目的探讨罗哌卡因复合布托啡诺腹横肌平面阻滞麻醉在腹腔镜腹部手术中的应用效果。方法选取2020年6月至2021年6月我院收治的200例腹腔镜腹部手术患者,按单双号随机分组形式将其分为对照组和观察组,各100例。所有患者均在麻醉诱导后行双...目的探讨罗哌卡因复合布托啡诺腹横肌平面阻滞麻醉在腹腔镜腹部手术中的应用效果。方法选取2020年6月至2021年6月我院收治的200例腹腔镜腹部手术患者,按单双号随机分组形式将其分为对照组和观察组,各100例。所有患者均在麻醉诱导后行双侧腹横肌平面阻滞,对照组每侧注入20 mL 0.375%罗哌卡因+1 mL生理盐水,观察组每侧注入20 mL 0.375%罗哌卡因+1 mL 0.1%布托啡诺。比较两组的麻醉效果。结果手术10 min(T_(1))及术毕即刻(T_(2))时,观察组的皮质醇(Cor)、去甲肾上腺素(NE)水平、心率(HR)、平均动脉压(MAP)低于对照组(P<0.05)。观察组的40项术后恢复质量评分量表(QoR-40)评分高于对照组(P<0.05)。两组的肠道功能恢复时间、下床活动时间、不良反应总发生率无明显差异(P>0.05)。结论临床对腹腔镜腹部手术患者采用罗哌卡因复合布托啡诺腹横肌平面阻滞有助于减轻其机体应激反应,提高麻醉效果,值得推广。展开更多
Scallop is a popular sea food and an important aquaculture shellfish.Identification of genes and genetic variants relating to scallop growth could benefit high-yielding scallop breeding.Myostatin(MSTN) is a conservati...Scallop is a popular sea food and an important aquaculture shellfish.Identification of genes and genetic variants relating to scallop growth could benefit high-yielding scallop breeding.Myostatin(MSTN) is a conservative regulator of muscle growth,and has become one of the most important target genes for genetic improvement of the production of farmed animals.In this study,four single nucleotide polymorphisms(SNPs) were identified in the 5' flanking region of MSTN gene(Cf MSTN) in Zhikong scallop(Chlamys farreri).The association of these SNPs with scallop growth traits,including shell length,shell height,body weight and striated muscle weight was analyzed.The SNP g-1162G>T was found to associate with shell length,shell height,and striated muscle weight.The TT type scallops showed significantly higher trait values than those of GT type,and the GG type individuals exhibited median values.On the contrary,significantly more Cf MSTN transcripts were detected in the striated muscle of GT type scallops than in those of TT and GG type ones.Our results suggested that Cf MSTN might regulate the scallop muscle growth negatively,and SNP g-1162G>T can be used as a candidate marker for the selective breeding of high-yielding scallop.展开更多
文摘目的探讨罗哌卡因复合布托啡诺腹横肌平面阻滞麻醉在腹腔镜腹部手术中的应用效果。方法选取2020年6月至2021年6月我院收治的200例腹腔镜腹部手术患者,按单双号随机分组形式将其分为对照组和观察组,各100例。所有患者均在麻醉诱导后行双侧腹横肌平面阻滞,对照组每侧注入20 mL 0.375%罗哌卡因+1 mL生理盐水,观察组每侧注入20 mL 0.375%罗哌卡因+1 mL 0.1%布托啡诺。比较两组的麻醉效果。结果手术10 min(T_(1))及术毕即刻(T_(2))时,观察组的皮质醇(Cor)、去甲肾上腺素(NE)水平、心率(HR)、平均动脉压(MAP)低于对照组(P<0.05)。观察组的40项术后恢复质量评分量表(QoR-40)评分高于对照组(P<0.05)。两组的肠道功能恢复时间、下床活动时间、不良反应总发生率无明显差异(P>0.05)。结论临床对腹腔镜腹部手术患者采用罗哌卡因复合布托啡诺腹横肌平面阻滞有助于减轻其机体应激反应,提高麻醉效果,值得推广。
基金supported by the National High-Tech R&D Program (863 Program,2012AA10A402)Doctoral Fund of Ministry of Education of China (20120132130 002)the National Key Technology R&D Program of China (2011BAD13B06)
文摘Scallop is a popular sea food and an important aquaculture shellfish.Identification of genes and genetic variants relating to scallop growth could benefit high-yielding scallop breeding.Myostatin(MSTN) is a conservative regulator of muscle growth,and has become one of the most important target genes for genetic improvement of the production of farmed animals.In this study,four single nucleotide polymorphisms(SNPs) were identified in the 5' flanking region of MSTN gene(Cf MSTN) in Zhikong scallop(Chlamys farreri).The association of these SNPs with scallop growth traits,including shell length,shell height,body weight and striated muscle weight was analyzed.The SNP g-1162G>T was found to associate with shell length,shell height,and striated muscle weight.The TT type scallops showed significantly higher trait values than those of GT type,and the GG type individuals exhibited median values.On the contrary,significantly more Cf MSTN transcripts were detected in the striated muscle of GT type scallops than in those of TT and GG type ones.Our results suggested that Cf MSTN might regulate the scallop muscle growth negatively,and SNP g-1162G>T can be used as a candidate marker for the selective breeding of high-yielding scallop.
