Accurate classification of pulmonary nodules is critical for early diagnosis of lung cancer. However, non-invasive and accurate diagnosis of benign and malignant pulmonary nodules faces great challenges. In this study...Accurate classification of pulmonary nodules is critical for early diagnosis of lung cancer. However, non-invasive and accurate diagnosis of benign and malignant pulmonary nodules faces great challenges. In this study, we develop a nano zero-valent iron(nZVI)-assisted laser desorption/ionization mass spectrometry(LDI MS) platform, which enables ultra-high-throughput acquisition of abundant metabolic fingerprint information of serum in negative ion mode. We further recruit a large-scale multicenter prospective cohort and collect 1099 serum samples from participants with benign and malignant nodules. The accurate machine learning models are built and validated based on n ZVI-assisted LDI MS metabolomics to achieve efficient classification of benign and malignant nodules. Using our established stacking ensemble learning model, the AUC of the ROC curve for benign and malignant lung nodule classification can be as high as 0.9, and the sensitivity can reach 85.5%, which is significantly better than existing clinical models. This work provides an integrated workflow from detection technology to diagnostic models for biomarkerbased pulmonary nodule diagnosis, which would be widely used in rapid and large-scale screening of pulmonary nodules.展开更多
目的:探究银杏叶片联合多奈哌齐+丁苯酞治疗老年痴呆的疗效,并分析其对神经损伤因子的影响。方法:回顾性选取本院2021年2月至2023年2月收治的老年痴呆患者102例为研究对象,依据治疗方案分为对照组51例(多奈哌齐+丁苯酞治疗)、观察组51例...目的:探究银杏叶片联合多奈哌齐+丁苯酞治疗老年痴呆的疗效,并分析其对神经损伤因子的影响。方法:回顾性选取本院2021年2月至2023年2月收治的老年痴呆患者102例为研究对象,依据治疗方案分为对照组51例(多奈哌齐+丁苯酞治疗)、观察组51例(银杏叶片联合多奈哌齐+丁苯酞治疗)。对比两组临床疗效、安全性及治疗前后痴呆症状、认知功能、日常生活能力、神经损伤因子[脂蛋白相关磷脂酶A2(Lipoprotein-associated phospholipaseA2,Lp-PLA2)、脑源性神经营养因子(Brain-derived neuro-trophic factor,BDNF)、神经元特异性烯醇化酶(Neuron specific enolase,NSE)]、氧化应激[谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)、超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)]水平。结果:观察组总有效率高于对照组(P<0.05);治疗2 m后,观察组临床痴呆评定量表(Clinical dementia rating,CDR)、日常生活能力评估量表(Activity of Daily Living Scale,ADL)评分低于对照组,简易精神状态量表(Minimental state examination,MMSE)评分高于对照组(P<0.05);治疗1m后、2m后,观察组血清Lp-PLA2、NSE、MDA水平低于对照组,BDNF、GSH-Px、SOD水平高于对照组(P<0.05);两组不良反应发生率对比无显著差异。结论:银杏叶片联合多奈哌齐+丁苯酞治疗老年痴呆的疗效确切,可改善痴呆症状、认知功能,提高日常生活能力,减轻神经损伤,纠正高氧化应激状态,且具有一定安全性。展开更多
The metal-carbon dioxide batteries,emerging as high-energy-density energy storage devices,enable direct CO_(2)utilization,offering promising prospects for CO_(2)capture and utilization,energy conversion,and storage.Ho...The metal-carbon dioxide batteries,emerging as high-energy-density energy storage devices,enable direct CO_(2)utilization,offering promising prospects for CO_(2)capture and utilization,energy conversion,and storage.However,the electrochemical performance of M-CO_(2)batteries faces significant challenges,particularly at extreme temperatures.Issues such as high overpotential,poor charge reversibility,and cycling capacity decay arise from complex reaction interfaces,sluggish oxidation kinetics,inefficient catalysts,dendrite growth,and unstable electrolytes.Despite significant advancements at room temperature,limited research has focused on the performance of M-CO_(2)batteries across a wide-temperature range.This review examines the effects of low and high temperatures on M-CO_(2)battery components and their reaction mechanism,as well as the advancements made in extending operational ranges from room temperature to extremely low and high temperatures.It discusses strategies to enhance electrochemical performance at extreme temperatures and outlines opportunities,challenges,and future directions for the development of M-CO_(2)batteries.展开更多
