We read with great interest the study by Zhang et al on Yiyi Fuzi Baijiang powder(YFB),which exemplifies the power of modern methods to validate traditional Chinese medicine(TCM).The key insight is that YFB doesn’t m...We read with great interest the study by Zhang et al on Yiyi Fuzi Baijiang powder(YFB),which exemplifies the power of modern methods to validate traditional Chinese medicine(TCM).The key insight is that YFB doesn’t merely alter“good”or“bad”bacteria but restores the gut microbiota’s holistic equilibrium.This is powerfully shown by its paradoxical reduction of anaerobic probiotics like Bifidobacterium,rectifying the diseased,hypoxic environment,causing their aberrant overgrowth.This challenges the conventional probiotic paradigm and underscores a core TCM principle:Herbal formulas treat disease by restoring the body’s overall functional balance.Future research should focus on the interplay between herbal components,intestinal oxygen,and microbial metabolites to further unravel this sophisticated dialogue.展开更多
Objective： To test the neural electrophysiological basis of acupuncture treatment on attention deficit of insomnia patients.Methods： Thirty insomnia attention deficit patients were enrolled as the patient group in t...Objective： To test the neural electrophysiological basis of acupuncture treatment on attention deficit of insomnia patients.Methods： Thirty insomnia attention deficit patients were enrolled as the patient group in this study, and30 normal people were collected as the normal group as the compare. In patient group, acupuncture was adopted and the acupoints were Bǎihui（百会GV20）, Shéntíng（神庭 GV24）, Sìshéncōng（四神聪 EX-HN1）,Shenmen（神门 HT7） and Sānyīnjiāo（三阴交 SP6）, even reinforcing and reducing method, once a day, 10 times as a course and totally 2 courses. There was no intervention for the normal group. Pittsburg Sleep Quality Index（PSQI） for assessing the sleep quality, Schulte grid scale and the event-related potential（ERP） for assessing the attention deficit were evaluated before the treatment, 10 days after the treatment and after the treatment. The normal group were taken evaluation at the same time point.Results： 1. PSQI. The PSQI score in the patient group before the treatment was（16.20 ±2.02） and was（4.20 ±1.64） after the treatment. The difference was statistically significant（P0.05）. The normal group was（4.00 ± 1.52） at the same point after the treatment, and the differences was not statistically significant（P〈0.05）. 2. Schulte grid scale. The Schulte grid scale rating score was decrease from（32.87 ± 6.71）s before the treatment to（12.82 ±3.40） s after the treatment, and the difference was statistically significant（P〈0.05）. The normal group was（12.29 ± 3.47） s at the same point after the treatment, and the differences was not statistically significant（P〈0.05）. 3. ERP.（1） P300： in the patient group, the latency of P3 a decreased from（316.60 ± 18.42） ms before the treatment to（300.10 ± 12.03） ms after the treatment;the latency of P3 b decreased from（328.32 士 16.32） ms before the treatment to（304.63 ± 13.248） ms after the treatment; the amplitude of P3 a increased from（5.501.16） μV before the treatment to（15.20 士 2.12）μV after the treatment; the amplitude of P3 b increased from（5.76 士 1.87） μV before the treatment to（16.76 ± 2.37） μV after the treatment, and the differences were statistically significant（all P〈0.05）.（2）CNV： in the patient group, the latency of point A decreased from（404 ±129） ms before the treatment to（369 ± 105） ms after the treatment; the latency of point C decreased from（2584 ± 563） ms before the treatment to（2308 士 369） ms after the treatment; the amplitude of A-B increased from（10.3 ±17.4）μV before the treatment to（13.7 ±24.8） μV after the treatment, and the differences were statistically significant（all P〈0.05）.Conclusion： Acupuncture can improve the sleep quality and the attention deficit condition of insomnia attention deficit patients by regulating the nerve electrophysiology of the brain.展开更多
Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treat...Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of Ml.As chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.展开更多
文摘We read with great interest the study by Zhang et al on Yiyi Fuzi Baijiang powder(YFB),which exemplifies the power of modern methods to validate traditional Chinese medicine(TCM).The key insight is that YFB doesn’t merely alter“good”or“bad”bacteria but restores the gut microbiota’s holistic equilibrium.This is powerfully shown by its paradoxical reduction of anaerobic probiotics like Bifidobacterium,rectifying the diseased,hypoxic environment,causing their aberrant overgrowth.This challenges the conventional probiotic paradigm and underscores a core TCM principle:Herbal formulas treat disease by restoring the body’s overall functional balance.Future research should focus on the interplay between herbal components,intestinal oxygen,and microbial metabolites to further unravel this sophisticated dialogue.
