Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrat...Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC.展开更多
Two new Mn(Ⅱ)coordination polymers,namely{[Mn_(2)(HL)(phen)_(3)(H_(2)O)_(2)]·7.5H_(2)O}_n(1)and[Mn_(4)(HL)_(2)(1,4-bib)_(3)(H_(2)O)_(2)]_n(2),were synthesized under hydrothermal conditions by using Mn(Ⅱ)ions an...Two new Mn(Ⅱ)coordination polymers,namely{[Mn_(2)(HL)(phen)_(3)(H_(2)O)_(2)]·7.5H_(2)O}_n(1)and[Mn_(4)(HL)_(2)(1,4-bib)_(3)(H_(2)O)_(2)]_n(2),were synthesized under hydrothermal conditions by using Mn(Ⅱ)ions and 6-(3',4'-dicarboxylphenoxy)-1,2,4-benzenetricarboxylic acid(H_(5)L)in the presence of N-auxiliary ligands 1,10-phenanthroline(phen)and1,4-bis(1H-imidazol-1-yl)benzene(1,4-bib).The structures of coordination polymers 1 and 2 were characterized by infrared spectroscopy,single-crystal X-ray diffraction,thermogravimetric analysis,and powder X-ray diffraction.Single-crystal X-ray diffraction reveals that 1 has a 1D chain structure based on binuclear Mn(Ⅱ)units,while 2 features a(3,8)-connected 3D network structure based on tetranuclear Mn(Ⅱ)units.Magnetic studies show that 1 and 2exhibit antiferromagnetic interactions between manganese ions.2 shows stronger antiferromagnetic interactions due to the shorter Mn…Mn distances within the tetranuclear manganese units.CCDC:2357601,1;2357602,2.展开更多
目的探究基于“整体观念”理论头体针结合治疗脑卒中后偏瘫患者肢体功能障碍的短期临床疗效。方法将72例符合纳入标准的卒中后偏瘫患者采用统计产品与服务解决方案(Statistical product and service solutions,SPSS)软件随机分为观察组...目的探究基于“整体观念”理论头体针结合治疗脑卒中后偏瘫患者肢体功能障碍的短期临床疗效。方法将72例符合纳入标准的卒中后偏瘫患者采用统计产品与服务解决方案(Statistical product and service solutions,SPSS)软件随机分为观察组和对照组,各36例。两组均给予脑卒中常规药物治疗及康复训练,观察组遵循中医整体观念理论采用整体选穴与头针相结合的治疗方案,对照组采取偏瘫侧阳明经取穴为主的常规针刺治疗。1天1次,1周6天连续治疗2周。治疗前后对两组患者进行评估,参照洛维特肌力分级标准(Lovett肌力分级)、肢体运动功能评分量表(Fugl-Meyer,FMA)、日常生活活动能力量表(Barthel指数,BI)及临床疗效观察。结果与治疗前比较,治疗后两组患者肌力评定均有提升(P<0.05),且观察组优于对照组(P<0.05);治疗后,观察组FMA评分和BI指数均有明显提升(P<0.01),且显著高于对照组治疗后(P<0.01);然而,对照组与其治疗前阶段相比,FMA、Bl指数无显著性差异(P>0.05)。观察组总有效率94.4%(34/36),对照组47.2%(17/36),两组之间差异具有统计学意义(P<0.05)。结论遵循中医整体观念原则采用整体选穴与头针相结合的治疗方案对脑卒中后偏瘫患者肢体运动功能的临床疗效确切,在短期内的针刺效应更强、疗效显著。展开更多
基金supported by the Natural Science Foundation of Hunan Province (2022JJ30987)the Key Research and Development Project of Hunan Province (2024JK2107),China。
文摘Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC.
文摘Two new Mn(Ⅱ)coordination polymers,namely{[Mn_(2)(HL)(phen)_(3)(H_(2)O)_(2)]·7.5H_(2)O}_n(1)and[Mn_(4)(HL)_(2)(1,4-bib)_(3)(H_(2)O)_(2)]_n(2),were synthesized under hydrothermal conditions by using Mn(Ⅱ)ions and 6-(3',4'-dicarboxylphenoxy)-1,2,4-benzenetricarboxylic acid(H_(5)L)in the presence of N-auxiliary ligands 1,10-phenanthroline(phen)and1,4-bis(1H-imidazol-1-yl)benzene(1,4-bib).The structures of coordination polymers 1 and 2 were characterized by infrared spectroscopy,single-crystal X-ray diffraction,thermogravimetric analysis,and powder X-ray diffraction.Single-crystal X-ray diffraction reveals that 1 has a 1D chain structure based on binuclear Mn(Ⅱ)units,while 2 features a(3,8)-connected 3D network structure based on tetranuclear Mn(Ⅱ)units.Magnetic studies show that 1 and 2exhibit antiferromagnetic interactions between manganese ions.2 shows stronger antiferromagnetic interactions due to the shorter Mn…Mn distances within the tetranuclear manganese units.CCDC:2357601,1;2357602,2.
文摘目的探究基于“整体观念”理论头体针结合治疗脑卒中后偏瘫患者肢体功能障碍的短期临床疗效。方法将72例符合纳入标准的卒中后偏瘫患者采用统计产品与服务解决方案(Statistical product and service solutions,SPSS)软件随机分为观察组和对照组,各36例。两组均给予脑卒中常规药物治疗及康复训练,观察组遵循中医整体观念理论采用整体选穴与头针相结合的治疗方案,对照组采取偏瘫侧阳明经取穴为主的常规针刺治疗。1天1次,1周6天连续治疗2周。治疗前后对两组患者进行评估,参照洛维特肌力分级标准(Lovett肌力分级)、肢体运动功能评分量表(Fugl-Meyer,FMA)、日常生活活动能力量表(Barthel指数,BI)及临床疗效观察。结果与治疗前比较,治疗后两组患者肌力评定均有提升(P<0.05),且观察组优于对照组(P<0.05);治疗后,观察组FMA评分和BI指数均有明显提升(P<0.01),且显著高于对照组治疗后(P<0.01);然而,对照组与其治疗前阶段相比,FMA、Bl指数无显著性差异(P>0.05)。观察组总有效率94.4%(34/36),对照组47.2%(17/36),两组之间差异具有统计学意义(P<0.05)。结论遵循中医整体观念原则采用整体选穴与头针相结合的治疗方案对脑卒中后偏瘫患者肢体运动功能的临床疗效确切,在短期内的针刺效应更强、疗效显著。
