Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and se...Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.展开更多
The precision modeling of dam break floods can lead to formulation of proper emergency action plan to minimize flood impacts within the economic lifetime of the assets.Application of GIS techniques in integration with...The precision modeling of dam break floods can lead to formulation of proper emergency action plan to minimize flood impacts within the economic lifetime of the assets.Application of GIS techniques in integration with hydrological modeling for mapping of the flood inundated areas can play a momentous role in further minimizing the risk and likely damages.In the present study,dam break analysis using DAMBRK model was performed under various likely scenarios.Probable Maximum Flood (PMF)calculated for a return period of 1000 years using deterministic approach was adopted for dam break analysis of the proposed dam under various combinations of breach dimensions.The available downstream river cross-sections data sets were used as input in the model to generate the downstream flood profile.Dam break flow depths generated by the DAMBRK model under various combinations of structural failure are subsequently plotted on Digital Elevation Model(DEM)of the downstream of dam site to map the likely affected area.The simulation results reveals that in one particular case the flood without dam may be more intense if a rainfall of significant intensity takes place.展开更多
基金supported by research grants R01 HL112597,R01 HL116042,and R01 HL120659(to DKA)
文摘Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.
文摘The precision modeling of dam break floods can lead to formulation of proper emergency action plan to minimize flood impacts within the economic lifetime of the assets.Application of GIS techniques in integration with hydrological modeling for mapping of the flood inundated areas can play a momentous role in further minimizing the risk and likely damages.In the present study,dam break analysis using DAMBRK model was performed under various likely scenarios.Probable Maximum Flood (PMF)calculated for a return period of 1000 years using deterministic approach was adopted for dam break analysis of the proposed dam under various combinations of breach dimensions.The available downstream river cross-sections data sets were used as input in the model to generate the downstream flood profile.Dam break flow depths generated by the DAMBRK model under various combinations of structural failure are subsequently plotted on Digital Elevation Model(DEM)of the downstream of dam site to map the likely affected area.The simulation results reveals that in one particular case the flood without dam may be more intense if a rainfall of significant intensity takes place.
