The Wide Field Survey Telescope(WFST)is located at 4200 m on Saishiteng Mountain in Lenghu,Qinghai Province,China.It features a primary mirror with a diameter of 2.5 m and a camera equipped with nine CCDs,providing a ...The Wide Field Survey Telescope(WFST)is located at 4200 m on Saishiteng Mountain in Lenghu,Qinghai Province,China.It features a primary mirror with a diameter of 2.5 m and a camera equipped with nine CCDs,providing a wide field of view of approximately 3×3 square degrees.Calibration parameters are essential to ensure the precision of astrometric observations with the WFST.These parameters are derived from geometric distortion(GD)and gaps through astrometric modeling and are subsequently validated via the Yao’An High Precision Telescope(YAHPT).The GD solutions show maximum distortions between 1.18 and 10.29 pixels for the WFST chips,with central chips exhibiting lower distortion.After applying the GD correction,the precision of the WFST reaches 4 mas.The interchip gaps of the WFST range from 1.922 mm to 7.765 mm,corresponding to 10μm/pixel,aligning with the design and measurements.The calibrated parameters guarantee that the WFST can perform highly accurate astrometric measurements.Furthermore,as the WFST undergoes updates,the parameter model remains consistently applicable.展开更多
Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate met...Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate metabolism and its receptor,hydroxycarboxylic acid receptor 1(HCAR1),in ferroptosis regulation in gastric cancer(GC)remains poorly understood.Focusing specifically on its effects on cell proliferation,ferroptosis regulation,and the disruption of lactate-mediatedmetabolic pathways,the study aimed to clarify the role ofHCAR1 in GC progression.Methods:Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC.Receiver operating characteristic(ROC)curves were generated to assess the diagnostic potential of the predictive genes.The biological role of HCAR1 was investigated through gain and loss-of-function experiments in GC cell lines,followed by assessments of cell viability,oxidative stress indicators,gene/protein expression,and ferroptosis sensitivity under lactate stimulation or HCAR1modulation.Results:HCAR1 was significantly upregulated in GC tissues and linked to poor patient outcomes.Silencing HCAR1 inhibited GC cell growth and induced ferroptosis,as shown by increased levels of reactive oxygen species(ROS)and malondialdehyde(MDA),along with decreased expression of solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).Conversely,HCAR1 overexpression or exposure to extracellular lactate inhibited ferroptosis and activated antioxidant defenses.Mechanistically,lactate activation of HCAR1 increases ATP levels,which in turn inactivates AMP-activated protein kinase(AMPK).It also upregulates stearoyl-CoA desaturase 1(SCD1)through the sterol regulatory element binding protein 1(SREBP1)signaling pathway.Blocking HCAR1 reversed these effects and restored ferroptosis sensitivity.Conclusion:HCAR1 mediates lactate-driven ferroptosis resistance in GC through the AMPK-SCD1 signaling pathway.Targeting the HCAR1-lactate axis may offer a promising strategy for overcoming metabolic adaptation and improving GC treatment outcomes.展开更多
BACKGROUND In recent years,the rapid development of artificial intelligence(AI)in hepatobiliary surgery research has led to an increase in articles exploring its benefits.We performed a bibliometric analysis of AI app...BACKGROUND In recent years,the rapid development of artificial intelligence(AI)in hepatobiliary surgery research has led to an increase in articles exploring its benefits.We performed a bibliometric analysis of AI applications in hepatobiliary surgery to better delineate the contemporary state of AI application in hepatobiliary surgery and potential future trajectories.AIM To provide clinical practitioners with a reliable reference point.It offers a detailed overview of the development of AI in hepatobiliary surgery by systematically examining the contributions of authors,countries,institutions,journals,and keywords in this domain over the last 10 years.METHODS The academic resources utilized in this study were obtained from the Web of Science Core Collection database.The search results were subsequently integrated and imported into CiteSpace and VOSviewer software for the purpose of visual analysis.RESULTS The study analyzed 2552 publications during 2014–2024.These publications collectively garnered 32628 citations,averaging 15.66 citations per paper.The top contributor to this field was China.The USA had the highest citation count.The author with the highest citation count was Summers RM.In terms of the number of articles published,the leading journals were Medical Physics.Excluding the subject search terms,the most frequently used keywords included“classification”,“CT and“diagnosis”.CONCLUSION This bibliometric analysis indicates that research on AI in hepatobiliary surgery has entered a period of rapid development,particularly in the domain of disease imaging diagnostics.展开更多
Objective:To investigate the application effects of intelligent guidance systems in optimizing health check-up process management.Methods:A total of 400 examinees who underwent physical examinations at the hospital’s...Objective:To investigate the application effects of intelligent guidance systems in optimizing health check-up process management.Methods:A total of 400 examinees who underwent physical examinations at the hospital’s Health Management Center from January to December 2024 were randomly divided into a control group(200 cases)and an observation group(200 cases).The control group used traditional manual guidance methods,while the observation group employed the intelligent guidance system.The study compared two groups in terms of completion time,waiting time for each procedure,check-up efficiency scores,examinee satisfaction,and report issuance time.Results:The overall examination time in the observation group(85.3±12.7 minutes)was significantly shorter than that in the control group(142.6±18.5 minutes)(P<0.01);average waiting time per procedure decreased by 62.4%;check-up efficiency scores(8.9±0.8 points)were significantly higher than those in the control group(5.2±1.1 points)(P<0.01);satisfaction reached 96.5%,significantly higher than the control group’s 78.0%(P<0.01);and report issuance time was advanced by 1.5 days.Conclusion:Intelligent guidance systems can significantly optimize check-up processes,improve work efficiency,and examinee satisfaction,demonstrating significant clinical application value.展开更多
