Perovskites showcased potential promise for innovative circularly polarized luminescence (CPL)-active multi-channelinformation encryption, owing to the exceptional luminescence brightness. It was still a formidablecha...Perovskites showcased potential promise for innovative circularly polarized luminescence (CPL)-active multi-channelinformation encryption, owing to the exceptional luminescence brightness. It was still a formidablechallenge to fabricate CPL-active perovskites with significant luminescent asymmetry factor (glum) and full-colour-tailorableCPL properties. Indeed, compared to isotropic perovskites, anisotropic perovskite nanowires (NWs)were conducive to carrier separation and transport for polarization enhancement. Herein, three types of CsPb(Br/I)3 NWs with green, orange, red fluorescence (FL) were respectively synthesized and assembled into chiral NWfilms. The right-handed/left-handed chiral NW films constructed by 4+4 layers and 45° inter-angles exhibitshighly symmetric and mirror-like chiral signals. The strongest chiral intensity is more than 3000 medg. CPLsignals with wide colour gamut produce ranging from 480 nm to 800 nm, and tailorable CPL wavelengths aremanipulated by the emission wavelength of perovskite NWs. A giant CPL signal with a maximum glum of up to 10^(-1) is achieved. The polarization imaging of chiral NW films produces brilliant differential circularly polarizedstructural colours, making it more widely used in multilevel anti-counterfeiting systems. A significant break-throughlies in the development of advanced chiral perovskite materials with remarkable glum and tailorable CPLproperties, which sheds new light on optical anti-counterfeiting and intelligent information encryption.展开更多
One-dimensional perovskites possess unique photoelectric properties that distinguish them from other perovskitetypes, making them a focal point in photoelectric research. In recent years, there has been a significant ...One-dimensional perovskites possess unique photoelectric properties that distinguish them from other perovskitetypes, making them a focal point in photoelectric research. In recent years, there has been a significant surge ininterest surrounding the synthesis and application of one-dimensional anisotropic perovskites, spurred by ad-vancementsin synthesis techniques and notable breakthroughs in novel methodologies and application proper-ties.This article provides a comprehensive review of the progress made in research on one-dimensionalanisotropic perovskites, detailing the synthesis mechanisms and potential pathways for performance enhance-mentin various applications. We highlight the crucial role of controllable synthesis and heterogeneous effect intailoring perovskite properties to boost application efficacy. Initially, this review examines the primary synthesismethods and mechanisms for creating heterogeneously induced one-dimensional anisotropic perovskites, cate-gorizingthem into two main approaches: the classical wet chemical synthesis, which utilizes selective ligands, andthe ligand-free, substrate-assisted method. The precision in controllable synthesis is essential for fabricatingheterogeneous structures, where the synthesized precursor, shape, and surface ligand significantly influence theinterfacial strength of the heterogenic interface. We also discuss the key features that must be improved for high-performanceapplications, exploring how heterogeneous effects can enhance performance and drive the devel-opmentof heterogeneous devices in various applications, such as photodetectors, solar cells, light-emitting di-odes,and photocatalysis. Conclusively, by highlighting the emerging potential and promising opportunitiesoffered by strategic heterogeneous construction, we forecast a dynamic and transformative future for their pro-ductionand application landscapes.展开更多
In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In ord...In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In order to improve the patient’s appearance and functional impairment,we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic testing.The 18-month follow-up confirmed that the effect was satisfactory without obvious recurrence.Based on this outcome,we have developed a diagnosis and treat-ment process for patients with MFT,aiming to provide a reference for standardized treatment of this rare disease.展开更多
