OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a mor...OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.展开更多
Accurate prediction of droplet impingement on wind turbine blade is one of the most important premises of anti-icing and de-icing system design.In a super-cooled large droplets(SLD)conditions,droplet no longer maintai...Accurate prediction of droplet impingement on wind turbine blade is one of the most important premises of anti-icing and de-icing system design.In a super-cooled large droplets(SLD)conditions,droplet no longer maintains a sphere shape,and it may deform,break up,and splash when moving or impinging on the surface.Semi-empirical models of droplet dynamic behaviours are embedded into the Eulerian droplet model to improve the accuracy of the numerical simulation of droplet impingement limits and local collection efficiency.Eulerian droplet model(Model 1)for small droplets and improved Eulerian droplet model(Model 2)for large droplet are both validated by comparing to the wind tunnel experiment results.Using the proposed methods,droplet impingement limitation and local collection efficiency on the S809 airfoil are calculated in various conditions.A detailed derivation of Model 1and Model 2is presented along with a comparison of numerical trajectories,drag coefficient and collection efficiency distributions.The results show that droplet dynamic behaviours,including splashing,break-up and deforming,must be considered to accurately simulate the impingement behaviour in the SLD conditions.And with the increase of the droplet diameters,the effects of the droplet dynamic behaviors on the impingement characteristics are more obvious.展开更多
An impact angle constrained fuzzy adaptive fault tolerant integrated guidance and control method for Ski-to-Turn(STT)missiles subject to unsteady aerodynamics and multiple disturbances is proposed.Unsteady aerodynamic...An impact angle constrained fuzzy adaptive fault tolerant integrated guidance and control method for Ski-to-Turn(STT)missiles subject to unsteady aerodynamics and multiple disturbances is proposed.Unsteady aerodynamics appears when flight vehicles are in a transonic state or confronted with unstable airflow.Meanwhile,actuator failures and multisource model uncertainties are introduced.However,the boundaries of these multisource uncertainties are assumed unknown.The target is assumed to execute high maneuver movement which is unknown to the missile.Furthermore,impact angle constraint puts forward higher requirements for the interception accuracy of the integrated guidance and control(IGC)method.The impact angle constraint and the precise interception are established as the object of the IGC method.Then,the boundaries of the lumped disturbances are estimated,and several fuzzy logic systems are introduced to compensate the unknown nonlinearities and uncertainties.Next,a series of adaptive laws are developed so that the undesirable effects arising from unsteady aerodynamics,actuator failures and unknown uncertainties could be suppressed.Consequently,an impact angle constrained fuzzy adaptive fault tolerant IGC method with three loops is constructed and a perfect hit-to-kill interception with specified impact angle can be implemented.Eventually,the numerical simulations are conducted to verify the effectiveness and superiority of the proposed method.展开更多
基金National Key Research and Development Project:Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(No.2019YFC1710102)。
文摘OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.
基金supported by the National Basic Research Program of China(″973″Program)(No.2014CB046200)the National Natural Science Foundation of China(Nos.11402114,51506089)+1 种基金the Fundamental Research Funds for Central UniversitiesNanjing University of Aeronautics,and Astronautics Basic Scientific Research Projects for Youth Science(No.NS2014014)
文摘Accurate prediction of droplet impingement on wind turbine blade is one of the most important premises of anti-icing and de-icing system design.In a super-cooled large droplets(SLD)conditions,droplet no longer maintains a sphere shape,and it may deform,break up,and splash when moving or impinging on the surface.Semi-empirical models of droplet dynamic behaviours are embedded into the Eulerian droplet model to improve the accuracy of the numerical simulation of droplet impingement limits and local collection efficiency.Eulerian droplet model(Model 1)for small droplets and improved Eulerian droplet model(Model 2)for large droplet are both validated by comparing to the wind tunnel experiment results.Using the proposed methods,droplet impingement limitation and local collection efficiency on the S809 airfoil are calculated in various conditions.A detailed derivation of Model 1and Model 2is presented along with a comparison of numerical trajectories,drag coefficient and collection efficiency distributions.The results show that droplet dynamic behaviours,including splashing,break-up and deforming,must be considered to accurately simulate the impingement behaviour in the SLD conditions.And with the increase of the droplet diameters,the effects of the droplet dynamic behaviors on the impingement characteristics are more obvious.
基金supported by the National Natural Science Foundation of China(62003264).
文摘An impact angle constrained fuzzy adaptive fault tolerant integrated guidance and control method for Ski-to-Turn(STT)missiles subject to unsteady aerodynamics and multiple disturbances is proposed.Unsteady aerodynamics appears when flight vehicles are in a transonic state or confronted with unstable airflow.Meanwhile,actuator failures and multisource model uncertainties are introduced.However,the boundaries of these multisource uncertainties are assumed unknown.The target is assumed to execute high maneuver movement which is unknown to the missile.Furthermore,impact angle constraint puts forward higher requirements for the interception accuracy of the integrated guidance and control(IGC)method.The impact angle constraint and the precise interception are established as the object of the IGC method.Then,the boundaries of the lumped disturbances are estimated,and several fuzzy logic systems are introduced to compensate the unknown nonlinearities and uncertainties.Next,a series of adaptive laws are developed so that the undesirable effects arising from unsteady aerodynamics,actuator failures and unknown uncertainties could be suppressed.Consequently,an impact angle constrained fuzzy adaptive fault tolerant IGC method with three loops is constructed and a perfect hit-to-kill interception with specified impact angle can be implemented.Eventually,the numerical simulations are conducted to verify the effectiveness and superiority of the proposed method.
