目的:明确不同糖皮质激素给药途径对儿童分泌性中耳炎治疗效果及免疫功能的影响。方法:纳入分析2016年1月至2016年6月我院收治的儿童分泌性中耳炎患儿的临床资料。采用随机数字表法,将患儿随机分为观察组(鼓室内注射)及对照组(口服),并...目的:明确不同糖皮质激素给药途径对儿童分泌性中耳炎治疗效果及免疫功能的影响。方法:纳入分析2016年1月至2016年6月我院收治的儿童分泌性中耳炎患儿的临床资料。采用随机数字表法,将患儿随机分为观察组(鼓室内注射)及对照组(口服),并采用相应的糖皮质激素给药途径。治疗一周后对比两组听力恢复情况、外周血T细胞亚群和细胞因子变化及治疗后1年累积复发率。结果:共纳入观察组45例(45耳),对照组42(42耳)。两组患儿治疗后听力指标显著改善(P<0.05),且观察组优于对照组(P<0.05)。观察组患儿治愈率显著高于对照组(91.1%,41/45 vs 73.8%,31/42;χ~2=4.558,P=0.033)。治疗后两组患儿总CD3^+T、CD4^+T细胞及CD4^+T/CD8^+T均显著升高(P<0.05),而CD8^+T细胞显著降低(P<0.05),但观察组患儿变化显著优于对照组(P<0.05)。治疗后两组患儿Th2细胞因子IL-4、Th1细胞因子IFN-γ及IL-4/IFN-γ水平均显著降低(P<0.05),但观察组变化显著优于对照组(P<0.05)。观察组患儿治疗后1年累积复发率显著低于对照组(9.76%,4/41 vs 29.03%,9/31;Log-rank χ~2=4.698,P=0.030)。结论:儿童分泌性中耳炎治疗中,采用鼓室内注射糖皮质激素的治疗效果优于系统性给予糖皮质激素。展开更多
As an important food crop and oil crop, soybean(Glycine max [L.] Merr.) is capable of nitrogen-fixing by root nodule. Previous studies showed that GmNMH7, a transcription factor of MADS-box family, is associated with ...As an important food crop and oil crop, soybean(Glycine max [L.] Merr.) is capable of nitrogen-fixing by root nodule. Previous studies showed that GmNMH7, a transcription factor of MADS-box family, is associated with nodule development, but its specific function remained unknown. In this study, we found that GmN MH7 was specifically expressed in root and nodule and the expression pattern of GmNMH7 was similar to several genes involved in early development of nodule(GmENOD40-1, GmENOD40-2, GmNFR1 a, GmNFR5 a, and GmNIN) after rhizobia inoculation. The earlier expression peak of GmNMH7 compared to the other genes(GmENOD40-1, GmENOD40-2, GmNFR1 a, GmNFR5 a, and GmNIN) indicated that the gene is related to the nod factor(NF) signaling pathway and functions at the early development of nodule. Over-expression of GmNMH7 in hairy roots significantly reduced the nodule number and the root length. In the transgenic hairy roots, overexpression of GmN MH7 significantly down-regulated the expression levels of GmE NOD40-1, GmE NOD40-2, and GmN FR5α. Moreover, the expression of GmNMH7 could respond to abscisic acid(ABA) and gibberellin(GA_3) treatment in the root of Zigongdongdou seedlings. Over-expressing GmNMH7 gene reduced the content of ABA, and increased the content of GA_3 in the positive transgenic hairy roots. Therefore, we concluded that GmNMH7 might participate in the NF signaling pathway and negatively regulate nodulation probably through regulating the content of GA_3.展开更多
To solve soil shortage in reclaiming subsided land of coal mines, the principal chemical properties of artificial soil formed by mixing organic furfural residue and inorganic fly ash were examined. The results indicat...To solve soil shortage in reclaiming subsided land of coal mines, the principal chemical properties of artificial soil formed by mixing organic furfural residue and inorganic fly ash were examined. The results indicated that the artificial soil was suitable for agriculture use after irrigation and desalination, the available nutrients in the artificial soil could satisfy the growth demand of plants, and the pH tended to the neutrality.展开更多
This paper discussed the adaptability of the alfalfa and ryegrass to the new artificial soil that was composed of fly ash and furfural residue. The potted experiments were taken to compare the growth conditions, yield...This paper discussed the adaptability of the alfalfa and ryegrass to the new artificial soil that was composed of fly ash and furfural residue. The potted experiments were taken to compare the growth conditions, yields, and qualities of both grasses. Some pots were covered with wheat stalks and others without. The medium Fluvo-aquic soil was taken as control. The results indicated that the growth of two grasses in the mixture were inferior to their growth in the control in initial period. With the leaching of rain and irrigation, the two grasses improved gradually. The alfalfa and ryegrass both could grow in the new mixture, and the ryegrass would be better to plant in no covered material and the alfalfa in covered. This will be a new way to reclaim subsided land and to imorove the environment in mining area.展开更多
