles by considering energy release rate,dry-wet damage and macro-micro damage.Therewith,the damage mechanisms and complex microcrack propagation patterns of rocks were investigated.Research indicates that sandstone degradation after a limited cycle count primarily exhibits exsolution of internal fillers,progressing to grain skeleton alteration and erosion with increased cycles.Compared with conventional methods,the D_(R) and Y_(R) methodologies exhibit heightened sensitivity to microcrack closure during compaction and abrupt energy release at the point of failure.Based on D_(R) and Y_(R),the failure process of fractured sandstone can be classified into six stages:stress adjustment(I),microcracks equal closure(II),nonlinear slow closure(III),low-speed extension(IV),rapid extension(V),and macroscopic main fracture emergence(VI).The abrupt change in damage energy release rate during stage V may serve as a reliable precursor for inducing failure.The stage-based classification may enhance traditional methods by tracking damage progression and accurately identifying rock failure precursors.The findings are expected to provide a scientific basis for understanding damage mechanisms and enabling early warning of reservoir-bank slope failure. 展开更多
关键词 Dry-wet cycle Energy evolution Coupled damage Damage energy release rate Fractured sandstone
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依达拉奉对急性脑梗死的疗效及其对出血性转化的影响 被引量:28
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作者 孙凡 刘恒 +3 位作者 徐倩倩 卜一 马征 高燕军 《中国现代医学杂志》 CAS 2019年第3期78-82,共5页
目的探究依达拉奉联合阿替普酶治疗急性脑梗死的疗效及其对出血性转化(HT)、五聚素3(PTX3)与血浆脂蛋白相关磷脂酶A2(Lp-PLA2)的影响。方法选取2014年1月—2017年1月承德医学院附属医院收治的116例急性脑梗死患者。根据随机数字表法分... 目的探究依达拉奉联合阿替普酶治疗急性脑梗死的疗效及其对出血性转化(HT)、五聚素3(PTX3)与血浆脂蛋白相关磷脂酶A2(Lp-PLA2)的影响。方法选取2014年1月—2017年1月承德医学院附属医院收治的116例急性脑梗死患者。根据随机数字表法分为观察组和对照组,每组58例。对照组给予阿替普酶治疗,观察组在对照组基础上给予依达拉奉治疗。比较两组患者的临床疗效、HT的发生率及治疗前后NIHSS评分、ADL评分,同时监测治疗前后血清PTX-3、Lp-PLA2水平及治疗过程中不良反应发生率。结果治疗后两组NIHHS评分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);对照组、观察组总有效率分别为50.00%和74.14%,观察组高于对照组(P<0.05);对照组、观察组出血性转化发生率分别为24.14%和10.34%,观察组低于对照组(P <0.05);治疗后两组PTX-3、Lp-PLA2均较治疗前下降(P <0.05),且观察组低于对照组(P <0.05);观察组和对照组不良反应总发生率为10.34%和12.07%,差异无统计学意义(P>0.05)。结论依达拉奉联合阿替普酶治疗急性脑梗死,可以有效改善神经功能缺损,提高临床疗效,预防出血性转化,降低血清Lp-PLA2、PTX3水平,减轻炎症反应,且安全性较好。 展开更多
关键词 脑梗死/脑梗塞 依达拉奉/处方药 阿替普酶/处方药 出血性转化/脑出血
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地方官员变更与企业金融化--基于地级市市委书记和市长的数据
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作者 杜勇 孙帆 杨洋 《会计论坛》 2022年第2期1-21,共21页
地方官员变更导致的政策不确定性会对企业行为产生重要影响,它如何影响企业金融资产配置是本文关注的问题。本文以2007~2021年中国沪深两市A股上市公司为研究样本,考察了地方官员变更对企业金融化的影响。研究发现:地方官员变更会显著... 地方官员变更导致的政策不确定性会对企业行为产生重要影响,它如何影响企业金融资产配置是本文关注的问题。本文以2007~2021年中国沪深两市A股上市公司为研究样本,考察了地方官员变更对企业金融化的影响。研究发现:地方官员变更会显著抑制企业金融资产配置的“投机”动机,从而抑制企业金融化。这一结论在使用多种方法控制内生性和稳健性问题后依然成立。作用机制检验表明,地方官员变更导致企业面临的外部不确定性和外部融资约束削弱了金融资产配置的“投机”动机,从而减少了企业金融资产投资。进一步分析发现,在民营企业、经济发达地区,地方官员变更的影响更强。本文从宏观环境方面丰富了企业金融化的影响因素研究,有助于明晰政策不确定性引起的经济后果,并为采取合理的保障措施提供了政策启示。 展开更多
关键词 地方官员变更 政策不确定性 政府干预 企业金融化
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DEB-TACE联合I125放射性粒子治疗肝细胞癌合并门脉癌栓的疗效分析 被引量:2
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作者 范隼 李庆源 +2 位作者 周志涛 关守海 巫兆国 《临床医学工程》 2020年第1期53-54,共2页
目的探讨载药微球经动脉化疗栓塞(DEB-TACE)联合I125放射性粒子治疗肝细胞癌合并门脉癌栓的临床疗效。方法将30例肝细胞癌合并门脉癌栓患者根据治疗方法不同分为对照组(n=15)和研究组(n=15)。对照组采用DEB-TACE治疗,研究组采用DEB-TAC... 目的探讨载药微球经动脉化疗栓塞(DEB-TACE)联合I125放射性粒子治疗肝细胞癌合并门脉癌栓的临床疗效。方法将30例肝细胞癌合并门脉癌栓患者根据治疗方法不同分为对照组(n=15)和研究组(n=15)。对照组采用DEB-TACE治疗,研究组采用DEB-TACE联合I125放射性粒子治疗。比较两组的临床疗效。结果研究组的客观反应率为66.67%,高于对照组的26.67%(P<0.05)。研究组的1年生存率为53.33%,高于对照组的13.33%(P<0.05)。研究组的OS、TTP长于对照组(P<0.05)。两组的腹腔感染、腹痛、肝肾功能损伤、出血发生率比较差异无统计学意义(P>0.05)。结论DEB-TACE联合I125放射性粒子治疗肝细胞癌合并门脉癌栓的近期疗效理想,且能够延长OS、TTP,不良反应少。 展开更多
关键词 肝细胞癌 门脉癌栓 DEB-TACE I125放射性粒子