Regional turbofan aircraft,which are used for medium-short distances,have a heightened risk of high-altitude Wake Vortices(VV)because of their tail-mounted engines and high horizontal tail configurations.For some regi...Regional turbofan aircraft,which are used for medium-short distances,have a heightened risk of high-altitude Wake Vortices(VV)because of their tail-mounted engines and high horizontal tail configurations.For some regional medium-short-range turbofan aircraft,this threat is higher than that for conventionally designed aircraft.To analyze the flight safety of turbofan aircraft during cruise,this study developed a model to assess wake vortex encounters based on evolutionary high-altitude wake flow patterns.First,the high-altitude wake vortex aircraft dissipation patterns were analyzed by combining Quick Access Recorder(QAR)flight data with the wake vortex evolution model.Then,to consider the uniqueness of the medium-short-range turbofan aircraft,the severity of the wake vortex encounters was simulated using an induced roll moment coefficient.The proposed high-altitude wake vortex encounter model was able to identify and assess the highaltitude wake vortex changes,the bearing moments at different altitudes,and the atmospheric pressure conditions.Using the latest wake separation standards from the International Civil Aviation Organization(ICAO),acceptable safety wake intervals for follower aircraft in different scenarios were determined for the safety assessment.The results indicate that compared to mid and low altitudes,the high-altitude aircraft wake vortex dissipation rate is faster,the ultimate bearing moment is weaker,and the roll moment coefficient is higher,which confirm that there is elevated wake vortex encounter severity for regional turbofan aircraft.As safety is found to deteriorate when encountering wake vortices at altitudes higher than 8 km,new medium-short-range turbofan regional aircraft require higher safety margins than the latest wake separation standards.展开更多
Glial fibrillary acidic protein(GFAP)is one of the discriminative biomarkers for diagnosing traumatic brain injury(TBI),and accurate determination of GFAP is clinically significant.In this study,a novel fluorescence i...Glial fibrillary acidic protein(GFAP)is one of the discriminative biomarkers for diagnosing traumatic brain injury(TBI),and accurate determination of GFAP is clinically significant.In this study,a novel fluorescence immunoassay system was designed.We encapsulated carbon dots with a high fluorescence quantum yield(QY=92.5%)inside silicon nanocapsules to serve as fluorescent markers.These markers were then integrated with the streptavidin(SA)-biotin biomagnification system and immunomagnetic separation technology for the sensitive detection of GFAP.Based on the signal cascade amplification effect of the silicon nanocapsules and SA-biotin,the fluorescence signal of the SA-biotin-modified immunofluorescence nanocapsules increased 3.6-fold compared to the carbon dot-based immunoprobe.The fluorescence immunoassay system was constructed for GFAP using SA-biotin-modified immunocapsules as the sensing probe and immunomagnetic nanoparticles as the immunorecognition probe.The fluorescence immunoassay system can specifically and ultra-sensitively quantify GFAP in blood samples,with a detection range of 10 pg/mL–10 ng/mL and detection limits of 3.2 pg/mL(serum)and 3.6 pg/mL(plasma).Moreover,the fluorescence immunoassay system exhibited prominent recoveries of 99.4%–100.4%(phosphate buffered saline),96%–102.6%(serum),and 93.2%–110.2%(plasma),with favorable specificity and excellent stabilization.The novel fluorescence immunoassay system provides a new approach to the clinical analysis of GFAP and may serve as a potential tool for screening and diagnosing TBI.展开更多
The adsorption of pollutants can not only promote the direct surface reaction,but also modify the catalyst itself to improve its photoelectric characteristics,which is rarely studied for water treatment with inorganic...The adsorption of pollutants can not only promote the direct surface reaction,but also modify the catalyst itself to improve its photoelectric characteristics,which is rarely studied for water treatment with inorganic photocatalyst.A highly crystalline BiOBr(c-BiOBr)was synthesized by a two-step preparation process.Owing to the calcination,the highly crystalline enhanced the interface interaction between pollutant and c-BiOBr.The complex of organic pollutant and[Bi_(2)O_(2)]^(2+)could promote the active electron transfer from the adsorbed pollutant to c-BiOBr for the direct pollutant degradation by holes(h^(+)).Moreover,the pollutant adsorption actually modified c-BiOBr and promoted more unpaired electrons,which would coupling with the photoexcitation to promote generate more O_(2)^(•-).The molecular modification effect derived from pollutant adsorption significantly improved the removal of pollutants.This work strongly deepens the understanding of the molecularmodification effect from the pollutant adsorption and develops a novel and efficient approach for water treatment.展开更多
