In order to accelerate breeding progress of oil-used hemp, 8 quality traits related to lipid component were measured and analyzed in 55 representative hemp germplasms. Results showed that linolenic acid content had th...In order to accelerate breeding progress of oil-used hemp, 8 quality traits related to lipid component were measured and analyzed in 55 representative hemp germplasms. Results showed that linolenic acid content had the highest variance coefficient of 51.67% as well as protein content had minimum variance coefficient of 4.07%. Correlation analysis showed that total oil content was significantly positively correlated to linolenic acid, while significantly negatively correlated with oleinic acid. Protein content was significantly positively correlated with linolenic acid but significantly negatively with stearic acid. Both total oil and protein content were closely correlated with other traits. The first 3 PCs from principal component analysis of 8 traits accounted for 83.53% contribution. All hemp germplasms were classified into 3 groups at the level of euclidian distance D=8.5 using cluster analysis. The above analysis and classification may provide a reliable theoretical basis and technological guidance for germplasms utilizing and accelerating breeding process.展开更多
Large-pixel-array infrared emitters are attractive in the applications of infrared imaging and detection.However,the array scale has been restricted in traditional technologies.Here,we demonstrated a light-driven phot...Large-pixel-array infrared emitters are attractive in the applications of infrared imaging and detection.However,the array scale has been restricted in traditional technologies.Here,we demonstrated a light-driven photothermal transduction approach for an ultralarge pixel array infrared emitter.A metal-black coating with nanoporous structures and a silicon(Si)layer with microgap structures were proposed to manage the thermal input and output issues.The effects of the nanoscale structures in the black coating and microscale structures in the Si layer were investigated.Remarkable thermal modulation could be obtained by adjusting the nanoscale and microscale structures.The measured stationary and transient results of the fabricated photothermal transducers agreed well with the simulated results.From the input view,due to its wide spectrum and high absorption,the black coating with nanoscale structures contributed to a 5.6-fold increase in the temperature difference compared to that without the black coating.From the output view,the microgap structures in the Si layer eliminated the in-plane thermal crosstalk.The temperature difference was increased by 340%by modulating the out-of-plane microstructures.The proposed photothermal transducer had a rising time of 0.95 ms and a falling time of 0.53 ms,ensuring a fast time response.This method is compatible with low-cost and mass manufacturing and has promising potential to achieve ultralarge-array pixels beyond ten million.展开更多
Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which ...Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which may progress to malignancy through atypical hyperplasia.However,there are currently no fully targeted drugs for the treatment of UC.In this review,we discuss several cellular processes,such as autophagy,endoplasmic reticulum stress,mitochondrial dysfunction,macrophage polarization,ferroptosis and the Th/Treg cell balance,which are associated with the occurrence and development of UC.Many molecular targets and signaling pathways,such as nuclear factor kappa-B(NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT),Wnt/β-catenin,adenosine 5’-monophosphate-activated protein kinase(AMPK),toll-like receptor(TLR),Janus kinase/signal transducer and activator of transcription(JAK/STAT),long noncoding RNAs(lncRNAs),and microRNAs(miRNAs),play crucial roles in the progression of UC.We also summarize the common treatment strategies for UC,including lifestyle interventions,aminosalicylic acid preparations,corticosteroid drugs,biologics,fecal microbiota transplantation,and other drugs for symptomatic treatment.This review provides a detailed theoretical basis for the pathology and treatment of UC.Future research could focus on optimizing the treatment plan and achieving more precise and personalized treatment with multiple targets in multiple aspects.展开更多
基金the China Agriculture Technology Research System and Agricultural Science and Technology Innovation Program (ASTIP-IBFC03) for financial support
文摘In order to accelerate breeding progress of oil-used hemp, 8 quality traits related to lipid component were measured and analyzed in 55 representative hemp germplasms. Results showed that linolenic acid content had the highest variance coefficient of 51.67% as well as protein content had minimum variance coefficient of 4.07%. Correlation analysis showed that total oil content was significantly positively correlated to linolenic acid, while significantly negatively correlated with oleinic acid. Protein content was significantly positively correlated with linolenic acid but significantly negatively with stearic acid. Both total oil and protein content were closely correlated with other traits. The first 3 PCs from principal component analysis of 8 traits accounted for 83.53% contribution. All hemp germplasms were classified into 3 groups at the level of euclidian distance D=8.5 using cluster analysis. The above analysis and classification may provide a reliable theoretical basis and technological guidance for germplasms utilizing and accelerating breeding process.
基金This work was partially supported by the National Key Research and Development Program of China(2018YFF01010304,2018AAA0100301)National Natural Science Foundation of China(No.61875011,61704166)+1 种基金Beijing Institute of Technology Research Fund Program for Young Scholars(201904006)China Scholarship Council(student ID:202106030163).
文摘Large-pixel-array infrared emitters are attractive in the applications of infrared imaging and detection.However,the array scale has been restricted in traditional technologies.Here,we demonstrated a light-driven photothermal transduction approach for an ultralarge pixel array infrared emitter.A metal-black coating with nanoporous structures and a silicon(Si)layer with microgap structures were proposed to manage the thermal input and output issues.The effects of the nanoscale structures in the black coating and microscale structures in the Si layer were investigated.Remarkable thermal modulation could be obtained by adjusting the nanoscale and microscale structures.The measured stationary and transient results of the fabricated photothermal transducers agreed well with the simulated results.From the input view,due to its wide spectrum and high absorption,the black coating with nanoscale structures contributed to a 5.6-fold increase in the temperature difference compared to that without the black coating.From the output view,the microgap structures in the Si layer eliminated the in-plane thermal crosstalk.The temperature difference was increased by 340%by modulating the out-of-plane microstructures.The proposed photothermal transducer had a rising time of 0.95 ms and a falling time of 0.53 ms,ensuring a fast time response.This method is compatible with low-cost and mass manufacturing and has promising potential to achieve ultralarge-array pixels beyond ten million.
基金supported by the National Natural Science Foundation of China(82073313 to D.L.)the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province(GZY-KJS-SD-2023-094)+1 种基金the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital(2023ZYZX02)the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project(to D.L.).
文摘Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which may progress to malignancy through atypical hyperplasia.However,there are currently no fully targeted drugs for the treatment of UC.In this review,we discuss several cellular processes,such as autophagy,endoplasmic reticulum stress,mitochondrial dysfunction,macrophage polarization,ferroptosis and the Th/Treg cell balance,which are associated with the occurrence and development of UC.Many molecular targets and signaling pathways,such as nuclear factor kappa-B(NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT),Wnt/β-catenin,adenosine 5’-monophosphate-activated protein kinase(AMPK),toll-like receptor(TLR),Janus kinase/signal transducer and activator of transcription(JAK/STAT),long noncoding RNAs(lncRNAs),and microRNAs(miRNAs),play crucial roles in the progression of UC.We also summarize the common treatment strategies for UC,including lifestyle interventions,aminosalicylic acid preparations,corticosteroid drugs,biologics,fecal microbiota transplantation,and other drugs for symptomatic treatment.This review provides a detailed theoretical basis for the pathology and treatment of UC.Future research could focus on optimizing the treatment plan and achieving more precise and personalized treatment with multiple targets in multiple aspects.