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Load-forecasting method for IES based on LSTM and dynamic similar days with multi-features 被引量:5
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作者 fan sun Yaojia Huo +3 位作者 Lei Fu Huilan Liu Xi Wang Yiming Ma 《Global Energy Interconnection》 EI CSCD 2023年第3期285-296,共12页
To fully exploit the rich characteristic variation laws of an integrated energy system(IES)and further improve the short-term load-forecasting accuracy,a load-forecasting method is proposed for an IES based on LSTM an... To fully exploit the rich characteristic variation laws of an integrated energy system(IES)and further improve the short-term load-forecasting accuracy,a load-forecasting method is proposed for an IES based on LSTM and dynamic similar days with multi-features.Feature expansion was performed to construct a comprehensive load day covering the load and meteorological information with coarse and fine time granularity,far and near time periods.The Gaussian mixture model(GMM)was used to divide the scene of the comprehensive load day,and gray correlation analysis was used to match the scene with the coarse time granularity characteristics of the day to be forecasted.Five typical days with the highest correlation with the day to be predicted in the scene were selected to construct a“dynamic similar day”by weighting.The key features of adjacent days and dynamic similar days were used to forecast multi-loads with fine time granularity using LSTM.Comparing the static features as input and the selection method of similar days based on non-extended single features,the effectiveness of the proposed prediction method was verified. 展开更多
关键词 Integrated energy system Load forecast Long short-term memory Dynamic similar days Gaussian mixture model
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Design and application of an Electric Tail Rotor Drive Control(ETRDC) for helicopters with performance tests 被引量:4
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作者 Yuwen ZHANG Chen JIANG +2 位作者 Yunjie WANG fan sun Haowen WANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2018年第9期1894-1901,共8页
With the development of electric helicopters’ motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rotor,... With the development of electric helicopters’ motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rotor, the wake of the main rotor influences the tail rotor’s inflow and wake.In the procedure of controlling, crosswind will also cause changes to the tail disk load. This paper describes requirements and design principles of an electric motor drive and variable pitch tail rotor system. A particular spoke-type architecture of the motor is designed, and the performance of blades is analyzed by the CFD method. The demand for simplicity of moving parts and strict constraints on the weight of a helicopter makes the design of electrical and mechanical components challenging. Different solutions have been investigated to propose an effective alternative to the mechanical actuation system. A test platform is constructed which can collect the dynamic response of the thrust control. The enhancement of the response speed due to an individual motor speed control and variable-pitch system is validated. 展开更多
关键词 Electric tail rotor HELICOPTER More Electric Aircraft(MEA) Propulsion optimization Tail rotor
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The IES dynamic time-scale scheduling strategy based on multiple load forecasting errors 被引量:6
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作者 fan sun Ran Li +3 位作者 Yi Han Shouang Liu fanrui Liu Huilan Liu 《Global Energy Interconnection》 CAS CSCD 2021年第1期58-68,共11页