Objective:To investigate the impact of programmed harmonious nursing combined with hierarchical management on nursing quality and satisfaction in a health management center.Methods:A total of 100 patients who received...Objective:To investigate the impact of programmed harmonious nursing combined with hierarchical management on nursing quality and satisfaction in a health management center.Methods:A total of 100 patients who received care at this health management center from January 2024 to January 2025 were selected as subjects.Using a random number table method,they were divided into an observation group(n=50)and a control group(n=50).The control group followed traditional methods,while the observation group integrated programmed harmonious nursing with hierarchical management.Comparative analysis was conducted on nursing quality scores,adverse event occurrence rates,and patient satisfaction between the two groups.Results:The observation group showed significantly improved nursing quality scores(P<0.05)and markedly reduced incidence of adverse events(P<0.05),with statistically significant differences compared to pre-treatment conditions(P<0.05).Conclusion:The combination of hierarchical management and programmed harmonious nursing demonstrates effectiveness in enhancing medical service quality,reducing adverse reactions,and improving patient satisfaction—a method worthy of promotion.展开更多
Fermentation substrates of rice with different milling degrees(MDs) were prepared and fermented with human feces to compare their fermentation properties and effects on gut microbiota.MD 0s,MD 5s and MD 60s represente...Fermentation substrates of rice with different milling degrees(MDs) were prepared and fermented with human feces to compare their fermentation properties and effects on gut microbiota.MD 0s,MD 5s and MD 60s represented brown rice,moderately-milled rice and white rice,respectively.After in vitro fermentation,the MD 5s group showed higher starch utilization,compared with the MD 0s and 60s groups evaluated by Fourier transform infrared spectrometer,and confocal laser scanning microscope.Effects of fermentation substrates of rice with different MDs on gut microbiota were evaluated by 16S rDNA sequencing.All the sample groups reduced the pH and produced short-chain fatty acids(SCFAs) and branched-chain fatty acids.The MD 5s group exhibited higher α-diversity than the MD 0s and 60s groups.Abundances of Phascolarctobacterium,Blautia and norank_f_Ruminococcaceae were higher in the MD 0s and 5s groups,compared with the MD 60s group.These bacteria were also positively correlated with the SCFAs production via Spearman correlation analysis.In vitro culture assay revealed that fermentation substrates of MD 0s and 5s promoted the growth of two probiotics(Akkermansia muciniphila and Bifidobacterium adolescentis).Our results showed that moderate milling might be an appropriate way to produce rice products with richer nutrients and better fermentation properties.展开更多
Solid polymer electrolytes(SPEs)have become increasingly important in advanced lithium-ion batteries(LIBs)due to their improved safety and mechanical properties compared to organic liquid electrolytes.Cross-linked pol...Solid polymer electrolytes(SPEs)have become increasingly important in advanced lithium-ion batteries(LIBs)due to their improved safety and mechanical properties compared to organic liquid electrolytes.Cross-linked polymers have the potential to further improve the mechanical property without trading off Li-ion conductivity.In this study,focusing on a recently developed cross-linked SPE,i.e.,the one based on poly(vinylene carbonate)-poly(ethylene oxide)cross-linked network(PVCN),we used solid-state nuclear magnetic resonance(NMR)techniques to investigate the fundamental interaction between the chain segments and Li ions,as well as the lithium-ion motion.By utilizing homonuclear/heteronuclear correlation,CP(cross-polarization)kinetics,and spin-lattice relaxation experiments,etc.,we revealed the structural characteristics and their relations to lithium-ion mobilities.It is found that the network formation prevents poly(ethylene oxide)chains from crystallization,which could create sufficient space for segmental tumbling and Li-ion co nductio n.As such,the mechanical property is greatly improved with even higher Li-ion mobilities compared to the poly(vinylene carbonate)or poly(ethylene oxide)based SPE analogues.展开更多
Fusarium head blight(FHB),mainly caused by the fungal pathogen Fusarium graminearum,is one of the most destructive wheat diseases.Besides directly affecting the yield,the mycotoxin residing in the kernel greatly threa...Fusarium head blight(FHB),mainly caused by the fungal pathogen Fusarium graminearum,is one of the most destructive wheat diseases.Besides directly affecting the yield,the mycotoxin residing in the kernel greatly threatens the health of humans and livestock.Xinong 979(XN979)is a widely cultivated wheat elite with high yield and FHB resistance.However,its resistance mechanism remains unclear.In this study,we studied the expression of genes involved in plant defense in XN979 by comparative transcriptomics.We found that the FHB resistance in XN979 consists of two lines of defense.The first line of defense,which is constitutive,is knitted via the enhanced basal expression of lignin and jasmonic acid(JA)biosynthesis genes.The second line of defense,which is induced upon F.graminearum infection,is contributed by the limited suppression of photosynthesis and the struggle of biotic stress-responding genes.Meanwhile,the effective defense in XN979 leads to an inhibition of fungal gene expression,especially in the early infection stage.The formation of the FHB resistance in XN979 may coincide with the breeding strategies,such as selecting high grain yield and lodging resistance traits.This study will facilitate our understanding of wheat-F.graminearum interaction and is insightful for breeding FHB-resistant wheat.展开更多
