Water hydraulic technology is a potential application to deep-sea manipulators and their proportional valves.In the ocean,water is a better choice as the working medium than mineral oil because of its environmentally ...Water hydraulic technology is a potential application to deep-sea manipulators and their proportional valves.In the ocean,water is a better choice as the working medium than mineral oil because of its environmentally friendly advantages.However,no water hydraulic proportional valve for deep sea exists yet.In this study,a novel water hydraulic rotary proportional valve with a four-way,three-position principle and a plane sealing method for the environment-friendly manipulator is invented.The static and dynamic performance of the proportional valve is studied using a mathematical model and experiments.A valve-control swing cylinder system,which simulates the working state of the manipulator,is also facilitated in a deep-sea simulation device for simulating a depth of 6500 m in the ocean.Results show that the numerical and experimental data match well.The proportional valve can achieve zero leakage,and the dead zone is approximately 10%.The bandwidths are 30 and 6 Hz when the input signal amplitude is 5%and 100%of the valve’s full stroke,respectively.The proportional valve can accurately control the swing cylinder on the manipulator’s elbow joint with a rotation angle error of±0.1°.The rotary proportional valve has excellent application to deep-sea manipulators.展开更多
In ocean exploration,underwater hydraulic manipulators(UHMs)driven by water hydraulics may become favored over oil-based systems because of their eco-friendliness and ability for continuous operation.A water hydraulic...In ocean exploration,underwater hydraulic manipulators(UHMs)driven by water hydraulics may become favored over oil-based systems because of their eco-friendliness and ability for continuous operation.A water hydraulic high-speed on/off valve(WHSV),with good sealing and fast response,may be used as a core control component of UHM.The comprehensive performance of the WHSV needs to be improved to enhance the accuracy,continuity,and reliability of UHM.In this study,the relationship between the negative voltage and the WHSV characteristics,including dynamic performance,power losses,and impact performance,is studied by finite element simulation.Furthermore,a multi-objective optimization method is proposed to improve the comprehensive performance of the WHSV.This method integrates the optimal Latin hypercube sampling method,universal Kriging surrogate model,non-dominated sorting genetic algorithm II,and Technique for Order Preference by Similarity to Ideal Solution methods to optimize the equivalent amplitude and duration of the negative voltage.Our findings reveal that the closing time decreases with the increase in the equivalent amplitude and duration of the negative voltage,while the opposite is observed in the power losses and maximum impact equivalent stress of the valve seat.Optimization results show a slight 3.3%increase in closing time of the WHSV but significant reductions in total power loss(9.8%),maximum impact equivalent stress(14.5%),and maximum total deformation(19.8%).This study provides a practical optimization approach for enhancing the comprehensive performance of the WHSV for improved UHM operation.展开更多
Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related pr...Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases,especially tumours.Encouragingly,selective PPI-based therapeutic agents have been rapidly advancing over the past decade,providing promising perspectives for novel therapies for patients with cancer.In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects,focusing on PPIs in disease,drug design and discovery strategies,structure-activity relationships,inherent dilemmas,and future directions.展开更多
With the enhancement of environmental protection awareness of the international community and the continuous promotion of green and sustainable development of manufacturing industry,water lubrication instead of minera...With the enhancement of environmental protection awareness of the international community and the continuous promotion of green and sustainable development of manufacturing industry,water lubrication instead of mineral oil has become the future development trend due to its green,pollution-free,clean,safe,and sustainable advantages especially in ships,marine,coal mining,and other fields.In recent years,with the rapid development of water lubrication research,significant progress has been made in related research knowledge domain and discipline.A systematic and extensive assessment of water lubrication research has become increasingly important.The objective of this research is to reveal the research status,research hotspots,and development trends in the field of water lubrication.Therefore,CiteSpace was used to conduct a systematic bibliometric and scientometrical analysis of 1,792 publications from Web of Science core collection database(1997–2021).The results show that China and USA are the most productive countries in the field of water lubrication and have made outstanding contributions.Through the analysis of hot key words and co-citation references,this paper reviews the research status of water lubrication in three aspects:(1)lubricating medium modification;(2)material preparation;(3)surface optimization.It has become a research hotspot to promote the superlubricity contact interface and the application of nanotechnology.The results of this study can make a significant contribution to the development of water lubrication by providing a comprehensive understanding of the research status and research hotspots in this field.Personal understanding and discussion of research hotspots and research status are expected to provide insights into future research trends.In addition,this study will provide valuable references and guidelines for researchers who are interested in this field.展开更多
