Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LM...Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.展开更多
脑和肌肉组织芳香烃受体核转运蛋白的类似蛋白1(brain and muscle Arnt-like protein 1,Bmal1)是生物钟的核心元件之一,常呈现出昼夜节律性表达。Bmal1在肿瘤中的作用及其调控机制复杂多样,目前研究显示Bmal1可以受多种信号通路的正负...脑和肌肉组织芳香烃受体核转运蛋白的类似蛋白1(brain and muscle Arnt-like protein 1,Bmal1)是生物钟的核心元件之一,常呈现出昼夜节律性表达。Bmal1在肿瘤中的作用及其调控机制复杂多样,目前研究显示Bmal1可以受多种信号通路的正负反馈性调控,通过调控原癌基因和抑癌基因与某些信号通路发生相互作用,从而在肿瘤的发生发展过程中发挥抑癌或促癌的作用。此外,Bmal1也可以被表观遗传调控因子调控进而影响其表达。Bmal1的表达会影响化疗药物的敏感性,因此,针对个性化治疗,Bmal1可以作为直接分子目标确定最佳药物管理时间,从而提高抗癌药物的疗效。本文主要综述Bmal1在不同肿瘤中发挥的作用及其调控机制。展开更多
基金National Natural Science Foundation of China,No.42161006Yunnan Fundamental Research Projects No.202201AT070094,No.202301BF070001-004+1 种基金Special Project for High-level Talents of Yunnan Province for Young Top Talents,No.C6213001159European Research Council(ERC)Starting-Grant STORIES,No.101040939。
文摘Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.
文摘脑和肌肉组织芳香烃受体核转运蛋白的类似蛋白1(brain and muscle Arnt-like protein 1,Bmal1)是生物钟的核心元件之一,常呈现出昼夜节律性表达。Bmal1在肿瘤中的作用及其调控机制复杂多样,目前研究显示Bmal1可以受多种信号通路的正负反馈性调控,通过调控原癌基因和抑癌基因与某些信号通路发生相互作用,从而在肿瘤的发生发展过程中发挥抑癌或促癌的作用。此外,Bmal1也可以被表观遗传调控因子调控进而影响其表达。Bmal1的表达会影响化疗药物的敏感性,因此,针对个性化治疗,Bmal1可以作为直接分子目标确定最佳药物管理时间,从而提高抗癌药物的疗效。本文主要综述Bmal1在不同肿瘤中发挥的作用及其调控机制。