Considering the complex coupling of multiple energies and the varying load forecasting errors for an integrated energy system(IES),this study proposes a dynamic time-scale scheduling strategy based on long short-term ... Considering the complex coupling of multiple energies and the varying load forecasting errors for an integrated energy system(IES),this study proposes a dynamic time-scale scheduling strategy based on long short-term memory(LSTM)and multiple load forecasting errors.This strategy dynamically selects a hybrid timescale which is suitable for a variety of energies for each month.This is obtained by combining the mean absolute percentage error(MAPE)curve of the load forecasting with the error restriction requirements of the dispatcher.Based on the day-ahead scheduling plan,the output of the partial equipment is selectively adjusted at each time-scale to realize multi-energy collaborative optimization and gives full play to the comprehensive advantages of the IES.This is achieved by considering the differences in the response speed for each piece of equipment within the intra-day scheduling.This study uses the IES as an example,and it dynamically determines the time scale of the energy monthly.In addition,this investigation presents a detailed analysis of the output plan of the key equipment to demonstrate the necessity and the advantages of the strategy. 展开更多
关键词 integrated energy system long short-term memory dynamic time-scale multi-layer optimization
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OstMAPKKK5, a truncated mitogen-activated protein kinase kinase kinase 5, positively regulates plant height and yield in rice 被引量:2
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作者 Yahui Liu Yu Zhu +4 位作者 Xuding Xu fan sun Jingshui Yang Liming Cao Xiaojin Luo 《The Crop Journal》 SCIE CAS CSCD 2019年第5期707-714,共8页
Rice(Oryza sativa L.)is a major food crop worldwide.Plant height and yield are important agronomic traits of rice.Several genes regulating plant height and/or yield have been cloned.However,the molecular mechanisms co... Rice(Oryza sativa L.)is a major food crop worldwide.Plant height and yield are important agronomic traits of rice.Several genes regulating plant height and/or yield have been cloned.However,the molecular mechanisms coordinating plant height and yield are not fully characterized.Here,we report a novel gene,OstMAPKKK5 that encodes a truncated variant of a mitogen-activated protein kinase kinase kinase 5(OsMAPKKK5)lacking an intact kinase domain.Transgenic plants overexpressing OstMAPKKK5 in indica cultivar 9311 showed increased plant height,grain length,grain width,1000-grain weight,grain number per main panicle,and yield.Real-time quantitative PCR showed that OstMAPKKK5 was widely expressed in various tissues and developmental stages.The increased plant height and yield were attributed to enlarged cell size.Overexpression of OstMAPKKK5 led to higher contents of various forms of endogenous gibberellin(GA),especially the most common active forms,GA1,GA3,GA4.We concluded that OstMAPKKK5 positively regulates plant height and yield in rice by affecting cell size,and that its underlying mechanism is based on increased endogenous GA content. 展开更多
关键词 OstMAPKKK5 Plant height and YIELD Cell size GIBBERELLIN ORYZA SATIVA
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In-situ microstructural investigations of the TRIP-to-TWIP evolution in Ti-Mo-Zr alloys as a function of Zr concentration 被引量:2
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作者 Bingnan Qian Jinyong Zhang +5 位作者 Yangyang Fu fan sun Yuan Wu Jun Cheng Philippe Vermaut Frederic Prima 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第6期228-237,共10页