Balance valve is a core component of the 11000-meter manned submersible“struggle,”and its sealing performance is crucial and challenging when the maximum pressure difference is 118 MPa.The increasing sealing force i...Balance valve is a core component of the 11000-meter manned submersible“struggle,”and its sealing performance is crucial and challenging when the maximum pressure difference is 118 MPa.The increasing sealing force improves the sealing performance and increases the system’s energy consumption at the same time.A hybrid analytical–numerical–experimental(ANE)model is proposed to obtain the minimum sealing force,ensuring no leakage at the valve port and reducing energy consumption as much as possible.The effects of roundness error,environmental pressure,and materials on the minimum sealing force are considered in the ANE model.The basic form of minimum sealing force equations is established,and the remaining unknown coefficients of the equations are obtained by the finite element method(FEM).The accuracy of the equation is evaluated by comparing the independent FEM data to the equation data.Results of the comparison show good agreement,and the difference between the independent FEM data and equation data is within 3%when the environmental pressure is 0–118 MPa.Finally,the minimum sealing force equation is applied in a balance valve to be experimented using a deep-sea simulation device.The balance valve designed through the minimum sealing force equation is leak-free in the experiment.Thus,the minimum sealing force equation is suitable for the ultrahigh pressure balance valve and has guiding significance for evaluating the sealing performance of ultrahigh pressure balance valves.展开更多
基金the National Natural Science Foundation of China(Grant No.52122502)the National Key Research and Development Program of China(Grant Nos.2022YFC2805705 and 2022YFC2805501).
文摘Water hydraulic technology is a potential application to deep-sea manipulators and their proportional valves.In the ocean,water is a better choice as the working medium than mineral oil because of its environmentally friendly advantages.However,no water hydraulic proportional valve for deep sea exists yet.In this study,a novel water hydraulic rotary proportional valve with a four-way,three-position principle and a plane sealing method for the environment-friendly manipulator is invented.The static and dynamic performance of the proportional valve is studied using a mathematical model and experiments.A valve-control swing cylinder system,which simulates the working state of the manipulator,is also facilitated in a deep-sea simulation device for simulating a depth of 6500 m in the ocean.Results show that the numerical and experimental data match well.The proportional valve can achieve zero leakage,and the dead zone is approximately 10%.The bandwidths are 30 and 6 Hz when the input signal amplitude is 5%and 100%of the valve’s full stroke,respectively.The proportional valve can accurately control the swing cylinder on the manipulator’s elbow joint with a rotation angle error of±0.1°.The rotary proportional valve has excellent application to deep-sea manipulators.
基金the National Natural Science Foundation of China(Grant No.52122502)the National Key Research&Development Program of China(Grant No.2022YFC2805705)+1 种基金the Fundamental Research Funds for the Central Universities,China(Grant No.YCJJ20230358)the Key Technology Tackling Project of Cold Spring Device of Chinese Academy of Sciences,China(Grant No.LQ-GJ-01)for their financial support for this research。
文摘In ocean exploration,underwater hydraulic manipulators(UHMs)driven by water hydraulics may become favored over oil-based systems because of their eco-friendliness and ability for continuous operation.A water hydraulic high-speed on/off valve(WHSV),with good sealing and fast response,may be used as a core control component of UHM.The comprehensive performance of the WHSV needs to be improved to enhance the accuracy,continuity,and reliability of UHM.In this study,the relationship between the negative voltage and the WHSV characteristics,including dynamic performance,power losses,and impact performance,is studied by finite element simulation.Furthermore,a multi-objective optimization method is proposed to improve the comprehensive performance of the WHSV.This method integrates the optimal Latin hypercube sampling method,universal Kriging surrogate model,non-dominated sorting genetic algorithm II,and Technique for Order Preference by Similarity to Ideal Solution methods to optimize the equivalent amplitude and duration of the negative voltage.Our findings reveal that the closing time decreases with the increase in the equivalent amplitude and duration of the negative voltage,while the opposite is observed in the power losses and maximum impact equivalent stress of the valve seat.Optimization results show a slight 3.3%increase in closing time of the WHSV but significant reductions in total power loss(9.8%),maximum impact equivalent stress(14.5%),and maximum total deformation(19.8%).This study provides a practical optimization approach for enhancing the comprehensive performance of the WHSV for improved UHM operation.
