Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement...Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement and policy formulation.Methods Semi-structured personal interviews were used to collect data.Ten Tibetans with dysfunction representing three categories of different economic level areas in Lhasa,Xizang were selected to participate in the study by purposive sampling method from September to December 2021.The data were analyzed using Colaizzi’s seven-step method.Results The results present three themes and seven sub-themes:identification of tangible benefits from assistive devices(enhancing self-care ability for persons with dysfunction,assisting family members with caregiving and promoting harmonious family relationships),problems and burdens(difficulty in accessing professional services and cumbersome processes,not knowing how to use it correctly,psychological burden:fear of falling and stigmatization),and needs and expectations(providing social support to reduce the cost of use,enhancing the accessibility of barrier-free facilities at the grassroots level and improving the environment for the use of assistive devices).Conclusion A proper understanding of the problems and challenges faced by Tibetans with dysfunction in the process of accepting assistive device services,focusing on the real-life experiences of people with functional impairment,and proposing targeted suggestions for improving and optimizing the user experience can provide reference and basis for future intervention studies and related policy formulation.展开更多
High-altitude polycythemia(HAPC)is a prevalent chronic condition affecting individuals at high altitudes,including both highland and plains populations.This study,involving 2248 participants,explored genetic susceptib...High-altitude polycythemia(HAPC)is a prevalent chronic condition affecting individuals at high altitudes,including both highland and plains populations.This study,involving 2248 participants,explored genetic susceptibility to HAPC among ethnic groups,with 898 HAPC patients(450 Han,448 Tibetan).The Genome-wide Association Study,encompassing 198 cases(100 Han,98 Tibetan),identified eight Tibetan HAPC-susceptibility single-nucleotide polymorphisms and four in Han individuals.The common polymorphism locus rs7618658(SNX4,pcombine<5×10^(-8))was validated in both popula-tions.The investigation of Tibetan EPAS1 revealed the rs1374749 locus,along with linked loci,as a potential prevalence factor for HAPC.The GGTAC haplotype containing this locus emerged as a Protect haplotype for HAPC(p=2.461×10^(-12),OR=0.344).Enrichment analysis revealed that Tibetans exhibited susceptibility in oxygen-sensing pathways,such as EPAS1,associated with phenotypes like hemoglobin and platelets.In contrast,Han Chinese showed significant sensitivity in cell differentiation and angiogenesis,closely linked to hemoglobin,hematocrit,and platelets.展开更多
基金This research was funded by The National Key Research and Development Program of China(No.2020YFC2005900)The Key Research and Development Program Jointly Implemented by Sichuan and Chongqing(No.cstc2020jscx-cylhX002).
文摘Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement and policy formulation.Methods Semi-structured personal interviews were used to collect data.Ten Tibetans with dysfunction representing three categories of different economic level areas in Lhasa,Xizang were selected to participate in the study by purposive sampling method from September to December 2021.The data were analyzed using Colaizzi’s seven-step method.Results The results present three themes and seven sub-themes:identification of tangible benefits from assistive devices(enhancing self-care ability for persons with dysfunction,assisting family members with caregiving and promoting harmonious family relationships),problems and burdens(difficulty in accessing professional services and cumbersome processes,not knowing how to use it correctly,psychological burden:fear of falling and stigmatization),and needs and expectations(providing social support to reduce the cost of use,enhancing the accessibility of barrier-free facilities at the grassroots level and improving the environment for the use of assistive devices).Conclusion A proper understanding of the problems and challenges faced by Tibetans with dysfunction in the process of accepting assistive device services,focusing on the real-life experiences of people with functional impairment,and proposing targeted suggestions for improving and optimizing the user experience can provide reference and basis for future intervention studies and related policy formulation.
基金National Key R&D Program of China(2023YFA1801200)National Science Foundation of China(32288101,32200536,82241023)+9 种基金The Science and Technology Department of Tibet(08080002)2019 School-level Cultivation Project of Tibet University(ZDTSJH19-08)Special Funds from the Central Finance to Support the Development of Local Universities(2018)No.54(2019)No.1-19(2020)No.79,(2021])No.1,(00060695/003)Special of the Disposal of the Science and Technology Department of Tibet Autonomous Region in 2023(18080280)Tibet Autonomous Region Natural Science Foundation Group Medical Assistance Project Plan(XZ2023ZR-ZY34(Z))Municipal Natural Science Foundation(joint)project(RKZ2023ZR-014(Z))Shanghai Municipal Science and Technology Major Project(2023SHZDZX02,2017SHZDZX01)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-066).
文摘High-altitude polycythemia(HAPC)is a prevalent chronic condition affecting individuals at high altitudes,including both highland and plains populations.This study,involving 2248 participants,explored genetic susceptibility to HAPC among ethnic groups,with 898 HAPC patients(450 Han,448 Tibetan).The Genome-wide Association Study,encompassing 198 cases(100 Han,98 Tibetan),identified eight Tibetan HAPC-susceptibility single-nucleotide polymorphisms and four in Han individuals.The common polymorphism locus rs7618658(SNX4,pcombine<5×10^(-8))was validated in both popula-tions.The investigation of Tibetan EPAS1 revealed the rs1374749 locus,along with linked loci,as a potential prevalence factor for HAPC.The GGTAC haplotype containing this locus emerged as a Protect haplotype for HAPC(p=2.461×10^(-12),OR=0.344).Enrichment analysis revealed that Tibetans exhibited susceptibility in oxygen-sensing pathways,such as EPAS1,associated with phenotypes like hemoglobin and platelets.In contrast,Han Chinese showed significant sensitivity in cell differentiation and angiogenesis,closely linked to hemoglobin,hematocrit,and platelets.
