目的:评价带状疱疹后神经痛(postherpetic neuralgia,PHN)病人的自主神经功能。方法:选取中日友好医院疼痛科2021年1月至2021年6月PHN病人33例为实验组(O组),同时段健康受试者47例为对照组(C组),两组均行24 h动态心电图检测,比较两组心...目的:评价带状疱疹后神经痛(postherpetic neuralgia,PHN)病人的自主神经功能。方法:选取中日友好医院疼痛科2021年1月至2021年6月PHN病人33例为实验组(O组),同时段健康受试者47例为对照组(C组),两组均行24 h动态心电图检测,比较两组心率变异性(heart rate variability,HRV)指标和昼夜变化情况。结果:组间比较:O组受试者24 h的SDNN(standard deviation of NN intervals)、SDANN(standard deviation of the average NN intervals)、SDNN Index(the average value of SDANN)、rMSSD(root mean square successive differences between successive R-R intervals)、pNN50(the proportion of adjacent NN intervals differing by>50 ms)、总功率(total power,TP)、极低频功率(very low frequence,VLF)、低频功率(low frequence,LF)、高频功率(high frequence,HF)均明显低于C组(P<0.05),LF/HF与C组相似(P>0.05);O组受试者昼间rMSSD与C组相近,其余指标均明显低于C组;O组受试者夜间LF/HF与C组相近,其余指标均明显低于C组。组内比较:O组受试者昼间的SDNN和LF/HF明显高于夜间(P<0.05),LF、rMSSD与夜间相近(P>0.05),其余指标均明显低于夜间;C组受试者昼间的SDNN与夜间相近,LF和LF/HF均明显高于夜间,其余指标均明显低于夜间(P<0.05)。结论:PHN病人的自主神经功能较正常下降,交感、副交感神经功能均减弱,昼夜的自主神经功能均低于正常水平;交感神经功能昼夜无差异,副交感神经功能日间减弱,夜间增强。展开更多
目的:运用网络药理学方法,分析天南星-生姜药对治疗疼痛的潜在靶点和作用机制。方法:通过中药系统药理学数据库和分析平台(TCMSP)检索出天南星和生姜的活性成分和靶点。以“pain”为关键词,通过Dis Ge Net数据库检索出和疼痛相关的靶基...目的:运用网络药理学方法,分析天南星-生姜药对治疗疼痛的潜在靶点和作用机制。方法:通过中药系统药理学数据库和分析平台(TCMSP)检索出天南星和生姜的活性成分和靶点。以“pain”为关键词,通过Dis Ge Net数据库检索出和疼痛相关的靶基因,并得到共同的靶点。通过String数据库构建蛋白互作网络图(protein-protein interaction,PPI)并进行分析,筛选出重要靶点。通过DAVID网站对共同靶点进行GO富集分析和KEGG通路富集分析。结果:从天南星和生姜药对中共筛选出10个有效成分,药物与疾病有63个共同靶点,包括CNR1、ESR1、MAPK3、CYP3A4、JUN、HDAC1等。GO分析得出的生物学过程包括炎症反应过程、EKR1和EKR2级联的正向调控、RNA聚合酶II启动子转录过程、G蛋白偶联受体信号通路等。KEGG富集共得到53条通路,其中与疼痛关系较为密切的包括钙信号通路、胆碱能突触信号传递、雌激素信号通路、癌症途径、5-羟色胺能通路等。结论:天南星-生姜药中的豆甾醇、β-谷甾醇、二氢辣椒碱等有效成分可能通过作用于CNR1、ESR1、MAPK3、CYP3A4、JUN、HDAC1等靶点,调节细胞内钙离子传导、胆碱能突出信号传递、癌症信号通路等对多种类型疼痛均可发挥作用,为进一步的实验设计提供理论基础。展开更多
OBJECTIVE:To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction(YHJD)on patients with advanced epithelial ovarian cancer(EOC).METHODS:All 330 enrolled participants diagnosed with stageⅢc EOC wer...OBJECTIVE:To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction(YHJD)on patients with advanced epithelial ovarian cancer(EOC).METHODS:All 330 enrolled participants diagnosed with stageⅢc EOC were randomly divided into two groups that received YHJD or a placebo.The primary end point was health-related quality of life(HRQL)measured by the functional assessment of cancer therapy-ovary cancer(FACT-O)questionnaire.The secondary end point was progression-free survival(PFS).RESULTS:A total of 299 participants completed the trial with 153 and 146 in YHJD and control groups,respectively.After 6 months of treatment,YHJD increased physical wellbeing(PWB),functional wellbeing(FWB),additional concerns(AC),and the trial outcome index(TOI)(P<0.05)by various degrees compared with the baseline.YHJD also had notable advantages over the placebo at 3 and 6 months in terms of PWB,FWB,AC(P<0.05),and TOI(P<0.01).In addition,YHJD had a significant advantage in terms of PFS compared with the placebo(21 vs18 months,P<0.05).No adverse events were reported.CONCLUSION:YHJD is an effective and safe choice as a complementary therapy to improve HRQL and prolong PFS of stageⅢc EOC patients.展开更多