High energy consumption has seriously hindered the development of Fenton-like reactions for the removal of refractory organic pollutants in water.To solve this problem,we designed a novel Fenton-like catalyst(Cu-PAN3)...High energy consumption has seriously hindered the development of Fenton-like reactions for the removal of refractory organic pollutants in water.To solve this problem,we designed a novel Fenton-like catalyst(Cu-PAN3)by coprecipitation and carbon thermal reduction.The catalyst exhibits excellent Fenton-like catalytic activity and stability for the degradation of various pollutants with low H_(2)O_(2)consumption.The experimental results indicate that the dual reaction centers(DRCs)are composed of Cu-N-C and Cu-O-C bridges between copper and graphene-like carbon,which form electron-poor/rich centers on the catalyst surface.H_(2)O_(2)is mainly reduced at electron-rich Cu centers to free radicals for pollutant degradation.Meanwhile,pollutants can be oxidized by donating electrons to the electron-poor C centers of the catalyst,which inhibits the ineffective decomposition of H_(2)O_(2)at the electron-poor centers.This therefore significantly reduces the consumption of H_(2)O_(2)and reduces energy consumption.展开更多
Layered rare-earth hydroxides(LREHs) draw wide research interest because of their peculiar crystal structure,rich interlayer chemistry and abundant functionality of the RE element,but are limited to the two categories...Layered rare-earth hydroxides(LREHs) draw wide research interest because of their peculiar crystal structure,rich interlayer chemistry and abundant functionality of the RE element,but are limited to the two categories of RE_(2)(OH)_(5)A·nH_(2)O(A:typical of Cl^(-)or NO_(3)^(-)) and RE_(2)(OH)_(4)SO_(4)·nH_(2)O.On the other hand,rare-earth oxysulfates(RE_(2)O_(2)SO_(4)) have attracted attention due to their properties of large-capacity oxygen storage,low-temperature magnetism and luminescence,but their preparation procedure mostly involves toxic SO_(x) gases and/or complicated procedures.In this work,RE_(2)(OH)_(2)CO_(3)SO_(4)·nH_(2)O as a new family of LREHs(RE=Gd-Lu lanthanides and Y) were produced via hydrothermal reaction,from which phase-pure RE_(2)O_(2)SO_(4) was derived via subsequent annealing at 800℃ in air without the involvement of SO_(x),The compounds were thoroughly characterized to reveal the intrinsic influence of lanthanide contraction(RE^(3+) radius) on crystal structure,thermal behavior(dehydroxylation/decarbonation/desulfurization),vibrational property and crystallite morphology.Through analyzing the photoluminescence of Eu^(3+) and Sm^(3+)in the Gd_(2)O_(2)SO_(4) typical host it is found that the 617 nm(Eu^(3+),λ_(ex)=275 nm) and 608 nm(Sm^(3+),λ_(ex)=407 nm) main emissions can retain as high as ^(7)9.6% and 85.5%of their room-temperature intensities at 423 K,with activation energies of ~0.19 and 0.21 eV for thermal quenching,respectively.Application also indicates that both the phosphors have the potential for optical temperature sensing via the fluorescence intensity ratio(FIR) technology,whose maximum relative sensitivity reaches -2.70%/K for Eu^(3+)and 1.73%/K for Sm^(3+) at 298 K.展开更多
Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains unknown.We searched for G5 JEV-infected cases a...Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains unknown.We searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of China.Methods In this study,we collected serum specimens from patients with JE in three coastal provinces of China(Guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and G5.Results Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and Guangdong(77 patients),China,from 2018 to 2020.Seventy of the 361 serum specimens were laboratory-confirmed to be infected with JEV.Two cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 JEV.Conclusion G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.展开更多
Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,w...Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,we propose Rail-PillarNet,a three-dimensional(3D)LIDAR(Light Detection and Ranging)railway foreign object detection method based on the improvement of PointPillars.Firstly,the parallel attention pillar encoder(PAPE)is designed to fully extract the features of the pillars and alleviate the problem of local fine-grained information loss in PointPillars pillars encoder.Secondly,a fine backbone network is designed to improve the feature extraction capability of the network by combining the coding characteristics of LIDAR point cloud feature and residual structure.Finally,the initial weight parameters of the model were optimised by the transfer learning training method to further improve accuracy.The experimental results on the OSDaR23 dataset show that the average accuracy of Rail-PillarNet reaches 58.51%,which is higher than most mainstream models,and the number of parameters is 5.49 M.Compared with PointPillars,the accuracy of each target is improved by 10.94%,3.53%,16.96%and 19.90%,respectively,and the number of parameters only increases by 0.64M,which achieves a balance between the number of parameters and accuracy.展开更多
0 INTRODUCTION Due to the ability to comprehensively utilize P and S wave information,multi-component seismic exploration has already played an important role in fracture detection,lithology prediction,fluid identific...0 INTRODUCTION Due to the ability to comprehensively utilize P and S wave information,multi-component seismic exploration has already played an important role in fracture detection,lithology prediction,fluid identification,etc.,and it has also become an important technology for complex reservoir exploration(Yuan et al.,2021;Stewart et al.,2003).展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA0350300)the National Natural Science Foundation of China(12203105,12103091,62394351,12073008)the China Manned Space Project(CMS-CSST-2021-A12,CMS-CSST-2021-B10).
