The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like a...The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like absorbent gauze or absorbent cotton,possess limited therapeutic effects and require repeated use,which further exaggerates patients’suffering.In contrast,hydrogels films present a promising alternative to improve healing by guaranteeing a moisture balance at the wound site.The aim of the current study was to synthesize Tamarix aphylla(T.aphylla)extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties.The Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis,FTIR,surface morphology,rheology,tensile strength,swelling behavior,drug release kinetics,and in vivo wound healing in an animal model.FTIR confirmed the existence of strong interaction between both polymers but no interaction with the extract.SEM photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and homogenous morphology.Rheological and texture profiles indicated that hydrogels behaved as strong gels.Swelling and erosion were dependent on the amount of the CMC.HPLC showed drug content of three selected formulation(A3,E3 and S3)as 85±0.1%,82.5±0.4%and 80±0.3%,respectively.The release of the drug from the hydrogel was controlled by a Fickian diffusion mechanism.In vivo wound healing activity of hydrogel film confirmed that T.aphylla extract successfully promoted healing rate by significantly reducing(P<0.05)the size of wound closure compared to the control group,evidenced by intensive collagen formation in histopathological and biochemical analysis.The capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of safe and effective medication.展开更多
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss caused by the degeneration of neurons and the accumulation of amyloid plaques and tau tangles in...Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss caused by the degeneration of neurons and the accumulation of amyloid plaques and tau tangles in the brain. The exact etiology of AD remains unclear, although both genetic and environmental factors play important roles. Key pathological features include synaptic dysfunction, oxidative stress, and neuroinflammation. Current treatments focus mainly on symptom relief through cholinesterase inhibitors andN-methyl-D-aspartate receptor antagonists. However, there is an ongoing effort to discover disease-modifying therapies. Recent clinical trials are investigating innovative approaches such as amyloid-targeting agents, tau aggregation inhibitors, and gene therapies. This paper offers a thorough overview of AD, presenting its fundamental aspects, contributing factors, primary disease mechanisms, current therapeutic strategies, and a detailed examination of ongoing clinical trials. In the context of advancing research, this paper provides valuable insights into the multifaceted approaches being explored to improve the understanding and management of this challenging neurodegenerative disorder.展开更多
文摘The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like absorbent gauze or absorbent cotton,possess limited therapeutic effects and require repeated use,which further exaggerates patients’suffering.In contrast,hydrogels films present a promising alternative to improve healing by guaranteeing a moisture balance at the wound site.The aim of the current study was to synthesize Tamarix aphylla(T.aphylla)extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties.The Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis,FTIR,surface morphology,rheology,tensile strength,swelling behavior,drug release kinetics,and in vivo wound healing in an animal model.FTIR confirmed the existence of strong interaction between both polymers but no interaction with the extract.SEM photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and homogenous morphology.Rheological and texture profiles indicated that hydrogels behaved as strong gels.Swelling and erosion were dependent on the amount of the CMC.HPLC showed drug content of three selected formulation(A3,E3 and S3)as 85±0.1%,82.5±0.4%and 80±0.3%,respectively.The release of the drug from the hydrogel was controlled by a Fickian diffusion mechanism.In vivo wound healing activity of hydrogel film confirmed that T.aphylla extract successfully promoted healing rate by significantly reducing(P<0.05)the size of wound closure compared to the control group,evidenced by intensive collagen formation in histopathological and biochemical analysis.The capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of safe and effective medication.
文摘Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss caused by the degeneration of neurons and the accumulation of amyloid plaques and tau tangles in the brain. The exact etiology of AD remains unclear, although both genetic and environmental factors play important roles. Key pathological features include synaptic dysfunction, oxidative stress, and neuroinflammation. Current treatments focus mainly on symptom relief through cholinesterase inhibitors andN-methyl-D-aspartate receptor antagonists. However, there is an ongoing effort to discover disease-modifying therapies. Recent clinical trials are investigating innovative approaches such as amyloid-targeting agents, tau aggregation inhibitors, and gene therapies. This paper offers a thorough overview of AD, presenting its fundamental aspects, contributing factors, primary disease mechanisms, current therapeutic strategies, and a detailed examination of ongoing clinical trials. In the context of advancing research, this paper provides valuable insights into the multifaceted approaches being explored to improve the understanding and management of this challenging neurodegenerative disorder.