Aiming at overcoming the strength-ductility trade-off in structural Ti-alloys,a new family of TRIP/TWIP Ti-alloys was developed in the past decade(TWIP:twinning-induced plasticity;TRIP:transformationinduced plasticity... Aiming at overcoming the strength-ductility trade-off in structural Ti-alloys,a new family of TRIP/TWIP Ti-alloys was developed in the past decade(TWIP:twinning-induced plasticity;TRIP:transformationinduced plasticity).Herein,we study the tunable nature of deformation mechanisms with various TWIP and TRIP contributions by fine adjustment of the Zr content on ternary Ti-12 Mo-xZr(x=3,6,10)alloys.The microstructure and deformation mechanisms of the Ti-Mo-Zr alloys are explored by using in-situ electron backscatter diffraction(EBSD)and transmission electron microscopy(TEM).The results show that a transition of the dominant deformation mode occurred,going from TRIP to TWIP major mechanism with increasing Zr content.In the Ti-12 Mo-3 Zr alloy,the stress-induced martensitic transformation(SIM)is the major deformation mode which accommodates the plastic flow.Regarding the Ti-12 Mo-6 Zr alloy,the combined deformation twinning(DT)and SIM modes both contribute to the overall plasticity with enhanced strain-hardening rate and subsequent large uniform ductility.Further increase of the Zr content in Ti-12 Mo-10 Zr alloy leads to an improved yield stress involving single DT mode as a dominant deformation mechanism throughout the plastic regime.In the present work,a set of comprehensive in-situ and ex-situ microstructural investigations clarify the evolution of deformation microstructures during tensile loading and unloading processes. 展开更多
关键词 Metastable beta(β)Ti-alloys TRIP/TWIP effects Deformation mechanisms In-situ traction-EBSD TEM observation
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A kink-bands reinforced titanium alloy showing 1.3 GPa compressive yield strength:Towards extra high-strength/strain-transformable Ti alloys 被引量:2
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作者 Jinyong Zhang Bingnan Qian +6 位作者 Yijin Wu Yu Wang Jun Cheng Zheng Chen Jinshan Li fan sun Frederic Prima 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第15期21-26,共6页
1.Introduction In structural metallic materials,the occurrence of particular deformation mechanisms such as dislocation slip,deformation twins(DTs)[1,2]deformation kink bands(KBs)[3,4]or stressinduced phase transforma... 1.Introduction In structural metallic materials,the occurrence of particular deformation mechanisms such as dislocation slip,deformation twins(DTs)[1,2]deformation kink bands(KBs)[3,4]or stressinduced phase transformations(SIM)[5],are closely related to both their crystal structures[6–8](e.g.FCC,BCC and HCP)and loading conditions(e.g.temperature and/or strain rate). 展开更多
关键词 deformation strength STRAIN
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药物洗脱微球经动脉化疗栓塞与传统经导管动脉化疗栓塞在晚期肝细胞癌患者治疗中的疗效及安全性评估
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作者 彭翰斐 周志涛 +6 位作者 范隼 李庆源 何伟良 钟鹏 卢曼萍 李华 关守海 《消化肿瘤杂志(电子版)》 2024年第4期469-475,共7页
目的分析药物洗脱微球经动脉化疗栓塞(drug-eluting bead transarterial chemoembolization,DEB-TACE)和传统经导管动脉化疗栓塞(conventional transcatheter arterial chemoembolization,c-TACE)在晚期肝细胞癌患者治疗中的疗效及安全... 目的分析药物洗脱微球经动脉化疗栓塞(drug-eluting bead transarterial chemoembolization,DEB-TACE)和传统经导管动脉化疗栓塞(conventional transcatheter arterial chemoembolization,c-TACE)在晚期肝细胞癌患者治疗中的疗效及安全性。方法回顾性分析中山大学附属第三医院2021年3月至2023年2月收治的79例晚期肝细胞癌患者,其中39例接受DEB-TACE治疗(DEB-TACE组),40例接受c-TACE治疗(c-TACE组)。比较两组治疗后1个月、3个月时的客观缓解率(objective response rate,ORR)和疾病控制率(disease control rate,DCR),比较两组治疗后1周及1个月时的血常规指标(白细胞计数、红细胞计数、血小板计数)及肝功能指标(白蛋白、总胆红素、丙氨酸转氨酶、天冬氨酸转氨酶)的变化情况,观察患者治疗后的不良反应发生情况。比较随访期间两组患者的总生存(overall survival,OS)时间、无进展生存(progression-free survival,PFS)时间。结果治疗后1个月及3个月时,c-TACE组的ORR分别为2.50%、15.00%,DEB-TACE组分别为7.69%、25.64%,差异无统计学意义(P>0.05);DEB-TACE组的DCR分别为97.44%、79.49%,高于c-TACE组的80.00%、55.00%(P<0.05)。治疗后1周及1个月时,两组天冬氨酸转氨酶、白蛋白、白细胞计数、红细胞计数变化幅度差异无统计学意义(P>0.05);治疗后1周,c-TACE组患者丙氨酸转氨酶、总胆红素和血小板计数变化幅度大于DEB-TACE组(P<0.05);治疗后1个月时,两组丙氨酸转氨酶、总胆红素和血小板计数变化幅度差异无统计学意义(P>0.05)。DEB-TACE组轻度胃肠道反应、发热、血液系统反应的发生率均低于c-TACE组(P<0.05),两组中度胃肠道反应、发热、血液系统反应的发生率,轻度及中度皮肤反应、脱发的发生率差异无统计学意义(P>0.05)。c-TACE组1年PFS时间和1年OS时间分别为8.5个月(95%CI:7.7~9.2个月)、10.1个月(95%CI:9.3~10.7个月),DEB-TACE组分别为9.3个月(95%CI:8.6~10.1个月)、10.4个月(95%CI:9.5~10.8个月),差异无统计学意义(P>0.05)。结论晚期肝细胞癌患者采用DEB-TACE与c-TACE治疗后的ORR相似,但DEB-TACE治疗后的DCR高于c-TACE,且DEB-TACE治疗后短期内对肝功能的影响更小,不良反应发生率更低。 展开更多
