Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under ext...Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.展开更多
Biopolymeric nanocomposites have attracted considerable attention because of their biocompatibility,biodegradability,and unique physicochemical properties.It is essential to manufacture three-dimensional(3D)biocompati...Biopolymeric nanocomposites have attracted considerable attention because of their biocompatibility,biodegradability,and unique physicochemical properties.It is essential to manufacture three-dimensional(3D)biocompatible micro/nanostructures using biopolymeric nanocomposites.Herein,we demonstrate the high-fidelity fabrication of biocompatible 3D features with sub-50 nm resolution using femtosecond laser direct writing(FsLDW)of a biopolymeric nanocomposite composed of egg white and sulfonated graphene(S-graphene).The biopolymer nanocomposite acts as a negative photoresist suitable for water-based lithography.The introduction of S-graphene not only dramatically lowered the laser power threshold but also significantly modulated the morphology of the 3D features constructed by FsLDW.Microstructures with porous,rough,or smooth morphologies were obtained by optimizing the S-graphene concentration and laser scanning speed.The fabricated egg-white/S-graphene microstructures exhibited biocompatibility and environmental degradability.Egg white/S-graphene was also employed to fabricate diffractive gratings with superior optical quality.This study provides a promising method to manufacture biocompatible 3D features with controllable morphology,which has potential applications in biological and photonic fields.展开更多
基金financial support of the National Key R&D Program of China(Grant Nos.2024YFB4607402 and 2016YFA0200500)National Natural Science Foundation of China(NSFC,Grant Nos.61975213,61475164 and 61205194)International Partnership Program of Chinese Academy of Sciences(GJHZ2021130)。
文摘Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.
基金financially supported by the National Key Research and Development Program of China(Nos.2024YFB4607402 and 2016YFC1100502)the National Natural Science Foundation of China(Nos.51673208 and 61975213)。
文摘Biopolymeric nanocomposites have attracted considerable attention because of their biocompatibility,biodegradability,and unique physicochemical properties.It is essential to manufacture three-dimensional(3D)biocompatible micro/nanostructures using biopolymeric nanocomposites.Herein,we demonstrate the high-fidelity fabrication of biocompatible 3D features with sub-50 nm resolution using femtosecond laser direct writing(FsLDW)of a biopolymeric nanocomposite composed of egg white and sulfonated graphene(S-graphene).The biopolymer nanocomposite acts as a negative photoresist suitable for water-based lithography.The introduction of S-graphene not only dramatically lowered the laser power threshold but also significantly modulated the morphology of the 3D features constructed by FsLDW.Microstructures with porous,rough,or smooth morphologies were obtained by optimizing the S-graphene concentration and laser scanning speed.The fabricated egg-white/S-graphene microstructures exhibited biocompatibility and environmental degradability.Egg white/S-graphene was also employed to fabricate diffractive gratings with superior optical quality.This study provides a promising method to manufacture biocompatible 3D features with controllable morphology,which has potential applications in biological and photonic fields.