文摘目的:明确不同糖皮质激素给药途径对儿童分泌性中耳炎治疗效果及免疫功能的影响。方法:纳入分析2016年1月至2016年6月我院收治的儿童分泌性中耳炎患儿的临床资料。采用随机数字表法,将患儿随机分为观察组(鼓室内注射)及对照组(口服),并采用相应的糖皮质激素给药途径。治疗一周后对比两组听力恢复情况、外周血T细胞亚群和细胞因子变化及治疗后1年累积复发率。结果:共纳入观察组45例(45耳),对照组42(42耳)。两组患儿治疗后听力指标显著改善(P<0.05),且观察组优于对照组(P<0.05)。观察组患儿治愈率显著高于对照组(91.1%,41/45 vs 73.8%,31/42;χ~2=4.558,P=0.033)。治疗后两组患儿总CD3^+T、CD4^+T细胞及CD4^+T/CD8^+T均显著升高(P<0.05),而CD8^+T细胞显著降低(P<0.05),但观察组患儿变化显著优于对照组(P<0.05)。治疗后两组患儿Th2细胞因子IL-4、Th1细胞因子IFN-γ及IL-4/IFN-γ水平均显著降低(P<0.05),但观察组变化显著优于对照组(P<0.05)。观察组患儿治疗后1年累积复发率显著低于对照组(9.76%,4/41 vs 29.03%,9/31;Log-rank χ~2=4.698,P=0.030)。结论:儿童分泌性中耳炎治疗中,采用鼓室内注射糖皮质激素的治疗效果优于系统性给予糖皮质激素。
基金supported by the National Natural Science Foundation of China (31271636)the earmarked fund for China Agriculture Research System (CARS-04)
文摘As an important food crop and oil crop, soybean(Glycine max [L.] Merr.) is capable of nitrogen-fixing by root nodule. Previous studies showed that GmNMH7, a transcription factor of MADS-box family, is associated with nodule development, but its specific function remained unknown. In this study, we found that GmN MH7 was specifically expressed in root and nodule and the expression pattern of GmNMH7 was similar to several genes involved in early development of nodule(GmENOD40-1, GmENOD40-2, GmNFR1 a, GmNFR5 a, and GmNIN) after rhizobia inoculation. The earlier expression peak of GmNMH7 compared to the other genes(GmENOD40-1, GmENOD40-2, GmNFR1 a, GmNFR5 a, and GmNIN) indicated that the gene is related to the nod factor(NF) signaling pathway and functions at the early development of nodule. Over-expression of GmNMH7 in hairy roots significantly reduced the nodule number and the root length. In the transgenic hairy roots, overexpression of GmN MH7 significantly down-regulated the expression levels of GmE NOD40-1, GmE NOD40-2, and GmN FR5α. Moreover, the expression of GmNMH7 could respond to abscisic acid(ABA) and gibberellin(GA_3) treatment in the root of Zigongdongdou seedlings. Over-expressing GmNMH7 gene reduced the content of ABA, and increased the content of GA_3 in the positive transgenic hairy roots. Therefore, we concluded that GmNMH7 might participate in the NF signaling pathway and negatively regulate nodulation probably through regulating the content of GA_3.
文摘To solve soil shortage in reclaiming subsided land of coal mines, the principal chemical properties of artificial soil formed by mixing organic furfural residue and inorganic fly ash were examined. The results indicated that the artificial soil was suitable for agriculture use after irrigation and desalination, the available nutrients in the artificial soil could satisfy the growth demand of plants, and the pH tended to the neutrality.
基金Project J02L07 supported by Foundation of Shandong Provincial Education Department of Shandong Province
文摘This paper discussed the adaptability of the alfalfa and ryegrass to the new artificial soil that was composed of fly ash and furfural residue. The potted experiments were taken to compare the growth conditions, yields, and qualities of both grasses. Some pots were covered with wheat stalks and others without. The medium Fluvo-aquic soil was taken as control. The results indicated that the growth of two grasses in the mixture were inferior to their growth in the control in initial period. With the leaching of rain and irrigation, the two grasses improved gradually. The alfalfa and ryegrass both could grow in the new mixture, and the ryegrass would be better to plant in no covered material and the alfalfa in covered. This will be a new way to reclaim subsided land and to imorove the environment in mining area.
