对添加碳化硅球辅助微波干燥多孔硅酸钙进行试验和数值模拟,分析碳化硅球添加量和微波功率对硅酸钙干燥特性的影响.结果表明,碳化硅球的添加显著缩短了硅酸钙的干燥时间.在微波功率150 W时,15 g w(水)=75%的多孔硅酸钙中的碳化硅球最优...对添加碳化硅球辅助微波干燥多孔硅酸钙进行试验和数值模拟,分析碳化硅球添加量和微波功率对硅酸钙干燥特性的影响.结果表明,碳化硅球的添加显著缩短了硅酸钙的干燥时间.在微波功率150 W时,15 g w(水)=75%的多孔硅酸钙中的碳化硅球最优添加量为12颗,较未添加碳化硅球的样品平衡温度提升15℃,干燥能耗降低46%,干燥有效扩散系数为1.42×10^(-7) m^(2)/s.随着微波功率的增加,硅酸钙的干燥能耗和干燥时间减小,但减小趋势随功率的增加而减缓.在高微波功率下,添加碳化硅球会进一步减少硅酸钙的干燥时间和能耗.对干燥过程进行多物理场仿真,考察样品内部温度、电场强度、水分浓度场的实时分布.干燥初期,碳化硅球的添加对微波加热样品并未起到明显作用,在干燥后期形成热点,有效提升样品温度,加快了硅酸钙的干燥速度.展开更多
Objective Recent studies have highlighted the critical role of NUDT19 in the initiation,progression,and prognosis of specific cancer types.However,its involvement in pan-cancer analysis has not been fully characterize...Objective Recent studies have highlighted the critical role of NUDT19 in the initiation,progression,and prognosis of specific cancer types.However,its involvement in pan-cancer analysis has not been fully characterized.This study aims to systematically explore the expression patterns,clinical significance,and immune-related functions of NUDT19 in various cancer types through multi-omics analysis,further revealing its potential role in cancer,particularly its functional and therapeutic target value in leukemia.Methods To achieve this goal,various bioinformatics approaches were employed to evaluate the expression patterns,clinical significance,and immune-related functions of NUDT19 in tumors and normal tissues.Additionally,we analyzed the mutation characteristics of NUDT19 and its relationship with epigenetic modifications.Using the single-cell analysis tool SingleCellBase,we explored the distribution of NUDT19 across different cell subpopulations in tumors.To validate these findings,qRT-PCR was used to measure NUDT19 expression levels in specific tumor cell lines,and we established acute myeloid leukemia(AML)cell lines(HL-60 and THP-1)to conduct NUDT19 knockdown and overexpression experiments,assessing its effects on leukemia cell proliferation,apoptosis,and invasion.Results Pan-cancer analysis revealed the dysregulated expression of NUDT19 across multiple cancer types,which was closely associated with poor prognosis,clinical staging,and diagnostic markers.Furthermore,NUDT19 was significantly correlated with tumor biomarkers,immune-related genes,and immune cell infiltration in different cancers.Mutation analysis showed that multiple mutations in NUDT19 were significantly associated with epigenetic changes.Single-cell analysis revealed the heterogeneity of NUDT19 expression in cancer cells,suggesting its potentially diverse functional roles in different cell subpopulations.qRT-PCR experiments confirmed the significant upregulation of NUDT19 in various tumor cell lines.In AML cell lines,NUDT19 knockdown led to reduced cell proliferation and invasion,with increased apoptosis,while NUDT19 overexpression significantly enhanced cell proliferation and invasion while reducing apoptosis.Conclusion This study demonstrates the diverse roles of NUDT19 in various cancer types,with a particularly prominent functional role in leukemia.NUDT19 is not only associated with tumor initiation and progression but may also influence cancer progression through the regulation of immune microenvironment and epigenetic mechanisms.Our research highlights the potential of NUDT19 as a therapeutic target,particularly for targeted therapies in malignancies such as leukemia,with significant clinical application prospects.展开更多
文摘对添加碳化硅球辅助微波干燥多孔硅酸钙进行试验和数值模拟,分析碳化硅球添加量和微波功率对硅酸钙干燥特性的影响.结果表明,碳化硅球的添加显著缩短了硅酸钙的干燥时间.在微波功率150 W时,15 g w(水)=75%的多孔硅酸钙中的碳化硅球最优添加量为12颗,较未添加碳化硅球的样品平衡温度提升15℃,干燥能耗降低46%,干燥有效扩散系数为1.42×10^(-7) m^(2)/s.随着微波功率的增加,硅酸钙的干燥能耗和干燥时间减小,但减小趋势随功率的增加而减缓.在高微波功率下,添加碳化硅球会进一步减少硅酸钙的干燥时间和能耗.对干燥过程进行多物理场仿真,考察样品内部温度、电场强度、水分浓度场的实时分布.干燥初期,碳化硅球的添加对微波加热样品并未起到明显作用,在干燥后期形成热点,有效提升样品温度,加快了硅酸钙的干燥速度.
文摘Objective Recent studies have highlighted the critical role of NUDT19 in the initiation,progression,and prognosis of specific cancer types.However,its involvement in pan-cancer analysis has not been fully characterized.This study aims to systematically explore the expression patterns,clinical significance,and immune-related functions of NUDT19 in various cancer types through multi-omics analysis,further revealing its potential role in cancer,particularly its functional and therapeutic target value in leukemia.Methods To achieve this goal,various bioinformatics approaches were employed to evaluate the expression patterns,clinical significance,and immune-related functions of NUDT19 in tumors and normal tissues.Additionally,we analyzed the mutation characteristics of NUDT19 and its relationship with epigenetic modifications.Using the single-cell analysis tool SingleCellBase,we explored the distribution of NUDT19 across different cell subpopulations in tumors.To validate these findings,qRT-PCR was used to measure NUDT19 expression levels in specific tumor cell lines,and we established acute myeloid leukemia(AML)cell lines(HL-60 and THP-1)to conduct NUDT19 knockdown and overexpression experiments,assessing its effects on leukemia cell proliferation,apoptosis,and invasion.Results Pan-cancer analysis revealed the dysregulated expression of NUDT19 across multiple cancer types,which was closely associated with poor prognosis,clinical staging,and diagnostic markers.Furthermore,NUDT19 was significantly correlated with tumor biomarkers,immune-related genes,and immune cell infiltration in different cancers.Mutation analysis showed that multiple mutations in NUDT19 were significantly associated with epigenetic changes.Single-cell analysis revealed the heterogeneity of NUDT19 expression in cancer cells,suggesting its potentially diverse functional roles in different cell subpopulations.qRT-PCR experiments confirmed the significant upregulation of NUDT19 in various tumor cell lines.In AML cell lines,NUDT19 knockdown led to reduced cell proliferation and invasion,with increased apoptosis,while NUDT19 overexpression significantly enhanced cell proliferation and invasion while reducing apoptosis.Conclusion This study demonstrates the diverse roles of NUDT19 in various cancer types,with a particularly prominent functional role in leukemia.NUDT19 is not only associated with tumor initiation and progression but may also influence cancer progression through the regulation of immune microenvironment and epigenetic mechanisms.Our research highlights the potential of NUDT19 as a therapeutic target,particularly for targeted therapies in malignancies such as leukemia,with significant clinical application prospects.