关键词 晚期 肝细胞癌 药物洗脱微球 经导管动脉化疗栓塞
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Acetic acid additive in NaNO_(3)aqueous electrolyte for long-lifespan Mg-air batteries 被引量:1
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作者 Yaqing Zhou fan sun +4 位作者 Gunahua Lin Sandrine Zanna Antoine Seyeux Philippe Marcus Jolanta´Swiatowska 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第2期825-839,共15页
Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environ... Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environmental sustainability,and cost-effectiveness.However,the fast hydrogen evolution reaction(HER)in NaCl-based aqueous electrolytes impairs the performance of Mg-air batteries and leads to poor specific capacity,low energy density,and low utilization.Thus,the conventionally used NaCl solute was proposed to be replaced by NaNO_(3)and acetic acid additive as a corrosion inhibitor,therefore an electrolyte engineering for long-life time Mg-air batteries is reported.The resulting Mg-air batteries based on this optimized electrolyte demonstrate an improved discharge voltage reaching~1.8 V for initial 5 h at a current density of 0.5 mA/cm^(2) and significantly prolonged cells'operational lifetime to over 360 h,in contrast to only~17 h observed in NaCl electrolyte.X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry were employed to analyse the composition of surface film and scanning electron microscopy combined with transmission electron microscopy to clarify the morphology changes of the surface layer as a function of acetic acid addition.The thorough studies of chemical composition and morphology of corrosion products have allowed us to elucidate the working mechanism of Mg anode in this optimized electrolyte for Mg-air batteries. 展开更多
关键词 Acetic acid additive in NaNO_(3)electrolyte Electrolyte engineering Corrosion surface film Surface characterization Hydrogen evolution
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The morphology of the antennal lobe of Ambrostoma quadriimpressum(Coleoptera:Chrysomelidae) 被引量:1
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作者 Jihua Hu fan sun 《Journal of Forestry Research》 SCIE CAS CSCD 2020年第5期2005-2012,共8页
The structure of the primary olfactory brain center was studied in male and female adult Ambrostoma quadriimpressum by means of a series of histological sections labeled using the reduced-silver-stain technique.The an... The structure of the primary olfactory brain center was studied in male and female adult Ambrostoma quadriimpressum by means of a series of histological sections labeled using the reduced-silver-stain technique.The antennal lobe was elliptical,and the total number of glomeruli was approximately 50 in the antennal lobe in both sexes.There was no sexual dimorphism with respect to the size of the antennal lobe or the number and shape of glomeruli. 展开更多
关键词 OLFACTION GLOMERULI Antennal lobe Leaf beetle
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Potential risks and challenges of climate change in the arid region of northwestern China 被引量:13
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作者 Yaning Chen Xueqi Zhang +4 位作者 Gonghuan fang Zhi Li Fei Wang Jingxiu Qin fan sun 《Regional Sustainability》 2020年第1期20-30,共11页