文摘Objective： To test the neural electrophysiological basis of acupuncture treatment on attention deficit of insomnia patients.Methods： Thirty insomnia attention deficit patients were enrolled as the patient group in this study, and30 normal people were collected as the normal group as the compare. In patient group, acupuncture was adopted and the acupoints were Bǎihui（百会GV20）, Shéntíng（神庭 GV24）, Sìshéncōng（四神聪 EX-HN1）,Shenmen（神门 HT7） and Sānyīnjiāo（三阴交 SP6）, even reinforcing and reducing method, once a day, 10 times as a course and totally 2 courses. There was no intervention for the normal group. Pittsburg Sleep Quality Index（PSQI） for assessing the sleep quality, Schulte grid scale and the event-related potential（ERP） for assessing the attention deficit were evaluated before the treatment, 10 days after the treatment and after the treatment. The normal group were taken evaluation at the same time point.Results： 1. PSQI. The PSQI score in the patient group before the treatment was（16.20 ±2.02） and was（4.20 ±1.64） after the treatment. The difference was statistically significant（P0.05）. The normal group was（4.00 ± 1.52） at the same point after the treatment, and the differences was not statistically significant（P〈0.05）. 2. Schulte grid scale. The Schulte grid scale rating score was decrease from（32.87 ± 6.71）s before the treatment to（12.82 ±3.40） s after the treatment, and the difference was statistically significant（P〈0.05）. The normal group was（12.29 ± 3.47） s at the same point after the treatment, and the differences was not statistically significant（P〈0.05）. 3. ERP.（1） P300： in the patient group, the latency of P3 a decreased from（316.60 ± 18.42） ms before the treatment to（300.10 ± 12.03） ms after the treatment;the latency of P3 b decreased from（328.32 士 16.32） ms before the treatment to（304.63 ± 13.248） ms after the treatment; the amplitude of P3 a increased from（5.501.16） μV before the treatment to（15.20 士 2.12）μV after the treatment; the amplitude of P3 b increased from（5.76 士 1.87） μV before the treatment to（16.76 ± 2.37） μV after the treatment, and the differences were statistically significant（all P〈0.05）.（2）CNV： in the patient group, the latency of point A decreased from（404 ±129） ms before the treatment to（369 ± 105） ms after the treatment; the latency of point C decreased from（2584 ± 563） ms before the treatment to（2308 士 369） ms after the treatment; the amplitude of A-B increased from（10.3 ±17.4）μV before the treatment to（13.7 ±24.8） μV after the treatment, and the differences were statistically significant（all P〈0.05）.Conclusion： Acupuncture can improve the sleep quality and the attention deficit condition of insomnia attention deficit patients by regulating the nerve electrophysiology of the brain.
基金This study was supported by the National Key R&D Program of China(No.2019YFC1709001)the National Natural Science Foundation of China(No.81774434)+2 种基金the National Natural Science Foundation of China(No.81704187)the Department of Science and Technology of Sichuan Province(China)(No.2019YJ0587)the Department of Science and Technology of Sichuan Province(No.2018JY0482).
文摘Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of Ml.As chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.