基金financially supported by the Fundamental Research Funds for the Central Universities (No. WHU 2042024kf0009)National Key Research and Development Program of China (No. 2021YFC2700700)the National Natural Science Foundation of China (Nos. 22074111, 22004093)。
文摘Accurate classification of pulmonary nodules is critical for early diagnosis of lung cancer. However, non-invasive and accurate diagnosis of benign and malignant pulmonary nodules faces great challenges. In this study, we develop a nano zero-valent iron(nZVI)-assisted laser desorption/ionization mass spectrometry(LDI MS) platform, which enables ultra-high-throughput acquisition of abundant metabolic fingerprint information of serum in negative ion mode. We further recruit a large-scale multicenter prospective cohort and collect 1099 serum samples from participants with benign and malignant nodules. The accurate machine learning models are built and validated based on n ZVI-assisted LDI MS metabolomics to achieve efficient classification of benign and malignant nodules. Using our established stacking ensemble learning model, the AUC of the ROC curve for benign and malignant lung nodule classification can be as high as 0.9, and the sensitivity can reach 85.5%, which is significantly better than existing clinical models. This work provides an integrated workflow from detection technology to diagnostic models for biomarkerbased pulmonary nodule diagnosis, which would be widely used in rapid and large-scale screening of pulmonary nodules.
文摘目的:探究银杏叶片联合多奈哌齐+丁苯酞治疗老年痴呆的疗效,并分析其对神经损伤因子的影响。方法:回顾性选取本院2021年2月至2023年2月收治的老年痴呆患者102例为研究对象,依据治疗方案分为对照组51例(多奈哌齐+丁苯酞治疗)、观察组51例(银杏叶片联合多奈哌齐+丁苯酞治疗)。对比两组临床疗效、安全性及治疗前后痴呆症状、认知功能、日常生活能力、神经损伤因子[脂蛋白相关磷脂酶A2(Lipoprotein-associated phospholipaseA2,Lp-PLA2)、脑源性神经营养因子(Brain-derived neuro-trophic factor,BDNF)、神经元特异性烯醇化酶(Neuron specific enolase,NSE)]、氧化应激[谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)、超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)]水平。结果:观察组总有效率高于对照组(P<0.05);治疗2 m后,观察组临床痴呆评定量表(Clinical dementia rating,CDR)、日常生活能力评估量表(Activity of Daily Living Scale,ADL)评分低于对照组,简易精神状态量表(Minimental state examination,MMSE)评分高于对照组(P<0.05);治疗1m后、2m后,观察组血清Lp-PLA2、NSE、MDA水平低于对照组,BDNF、GSH-Px、SOD水平高于对照组(P<0.05);两组不良反应发生率对比无显著差异。结论:银杏叶片联合多奈哌齐+丁苯酞治疗老年痴呆的疗效确切,可改善痴呆症状、认知功能,提高日常生活能力,减轻神经损伤,纠正高氧化应激状态,且具有一定安全性。
基金support from the National Natural Science Foundation of China(No.52201278,No.21975260,No.22379103,No.22409074).
文摘The metal-carbon dioxide batteries,emerging as high-energy-density energy storage devices,enable direct CO_(2)utilization,offering promising prospects for CO_(2)capture and utilization,energy conversion,and storage.However,the electrochemical performance of M-CO_(2)batteries faces significant challenges,particularly at extreme temperatures.Issues such as high overpotential,poor charge reversibility,and cycling capacity decay arise from complex reaction interfaces,sluggish oxidation kinetics,inefficient catalysts,dendrite growth,and unstable electrolytes.Despite significant advancements at room temperature,limited research has focused on the performance of M-CO_(2)batteries across a wide-temperature range.This review examines the effects of low and high temperatures on M-CO_(2)battery components and their reaction mechanism,as well as the advancements made in extending operational ranges from room temperature to extremely low and high temperatures.It discusses strategies to enhance electrochemical performance at extreme temperatures and outlines opportunities,challenges,and future directions for the development of M-CO_(2)batteries.