In the arid region of northwestern China(ARNC),water resources are the most critical factor restricting socioeconomic development and influencing the stability of the area’s ecological systems.The region’s complex w... In the arid region of northwestern China(ARNC),water resources are the most critical factor restricting socioeconomic development and influencing the stability of the area’s ecological systems.The region’s complex water system and unique hydrological cycle show distinctive characteristics.Moreover,the intensified hydrological cycle and extreme climatic and hydrological events resulting from global warming have led to increased uncertainty around water resources as well as heightened conflict between water supply and water demand.All of these factors are exerting growing pressures on the socioeconomic development and vulnerable ecological environment in the region.This research evaluates the impacts of climate change on water resources,hydrological processes,agricultural system,and desert ecosystems in the ARNC,and addresses some associated risks and challenges specific to this area.The temperature is rising at a rate of 0.31C per decade during 1961–2017 and hydrological processes are being significantly influenced by changes in glaciers,snow cover,and precipitation form,especially in the rivers recharged primarily by melt water.Ecosystems are also largely influenced by climate change,with the Normalized Difference Vegetation Index(NDVI)of natural vegetation exhibited an increasing trend prior to 1998,and then reversed in Xinjiang while the Hexi Corridor of Gansu showed the opposite trends.Furthermore,the desert-oasis transition zone showed a reduction in area due to the warming trend and the recent rapid expansion of irrigated area.Both the warming and intensified drought are threatening agriculture security.The present study could shed light on sustainable development in this region under climate change and provides scientific basis to the construction of the“Silk Road Economic Belt”. 展开更多
关键词 Climate change Hydrological processes Desert ecosystem Sustainable development Water resources Arid region of northwestern China Silk Road Economic Belt
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Advances in Researches on Genetic Diversity of Lepidoptera Insects 被引量:1
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作者 Yuting WANG Ruixue LI +2 位作者 fan sun Wei WANG Taichu WANG 《Asian Agricultural Research》 2017年第4期74-76,共3页
This paper reviewed advances in researches on genetic diversity of Lepidoptera insects from chromosome polymorphism,protein polymorphism,and DNA polymorphism,and stated that DNA sequence variation will become main poi... This paper reviewed advances in researches on genetic diversity of Lepidoptera insects from chromosome polymorphism,protein polymorphism,and DNA polymorphism,and stated that DNA sequence variation will become main points of researches about genetic diversity. 展开更多
关键词 Lepidoptera insects Genetic diversity Advances in researches
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TWIP-assisted Zr alloys for medical applications:Design strategy,mechanical properties and first biocompatibility assessment
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作者 Junhui Tang Hongtao Yang +4 位作者 Bingnan Qian Yufeng Zheng Philippe Vermaut Frédéric Prima fan sun 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第17期32-42,共11页
