Objective:A preliminary trial is conducted to explore whether perioperative(preoperative,intraoperative,and postoperative)electroacupuncture is more effective than postoperative electroacupuncture in improving gastroi...Objective:A preliminary trial is conducted to explore whether perioperative(preoperative,intraoperative,and postoperative)electroacupuncture is more effective than postoperative electroacupuncture in improving gastrointestinal function for colorectal cancer patients.Methods and analysis:The study proposes a randomized,parallel-controlled,single-center trial involving 30 colorectal cancer patients aged 18-79 requiring elective surgery.Participants are randomly assigned to two groups,with equal allocation,where one group receives perioperative electroacupuncture,and the other group receives postoperative electroacupuncture.The treatment duration spans from preoperative to postoperative 72 h,with a subsequent 28-day follow-up period.The primary outcome is the time of first postoperative defecation.The secondary outcomes include the recovery time of postoperative bowel sounds,time of the first flatus,dietary recovery,postoperative gastrointestinal dysfunction frequency,quality of life scale,postoperative pain degree,time of the first ambulation,length of hospital stay,gastrointestinal hormone indicators,and adverse events.The coagulation function test,liver and renal function,and stool and blood routine serve as security biomarkers.The statistical analysis includes the t-test,rank-sum test,Chi-square test,and analysis of variance.A two-sided significance level is set at 5%.Discussion:This study aims to evaluate the feasibility and preliminary effectiveness of perioperative electroacupuncture for gastrointestinal function recovery following colorectal cancer surgery.The study’s strengths include its randomized design,well-defined intervention periods,and multi-dimensional outcome assessment.Nevertheless,limitations,such as the small sample size and single-center setting,may affect external validity.The findings will guide protocol refinement and sample size estimation for future large-scale multi-center randomized controlled trials.展开更多
Objective To observe the effect of electroacupuncture(EA)at different time points during the perioperative period on the recovery of gastrointestinal function after gastrointestinal malignant neoplasms surgery.Methods...Objective To observe the effect of electroacupuncture(EA)at different time points during the perioperative period on the recovery of gastrointestinal function after gastrointestinal malignant neoplasms surgery.Methods Sixty-three patients who needed radical surgery for gastrointestinal tumors were randomized into a control group,treatment group 1(postoperative EA group),and treatment group 2(intraoperative and postoperative EA group).The control group received surgery and conventional Western medicine treatment,and treatment groups 1 and 2 received additional EA treatment at different time points.The initial flatus time after the surgery,visual analog scale(VAS)score at different time points after the surgery,the proportion of using patient-controlled analgesia(PCA)after the surgery,and the times of adding analgesics were observed in the three groups.Results The initial flatus time after the surgery was earlier in treatment groups 1 and 2 than in the control group(P<0.05);the difference between treatment groups 1 and 2 was statistically insignificant(P>0.05).The VAS score was lower in treatment group 2 than in the control group at 6,12,24,and 72 h after the surgery(P<0.05);the VAS score was lower in treatment group 1 than in the control group only at 72 h after the surgery(P<0.05).There were no significant differences in the rate of using PCA among the three groups(P>0.05).Regarding the times of adding analgesics,it was less in treatment group 2 than in the control group at 12 h after the surgery(P<0.05).Conclusion Either EA during and after the surgery or only after the surgery can hasten the initial flatus and boost the recovery of gastrointestinal function in patients after radical resection of gastrointestinal neoplasms.Successive EA during and after the surgery should be superior to postoperative EA regarding the analgesic effect after the surgery.展开更多
文摘Objective:A preliminary trial is conducted to explore whether perioperative(preoperative,intraoperative,and postoperative)electroacupuncture is more effective than postoperative electroacupuncture in improving gastrointestinal function for colorectal cancer patients.Methods and analysis:The study proposes a randomized,parallel-controlled,single-center trial involving 30 colorectal cancer patients aged 18-79 requiring elective surgery.Participants are randomly assigned to two groups,with equal allocation,where one group receives perioperative electroacupuncture,and the other group receives postoperative electroacupuncture.The treatment duration spans from preoperative to postoperative 72 h,with a subsequent 28-day follow-up period.The primary outcome is the time of first postoperative defecation.The secondary outcomes include the recovery time of postoperative bowel sounds,time of the first flatus,dietary recovery,postoperative gastrointestinal dysfunction frequency,quality of life scale,postoperative pain degree,time of the first ambulation,length of hospital stay,gastrointestinal hormone indicators,and adverse events.The coagulation function test,liver and renal function,and stool and blood routine serve as security biomarkers.The statistical analysis includes the t-test,rank-sum test,Chi-square test,and analysis of variance.A two-sided significance level is set at 5%.Discussion:This study aims to evaluate the feasibility and preliminary effectiveness of perioperative electroacupuncture for gastrointestinal function recovery following colorectal cancer surgery.The study’s strengths include its randomized design,well-defined intervention periods,and multi-dimensional outcome assessment.Nevertheless,limitations,such as the small sample size and single-center setting,may affect external validity.The findings will guide protocol refinement and sample size estimation for future large-scale multi-center randomized controlled trials.
文摘Objective To observe the effect of electroacupuncture(EA)at different time points during the perioperative period on the recovery of gastrointestinal function after gastrointestinal malignant neoplasms surgery.Methods Sixty-three patients who needed radical surgery for gastrointestinal tumors were randomized into a control group,treatment group 1(postoperative EA group),and treatment group 2(intraoperative and postoperative EA group).The control group received surgery and conventional Western medicine treatment,and treatment groups 1 and 2 received additional EA treatment at different time points.The initial flatus time after the surgery,visual analog scale(VAS)score at different time points after the surgery,the proportion of using patient-controlled analgesia(PCA)after the surgery,and the times of adding analgesics were observed in the three groups.Results The initial flatus time after the surgery was earlier in treatment groups 1 and 2 than in the control group(P<0.05);the difference between treatment groups 1 and 2 was statistically insignificant(P>0.05).The VAS score was lower in treatment group 2 than in the control group at 6,12,24,and 72 h after the surgery(P<0.05);the VAS score was lower in treatment group 1 than in the control group only at 72 h after the surgery(P<0.05).There were no significant differences in the rate of using PCA among the three groups(P>0.05).Regarding the times of adding analgesics,it was less in treatment group 2 than in the control group at 12 h after the surgery(P<0.05).Conclusion Either EA during and after the surgery or only after the surgery can hasten the initial flatus and boost the recovery of gastrointestinal function in patients after radical resection of gastrointestinal neoplasms.Successive EA during and after the surgery should be superior to postoperative EA regarding the analgesic effect after the surgery.