AIM: To establish an accurate and rapid stem-loop reverse transcriptional real-time PCR (RT-PCR) method to quantify human let-7a miRNA in gastric cancer. METHODS: According to the sequence of let-7a miRNA,the stem-loo...AIM: To establish an accurate and rapid stem-loop reverse transcriptional real-time PCR (RT-PCR) method to quantify human let-7a miRNA in gastric cancer. METHODS: According to the sequence of let-7a miRNA,the stem-loop reverse transcriptional primer,the primers and quantitative MGB probes of real-time PCR were designed and synthesized. The dynamic range and the sensitivity of quantitative reverse transcriptional real-time PCR were determined. The levels of let-7a miRNA were examined in 32 gastric carcinoma samples by stem-loop RT-PCR method. RESULTS: The dynamic range and sensitivity of the let-7a miRNA quantification scheme were evaluated,the result showed the assay could precisely detect 10 copies of mature let-7a miRNA in as few as 0.05 ng of total RNA of gastric mucosa. The results of specificity analysis showed no fluorescence signal occurred even though 50 ng of human genomic DNA was added to the reverse transcription (RT) reaction. The expression level of let-7a miRNA in gastric tumor tissues was significantly lower compared to normal tissues in 14 samples from 32 patients. CONCLUSION: The stem-loop RT-PCR is a reliable method to detect let-7a miRNA which may play an important role in the development of gastric carcinoma.展开更多
Objective:To evaluate the analgesic effect of ultrasound-guided subcostal anterior quadratus lumborum block(QLB)for laparoscopic radical gastrectomy surgery.Methods:Patients(aged 20-65 years,ASA Ⅰ-Ⅱ,and weighing 40-...Objective:To evaluate the analgesic effect of ultrasound-guided subcostal anterior quadratus lumborum block(QLB)for laparoscopic radical gastrectomy surgery.Methods:Patients(aged 20-65 years,ASA Ⅰ-Ⅱ,and weighing 40-75 kg)scheduled for elective laparoscopic radical gastrectomy were enrolled in the current study.Sixty patients were randomly assigned to two groups by computer-generated randomization codes:an ultrasound-guided oblique subcostal transversus abdominis plane block(TAPB)group(group T,n=30)or an ultrasound-guided subcostal anterior QLB group(group Q,n=30).In both groups,bilateral ultrasound-guided oblique subcostal TAPB and subcostal anterior QLB were performed before general anesthesia with 0.25% ropivacaine 0.5 mL/kg.For postoperative management,all patients received patient-controlled intravenous analgesia(PCIA)with nalbuphine and sufentanil after surgery,maintaining visual analogue scale(VAS)scores<4 within 48 h.The intraoperative consumption of remifentanil,the requirement for sufentanil as a rescue analgesic,and the VAS scores at rest and coughing were recorded at 1,6,12,24 and 48 h after surgery.The recovery(extubation time after surgery,first ambulation time,first flatus time and length of postoperative hospital stay)and the adverse events(nausea and vomiting,skin pruritus,respiratory depression and nerve-block related complications)were observed and recorded.The primary outcome was the perioperative consumption of opioids.Results:Compared with group T,the intraoperative consumption of remifentanil,requirement for sufentanil and the frequency of PCIA were reduced in group Q.Meanwhile,VAS scores at all points of observation were significantly lower in group Q than in group T.Patients in group Q were also associated with shorter time to first out-of-bed activity and flatus,and shorter length of postoperative hospital stay than group T(P<0.05).There were no skin pruritus,respiratory depression or nerve-block related complications in both groups.Conclusion:Compared with ultrasound-guided oblique subcostal TAPB,ultrasound-guided subcostal anterior QLB provided greater opioid-sparing effect,lower visual analogue scores,and shorter postoperative hospital stay for laparoscopic radical gastrectomy.展开更多
We investigate the critical exponents and magnetocaloric effect of Co2-xZrSn polycrystal. The Co2-xZrSn undergoes a second-order ferromagnetism phase transition around the Curie temperature of Tc ~280 K. The critical ...We investigate the critical exponents and magnetocaloric effect of Co2-xZrSn polycrystal. The Co2-xZrSn undergoes a second-order ferromagnetism phase transition around the Curie temperature of Tc ~280 K. The critical behavior in the vicinity of the magnetic phase transition has been investigated by using modified Arrott plot and Kouvel–Fisher methods.The obtained critical exponents, β, γ, and δ can be well described by the scaling theory. The determined exponents of Co2-xZrSn obey the mean-field model with a long-range magnetic interaction. In addition, the maximum magnetic entropy change-?Sm ax M of Co2-xZrSn is about 0.57 J·kg-1·K-1 and the relative cooling power(RCP) is 14.68 J·kg-1 at 50 kOe(1 Oe = 79.5775 A·m-1).展开更多