文摘The Wide Field Survey Telescope(WFST)is located at 4200 m on Saishiteng Mountain in Lenghu,Qinghai Province,China.It features a primary mirror with a diameter of 2.5 m and a camera equipped with nine CCDs,providing a wide field of view of approximately 3×3 square degrees.Calibration parameters are essential to ensure the precision of astrometric observations with the WFST.These parameters are derived from geometric distortion(GD)and gaps through astrometric modeling and are subsequently validated via the Yao’An High Precision Telescope(YAHPT).The GD solutions show maximum distortions between 1.18 and 10.29 pixels for the WFST chips,with central chips exhibiting lower distortion.After applying the GD correction,the precision of the WFST reaches 4 mas.The interchip gaps of the WFST range from 1.922 mm to 7.765 mm,corresponding to 10μm/pixel,aligning with the design and measurements.The calibrated parameters guarantee that the WFST can perform highly accurate astrometric measurements.Furthermore,as the WFST undergoes updates,the parameter model remains consistently applicable.
文摘Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate metabolism and its receptor,hydroxycarboxylic acid receptor 1(HCAR1),in ferroptosis regulation in gastric cancer(GC)remains poorly understood.Focusing specifically on its effects on cell proliferation,ferroptosis regulation,and the disruption of lactate-mediatedmetabolic pathways,the study aimed to clarify the role ofHCAR1 in GC progression.Methods:Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC.Receiver operating characteristic(ROC)curves were generated to assess the diagnostic potential of the predictive genes.The biological role of HCAR1 was investigated through gain and loss-of-function experiments in GC cell lines,followed by assessments of cell viability,oxidative stress indicators,gene/protein expression,and ferroptosis sensitivity under lactate stimulation or HCAR1modulation.Results:HCAR1 was significantly upregulated in GC tissues and linked to poor patient outcomes.Silencing HCAR1 inhibited GC cell growth and induced ferroptosis,as shown by increased levels of reactive oxygen species(ROS)and malondialdehyde(MDA),along with decreased expression of solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).Conversely,HCAR1 overexpression or exposure to extracellular lactate inhibited ferroptosis and activated antioxidant defenses.Mechanistically,lactate activation of HCAR1 increases ATP levels,which in turn inactivates AMP-activated protein kinase(AMPK).It also upregulates stearoyl-CoA desaturase 1(SCD1)through the sterol regulatory element binding protein 1(SREBP1)signaling pathway.Blocking HCAR1 reversed these effects and restored ferroptosis sensitivity.Conclusion:HCAR1 mediates lactate-driven ferroptosis resistance in GC through the AMPK-SCD1 signaling pathway.Targeting the HCAR1-lactate axis may offer a promising strategy for overcoming metabolic adaptation and improving GC treatment outcomes.
基金Supported by the National Key Research and Development Program of China,No.2023YFC3605202Project of the Central Government in Guidance of Local Science and Technology Development,No.2024ZYD0270and Luzhou Science and Technology Bureau,No.2024SYF156.
文摘BACKGROUND In recent years,the rapid development of artificial intelligence(AI)in hepatobiliary surgery research has led to an increase in articles exploring its benefits.We performed a bibliometric analysis of AI applications in hepatobiliary surgery to better delineate the contemporary state of AI application in hepatobiliary surgery and potential future trajectories.AIM To provide clinical practitioners with a reliable reference point.It offers a detailed overview of the development of AI in hepatobiliary surgery by systematically examining the contributions of authors,countries,institutions,journals,and keywords in this domain over the last 10 years.METHODS The academic resources utilized in this study were obtained from the Web of Science Core Collection database.The search results were subsequently integrated and imported into CiteSpace and VOSviewer software for the purpose of visual analysis.RESULTS The study analyzed 2552 publications during 2014–2024.These publications collectively garnered 32628 citations,averaging 15.66 citations per paper.The top contributor to this field was China.The USA had the highest citation count.The author with the highest citation count was Summers RM.In terms of the number of articles published,the leading journals were Medical Physics.Excluding the subject search terms,the most frequently used keywords included“classification”,“CT and“diagnosis”.CONCLUSION This bibliometric analysis indicates that research on AI in hepatobiliary surgery has entered a period of rapid development,particularly in the domain of disease imaging diagnostics.
文摘Objective:To investigate the application effects of intelligent guidance systems in optimizing health check-up process management.Methods:A total of 400 examinees who underwent physical examinations at the hospital’s Health Management Center from January to December 2024 were randomly divided into a control group(200 cases)and an observation group(200 cases).The control group used traditional manual guidance methods,while the observation group employed the intelligent guidance system.The study compared two groups in terms of completion time,waiting time for each procedure,check-up efficiency scores,examinee satisfaction,and report issuance time.Results:The overall examination time in the observation group(85.3±12.7 minutes)was significantly shorter than that in the control group(142.6±18.5 minutes)(P<0.01);average waiting time per procedure decreased by 62.4%;check-up efficiency scores(8.9±0.8 points)were significantly higher than those in the control group(5.2±1.1 points)(P<0.01);satisfaction reached 96.5%,significantly higher than the control group’s 78.0%(P<0.01);and report issuance time was advanced by 1.5 days.Conclusion:Intelligent guidance systems can significantly optimize check-up processes,improve work efficiency,and examinee satisfaction,demonstrating significant clinical application value.
