Among women,breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mor-tality globally.Despite improvements in early detection and diagnosis,some risk factors have been on the ri...Among women,breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mor-tality globally.Despite improvements in early detection and diagnosis,some risk factors have been on the rise,includ-ing the decline in birth rate,the use of oral contraceptives,and the escalation in alcohol consumption and obesity.Thus,there is an imperative urgent need to expand accessible prevention and treatment options for breast cancer.Regarding these tumors,several natural compounds have shown efficacy in slowing or preventing their progres-sion,offering a promising therapeutic alternative.Among these,α-mangostin,a xanthone derived from mangosteen,has demonstrated promising antitumor effects against different malignancies,particularly breast cancer.The mecha-nisms involved in α-mangostin's therapeutic effects include downregulation of oncogenic ion channels,modulation of cell cycle progression,suppression of oncogene expression,and interference with steroid and growth factor recep-tors signaling.This review thoroughly explores these mechanisms,as well as updates information on α-mangostin chemical structure and its potential as a coadjuvant to conventional breast cancer therapies.Furthermore,we provide scientifically supported insights for the development of clinically applicable α-mangostin-based treatments,high-lighting the robust body of evidence supporting its cancer-fighting properties,despite the absence of clinical studies to date.展开更多
文摘Among women,breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mor-tality globally.Despite improvements in early detection and diagnosis,some risk factors have been on the rise,includ-ing the decline in birth rate,the use of oral contraceptives,and the escalation in alcohol consumption and obesity.Thus,there is an imperative urgent need to expand accessible prevention and treatment options for breast cancer.Regarding these tumors,several natural compounds have shown efficacy in slowing or preventing their progres-sion,offering a promising therapeutic alternative.Among these,α-mangostin,a xanthone derived from mangosteen,has demonstrated promising antitumor effects against different malignancies,particularly breast cancer.The mecha-nisms involved in α-mangostin's therapeutic effects include downregulation of oncogenic ion channels,modulation of cell cycle progression,suppression of oncogene expression,and interference with steroid and growth factor recep-tors signaling.This review thoroughly explores these mechanisms,as well as updates information on α-mangostin chemical structure and its potential as a coadjuvant to conventional breast cancer therapies.Furthermore,we provide scientifically supported insights for the development of clinically applicable α-mangostin-based treatments,high-lighting the robust body of evidence supporting its cancer-fighting properties,despite the absence of clinical studies to date.
