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基于因子模型对G蛋白偶联受体序列进行聚类
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作者 王华 白凤兰 刘立伟 《计算生物学》 2017年第3期31-38,共8页
G蛋白偶联受体(G Protein-Coupled Receptors, GPCRs)是一肽类膜蛋白家族,对GPCRs序列进行聚类分析有着重要的理论意义和应用价值。本文根据氨基酸的分类及其物化性质给出了蛋白质序列的特征向量表示,在此基础上用因子分析法对蛋白质序... G蛋白偶联受体(G Protein-Coupled Receptors, GPCRs)是一肽类膜蛋白家族,对GPCRs序列进行聚类分析有着重要的理论意义和应用价值。本文根据氨基酸的分类及其物化性质给出了蛋白质序列的特征向量表示,在此基础上用因子分析法对蛋白质序列的特征向量进行降维得到了因子模型,进而利用因子模型分析了40个GPCRs序列的相似性,并进行聚类分析,得到了较好的结果,为分析比较GPCRs序列提供新的手段。 展开更多
关键词 蛋白质序列 特征向量 因子模型 聚类分析
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CHAOS ANALYSIS AND CONTROL FOR A CLASS OF SIR EPIDEMIC MODEL WITH SEASONAL FLUCTUATION
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作者 YI ZHANG QINGLING ZHANG +1 位作者 FUZHEN ZHANG fenglan bai 《International Journal of Biomathematics》 2013年第1期41-51,共11页
In this paper, the problems of chaos and chaos control for a class of susceptible-infected- removed (SIR) epidemic model with seasonal fluctuation are investigated. The season- ality in outbreak is natural among inf... In this paper, the problems of chaos and chaos control for a class of susceptible-infected- removed (SIR) epidemic model with seasonal fluctuation are investigated. The season- ality in outbreak is natural among infectious diseases, as the common influenza, A type H1N1 influenza and so on. It is shown that there exist chaotic phenomena in the epidemic model. Furthermore, the tracking control method is used to control chaotic motions in the epidemic model. A feedback controller is designed to achieve tracking of an ideal out- put. Thus, the density of infected individuals can converge to zero, in other words, thedisease can be disappeared. Finally, numerical simulations illustrate that the controller is effective. 展开更多
关键词 Epidemic model differential-algebraic system seasonal fluctuation CHAOS tracking control.
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