To the editor In 2003,Schwabegger et al.proposed the muscle-sparing latissimus dorsi(MS-LD)flap[1],which preserved a portion of the latissimus dorsi(LD)muscle around the point where the thoracodorsal artery(TDA)perfor...To the editor In 2003,Schwabegger et al.proposed the muscle-sparing latissimus dorsi(MS-LD)flap[1],which preserved a portion of the latissimus dorsi(LD)muscle around the point where the thoracodorsal artery(TDA)perforator penetrates the muscle,having the advantages of a sufficient flap blood supply and reduced donor-site morbidity.However,the traditional MS-LD flap is still too bulky for the reconstruction of defects of the face and neck,and the size of the traditional flap is sometimes not enough to repair large defects.Thus,combining soft tissue expansion with a vascular supercharging technique,we propose a novel design of MS-LD flap,as well as its application strategy.展开更多
Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs...Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs)variation and neuropathy within keloids contribute to these uncomfortable sensations;however the underlying mechanisms remain unclear.This study aims to explore the potential role of fibroblasts(FBs)and SCs in pruritic and pain keloids.Methods:The activity of FBs and SCs was investigated using single-cell RNA sequencing(scRNA-seq)data of keloids.These bioinformatics analysis results were validated through in vitro cell culture,clinical samples,and in vivo experiments.The selected molecule was confirmed to be correlated with pain and itch and was subsequently used to treat cells in order to investigate its role in keloids.The in vivo inhibition assay was performed to evaluate its therapeutic potential.Results:Our scRNA-seq analysis identified specific types of FBs and SCs were present in higher proportions in keloids and exhibited neurogenesis-related functions.Upon conducting an interaction analysis of these two cell types,we identified a critical molecule,Midkine(MDK),which is positively correlated with the patients'pain and itching levels.Besides,MDK treatment facilitated the proliferation of SCs and their transition to a repairing phenotype,resulting in neuronal axonogenesis.This activation of repairing SCs promoted the release of substance P from nerve fibers,leading to clinical symptoms of pain and pruritus in keloid patients.Targeting MDK effectively reduces abnormal Schwann cell proliferation and subsequently inhibits the secretion of neuropeptides that trigger pain and pruritus.Conclusions:Our study uncovered the interaction between FBs and SCs in the development of keloidal pain and pruritus,offering a novel therapeutic strategy to alleviate the distressing symptoms of keloids.展开更多
基金supported by the National Natural Science Foundation of China(22278184,22272065)the Natural Science Foundation of Jiangsu Province(BK20211530)+1 种基金the Fundamental Research Funds for the Central Universities(JUSRP622018,JUSRP202404022)the Key Research and Development Special Project of Yichun City,Jiangxi Province,China(2023ZDYFZX06).
文摘Perovskites showcased potential promise for innovative circularly polarized luminescence (CPL)-active multi-channelinformation encryption, owing to the exceptional luminescence brightness. It was still a formidablechallenge to fabricate CPL-active perovskites with significant luminescent asymmetry factor (glum) and full-colour-tailorableCPL properties. Indeed, compared to isotropic perovskites, anisotropic perovskite nanowires (NWs)were conducive to carrier separation and transport for polarization enhancement. Herein, three types of CsPb(Br/I)3 NWs with green, orange, red fluorescence (FL) were respectively synthesized and assembled into chiral NWfilms. The right-handed/left-handed chiral NW films constructed by 4+4 layers and 45° inter-angles exhibitshighly symmetric and mirror-like chiral signals. The strongest chiral intensity is more than 3000 medg. CPLsignals with wide colour gamut produce ranging from 480 nm to 800 nm, and tailorable CPL wavelengths aremanipulated by the emission wavelength of perovskite NWs. A giant CPL signal with a maximum glum of up to 10^(-1) is achieved. The polarization imaging of chiral NW films produces brilliant differential circularly polarizedstructural colours, making it more widely used in multilevel anti-counterfeiting systems. A significant break-throughlies in the development of advanced chiral perovskite materials with remarkable glum and tailorable CPLproperties, which sheds new light on optical anti-counterfeiting and intelligent information encryption.
基金supported by the National Natural Science Foundation of China(22272065)the Natural Science Foundation of Jiangsu Province(BK20211530)+1 种基金the Fundamental Research Funds for the Central Universities(JUSRP62218)the Key Research and Development Special Project of Yi'chun City,Jiangxi Province,China(2023ZDYFZX06).