基金supported by Natural Science Foundation of Sichuan Province(Grants 2023NSFSC1839,2022NSFSC1290,China)the National Natural Science Foundation of China(Grant 22177083)+2 种基金the Sichuan University Postdoctoral Interdisciplinary Innovation Fund(JCXK2221,China)the Sichuan Science and Technology Program(2023NSFSC1688,China)the Full-time Postdoctoral Research and Development Fund of West China Hospital,Sichuan University(2023HXBH057,China)。
文摘Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases,especially tumours.Encouragingly,selective PPI-based therapeutic agents have been rapidly advancing over the past decade,providing promising perspectives for novel therapies for patients with cancer.In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects,focusing on PPIs in disease,drug design and discovery strategies,structure-activity relationships,inherent dilemmas,and future directions.
基金supported by the National Natural Science Foundation of China(52075192,52122502,and 52235001)China Coal Science and Technology Innovation and Entrepreneurship Fund(2019-TD-2-CXY005)A-class pilot of the Chinese Academy of Sciences(XDA22010303).
文摘With the enhancement of environmental protection awareness of the international community and the continuous promotion of green and sustainable development of manufacturing industry,water lubrication instead of mineral oil has become the future development trend due to its green,pollution-free,clean,safe,and sustainable advantages especially in ships,marine,coal mining,and other fields.In recent years,with the rapid development of water lubrication research,significant progress has been made in related research knowledge domain and discipline.A systematic and extensive assessment of water lubrication research has become increasingly important.The objective of this research is to reveal the research status,research hotspots,and development trends in the field of water lubrication.Therefore,CiteSpace was used to conduct a systematic bibliometric and scientometrical analysis of 1,792 publications from Web of Science core collection database(1997–2021).The results show that China and USA are the most productive countries in the field of water lubrication and have made outstanding contributions.Through the analysis of hot key words and co-citation references,this paper reviews the research status of water lubrication in three aspects:(1)lubricating medium modification;(2)material preparation;(3)surface optimization.It has become a research hotspot to promote the superlubricity contact interface and the application of nanotechnology.The results of this study can make a significant contribution to the development of water lubrication by providing a comprehensive understanding of the research status and research hotspots in this field.Personal understanding and discussion of research hotspots and research status are expected to provide insights into future research trends.In addition,this study will provide valuable references and guidelines for researchers who are interested in this field.
基金National Natural Science Foundation of China (Grant Nos.52122502,51879114,and 52075192).
文摘Balance valve is a core component of the 11000-meter manned submersible“struggle,”and its sealing performance is crucial and challenging when the maximum pressure difference is 118 MPa.The increasing sealing force improves the sealing performance and increases the system’s energy consumption at the same time.A hybrid analytical–numerical–experimental(ANE)model is proposed to obtain the minimum sealing force,ensuring no leakage at the valve port and reducing energy consumption as much as possible.The effects of roundness error,environmental pressure,and materials on the minimum sealing force are considered in the ANE model.The basic form of minimum sealing force equations is established,and the remaining unknown coefficients of the equations are obtained by the finite element method(FEM).The accuracy of the equation is evaluated by comparing the independent FEM data to the equation data.Results of the comparison show good agreement,and the difference between the independent FEM data and equation data is within 3%when the environmental pressure is 0–118 MPa.Finally,the minimum sealing force equation is applied in a balance valve to be experimented using a deep-sea simulation device.The balance valve designed through the minimum sealing force equation is leak-free in the experiment.Thus,the minimum sealing force equation is suitable for the ultrahigh pressure balance valve and has guiding significance for evaluating the sealing performance of ultrahigh pressure balance valves.
