AIM: To assess the effect of photoactivated chromophore for keratitis crosslinking(PACK-CXL) in case of severe keratitis with melting on the electrophysiological function of the retina and the optic nerve.METHODS: The...AIM: To assess the effect of photoactivated chromophore for keratitis crosslinking(PACK-CXL) in case of severe keratitis with melting on the electrophysiological function of the retina and the optic nerve.METHODS: The study included 32 eyes of 32 patients with smear positive severe infectious keratitis with corneal melting. The patients were randomly divided into two groups. Group I(control group) included 16 eyes received systemic and topical antimicrobial drugs guarded by culture and sensitivity test. Group II underwent CXL and then continued their antimicrobial treatment. Full field electroretinogram(ERG) and flash visual evoked potential(VEP) were done for each patient in both groups basically and then 1 wk, 1 and 3 mo post-treatment to assess the changes in the electrophysiological function of the retina and optic nerve.RESULTS: Healing of 10 eyes in group I in comparison to 14 eyes in group II was recorded. The mean duration of healing was 36.56±5.21 d in group I vs 20.2±4.4 d in group II(P<0.005). In group II, ERG showed an insignificant reduction of all parameters of ERG and VEP after CXL. The amplitude of scotopic rod response, oscillatory potential amplitude, flicker amplitude and photopic cone response were insignificantly decreased(P=0.4, 0.8, 0.1, and 0.3 respectively). There were insignificant prolongation of latencies of scotopic rod, oscillatory potential, flicker and photopic cone response(P=0.2, 0.7, 0.5 and 0.1). There was slight delay in latency of VEP without a significant reduction in amplitude.CONCLUSION: CXL is an effective technique in treatment of severe infectious keratitis with melting as it halts the melting process with acceptable safety on the retinal and optic nerve function.展开更多
Background:To record the corneal,and anterior chamber depth changes after performing recession versus resection of horizontal recti muscles.Methods:Consecutive patients who underwent isolated lateral rectus muscle rec...Background:To record the corneal,and anterior chamber depth changes after performing recession versus resection of horizontal recti muscles.Methods:Consecutive patients who underwent isolated lateral rectus muscle recession or resection February 2014 to January 2015 were prospectively studied.Refractive error(spherical equivalent);K1,K2,and mean k reading,anterior and posterior corneal elevation;and anterior chamber depth were measured(Pentacam)before,1 month,and 3 months after surgery.Patients who could not maintain reliable fixation and those with a history of eye surgery were excluded.Pre-and postoperative measurements were compared by analysis of variance.Results:A total of 36 eyes of 23 patients(average age,16 years)were included.Rectus muscle recession was performed in 24 eyes;and resection was performed in 12 eyes.Statistically significant changes in mean keratometry of recession group only.Central anterior elevation,and central anterior chamber depth were significant when both groups are compared at first month after surgery.Changes became regressive at the end of the third month.Although a significant change of central anterior elevation persisted.Conclusions:In recession group,the mean K was the only statistically significant variable by the first postoperative month.Comparing the both groups,the anterior corneal elevation,and central anterior chamber depth revealed a significant difference by the end of the first postoperative month.After 3 months,all parameters showed a statistical insignificant difference between the recession and resection groups except the anterior corneal elevation.展开更多
文摘AIM: To assess the effect of photoactivated chromophore for keratitis crosslinking(PACK-CXL) in case of severe keratitis with melting on the electrophysiological function of the retina and the optic nerve.METHODS: The study included 32 eyes of 32 patients with smear positive severe infectious keratitis with corneal melting. The patients were randomly divided into two groups. Group I(control group) included 16 eyes received systemic and topical antimicrobial drugs guarded by culture and sensitivity test. Group II underwent CXL and then continued their antimicrobial treatment. Full field electroretinogram(ERG) and flash visual evoked potential(VEP) were done for each patient in both groups basically and then 1 wk, 1 and 3 mo post-treatment to assess the changes in the electrophysiological function of the retina and optic nerve.RESULTS: Healing of 10 eyes in group I in comparison to 14 eyes in group II was recorded. The mean duration of healing was 36.56±5.21 d in group I vs 20.2±4.4 d in group II(P<0.005). In group II, ERG showed an insignificant reduction of all parameters of ERG and VEP after CXL. The amplitude of scotopic rod response, oscillatory potential amplitude, flicker amplitude and photopic cone response were insignificantly decreased(P=0.4, 0.8, 0.1, and 0.3 respectively). There were insignificant prolongation of latencies of scotopic rod, oscillatory potential, flicker and photopic cone response(P=0.2, 0.7, 0.5 and 0.1). There was slight delay in latency of VEP without a significant reduction in amplitude.CONCLUSION: CXL is an effective technique in treatment of severe infectious keratitis with melting as it halts the melting process with acceptable safety on the retinal and optic nerve function.
文摘Background:To record the corneal,and anterior chamber depth changes after performing recession versus resection of horizontal recti muscles.Methods:Consecutive patients who underwent isolated lateral rectus muscle recession or resection February 2014 to January 2015 were prospectively studied.Refractive error(spherical equivalent);K1,K2,and mean k reading,anterior and posterior corneal elevation;and anterior chamber depth were measured(Pentacam)before,1 month,and 3 months after surgery.Patients who could not maintain reliable fixation and those with a history of eye surgery were excluded.Pre-and postoperative measurements were compared by analysis of variance.Results:A total of 36 eyes of 23 patients(average age,16 years)were included.Rectus muscle recession was performed in 24 eyes;and resection was performed in 12 eyes.Statistically significant changes in mean keratometry of recession group only.Central anterior elevation,and central anterior chamber depth were significant when both groups are compared at first month after surgery.Changes became regressive at the end of the third month.Although a significant change of central anterior elevation persisted.Conclusions:In recession group,the mean K was the only statistically significant variable by the first postoperative month.Comparing the both groups,the anterior corneal elevation,and central anterior chamber depth revealed a significant difference by the end of the first postoperative month.After 3 months,all parameters showed a statistical insignificant difference between the recession and resection groups except the anterior corneal elevation.