文摘One-dimensional perovskites possess unique photoelectric properties that distinguish them from other perovskitetypes, making them a focal point in photoelectric research. In recent years, there has been a significant surge ininterest surrounding the synthesis and application of one-dimensional anisotropic perovskites, spurred by ad-vancementsin synthesis techniques and notable breakthroughs in novel methodologies and application proper-ties.This article provides a comprehensive review of the progress made in research on one-dimensionalanisotropic perovskites, detailing the synthesis mechanisms and potential pathways for performance enhance-mentin various applications. We highlight the crucial role of controllable synthesis and heterogeneous effect intailoring perovskite properties to boost application efficacy. Initially, this review examines the primary synthesismethods and mechanisms for creating heterogeneously induced one-dimensional anisotropic perovskites, cate-gorizingthem into two main approaches: the classical wet chemical synthesis, which utilizes selective ligands, andthe ligand-free, substrate-assisted method. The precision in controllable synthesis is essential for fabricatingheterogeneous structures, where the synthesized precursor, shape, and surface ligand significantly influence theinterfacial strength of the heterogenic interface. We also discuss the key features that must be improved for high-performanceapplications, exploring how heterogeneous effects can enhance performance and drive the devel-opmentof heterogeneous devices in various applications, such as photodetectors, solar cells, light-emitting di-odes,and photocatalysis. Conclusively, by highlighting the emerging potential and promising opportunitiesoffered by strategic heterogeneous construction, we forecast a dynamic and transformative future for their pro-ductionand application landscapes.
基金supported by the National Natural Science Foundation of China(grant nos.82272264 and 82072177).
文摘In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In order to improve the patient’s appearance and functional impairment,we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic testing.The 18-month follow-up confirmed that the effect was satisfactory without obvious recurrence.Based on this outcome,we have developed a diagnosis and treat-ment process for patients with MFT,aiming to provide a reference for standardized treatment of this rare disease.
文摘AIM: To establish an accurate and rapid stem-loop reverse transcriptional real-time PCR (RT-PCR) method to quantify human let-7a miRNA in gastric cancer. METHODS: According to the sequence of let-7a miRNA,the stem-loop reverse transcriptional primer,the primers and quantitative MGB probes of real-time PCR were designed and synthesized. The dynamic range and the sensitivity of quantitative reverse transcriptional real-time PCR were determined. The levels of let-7a miRNA were examined in 32 gastric carcinoma samples by stem-loop RT-PCR method. RESULTS: The dynamic range and sensitivity of the let-7a miRNA quantification scheme were evaluated,the result showed the assay could precisely detect 10 copies of mature let-7a miRNA in as few as 0.05 ng of total RNA of gastric mucosa. The results of specificity analysis showed no fluorescence signal occurred even though 50 ng of human genomic DNA was added to the reverse transcription (RT) reaction. The expression level of let-7a miRNA in gastric tumor tissues was significantly lower compared to normal tissues in 14 samples from 32 patients. CONCLUSION: The stem-loop RT-PCR is a reliable method to detect let-7a miRNA which may play an important role in the development of gastric carcinoma.
基金supported by Young Scholar Research Grant of Chinese Anesthesiologist Association(No.21800009).
文摘Objective:To evaluate the analgesic effect of ultrasound-guided subcostal anterior quadratus lumborum block(QLB)for laparoscopic radical gastrectomy surgery.Methods:Patients(aged 20-65 years,ASA Ⅰ-Ⅱ,and weighing 40-75 kg)scheduled for elective laparoscopic radical gastrectomy were enrolled in the current study.Sixty patients were randomly assigned to two groups by computer-generated randomization codes:an ultrasound-guided oblique subcostal transversus abdominis plane block(TAPB)group(group T,n=30)or an ultrasound-guided subcostal anterior QLB group(group Q,n=30).In both groups,bilateral ultrasound-guided oblique subcostal TAPB and subcostal anterior QLB were performed before general anesthesia with 0.25% ropivacaine 0.5 mL/kg.For postoperative management,all patients received patient-controlled intravenous analgesia(PCIA)with nalbuphine and sufentanil after surgery,maintaining visual analogue scale(VAS)scores<4 within 48 h.The intraoperative consumption of remifentanil,the requirement for sufentanil as a rescue analgesic,and the VAS scores at rest and coughing were recorded at 1,6,12,24 and 48 h after surgery.The recovery(extubation time after surgery,first ambulation time,first flatus time and length of postoperative hospital stay)and the adverse events(nausea and vomiting,skin pruritus,respiratory depression and nerve-block related complications)were observed and recorded.The primary outcome was the perioperative consumption of opioids.Results:Compared with group T,the intraoperative consumption of remifentanil,requirement for sufentanil and the frequency of PCIA were reduced in group Q.Meanwhile,VAS scores at all points of observation were significantly lower in group Q than in group T.Patients in group Q were also associated with shorter time to first out-of-bed activity and flatus,and shorter length of postoperative hospital stay than group T(P<0.05).There were no skin pruritus,respiratory depression or nerve-block related complications in both groups.Conclusion:Compared with ultrasound-guided oblique subcostal TAPB,ultrasound-guided subcostal anterior QLB provided greater opioid-sparing effect,lower visual analogue scores,and shorter postoperative hospital stay for laparoscopic radical gastrectomy.