基金supported by the National Natural Science Foundation of China(Nos.U2333209,U1733203)the National Key R&D Program of China(No.2021YFF0603904)the Civil Aviation Administration of China(No.AQ20200019)。
文摘Regional turbofan aircraft,which are used for medium-short distances,have a heightened risk of high-altitude Wake Vortices(VV)because of their tail-mounted engines and high horizontal tail configurations.For some regional medium-short-range turbofan aircraft,this threat is higher than that for conventionally designed aircraft.To analyze the flight safety of turbofan aircraft during cruise,this study developed a model to assess wake vortex encounters based on evolutionary high-altitude wake flow patterns.First,the high-altitude wake vortex aircraft dissipation patterns were analyzed by combining Quick Access Recorder(QAR)flight data with the wake vortex evolution model.Then,to consider the uniqueness of the medium-short-range turbofan aircraft,the severity of the wake vortex encounters was simulated using an induced roll moment coefficient.The proposed high-altitude wake vortex encounter model was able to identify and assess the highaltitude wake vortex changes,the bearing moments at different altitudes,and the atmospheric pressure conditions.Using the latest wake separation standards from the International Civil Aviation Organization(ICAO),acceptable safety wake intervals for follower aircraft in different scenarios were determined for the safety assessment.The results indicate that compared to mid and low altitudes,the high-altitude aircraft wake vortex dissipation rate is faster,the ultimate bearing moment is weaker,and the roll moment coefficient is higher,which confirm that there is elevated wake vortex encounter severity for regional turbofan aircraft.As safety is found to deteriorate when encountering wake vortices at altitudes higher than 8 km,new medium-short-range turbofan regional aircraft require higher safety margins than the latest wake separation standards.
基金supported by the AMS Funding Project(No.ZZB2023C7010).
文摘Glial fibrillary acidic protein(GFAP)is one of the discriminative biomarkers for diagnosing traumatic brain injury(TBI),and accurate determination of GFAP is clinically significant.In this study,a novel fluorescence immunoassay system was designed.We encapsulated carbon dots with a high fluorescence quantum yield(QY=92.5%)inside silicon nanocapsules to serve as fluorescent markers.These markers were then integrated with the streptavidin(SA)-biotin biomagnification system and immunomagnetic separation technology for the sensitive detection of GFAP.Based on the signal cascade amplification effect of the silicon nanocapsules and SA-biotin,the fluorescence signal of the SA-biotin-modified immunofluorescence nanocapsules increased 3.6-fold compared to the carbon dot-based immunoprobe.The fluorescence immunoassay system was constructed for GFAP using SA-biotin-modified immunocapsules as the sensing probe and immunomagnetic nanoparticles as the immunorecognition probe.The fluorescence immunoassay system can specifically and ultra-sensitively quantify GFAP in blood samples,with a detection range of 10 pg/mL–10 ng/mL and detection limits of 3.2 pg/mL(serum)and 3.6 pg/mL(plasma).Moreover,the fluorescence immunoassay system exhibited prominent recoveries of 99.4%–100.4%(phosphate buffered saline),96%–102.6%(serum),and 93.2%–110.2%(plasma),with favorable specificity and excellent stabilization.The novel fluorescence immunoassay system provides a new approach to the clinical analysis of GFAP and may serve as a potential tool for screening and diagnosing TBI.
基金supported by National Natural Science Foundation of China (Nos.52100032,51838005)Shandong Province Postdoctoral Program for Innovative Talent Support Plan (No.SDBX2022003)the Introduced Innovative R&D Team Project under the“The Pearl River Talent Recruitment Program”of Guangdong Province (2019ZT08L387).
文摘The adsorption of pollutants can not only promote the direct surface reaction,but also modify the catalyst itself to improve its photoelectric characteristics,which is rarely studied for water treatment with inorganic photocatalyst.A highly crystalline BiOBr(c-BiOBr)was synthesized by a two-step preparation process.Owing to the calcination,the highly crystalline enhanced the interface interaction between pollutant and c-BiOBr.The complex of organic pollutant and[Bi_(2)O_(2)]^(2+)could promote the active electron transfer from the adsorbed pollutant to c-BiOBr for the direct pollutant degradation by holes(h^(+)).Moreover,the pollutant adsorption actually modified c-BiOBr and promoted more unpaired electrons,which would coupling with the photoexcitation to promote generate more O_(2)^(•-).The molecular modification effect derived from pollutant adsorption significantly improved the removal of pollutants.This work strongly deepens the understanding of the molecularmodification effect from the pollutant adsorption and develops a novel and efficient approach for water treatment.