文摘目的:评价带状疱疹后神经痛(postherpetic neuralgia,PHN)病人的自主神经功能。方法:选取中日友好医院疼痛科2021年1月至2021年6月PHN病人33例为实验组(O组),同时段健康受试者47例为对照组(C组),两组均行24 h动态心电图检测,比较两组心率变异性(heart rate variability,HRV)指标和昼夜变化情况。结果:组间比较:O组受试者24 h的SDNN(standard deviation of NN intervals)、SDANN(standard deviation of the average NN intervals)、SDNN Index(the average value of SDANN)、rMSSD(root mean square successive differences between successive R-R intervals)、pNN50(the proportion of adjacent NN intervals differing by>50 ms)、总功率(total power,TP)、极低频功率(very low frequence,VLF)、低频功率(low frequence,LF)、高频功率(high frequence,HF)均明显低于C组(P<0.05),LF/HF与C组相似(P>0.05);O组受试者昼间rMSSD与C组相近,其余指标均明显低于C组;O组受试者夜间LF/HF与C组相近,其余指标均明显低于C组。组内比较:O组受试者昼间的SDNN和LF/HF明显高于夜间(P<0.05),LF、rMSSD与夜间相近(P>0.05),其余指标均明显低于夜间;C组受试者昼间的SDNN与夜间相近,LF和LF/HF均明显高于夜间,其余指标均明显低于夜间(P<0.05)。结论:PHN病人的自主神经功能较正常下降,交感、副交感神经功能均减弱,昼夜的自主神经功能均低于正常水平;交感神经功能昼夜无差异,副交感神经功能日间减弱,夜间增强。
文摘目的:运用网络药理学方法,分析天南星-生姜药对治疗疼痛的潜在靶点和作用机制。方法:通过中药系统药理学数据库和分析平台(TCMSP)检索出天南星和生姜的活性成分和靶点。以“pain”为关键词,通过Dis Ge Net数据库检索出和疼痛相关的靶基因,并得到共同的靶点。通过String数据库构建蛋白互作网络图(protein-protein interaction,PPI)并进行分析,筛选出重要靶点。通过DAVID网站对共同靶点进行GO富集分析和KEGG通路富集分析。结果:从天南星和生姜药对中共筛选出10个有效成分,药物与疾病有63个共同靶点,包括CNR1、ESR1、MAPK3、CYP3A4、JUN、HDAC1等。GO分析得出的生物学过程包括炎症反应过程、EKR1和EKR2级联的正向调控、RNA聚合酶II启动子转录过程、G蛋白偶联受体信号通路等。KEGG富集共得到53条通路,其中与疼痛关系较为密切的包括钙信号通路、胆碱能突触信号传递、雌激素信号通路、癌症途径、5-羟色胺能通路等。结论:天南星-生姜药中的豆甾醇、β-谷甾醇、二氢辣椒碱等有效成分可能通过作用于CNR1、ESR1、MAPK3、CYP3A4、JUN、HDAC1等靶点,调节细胞内钙离子传导、胆碱能突出信号传递、癌症信号通路等对多种类型疼痛均可发挥作用,为进一步的实验设计提供理论基础。
基金Supported by National Natural Science Foundation of China(NSFC)-funded Project:the Mechanisms of Tailored Immunotherapy of Yiqi Huoxue Jiedu Decoction Modulating T Regulatory Cells at the Level of the Tumor Microenvironment and Inherited Single Nucleotide Polymorphisms in Advanced Ovarian Cancer(No.81473566).
文摘OBJECTIVE:To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction(YHJD)on patients with advanced epithelial ovarian cancer(EOC).METHODS:All 330 enrolled participants diagnosed with stageⅢc EOC were randomly divided into two groups that received YHJD or a placebo.The primary end point was health-related quality of life(HRQL)measured by the functional assessment of cancer therapy-ovary cancer(FACT-O)questionnaire.The secondary end point was progression-free survival(PFS).RESULTS:A total of 299 participants completed the trial with 153 and 146 in YHJD and control groups,respectively.After 6 months of treatment,YHJD increased physical wellbeing(PWB),functional wellbeing(FWB),additional concerns(AC),and the trial outcome index(TOI)(P<0.05)by various degrees compared with the baseline.YHJD also had notable advantages over the placebo at 3 and 6 months in terms of PWB,FWB,AC(P<0.05),and TOI(P<0.01).In addition,YHJD had a significant advantage in terms of PFS compared with the placebo(21 vs18 months,P<0.05).No adverse events were reported.CONCLUSION:YHJD is an effective and safe choice as a complementary therapy to improve HRQL and prolong PFS of stageⅢc EOC patients.