基金Project supported by the Fundamental Research Funds for the Central Universities(Grant No.2017RC20)the Research Innovation Fund for College Students of Beijing University of Posts and Telecommunications
文摘We investigate the critical exponents and magnetocaloric effect of Co2-xZrSn polycrystal. The Co2-xZrSn undergoes a second-order ferromagnetism phase transition around the Curie temperature of Tc ~280 K. The critical behavior in the vicinity of the magnetic phase transition has been investigated by using modified Arrott plot and Kouvel–Fisher methods.The obtained critical exponents, β, γ, and δ can be well described by the scaling theory. The determined exponents of Co2-xZrSn obey the mean-field model with a long-range magnetic interaction. In addition, the maximum magnetic entropy change-?Sm ax M of Co2-xZrSn is about 0.57 J·kg-1·K-1 and the relative cooling power(RCP) is 14.68 J·kg-1 at 50 kOe(1 Oe = 79.5775 A·m-1).
基金supported by National Natural Science Foundation of China(82072177,82272264)the‘Hengjie’Program of Shanghai Health Youth Talent Reward Foundation.
文摘To the editor In 2003,Schwabegger et al.proposed the muscle-sparing latissimus dorsi(MS-LD)flap[1],which preserved a portion of the latissimus dorsi(LD)muscle around the point where the thoracodorsal artery(TDA)perforator penetrates the muscle,having the advantages of a sufficient flap blood supply and reduced donor-site morbidity.However,the traditional MS-LD flap is still too bulky for the reconstruction of defects of the face and neck,and the size of the traditional flap is sometimes not enough to repair large defects.Thus,combining soft tissue expansion with a vascular supercharging technique,we propose a novel design of MS-LD flap,as well as its application strategy.
基金supported by grants from National Natural Science Foundation of China(82072177,82272264,82472557)the China Postdoctoral Science Foundation(2024 M752023)Shanghai Plastic Surgery Research Center of Shanghai Priority Research Center(2023ZZ02023).
文摘Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs)variation and neuropathy within keloids contribute to these uncomfortable sensations;however the underlying mechanisms remain unclear.This study aims to explore the potential role of fibroblasts(FBs)and SCs in pruritic and pain keloids.Methods:The activity of FBs and SCs was investigated using single-cell RNA sequencing(scRNA-seq)data of keloids.These bioinformatics analysis results were validated through in vitro cell culture,clinical samples,and in vivo experiments.The selected molecule was confirmed to be correlated with pain and itch and was subsequently used to treat cells in order to investigate its role in keloids.The in vivo inhibition assay was performed to evaluate its therapeutic potential.Results:Our scRNA-seq analysis identified specific types of FBs and SCs were present in higher proportions in keloids and exhibited neurogenesis-related functions.Upon conducting an interaction analysis of these two cell types,we identified a critical molecule,Midkine(MDK),which is positively correlated with the patients'pain and itching levels.Besides,MDK treatment facilitated the proliferation of SCs and their transition to a repairing phenotype,resulting in neuronal axonogenesis.This activation of repairing SCs promoted the release of substance P from nerve fibers,leading to clinical symptoms of pain and pruritus in keloid patients.Targeting MDK effectively reduces abnormal Schwann cell proliferation and subsequently inhibits the secretion of neuropeptides that trigger pain and pruritus.Conclusions:Our study uncovered the interaction between FBs and SCs in the development of keloidal pain and pruritus,offering a novel therapeutic strategy to alleviate the distressing symptoms of keloids.