文摘Objective:To investigate the impact of programmed harmonious nursing combined with hierarchical management on nursing quality and satisfaction in a health management center.Methods:A total of 100 patients who received care at this health management center from January 2024 to January 2025 were selected as subjects.Using a random number table method,they were divided into an observation group(n=50)and a control group(n=50).The control group followed traditional methods,while the observation group integrated programmed harmonious nursing with hierarchical management.Comparative analysis was conducted on nursing quality scores,adverse event occurrence rates,and patient satisfaction between the two groups.Results:The observation group showed significantly improved nursing quality scores(P<0.05)and markedly reduced incidence of adverse events(P<0.05),with statistically significant differences compared to pre-treatment conditions(P<0.05).Conclusion:The combination of hierarchical management and programmed harmonious nursing demonstrates effectiveness in enhancing medical service quality,reducing adverse reactions,and improving patient satisfaction—a method worthy of promotion.
基金supported by the National Natural Science Foundation of China (32202051)the Shanghai Sailing Program (21YF1431800, 20YF1433400)+1 种基金Shanghai Agriculture Applied Technology Development Program, China (2021-02-08-0012-F00780 )the National Key R&D Program of China (2022YFF1100104, 2023YFF1103404)。
文摘Fermentation substrates of rice with different milling degrees(MDs) were prepared and fermented with human feces to compare their fermentation properties and effects on gut microbiota.MD 0s,MD 5s and MD 60s represented brown rice,moderately-milled rice and white rice,respectively.After in vitro fermentation,the MD 5s group showed higher starch utilization,compared with the MD 0s and 60s groups evaluated by Fourier transform infrared spectrometer,and confocal laser scanning microscope.Effects of fermentation substrates of rice with different MDs on gut microbiota were evaluated by 16S rDNA sequencing.All the sample groups reduced the pH and produced short-chain fatty acids(SCFAs) and branched-chain fatty acids.The MD 5s group exhibited higher α-diversity than the MD 0s and 60s groups.Abundances of Phascolarctobacterium,Blautia and norank_f_Ruminococcaceae were higher in the MD 0s and 5s groups,compared with the MD 60s group.These bacteria were also positively correlated with the SCFAs production via Spearman correlation analysis.In vitro culture assay revealed that fermentation substrates of MD 0s and 5s promoted the growth of two probiotics(Akkermansia muciniphila and Bifidobacterium adolescentis).Our results showed that moderate milling might be an appropriate way to produce rice products with richer nutrients and better fermentation properties.
基金financially supported by the National Natural Science Foundation of China(Grant No.22325405,22321002,22279153)Liaoning Revitalization Talents Program(XLYC1807207,XLYC2203134)DICP I202104。
文摘Solid polymer electrolytes(SPEs)have become increasingly important in advanced lithium-ion batteries(LIBs)due to their improved safety and mechanical properties compared to organic liquid electrolytes.Cross-linked polymers have the potential to further improve the mechanical property without trading off Li-ion conductivity.In this study,focusing on a recently developed cross-linked SPE,i.e.,the one based on poly(vinylene carbonate)-poly(ethylene oxide)cross-linked network(PVCN),we used solid-state nuclear magnetic resonance(NMR)techniques to investigate the fundamental interaction between the chain segments and Li ions,as well as the lithium-ion motion.By utilizing homonuclear/heteronuclear correlation,CP(cross-polarization)kinetics,and spin-lattice relaxation experiments,etc.,we revealed the structural characteristics and their relations to lithium-ion mobilities.It is found that the network formation prevents poly(ethylene oxide)chains from crystallization,which could create sufficient space for segmental tumbling and Li-ion co nductio n.As such,the mechanical property is greatly improved with even higher Li-ion mobilities compared to the poly(vinylene carbonate)or poly(ethylene oxide)based SPE analogues.
基金This work was supported by the grants from the National Key R&D Program of China(2022YFD1400100)the National Natural Science Foundation of China(32072505 and 31701747)+1 种基金the Chinese Universities Scientific Fund(2452020222)the National Innovation and Entrepreneurship Training Program for College Students China(202110712255)。
文摘Fusarium head blight(FHB),mainly caused by the fungal pathogen Fusarium graminearum,is one of the most destructive wheat diseases.Besides directly affecting the yield,the mycotoxin residing in the kernel greatly threatens the health of humans and livestock.Xinong 979(XN979)is a widely cultivated wheat elite with high yield and FHB resistance.However,its resistance mechanism remains unclear.In this study,we studied the expression of genes involved in plant defense in XN979 by comparative transcriptomics.We found that the FHB resistance in XN979 consists of two lines of defense.The first line of defense,which is constitutive,is knitted via the enhanced basal expression of lignin and jasmonic acid(JA)biosynthesis genes.The second line of defense,which is induced upon F.graminearum infection,is contributed by the limited suppression of photosynthesis and the struggle of biotic stress-responding genes.Meanwhile,the effective defense in XN979 leads to an inhibition of fungal gene expression,especially in the early infection stage.The formation of the FHB resistance in XN979 may coincide with the breeding strategies,such as selecting high grain yield and lodging resistance traits.This study will facilitate our understanding of wheat-F.graminearum interaction and is insightful for breeding FHB-resistant wheat.
