Pancreatic cancer is known to have high metastatic potential and low survival rates due to the failure of the therapeutic agents to reach the cancer cells having the dense desmoplastic microenvironment.Exosomes are co...Pancreatic cancer is known to have high metastatic potential and low survival rates due to the failure of the therapeutic agents to reach the cancer cells having the dense desmoplastic microenvironment.Exosomes are considered to be a promising therapeutic agent carrier due to their advantages such as low immunogenicity and easy targeting.More researches and future developments are needed,although exosome-based therapies need further research and development before they can be translated into clinical applications.In this review,we aimed to discuss comparatively two main exosome sources as mesenchymal stem cell(MSC)-derived and macrophage-derived exosomes on pancreatic cancer in terms of the therapeutic potential,advantages,disadvantages and also other comprehensive details.In vitro,in vivo and clinical phase studies examining the therapeutic potential of MSC-derived and macrophage-derived exosomes in pancreatic cancer will be discussed.We strongly believe that this review will guide the new investigations related to exosome-based targeted therapy in pancreatic cancer.In the meantime,we aimed to provide an overview of ongoing research on MSC and macrophage exosome-based therapies,focusing on their role in cancer treatment,particularly for pancreatic cancer.By examining current findings,this review will provide a broad perspective on the therapeutic potential and limitations of exosomes.展开更多
文摘Pancreatic cancer is known to have high metastatic potential and low survival rates due to the failure of the therapeutic agents to reach the cancer cells having the dense desmoplastic microenvironment.Exosomes are considered to be a promising therapeutic agent carrier due to their advantages such as low immunogenicity and easy targeting.More researches and future developments are needed,although exosome-based therapies need further research and development before they can be translated into clinical applications.In this review,we aimed to discuss comparatively two main exosome sources as mesenchymal stem cell(MSC)-derived and macrophage-derived exosomes on pancreatic cancer in terms of the therapeutic potential,advantages,disadvantages and also other comprehensive details.In vitro,in vivo and clinical phase studies examining the therapeutic potential of MSC-derived and macrophage-derived exosomes in pancreatic cancer will be discussed.We strongly believe that this review will guide the new investigations related to exosome-based targeted therapy in pancreatic cancer.In the meantime,we aimed to provide an overview of ongoing research on MSC and macrophage exosome-based therapies,focusing on their role in cancer treatment,particularly for pancreatic cancer.By examining current findings,this review will provide a broad perspective on the therapeutic potential and limitations of exosomes.