This study proposes a novel strategy for the design of a new family of metastable Zr alloys.These al-loys offer improved mechanical properties for implants,particularly in applications where conventional stainless ste... This study proposes a novel strategy for the design of a new family of metastable Zr alloys.These al-loys offer improved mechanical properties for implants,particularly in applications where conventional stainless steels and Co-Cr alloys are currently used but lack suitability.The design approach is based on the controlled twinning-induced plasticity(TWIP)effect,significantly enhancing the ductility and strain-hardenability of the Zr alloys.In order to draw a“blueprint”for the compositional design of biomedical T WIP(Bio-T WIP)Zr alloys-using only non-toxic elements,the study combines D-electron phase stability calculations(specifically bond order(Bo)and mean d-orbital energy(Md))with a systematic experimental screening of active deformation mechanisms within the Zr-Nb-Sn alloy system.This research aids in ac-curately identifying the TWIP line,which signifies the mechanism shift between TWIP and classic slip as the primary deformation mechanism.To demonstrate the efficacy of the TWIP mechanism in enhancing mechanical properties,Zr-12Nb-2Sn,Zr-13Nb-1Sn,and Zr-14Nb-3Sn alloys are selected.Results indicate that the TWIP mechanism leads to a significant improvement of strain-hardening rate and a uniform elongation of∼20%in Zr-12Nb-2Sn,which displays both{332}<113>mechanical twinning and disloca-tion slip as the primary deformation mechanisms.Conversely,Zr-14Nb-3Sn exhibits the typical mechan-ical properties found in stable body-centered cubic(BCC)alloys,characterized by the sole occurrence of dislocation slip.Cell viability tests confirm the superior biocompatibility of Zr-Nb-based alloys with deformation twins on the surface,in line with existing literature.Based on the whole set of results,a comprehensive design diagram is proposed. 展开更多
关键词 Zr alloys STRAIN-HARDENING Twinning-induced plasticity(TWIP) Bo-Md diagram BIOCOMPATIBILITY Biomedical materials
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Characteristics and influencing factors of frontal upwelling in the Yellow Sea in summer
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作者 fan sun Fei Yu +4 位作者 Guangcheng Si Jianfeng Wang Anqi Xu Jun Pan Ying Tang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2022年第7期84-96,共13页
Frontal upwelling is an important phenomenon in summer in the Yellow Sea(YS)and plays an essential role in the distribution of nutrients and biological species.In this paper,a three-dimensional hydrodynamic model is a... Frontal upwelling is an important phenomenon in summer in the Yellow Sea(YS)and plays an essential role in the distribution of nutrients and biological species.In this paper,a three-dimensional hydrodynamic model is applied to investigate the characteristics and influencing factors of frontal upwelling in the YS.The results show that the strength and distribution of frontal upwelling are largely dependent on the topography and bottom temperature fronts.The frontal upwelling in the YS is stronger and narrower near the eastern coast than near the western coast due to the steeper shelf slope.Moreover,external forcings,such as the meridional wind speed and air temperature in summer and the air temperature in the preceding winter and spring,have certain influences on the strength of frontal upwelling.An increase in air temperature in the previous winter and spring weakens the frontal upwelling in summer;in contrast,an increase in air temperature in summer strengthens the frontal upwelling.When the southerly wind in summer increases,the upwelling intensifies in the western YS and weakens in the eastern YS.The air temperature influences the strength of upwelling by changing the baroclinicity in the frontal region.Furthermore,the meridional wind speed in summer affects frontal upwelling via Ekman pumping. 展开更多
关键词 influencing factors Yellow Sea frontal upwelling bottom temperature fronts numerical study
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