基金supported by the National Natural Science Foundation of China(Nos.52150056,51838005,and 52100032)the Introduced Innovative R&D Team Project under the“Pearl River Talent Recruitment Program”of Guangdong Province(No.2019ZT08L387)+1 种基金the Special Basic Research Fund for Central Public Research Institutes of China(No.PMzx703-202204-152)the support from the BL14W1 beamline of Shanghai Synchrotron Radiation Facility(SSRF,China)。
文摘High energy consumption has seriously hindered the development of Fenton-like reactions for the removal of refractory organic pollutants in water.To solve this problem,we designed a novel Fenton-like catalyst(Cu-PAN3)by coprecipitation and carbon thermal reduction.The catalyst exhibits excellent Fenton-like catalytic activity and stability for the degradation of various pollutants with low H_(2)O_(2)consumption.The experimental results indicate that the dual reaction centers(DRCs)are composed of Cu-N-C and Cu-O-C bridges between copper and graphene-like carbon,which form electron-poor/rich centers on the catalyst surface.H_(2)O_(2)is mainly reduced at electron-rich Cu centers to free radicals for pollutant degradation.Meanwhile,pollutants can be oxidized by donating electrons to the electron-poor C centers of the catalyst,which inhibits the ineffective decomposition of H_(2)O_(2)at the electron-poor centers.This therefore significantly reduces the consumption of H_(2)O_(2)and reduces energy consumption.
基金supported in part by the National Natural Science Foundation of China (52172112,51972047)。
文摘Layered rare-earth hydroxides(LREHs) draw wide research interest because of their peculiar crystal structure,rich interlayer chemistry and abundant functionality of the RE element,but are limited to the two categories of RE_(2)(OH)_(5)A·nH_(2)O(A:typical of Cl^(-)or NO_(3)^(-)) and RE_(2)(OH)_(4)SO_(4)·nH_(2)O.On the other hand,rare-earth oxysulfates(RE_(2)O_(2)SO_(4)) have attracted attention due to their properties of large-capacity oxygen storage,low-temperature magnetism and luminescence,but their preparation procedure mostly involves toxic SO_(x) gases and/or complicated procedures.In this work,RE_(2)(OH)_(2)CO_(3)SO_(4)·nH_(2)O as a new family of LREHs(RE=Gd-Lu lanthanides and Y) were produced via hydrothermal reaction,from which phase-pure RE_(2)O_(2)SO_(4) was derived via subsequent annealing at 800℃ in air without the involvement of SO_(x),The compounds were thoroughly characterized to reveal the intrinsic influence of lanthanide contraction(RE^(3+) radius) on crystal structure,thermal behavior(dehydroxylation/decarbonation/desulfurization),vibrational property and crystallite morphology.Through analyzing the photoluminescence of Eu^(3+) and Sm^(3+)in the Gd_(2)O_(2)SO_(4) typical host it is found that the 617 nm(Eu^(3+),λ_(ex)=275 nm) and 608 nm(Sm^(3+),λ_(ex)=407 nm) main emissions can retain as high as ^(7)9.6% and 85.5%of their room-temperature intensities at 423 K,with activation energies of ~0.19 and 0.21 eV for thermal quenching,respectively.Application also indicates that both the phosphors have the potential for optical temperature sensing via the fluorescence intensity ratio(FIR) technology,whose maximum relative sensitivity reaches -2.70%/K for Eu^(3+)and 1.73%/K for Sm^(3+) at 298 K.
基金supported by the National Key Research and Development Program[2022YFC2302700].
文摘Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains unknown.We searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of China.Methods In this study,we collected serum specimens from patients with JE in three coastal provinces of China(Guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and G5.Results Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and Guangdong(77 patients),China,from 2018 to 2020.Seventy of the 361 serum specimens were laboratory-confirmed to be infected with JEV.Two cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 JEV.Conclusion G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.
基金supported by a grant from the National Key Research and Development Project(2023YFB4302100)Key Research and Development Project of Jiangxi Province(No.20232ACE01011)Independent Deployment Project of Ganjiang Innovation Research Institute,Chinese Academy of Sciences(E255J001).
文摘Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,we propose Rail-PillarNet,a three-dimensional(3D)LIDAR(Light Detection and Ranging)railway foreign object detection method based on the improvement of PointPillars.Firstly,the parallel attention pillar encoder(PAPE)is designed to fully extract the features of the pillars and alleviate the problem of local fine-grained information loss in PointPillars pillars encoder.Secondly,a fine backbone network is designed to improve the feature extraction capability of the network by combining the coding characteristics of LIDAR point cloud feature and residual structure.Finally,the initial weight parameters of the model were optimised by the transfer learning training method to further improve accuracy.The experimental results on the OSDaR23 dataset show that the average accuracy of Rail-PillarNet reaches 58.51%,which is higher than most mainstream models,and the number of parameters is 5.49 M.Compared with PointPillars,the accuracy of each target is improved by 10.94%,3.53%,16.96%and 19.90%,respectively,and the number of parameters only increases by 0.64M,which achieves a balance between the number of parameters and accuracy.
基金financially supported by the National Natural Science Foundation of China (Nos. 42374165, 41874165)
文摘0 INTRODUCTION Due to the ability to comprehensively utilize P and S wave information,multi-component seismic exploration has already played an important role in fracture detection,lithology prediction,fluid identification,etc.,and it has also become an important technology for complex reservoir exploration(Yuan et al.,2021;Stewart et al.,2003).
