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Intraseasonal variation and future projection of atmospheric diffusion conditions conducive to extreme haze formation over eastern China 被引量:1
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作者 feng weiyang WANG Minghuai +3 位作者 ZHANG Yang DAI Xianglin LIU Xiaohong XU Yangyang 《Atmospheric and Oceanic Science Letters》 CSCD 2020年第4期346-355,共10页
Future projection of diffusion conditions associated with extreme haze events over eastern China is of great importance to government emission regulations and public human health.Here,the diffusion conditions and thei... Future projection of diffusion conditions associated with extreme haze events over eastern China is of great importance to government emission regulations and public human health.Here,the diffusion conditions and their changes under future warming scenarios are examined.The relative strength of haze events in the Northern China Plain region increase from 150%during 2006–15 to 190%during 2090–99 under RCP8.5 scenarios,induced by a stronger and longer-lasting anticyclone anomaly in eastern China.The strengthened anticyclone anomaly is mainly induced by increased northern wave train convergence emanating from the Barents–Kara Sea,and the longer duration of the anticyclone anomaly is mainly induced by stronger local feedback that can extract more energy from the basic state to maintain the anticyclone anomaly in eastern China.Aerosol reduction is found to play a dominant role in strengthening the upstream wave train near the Barents–Kara Sea and the downstream anticyclone in eastern China,while the effects from increased greenhouse gases are small.The results of this study indicate that future aerosol emissions reduction can induce deteriorating diffusion conditions,suggesting more stringent regulations on aerosol emissions in China are needed to meet air quality standards. 展开更多
关键词 Haze diffusion conditions East Asian winter monsoon anticyclone anomaly RCP8.5 aerosol reduction greenhouse gases
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磷酸奥司他韦-乳铁蛋白吸入剂的制备及HPAEpiC细胞毒性与抑菌作用研究
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作者 冯伟扬 付传博 +1 位作者 闫佳慧 乐园 《北京化工大学学报(自然科学版)》 CAS CSCD 北大核心 2022年第2期72-81,共10页
采用喷雾干燥法制备了磷酸奥司他韦-乳铁蛋白干粉吸入剂。以m(L-亮氨酸)∶m(甘露醇)、溶液体积、进料速率、气体流量为影响因素,以收率、卡尔指数(Carr’s index)、空气动力学直径(D;)、体外肺部细微粒子沉积率(FPF)为主要指标,设计了4... 采用喷雾干燥法制备了磷酸奥司他韦-乳铁蛋白干粉吸入剂。以m(L-亮氨酸)∶m(甘露醇)、溶液体积、进料速率、气体流量为影响因素,以收率、卡尔指数(Carr’s index)、空气动力学直径(D;)、体外肺部细微粒子沉积率(FPF)为主要指标,设计了4因素3水平的正交试验,对制剂配方及喷雾干燥工艺参数进行优化,得到优化后的制备条件为:m(L-亮氨酸)∶m(甘露醇)=3∶0,溶液体积40 mL,进料速率约6.4 mL/min,气体流量约473 L/h。采用CCK-8法测试在优化条件下制备的干粉吸入剂对正常人肺泡上皮细胞(HPAEpiC)的毒性,并采用梯度稀释法和菌落计数法测试了干粉吸入剂对金黄色葡萄球菌(Staphylococcus aureus)的抑制作用,结果表明:当干粉吸入剂的质量浓度不高于600μg/mL(所含磷酸奥司他韦的质量浓度约为353μg/mL)时,HPAEpiC细胞的存活率大于90%,表明制备的干粉吸入剂在此浓度范围内对HPAEpiC细胞几乎没有损伤作用;在质量浓度为1 mg/mL时干粉吸入剂对金黄色葡萄球菌具有一定的抑制作用,抑菌率为22.50%。 展开更多
关键词 磷酸奥司他韦 乳铁蛋白 干粉吸入剂 细胞毒性 抑菌作用
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