Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy...Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).展开更多
The critical adsorption of semi-flexible pol.ymer chains on attractive surfaces is studied using Monte Carlo simulations.The results reveal that the critical adsorption point of a free polymer chain is the same as tha...The critical adsorption of semi-flexible pol.ymer chains on attractive surfaces is studied using Monte Carlo simulations.The results reveal that the critical adsorption point of a free polymer chain is the same as that of an end-grafted one.For the end-grafted polymer,we find that the finite-size scaling relation and the maximum fluctuation of adsorbed monomers are equivalent in estimating the critical adsorption point.The effect of chain stiffness on the critical adsorption is also investigated.The surface attraction strength for the critical adsorption of semi-flexible polymer chain decreases exponentially with an increase in the chain stiffness;In other words,lower adsorption energy is needed to adsorb a stiffer polymer chain.The result is explained from the viewpoint of the free energy profile for the adsorption.展开更多
Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been w...Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and analyzed.Methods and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be included.Assessment of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager 5.2.Ethics and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.展开更多
Background:Ma-Zi-Ren-Wan(MZRW)is a classic Chinese formula for treating human constipation.It is comprised of six herbs.Our previous studies have shown its great therapeutic effect.The absorbed compounds had been stud...Background:Ma-Zi-Ren-Wan(MZRW)is a classic Chinese formula for treating human constipation.It is comprised of six herbs.Our previous studies have shown its great therapeutic effect.The absorbed compounds had been studied in rat,while there was no study about its components in human body.Objectives:To observe the components of MZRW absorbed in health subjects and study the pharmacokinetics of major compounds.At the same time,to observe the renal excretion of MZRW in health subjects based on the quantification of major compounds.Methods:Health adults were randomly assigned to three dose groups(5 g,7.5 g and 10 g q.d.)of MZRW.Blood samples were collected from the medial cubital vein just before and at 0.25,0.5,1,2,4,8 and 12 h after administration.Urine samples were collected at 0 to 3 h,3 to 6 h,6 to 9 h and 9 to 12 h after MZRW administration,with the urine volume recorded for each time segment.Plasma and urine samples were analyzed by optimized LC-MSMS(Liquid chromatography-tandem mass spectrometry)method for pharmacokinetics and renal excretion study of MZRW.Results:Ten compounds of MZRW were observed in 23 health subjects.Due to the low concentration in plasma at the current dose,only four compounds(Albiflorin,paeoniflorin,magnolol and rhein)were quantified in the plasma sample.Honokiol,aloe emodin and emodin could only meet the LLOQ at some time points of the high dose group.Hesperidin,naringin and amygdalin could not be detected in plasma sample.While seven compounds(Amygdalin,albiflorin,paeoniflorin,magnolol,honokiol,rhein and aloe emodin)could be quantified in urine,the renal excretion was well studied.Conclusion:MZRW was safe and well tolerated in this clinical study.Albiflorin,paeoniflorin,magnolol and rhein was well quantified in plasma.The renal excretion of paeoniflorin,albiflorin and rhein were dose dependent for doses ranging between 5 and 10 g.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFA1602200)the National Natural Science Foundation of China(Nos.12341501 and 12405174)the Hefei Comprehensive National Science Center for the strong support on the STCF key technology research project.
文摘Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).
基金Supported by the National Natural Science Foundation of China under Grant Nos 11674277,11704210 and 21574117
文摘The critical adsorption of semi-flexible pol.ymer chains on attractive surfaces is studied using Monte Carlo simulations.The results reveal that the critical adsorption point of a free polymer chain is the same as that of an end-grafted one.For the end-grafted polymer,we find that the finite-size scaling relation and the maximum fluctuation of adsorbed monomers are equivalent in estimating the critical adsorption point.The effect of chain stiffness on the critical adsorption is also investigated.The surface attraction strength for the critical adsorption of semi-flexible polymer chain decreases exponentially with an increase in the chain stiffness;In other words,lower adsorption energy is needed to adsorb a stiffer polymer chain.The result is explained from the viewpoint of the free energy profile for the adsorption.
基金supported by the project of Traditional Chinese Medicine for Inflammatory Bowel Disease:Efficacy Confirmation and Basic Mechanism Study,HKBU/IRMS
文摘Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and analyzed.Methods and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be included.Assessment of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager 5.2.Ethics and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.
基金supported by Hong Kong Baptist University Faculty Research Grant Category II.Grant No.:HKBU/FRG2/13-14/025 and Shenzhen Science and Technology Innovation Committee JCYJ20140419130444178
文摘Background:Ma-Zi-Ren-Wan(MZRW)is a classic Chinese formula for treating human constipation.It is comprised of six herbs.Our previous studies have shown its great therapeutic effect.The absorbed compounds had been studied in rat,while there was no study about its components in human body.Objectives:To observe the components of MZRW absorbed in health subjects and study the pharmacokinetics of major compounds.At the same time,to observe the renal excretion of MZRW in health subjects based on the quantification of major compounds.Methods:Health adults were randomly assigned to three dose groups(5 g,7.5 g and 10 g q.d.)of MZRW.Blood samples were collected from the medial cubital vein just before and at 0.25,0.5,1,2,4,8 and 12 h after administration.Urine samples were collected at 0 to 3 h,3 to 6 h,6 to 9 h and 9 to 12 h after MZRW administration,with the urine volume recorded for each time segment.Plasma and urine samples were analyzed by optimized LC-MSMS(Liquid chromatography-tandem mass spectrometry)method for pharmacokinetics and renal excretion study of MZRW.Results:Ten compounds of MZRW were observed in 23 health subjects.Due to the low concentration in plasma at the current dose,only four compounds(Albiflorin,paeoniflorin,magnolol and rhein)were quantified in the plasma sample.Honokiol,aloe emodin and emodin could only meet the LLOQ at some time points of the high dose group.Hesperidin,naringin and amygdalin could not be detected in plasma sample.While seven compounds(Amygdalin,albiflorin,paeoniflorin,magnolol,honokiol,rhein and aloe emodin)could be quantified in urine,the renal excretion was well studied.Conclusion:MZRW was safe and well tolerated in this clinical study.Albiflorin,paeoniflorin,magnolol and rhein was well quantified in plasma.The renal excretion of paeoniflorin,albiflorin and rhein were dose dependent for doses ranging between 5 and 10 g.
